Public Health Commons^™

Cardiovascular Outcomes In Patients With Chronic Kidney Disease And Covid-19: A Multi-Regional Data-Linkage Study, Emilie J Lambourg, Peter J Gallacher, Robert W Hunter, Moneeza Siddiqui, Eve Miller-Hodges, James D Chalmers, Dan Pugh, Neeraj Dhaun, Samira Bell

Faculty, Staff and Student Publications

BACKGROUND: Data describing cardiovascular outcomes in patients with coronavirus disease 2019 (COVID-19) and chronic kidney disease (CKD) are lacking. We compared cardiovascular outcomes of patients with and without COVID-19, stratified by CKD status.

METHODS: This retrospective, multi-regional data-linkage study utilised individual patient-level data from two Scottish cohorts. All patients tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Cohort 1 between 1 February 2020 and 31 March 2021 and in Cohort 2 between 28 February 2020 and 8 February 2021 were included.

RESULTS: Overall, 86 964 patients were tested for SARS-CoV-2. There were 36 904 patients (mean±sd age 61±21 …

Usefulness Of A Perfusion Balloon For Intraprocedural Stent Thrombosis In A Patient With St-Segment Elevated Myocardial Infarction Complicated With Cardiogenic Shock, Taro Takeyama, Yukiko Mizutani, Tetsuya Ishikawa, Kota Yamada, Hidehiko Nakamura, Shiro Nakahara, Isao Taguchi

The Texas Heart Institute Journal

Intraprocedural stent thrombosis is a rare but serious complication of reperfusion therapy for acute coronary syndrome. There is currently no consensus on the intraprocedural management of intraprocedural stent thrombosis. It is difficult to attain thrombolysis in myocardial infarction flow grade 3, particularly in cases of cardiogenic shock. A 49-year-old man who presented with anterior ST-segment elevated acute myocardial infarction with cardiogenic shock underwent emergency percutaneous coronary intervention to diffuse proximal lesions in the left anterior descending artery under the support of intra-aortic balloon pumping. Intraprocedural stent thrombosis occurred following the postdilations with a 3.5- × 38-mm everolimus-eluting stent. Despite administration …

Loneliness And Alcohol-Related Problems Among College Students Who Report Binge Drinking Behavior: The Moderating Role Of Food And Alcohol Disturbance, Luke Herchenroeder, Stacy M Post, Michelle L Stock, Ellen W Yeung

Faculty, Staff and Student Publications

Loneliness and alcohol misuse are common among college students and pose a threat to public health. To better understand the longitudinal association between these public health concerns we examined food and alcohol disturbance (FAD; i.e., restricting one's caloric intake prior to drinking) as a moderator in the association between loneliness and alcohol-related problems. Participants were 456 college students from a mid-sized university who engaged in past 30-day binge drinking. The majority of participants identified as being White (67.1%), female (78.1%), and reported a mean age of 19.61 (SD = 1.54) years. Participants completed two surveys (3 weeks apart) over the …

The Impact Of Covid-19 On Opioid-Related Overdose Deaths In Texas, Karima Lalani, Christine Bakos-Block, Marylou Cardenas-Turanzas, Sarah Cohen, Bhanumathi Gopal, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Prior to the COVID-19 pandemic, the United States was facing an epidemic of opioid overdose deaths, clouding accurate inferences about the impact of the pandemic at the population level. We sought to determine the existence of increases in the trends of opioid-related overdose (ORO) deaths in the Greater Houston metropolitan area from January 2015 through December 2021, and to describe the social vulnerability present in the geographic location of these deaths. We merged records from the county medical examiner's office with social vulnerability indexes (SVIs) for the region and present geospatial locations of the aggregated ORO deaths. Time series analyses …

Prevalence Of Prediabetes And Diabetes Vary By Ethnicity Among Us Asian Adults At Healthy Weight, Overweight, And Obesity Ranges: An Electronic Health Record Study, William S Vicks, Joan C Lo, Lynn Guo, Jamal S Rana, Sherry Zhang, Nirmala D Ramalingam, Nancy P Gordon

Faculty, Staff and Student Publications

BACKGROUND: Asian adults develop Type 2 diabetes at a lower body mass index (BMI) compared to other racial/ethnic groups. We examined the variation in prevalence of prediabetes and diabetes among Asian ethnic groups within weight strata by comparing middle-aged Chinese, Filipino, South Asian, and White adults receiving care in the same integrated healthcare delivery system.

