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Full-Text Articles in COVID-19

Covid-19 Risk And Outcomes In Patients With Substance Use Disorders, Quangqiu Wang, David C. Kaelber, Rong Xu Sep 2020

Covid-19 Risk And Outcomes In Patients With Substance Use Disorders, Quangqiu Wang, David C. Kaelber, Rong Xu

Faculty Scholarship

The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US). Currently, there is limited data on risks, disparity, and outcomes for COVID-19 in individuals suffering from SUD. This is a retrospective case-control study of electronic health records (EHRs) data of 73,099,850 unique patients, of whom 12,030 had a diagnosis of COVID-19. Patients with a recent diagnosis of SUD (within past year) were at significantly increased risk for COVID-19 (adjusted odds ratio or AOR=8.699 [8.411–8.997], P<10−30), an effect that was strongest for individuals with OUD (AOR=10.244 [9.107–11.524], P<10−30), followed by individuals with tobacco use disorder (TUD) (AOR=8.222 ([7.925–8.530], P<10−30). Compared to patients without SUD, patients with SUD had significantly higher prevalence of chronic kidney, liver, lung diseases, cardiovascular diseases, type 2 diabetes, obesity and cancer. Among patients with recent diagnosis of SUD, African Americans had significantly higher risk of COVID-19 than Caucasians (AOR=2.173 [2.01–2.349], P<10−30), with strongest effect for OUD (AOR=4.162 [3.13–5.533], P<10−25). COVID-19 patients with SUD had significantly worse outcomes (death: 9.6%, hospitalization: 41.0%) than general COVID-19 patients (death: 6.6%, hospitalization: 30.1%) and African Americans with COVID-19 and SUD had worse outcomes (death: 13.0%, hospitalization: 50.7%) than Caucasians (death: 8.6%, hospitalization: 35.2%). These findings identify individuals with SUD, especially individuals with OUD and African Americans, as having increased risk for COVID-19 and its adverse outcomes, highlighting the need to screen and treat individuals with SUD as part of the strategy to control the pandemic while ensuring no disparities in access to healthcare support.


Can Lessons From The Covid-19 Pandemic Help Define A Strategy For Global Pediatric Radiology Education?, Jennifer Lynn Nicholas Sep 2020

Can Lessons From The Covid-19 Pandemic Help Define A Strategy For Global Pediatric Radiology Education?, Jennifer Lynn Nicholas

Faculty Scholarship

No abstract provided.


Quantifying The Decrease In Emergency Department Imaging Utilization During The Covid-19 Pandemic At A Multicenter Healthcare System In Ohio, Keval D. Parikh, Nikhil H. Ramaiya, Elias G. Kikano, Sree Harsha Tirumani, Jonathan Pierce, Carl Butcher, Jeffrey L. Sunshine, Donna M. Plecha Sep 2020

Quantifying The Decrease In Emergency Department Imaging Utilization During The Covid-19 Pandemic At A Multicenter Healthcare System In Ohio, Keval D. Parikh, Nikhil H. Ramaiya, Elias G. Kikano, Sree Harsha Tirumani, Jonathan Pierce, Carl Butcher, Jeffrey L. Sunshine, Donna M. Plecha

Faculty Scholarship

PURPOSE: To illustrate the change in emergency department (ED) imaging utilization at a multicenter health system in the state of Ohio during the COVID-19 pandemic. METHODS: A retrospective observational study was conducted assessing ED imaging volumes between March 1, 2020, and May 11, 2020, during the COVID-19 crisis. A rolling 7-day total value was used for volume tracking and comparison. Total imaging utilization in the ED was compared with new COVID-19 cases in our region. Utilization was first categorized by modality and then by plain films and computed tomography (CT) scans grouped by body part. CT imaging of the chest …


G-Csf And Gm-Csf Are Different. Which One Is Better For Covid-19?, Hillard M. Lazarus Aug 2020

G-Csf And Gm-Csf Are Different. Which One Is Better For Covid-19?, Hillard M. Lazarus

Faculty Scholarship

No abstract provided.


Comparison Of Abbott Id Now, Diasorin Simplexa, And Cdc Fda Emergency Use Authorization Methods For The Detection Of Sars-Cov-2 From Nasopharyngeal And Nasal Swabs From Individuals Diagnosed With Covid-19, Daniel D. Rhoads, Sree S. Cherian, Lisa M. Stempak, Christine L. Schmotzer, Navid Sadri Jul 2020

Comparison Of Abbott Id Now, Diasorin Simplexa, And Cdc Fda Emergency Use Authorization Methods For The Detection Of Sars-Cov-2 From Nasopharyngeal And Nasal Swabs From Individuals Diagnosed With Covid-19, Daniel D. Rhoads, Sree S. Cherian, Lisa M. Stempak, Christine L. Schmotzer, Navid Sadri

Faculty Scholarship

No abstract provided.


