Clinical Epidemiology Commons^™

Exploring The Impact Of Adverse Childhood Experiences On Preventive Healthcare Utilization In Rural Georgia, Ryan R. Traylor

College of Graduate Studies: Theses & Dissertations

This study examines the relationship between Adverse Childhood Experiences (ACEs) and preventive healthcare use among adults in Georgia, specifically within rural populations facing structural barriers. Using 2023 Georgia Behavioral Risk Factor Surveillance System (BRFSS) data, the research analyzes associations between ACE exposure, rural residence, and preventive care outcomes, including physical exams and flu vaccinations. Guided by an intersectionally adapted version of Andersen’s Behavioral Model of Health Services Use, the study evaluates how predisposing factors, enabling resources, and perceived barriers relate to healthcare engagement. Logistic regression analyses assess the correlation of ACE exposure, cost barriers, provider access, and sociodemographics with preventive …

Safety Constraint Optimization Of Combination Drug Therapy In Hypertension Clinical Trials, Victor Chukwu

College of Graduate Studies: Theses & Dissertations

In Clinical Practice, combination drug therapy has become common in treating many disease conditions. The purpose of these combinations is often to ensure optimal efficacy and to reduce adverse effects that may arise from monotherapy. Clinical trials have also been conducted to ensure efficacy and safety of these combinations before they are introduced into the market. However, adverse effects still occur with combination therapies. The objective of this study is to (1) To determine a region of optimum doses of Drug A and Drug B in combination while focusing on efficacy alone (2) To determine a region of optimum doses …

Improving The Inference Of Some Experiemtal Studies By Using Ranked Auxiliary Covariates, Rajai Jabrah

College of Graduate Studies: Theses & Dissertations

In many studies, the measurement of sampling units according to the response variable is costly or time consuming, however, it is possible to rank sampling units according to baseline auxiliary covariates, which are available, easily obtainable, and cost efficient. In these cases, when estimating the population mean, Ranked Set Sampling (RSS) can be a more efficient sampling method than the Simple Random Sampling (SRS) method. In this dissertation, we propose a modified approach of the RSS method to allocate units into an experimental study, aimed to compare two or more groups.

Ranked auxiliary covariates, which are typically correlated with the …