METHODS: Our retrospective cross-sectional U.S. study examined data from 283,110 (non-Hispanic) White, 33,263 Chinese, 38,766 Filipino, and 17,959 South Asian adults aged 45-64 years who were members of a Northern California health plan in 2016 and had measured height and weight. Prediabetes and diabetes were …

Association Of Mrna Vaccination With Clinical And Virologic Features Of Covid-19 Among Us Essential And Frontline Workers, The Heroes-Recover Network, Mark G Thompson, Sarang K Yoon, Allison L Naleway, Jennifer Meece, Thomas P Fabrizio, Alberto J Caban-Martinez, Jefferey L Burgess, Manjusha Gaglani, Lauren E W Olsho, Allen Bateman, Jessica Lundgren, Lauren Grant, Andrew L Phillips, Holly C Groom, Elisha Stefanski, Natasha Schaefer Solle, Katherine Ellingson, Karen Lutrick, Kayan Dunnigan, Meredith G Wesley, Kyley Guenther, Angela Hunt, Josephine Mak, Kurt T Hegmann, Jennifer L Kuntz, Adam Bissonnette, James Hollister, Spencer Rose, Tyler C Morrill, Karley Respet, Ashley L Fowlkes, Matthew S Thiese, Patrick Rivers, Meghan K Herring, Marilyn J Odean, Young M Yoo, Matthew Brunner, Edward J Bedrick, Deanna E Fleary, John T Jones, Jenna Praggastis, James Romine, Monica Dickerson, Sana M Khan, Julie Mayo Lamberte, Shawn Beitel, Richard J Webby, Harmony L Tyner

Faculty, Staff and Student Publications

IMPORTANCE: Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance.

OBJECTIVE: To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages.

DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infection confirmed by reverse transcriptase-polymerase chain reaction testing and lineage classified by whole genome sequencing of specimens self-collected weekly and at COVID-19 illness symptom onset. This analysis was conducted among 1199 participants with SARS-CoV-2 …

Measurement Of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens In Plasma Of Pediatric Patients With Acute Coronavirus Disease 2019 Or Multisystem Inflammatory Syndrome In Children Using An Ultrasensitive And Quantitative Immunoassay, George B Sigal, Tanya Novak, Anu Mathew, Janet Chou, Yubo Zhang, Navaratnam Manjula, Pradeepthi Bathala, Jessica Joe, Nikhil Padmanabhan, Daniel Romero, Gabriella Allegri-Machado, Jill Joerger, Laura L Loftis, Stephanie P Schwartz, Tracie C Walker, Julie C Fitzgerald, Keiko M Tarquinio, Matt S Zinter, Jennifer E Schuster, Natasha B Halasa, Melissa L Cullimore, Aline B Maddux, Mary A Staat, Katherine Irby, Heidi R Flori, Bria M Coates, Hillary Crandall, Shira J Gertz, Adrienne G Randolph, Nira R Pollock, Overcoming Covid-19 Investigators

Center for Medical Ethics and Health Policy Staff Publications

Background: Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood has high sensitivity in adults with acute coronavirus disease 2019 (COVID-19), but sensitivity in pediatric patients is unclear. Recent data suggest that persistent SARS-CoV-2 spike antigenemia may contribute to multisystem inflammatory syndrome in children (MIS-C). We quantified SARS-CoV-2 nucleocapsid (N) and spike (S) antigens in blood of pediatric patients with either acute COVID-19 or MIS-C using ultrasensitive immunoassays (Meso Scale Discovery).