Cbt-Informed Interventions For Essential Workers During The Covid-19 Pandemic, Kathy Benhamou, Alexandra Piedra Jul 2020

Cbt-Informed Interventions For Essential Workers During The Covid-19 Pandemic, Kathy Benhamou, Alexandra Piedra

Student Scholarship

Essential workers during the COVID-19 pandemic face heightened levels of anxiety and depression due to increased work demands, lack of adequate personal protective equipment, fear of contracting the virus, and fear of spreading it to loved ones. This is a time of urgent need for mental health support for workers affected by the pandemic crisis. Clinicians may employ empirically supported interventions derived from cognitive behavioral therapy (CBT) and related therapies. Psychological First Aid, an evidence-based crisis intervention, may be utilized to emphasize basic needs and support, but is intended as an acute disaster intervention. Given that a pandemic is an …


Covid-19 Pandemic Impact On Decreased Imaging Utilization: A Single Institutional Experience, Keval D. Parikh, Nikhil H. Ramaiya, Elias G. Kikano, Sree Harsha Tirumani, Himanshu Pandya, Bart Stovicek, Jeffrey L. Sunshine, Donna M. Plecha Jul 2020

Covid-19 Pandemic Impact On Decreased Imaging Utilization: A Single Institutional Experience, Keval D. Parikh, Nikhil H. Ramaiya, Elias G. Kikano, Sree Harsha Tirumani, Himanshu Pandya, Bart Stovicek, Jeffrey L. Sunshine, Donna M. Plecha

Faculty Scholarship

RATIONALE AND OBJECTIVES: Predictive models and anecdotal articles suggest radiology practices were losing 50-70% of their normal imaging volume during the COVID-19 pandemic. Using actual institutional data, we investigated the change in imaging utilization and revenue during this public health crisis. MATERIALS AND METHODS: Imaging performed within the 8-week span between March 8-April 30, 2020 was categorized into the COVID-19 healthcare crisis timeframe. The first week of this date range and the 10 weeks prior were used to derive the normal practice expected volume. A rolling seven-day total value was used for volume tracking and comparison. Total imaging utilization was …


Should Asymptomatic And Low-Risk Individuals Be Tested For Sars-Cov-2?, Ashwini R. Sehgal Jun 2020

Should Asymptomatic And Low-Risk Individuals Be Tested For Sars-Cov-2?, Ashwini R. Sehgal

Faculty Scholarship

Because people with asymptomatic SARS-CoV-2 infections are an important source of transmission, widespread testing has the potential to identify and isolate such individuals, quarantine their contacts, and prevent further spread. However, testing for a condition in a group with low disease prevalence may lead to numerous false positive results. This study quantifies the tradeoff between reducing transmission by true positives and unnecessary isolation and quarantine due to false positives.


Class A G Protein-Coupled Receptor Antagonist Famotidine As A Therapeutic Alternative Against Sars-Cov2: An In Silico Analysis, Joseph Thomas Ortega, Beata Jastrzebska Jun 2020

Class A G Protein-Coupled Receptor Antagonist Famotidine As A Therapeutic Alternative Against Sars-Cov2: An In Silico Analysis, Joseph Thomas Ortega, Beata Jastrzebska

Faculty Scholarship

The pandemic associated with Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV2) and its disease named COVID-19 challenged the scientific community to discover effective therapeutic solutions in a short period. Repurposing existing drugs is one viable approach that emphasizes speed during these urgent times. Famotidine, a class A G protein-coupled receptor antagonist used for the treatment of gastroesophageal reflux was recently identified in an in silico screening. Additionally, a recent retrospective clinical report showed that the treatment with famotidine provided a good outcome in patients infected with SARS-CoV2. A clinical trial testing effectiveness of famotidine in combination with hydroxychloroquine is …


Covid-19: Launching Neurosurgery Into The Era Of Telehealth In The United States, Christina Huang Wright, James Wright, Berje Shammassian May 2020

Covid-19: Launching Neurosurgery Into The Era Of Telehealth In The United States, Christina Huang Wright, James Wright, Berje Shammassian

Faculty Scholarship

The authors discuss the implications of the COVID-19 pandemic on the use of telehealth in the United States.


Antibody Testing For Covid-19: Can It Be Used As A Screening Tool In Areas With Low Prevalence?, Sweta Mathur May 2020

Antibody Testing For Covid-19: Can It Be Used As A Screening Tool In Areas With Low Prevalence?, Sweta Mathur

Faculty Scholarship

No abstract provided.


Steam Treatment For Rapid Decontamination Of N95 Respirators And Medical Face Masks, Sarah N. Redmond, Lucas D. Jones, Curtis J. Donskey May 2020

Steam Treatment For Rapid Decontamination Of N95 Respirators And Medical Face Masks, Sarah N. Redmond, Lucas D. Jones, Curtis J. Donskey

Faculty Scholarship

No abstract provided.


Management Of Patients With Cerebellar Ataxia During The Covid-19 Pandemic, Aasef G. Shaikh May 2020

Management Of Patients With Cerebellar Ataxia During The Covid-19 Pandemic, Aasef G. Shaikh

Faculty Scholarship

The current worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that causes coronavirus disease 2019 (COVID-19) has brought some medical systems to the brink of collapse. This crisis is also negatively impacting the care of patients with non-COVID-19 conditions, including those with cerebellar ataxia (CA). Older patients with CA and those with immune-mediated ataxias on immunosuppressive medication are potentially at high risk of developing serious complications of the infection, although it is also possible that immunosuppressive agents may provide a defense against cytokine storm. This has implications for even greater attention to preventing contracting the disease through physical distancing …


Flattening The Curve In Covid-19 Using Personalised Protective Equipment: Lessons From Air Pollution, Sanjay Rajagopalan May 2020

Flattening The Curve In Covid-19 Using Personalised Protective Equipment: Lessons From Air Pollution, Sanjay Rajagopalan

Faculty Scholarship

No abstract provided.


Aga Institute Rapid Review Of The Gi And Liver Manifestations Of Covid-19, Meta-Analysis Of International Data, And Recommendations For The Consultative Management Of Patients With Covid-19, Perica Davitkov, Yngve Falck-Ytter May 2020

Aga Institute Rapid Review Of The Gi And Liver Manifestations Of Covid-19, Meta-Analysis Of International Data, And Recommendations For The Consultative Management Of Patients With Covid-19, Perica Davitkov, Yngve Falck-Ytter

Faculty Scholarship

Background & aims: Multiple gastrointestinal (GI) symptoms, including diarrhea, nausea/vomiting, and abdominal pain, as well as liver enzyme abnormalities, have been variably reported in patients with coronavirus disease 2019 (COVID-19). This document provides best practice statements and recommendations for consultative management based on a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19. Methods: We performed a systematic literature search to identify published and unpublished studies using OVID Medline and preprint servers (medRxiv, LitCovid, and SSRN) up until April 5, 2020; major journal sites were monitored for US publications until April 19, 2020. We pooled …


Adapting To Uncertainty: Nursing Responsiveness To Covid-19, Scott Emory Moore May 2020

Adapting To Uncertainty: Nursing Responsiveness To Covid-19, Scott Emory Moore

Faculty Scholarship

No abstract provided.


Changes In Gastroenterology And Endoscopy Practices In Response To The Covid-19 Pandemic: Results From A North American Survey, Zachary L. Smith May 2020

Changes In Gastroenterology And Endoscopy Practices In Response To The Covid-19 Pandemic: Results From A North American Survey, Zachary L. Smith

Faculty Scholarship

Digestive manifestations appear to be common in patients with coronavirus disease 2019 (COVID19). Gastroenterologists will invariably come into contact with infected patients, and the risk of intraprocedural exposure is well established. Recommendations have been issued to guide personal protective equipment (PPE) use and the triage of procedural urgency, among other operational considerations. In response, institutions providing gastroenterology and endoscopy services have taken urgent action to protect patients and staff, but the uptake and extent of these practice changes in North America is unknown. We conducted a survey of gastroenterology and endoscopy practices to assess the response to the COVID-19 pandemic …


Effectiveness Of Ultraviolet-C Light And A High-Level Disinfection Cabinet For Decontamination Of N95 Respirators, Curtis J. Donskey May 2020

Effectiveness Of Ultraviolet-C Light And A High-Level Disinfection Cabinet For Decontamination Of N95 Respirators, Curtis J. Donskey