Methods: Plasma was collected from inpatients (< 21 years) enrolled across 15 hospitals in 15 US states. Acute COVID-19 patients (n = 36) had a range of disease severity and positive nasopharyngeal SARS-CoV-2 RT-PCR within 24 hours of blood collection. Patients with MIS-C (n = 53) met CDC criteria and tested positive for SARS-CoV-2 (RT-PCR or serology). Controls were patients pre-COVID-19 (n = 67) or within 24 hours of negative RT-PCR (n = 43).

Results: Specificities of N and S assays were 95-97% and 100%, respectively. In acute COVID-19 patients, N/S plasma assays …

The Association Of Baseline Plasma Sars-Cov-2 Nucleocapsid Antigen Level And Outcomes In Patients Hospitalized With Covid-19, Activ-3/Tico Study Group, Angela J Rogers, Deborah Wentworth, Andrew Phillips, Katy Shaw-Saliba, Robin L Dewar, Neil R Aggarwal, Abdel G Babiker, Weizhong Chang, Nila J Dharan, Victoria J Davey, Elizabeth S Higgs, Norman Gerry, Adit A Ginde, J W Awori Hayanga, Helene Highbarger, Jeroen L Highbarger, Mamta K Jain, Virginia Kan, Kami Kim, Perrine Lallemand, Bradley G Leshnower, Joseph K Lutaakome, Gail Matthews, Ahmad Mourad, Eleftherios Mylonakis, Ven Natarajan, Maria L Padilla, Lavannya M Pandit, Roger Paredes, Sarah Pett, Srikanth Ramachandruni, M Tauseef Rehman, Brad T Sherman, D Clark Files, Samuel M Brown, Michael A Matthay, B Taylor Thompson, James D Neaton, H Clifford Lane, Jens D Lundgren

Faculty, Staff and Students Publications

BACKGROUND: Levels of plasma SARS-CoV-2 nucleocapsid (N) antigen may be an important biomarker in patients with COVID-19 and enhance our understanding of the pathogenesis of COVID-19.

OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral factors associated with plasma antigen levels in hospitalized patients with SARS-CoV-2.

DESIGN: Cross-sectional study of baseline plasma antigen level from 2540 participants enrolled in the TICO (Therapeutics for Inpatients With COVID-19) platform trial from August 2020 to November 2021, with additional data on day 5 outcome and time to discharge.

SETTING: 114 centers in 10 countries. …

Relationship Between Preexisting Cardiovascular Disease And Death And Cardiovascular Outcomes In Critically Ill Patients With Covid-19, Alexi Vasbinder, Chelsea Meloche, Tariq U Azam, Elizabeth Anderson, Tonimarie Catalan, Husam Shadid, Hanna Berlin, Michael Pan, Patrick O'Hayer, Kishan Padalia, Pennelope Blakely, Ibrahim Khaleel, Erinleigh Michaud, Yiyuan Huang, Lili Zhao, Rodica Pop-Busui, Shruti Gupta, Kim Eagle, David E Leaf, Salim S Hayek

Faculty, Staff and Student Publications

BACKGROUND: Preexisting cardiovascular disease (CVD) is perceived as a risk factor for poor outcomes in patients with COVID-19. We sought to determine whether CVD is associated with in-hospital death and cardiovascular events in critically ill patients with COVID-19.

METHODS: This study used data from a multicenter cohort of adults with laboratory-confirmed COVID-19 admitted to intensive care units at 68 centers across the United States from March 1 to July 1, 2020. The primary exposure was CVD, defined as preexisting coronary artery disease, congestive heart failure, or atrial fibrillation/flutter. Myocardial injury on intensive care unit admission defined as a troponin I …

Chronic Illness Education 2022: Reducing Modifiable Risk Factors For Cardiovascular Disease, David Asebiode, Francis Lauzier, Jonathan Lutchka, Megan Rasaiah, Min Yi Wu, Sanjana Rao

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Heart Health: It Starts Now, Heba Osman, Alejandro Ponce Sepulveda, Doo Hee Kim, Enoch Kim, Lauren Larson, Sadie Knill, Shagane Kotcharian