Faculty Scholarship

Background: Shortages of personal protective equipment (PPE) including N95 respirators are an urgent concern in the setting of the global COVID-19 pandemic. Decontamination of PPE could be useful to maintain adequate supplies, but there is uncertainty regarding the efficacy of decontamination technologies. Methods: A modification of the American Society for Testing and Materials standard quantitative carrier disk test method (ASTM E-2197-11) was used to examine the effectiveness of 3 methods, including ultraviolet-C (UV-C) light, a high-level disinfection cabinet that generates aerosolized peracetic acid and hydrogen peroxide, and dry heat at 70°C for 30 minutes. We assessed the decontamination of 3 …


Head And Neck Survivorship Care In The Times Of The Sars-Cov-2 Pandemic, Victoria Huang May 2020

Head And Neck Survivorship Care In The Times Of The Sars-Cov-2 Pandemic, Victoria Huang

Faculty Scholarship

With the arrival of the coronavirus disease (SARS-CoV-2) in the United States, care practice paradigms have drastically changed. Data from China suggest that the new virus poses additional risks as case fatality of patients with cancer was higher at 5.6% compared to 2.3% of the general population. There are three proposed major strategies to address care for patients with cancer in this SARS-CoV-2 pandemic with postponing treatment for those with stable cancer, increasing personal protection provisions for patients with cancer, and increasing monitoring if a patient becomes infected with SARS-CoV-2. In this present commentary, we discuss the unique mental health …


How Big Data And Artificial Intelligence Can Help Better Manage The Covid-19 Pandemic, Giovanni Damiani May 2020

How Big Data And Artificial Intelligence Can Help Better Manage The Covid-19 Pandemic, Giovanni Damiani

Faculty Scholarship

SARS-CoV2 is a novel coronavirus, responsible for the COVID-19 pandemic declared by the World Health Organization. Thanks to the latest advancements in the field of molecular and computational techniques and information and communication technologies (ICTs), artificial intelligence (AI) and Big Data can help in handling the huge, unprecedented amount of data derived from public health surveillance, real-time epidemic outbreaks monitoring, trend now-casting/forecasting, regular situation briefing and updating from governmental institutions and organisms, and health facility utilization information. The present review is aimed at overviewing the potential applications of AI and Big Data in the global effort to manage the pandemic. …


Physical Distancing With Social Connectedness, Kurt C. Stange May 2020

Physical Distancing With Social Connectedness, Kurt C. Stange

Faculty Scholarship

In light of concerns over the potential detrimental effects of declining care continuity, and the need for connection between patients and health care providers, our multidisciplinary group considered the possible ways that relationships might be developed in different kinds of health care encounters.We were surprised to discover many avenues to invest in relationships, even in non-continuity consultations, and how meaningful human connections might be developed even in telehealth visits. Opportunities range from the quality of attention or the structure of the time during the visit, to supporting relationship development in how care is organized at the local or system level …


Anticoagulation In Covid-19, Bassam Atallah Apr 2020

Anticoagulation In Covid-19, Bassam Atallah

Faculty Scholarship

No abstract provided.


Geospatial Analysis Of Covid-19 And Otolaryngologists Above Age 60, Jeremy S. Ruthberg, Humzah A. Quereshy, Tarun K. Jella, Brian D'Anza, Nicole Maronian, Todd D. Otteson Apr 2020

Geospatial Analysis Of Covid-19 And Otolaryngologists Above Age 60, Jeremy S. Ruthberg, Humzah A. Quereshy, Tarun K. Jella, Brian D'Anza, Nicole Maronian, Todd D. Otteson

Faculty Scholarship

Objective: The 2019 novel coronavirus (COVID-19) is disproportionately impacting older individuals and healthcare workers. Otolaryngologists are especially susceptible with the elevated risk of aerosolization and corresponding high viral loads. This study utilizes a geospatial analysis to illustrate the comparative risks of older otolaryngologists across the United States during the COVID-19 pandemic. Methods and materials: Demographic and state population data were extracted from the State Physician Workforce Reports published by the AAMC for the year 2018. A geospatial heat map of the United States was then constructed to illustrate the location of COVID-19 confirmed case counts and the distributions of ENTs …


A Marker Of Systemic Inflammation Or Direct Cardiac Injury: Should Cardiac Troponin Levels Be Monitored In Covid-19 Patients?, Bassam Atallah Apr 2020

A Marker Of Systemic Inflammation Or Direct Cardiac Injury: Should Cardiac Troponin Levels Be Monitored In Covid-19 Patients?, Bassam Atallah

Faculty Scholarship

No abstract provided.