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Obesity Awareness In Adults, Tyler Mumm, Daniel Kim, Jacob Katzman, Liana De La Torre, Mariam Samir, Parker Marsh, Pragathi Pathanjeli

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Chronic Kidney Disease Prevention In Patients With Hypertension And Diabetes., Ruchi Mangal, Lara Zraik, Nicolas Baroni, Sara Ma, Tulsi Sadasivan, Wouter Ritsema

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Adult Obesity Intervention Within Detroit Community, Dhruvil Patel, Andrew Kirmse, Andrew Mizerowski, Bethani Dunlap, Jacob Sullivan, Nicole Naidoo, Shirley Elfishawy

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Wound Care Vigilance In Adult Diabetic Patients With Neuropathy, Gowri Chandrashekar, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Reducing The Stigma Of Hiv In Southeast Michigan, Ruchi Mangal, Alex Rodriguez, David Greiver, Johan Harris, Kathy Lu, Minisha Kanakarajan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Addressing Common Causes Of Hypertension In The Detroit Adult Population, Kassandra Solrud, Crisshy Auguste, Kayvon Sanjasaz, Matthew Zabat, Rana Khamis, Soham Desai, Zeynoire Anderson

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Diabetes Mellitus Education For Adults In Southeast Michigan, Muhammad Ahmed, Ahmad Kofahi, Caleb Richard, Hadi El Ammar, Huda Warsame, Janice Gibbons, Jodene Takahashi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Hypertension In Adults, Ahmad El-Moussa, Bhavana Garapati, Jhonny Lopez, Mariam Abdelmesih, Matthew Hansen, Omar Abbas, Shreya Balusu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Adult Hiv Prevention, Screening, And Treatment, Mohamad Almujarkesh, Lillian Baumann, Michael Escobar, Michael Melhem, Nicholas Pryde, Quynh Nguyen (Liu), Victoria Kelley

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Heart Disease: Ways Of Combating The Silent Killer, Amer Tamr, Alexander Wind, Alexandra Breves, Brandon Holland, Coltrane Groves, Mina Juma, Sydney Colbert

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Food Choices Made Easy: Eating Well With Ckd, Arqam Husain, Amir Kalantar, Ismail Aijazuddin, Nada Jaradat, Raisa Zahir, Rubab Imtiaz, Tristan Papcun

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Managing Chronic Kidney Disease With Exercise, Kelsey Trulik, Adlai Nelson, Arsh Kaiser, Chelsea Yu, Collin Gustafson, Erin Madden, Matthew Myhand

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Prevention Of High Blood Pressure In Adult Populations, Gabrielle Barthel, Allison Boland, Alyssa Dsouza, Hassan Ahmad, Nicholas Zura, Samuel Grand, Sreenavya Gandikota

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Chronic Obstructive Pulmonary Disease, Teresa Alfauhernandez, Ajith Dupati, Daniel Settecerri, Elsa Nylund, Leah Warren, Unie Gu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: A Recipe For Healthy Living, Awad Maria, Andrew Gregory, Andrew Rabah, Kia Sweeney, Laura Aravena, Nicholas Livingston, Tabassum Chowdhury

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Education About Depression And Anxiety Among Middle Aged Men, Rebecca White, Amanda Paskavitz, Andrew Demko, Christelle Wharram, Eli Tanenbaum, Jennifer Schmidt, Justin Bennie

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Improving Support For Young Adult Women Suffering From Suicidal Ideation, Rebecca White, Colt Maccaughan, Cristian Diaz Alvarenga, Hannah Michelakis, Samuel Goorman, Soumeeka Koneru, Victoria Qian

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Type Ii Diabetes Management In Adults: Medications And Community Resources, Varag Abed, Camila Arellano, Carolyn Baldwin, Ethan Ervin, Haya Beydoun, Mahnoor Ayub, Yoshio Wagner

Patient Education Projects

No abstract provided.