Sars-Cov-2 Infection In A Patient On Chronic Hydroxychloroquine Therapy: Implications For Prophylaxis, Khalid M. Dousa, Sharad S. Malavade, Jennifer Furin, Barbara Gripshover, Marjorie Hatszegi, Leila Hojat, Elie Saade, Robert A. Salata Apr 2020

Sars-Cov-2 Infection In A Patient On Chronic Hydroxychloroquine Therapy: Implications For Prophylaxis, Khalid M. Dousa, Sharad S. Malavade, Jennifer Furin, Barbara Gripshover, Marjorie Hatszegi, Leila Hojat, Elie Saade, Robert A. Salata

Faculty Scholarship

People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy.


Infectious Diseases Society Of America Guidelines On The Treatment And Management Of Patients With Covid-19, Amy Hirsch, Yngve Falck-Ytter Apr 2020

Infectious Diseases Society Of America Guidelines On The Treatment And Management Of Patients With Covid-19, Amy Hirsch, Yngve Falck-Ytter

Faculty Scholarship

Background: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. Objective: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. Methods: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and …


It's Not The Heat, It's The Humidity: Effectiveness Of A Rice Cooker-Steamer For Decontamination Of Cloth And Surgical Face Masks And N95 Respirators, Sarah N. Redmond, Lucas D. Jones, Curtis J. Donskey Apr 2020

It's Not The Heat, It's The Humidity: Effectiveness Of A Rice Cooker-Steamer For Decontamination Of Cloth And Surgical Face Masks And N95 Respirators, Sarah N. Redmond, Lucas D. Jones, Curtis J. Donskey

Faculty Scholarship

No abstract provided.


What Constitutes Urgent Endoscopy? A Social Media Snapshot Of Gastroenterologists' Views During The Covid-19 Pandemic, Zachary L. Smith Apr 2020

What Constitutes Urgent Endoscopy? A Social Media Snapshot Of Gastroenterologists' Views During The Covid-19 Pandemic, Zachary L. Smith

Faculty Scholarship

Background and study aims: There is a consensus among gastroenterology organizations that elective endoscopic procedures should be deferred during the COVID-19 pandemic. While the decision to perform urgent procedures and to defer entirely elective procedures is mostly evident, there is a wide "middle ground" of time-sensitive but not technically urgent or emergent endoscopic interventions. We aimed to survey gastroenterologists worldwide using Twitter to help elucidate these definitions using commonly encountered clinical scenarios during the COVID-19 pandemic. Methods: A 16-question survey was designed by the authors to include common clinical scenarios that do not have clear guidelines regarding the timing or …


Virtual Visits For Care Of Patients With Heart Failure In The Era Of Covid-19: A Statement From The Heart Failure Society Of America, Eiran Z. Gorodeski Apr 2020

Virtual Visits For Care Of Patients With Heart Failure In The Era Of Covid-19: A Statement From The Heart Failure Society Of America, Eiran Z. Gorodeski

Faculty Scholarship

In response to the COVID-19 pandemic, US federal and state governments have implemented wide-ranging stay-at-home recommendations as a means to reduce spread of infection. As a consequence, many US healthcare systems and practices have curtailed ambulatory clinic visits—pillars of care for patients with heart failure (HF). In this context, synchronous audio/video interactions, also known as virtual visits (VVs), have emerged as an innovative and necessary alternative. This scientific statement outlines the benefits and challenges of VVs, enumerates changes in policy and reimbursement that have increased the feasibility of VVs during the COVID-19 era, describes platforms and models of care for …


Practice Recommendations For Lung Cancer Radiotherapy During The Covid-19 Pandemic: An Estro-Astro Consensus Statement, Gregory Videtic Apr 2020

Practice Recommendations For Lung Cancer Radiotherapy During The Covid-19 Pandemic: An Estro-Astro Consensus Statement, Gregory Videtic

Faculty Scholarship

Background: The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients and healthcare staff. An international group of experts in lung cancer radiotherapy established this practice recommendation pertaining to whether and how to adapt radiotherapy for lung cancer in the COVID-19 pandemic. Methods: For this ESTRO & ASTRO endorsed project, 32 experts in lung cancer radiotherapy contributed to a modified Delphi consensus process. We assessed potential adaptations of radiotherapy in two pandemic scenarios. The first, an early pandemic scenario of risk mitigation, is characterized by an altered risk-benefit ratio of radiotherapy for lung …