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Articles 601 - 630 of 1109

Full-Text Articles in Public Health

Chronic Illness Education 2023: Analyzing Effective And In-Effective Treatment Options For Physicians In Training With Anxiety And Depression., Sophia Gandarillas, Cyra Kharas, Robert Leone, Mihika Sridhar, Kishwar Basith Sep 2023

Chronic Illness Education 2023: Analyzing Effective And In-Effective Treatment Options For Physicians In Training With Anxiety And Depression., Sophia Gandarillas, Cyra Kharas, Robert Leone, Mihika Sridhar, Kishwar Basith

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Prevalence Of Anxiety In First And Second-Generation American Medical Students, Cyrus Amirfazli, Nina Brahmbhatt, Adam Chaban, Aminah Fayyaz, Karina Haleblian, Ajay Pradhan, Kishwar Basith Sep 2023

Chronic Illness Education 2023: Prevalence Of Anxiety In First And Second-Generation American Medical Students, Cyrus Amirfazli, Nina Brahmbhatt, Adam Chaban, Aminah Fayyaz, Karina Haleblian, Ajay Pradhan, Kishwar Basith

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Managing Cholesterol, Gabriella Gonzales, Leane Kuo, Tannia M. Rodriguez, Anah Nicolai, Mitchell Wu, Michelle Malik Sep 2023

Chronic Illness Education 2023: Managing Cholesterol, Gabriella Gonzales, Leane Kuo, Tannia M. Rodriguez, Anah Nicolai, Mitchell Wu, Michelle Malik

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Deciphering Food Labels, Paige Awtrey, Jessica Elderkin, Hajirah Farah, Dylan Kato, Michael Salloum, Jack Visser, George Kidess Sep 2023

Chronic Illness Education 2023: Deciphering Food Labels, Paige Awtrey, Jessica Elderkin, Hajirah Farah, Dylan Kato, Michael Salloum, Jack Visser, George Kidess

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Prevention And Treatment Of Cardiovascular Disease Amid Food Insecurity In Southeast Michigan, Kirsten Brinkmeier, John Gallagher, Hovhannes Hayrapetyan, Nasser Junedi, Julia Malewicz, Alisha Williams Sep 2023

Chronic Illness Education 2023: Prevention And Treatment Of Cardiovascular Disease Amid Food Insecurity In Southeast Michigan, Kirsten Brinkmeier, John Gallagher, Hovhannes Hayrapetyan, Nasser Junedi, Julia Malewicz, Alisha Williams

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Healthy Heart Habits For Kids, Chase Aaron, Jane Dow, Max Jones, Karamoja Monchamp, Ingrid Rocha, Arhan Shetty, Kelsey Gockman Sep 2023

Chronic Illness Education 2023: Healthy Heart Habits For Kids, Chase Aaron, Jane Dow, Max Jones, Karamoja Monchamp, Ingrid Rocha, Arhan Shetty, Kelsey Gockman

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Adult Obesity & Sedentary Lifestyle In Detroit, Lisa Doan, Kimera Harris, Cornelius Lau, Hani Nasr, Ciara White, Pooja Polamarasetti Sep 2023

Chronic Illness Education 2023: Adult Obesity & Sedentary Lifestyle In Detroit, Lisa Doan, Kimera Harris, Cornelius Lau, Hani Nasr, Ciara White, Pooja Polamarasetti

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Increasing Nutritional Literacy For Adults Living With Type Ii Diabetes In Detroit, Mi, Morolayo Ilori, Katherine Gavagan, Izma Khaliq, Srikanth Pillai, Nabeel Sumbal, Derya Turk, Zechariah Jean Sep 2023

Chronic Illness Education 2023: Increasing Nutritional Literacy For Adults Living With Type Ii Diabetes In Detroit, Mi, Morolayo Ilori, Katherine Gavagan, Izma Khaliq, Srikanth Pillai, Nabeel Sumbal, Derya Turk, Zechariah Jean

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Simplifying Treatment Options For Type Ii Diabetes Mellitus, Mura Abdul-Nabi, Lukas Biel, Nitya Deshpande, Melissa Elmali, Joseph Mccormick, Emily Smith, Matthew Corsi Sep 2023

Chronic Illness Education 2023: Simplifying Treatment Options For Type Ii Diabetes Mellitus, Mura Abdul-Nabi, Lukas Biel, Nitya Deshpande, Melissa Elmali, Joseph Mccormick, Emily Smith, Matthew Corsi

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Diabetes Management In Arab American Communities With Middle Eastern Cuisine, Neeti Gandra, Uzair Khan, Christopher Rittle, Nora Sharba, Josiah Stryd, Gretchen Swift, Kinan Sawar Sep 2023

Chronic Illness Education 2023: Diabetes Management In Arab American Communities With Middle Eastern Cuisine, Neeti Gandra, Uzair Khan, Christopher Rittle, Nora Sharba, Josiah Stryd, Gretchen Swift, Kinan Sawar

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Implications Of Uncontrolled Type Ii Diabetes On Healthspan And Strategies Of Prevention, Chanel Harvey, Brian Hughes, Neeraj Ochaney, Aalia Siddiqui, Anna Zhao, Anneliese Rademacher Sep 2023

Chronic Illness Education 2023: Implications Of Uncontrolled Type Ii Diabetes On Healthspan And Strategies Of Prevention, Chanel Harvey, Brian Hughes, Neeraj Ochaney, Aalia Siddiqui, Anna Zhao, Anneliese Rademacher

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: A Comprehensive Survey To Follow-Up With Young Individuals Recently Diagnosed With Hiv, Brock Bradley, Pranally Desai, Nathan Li, Eve Sherbin, Jeremy Taigman, Zachary Vaishampayan Sep 2023

Chronic Illness Education 2023: A Comprehensive Survey To Follow-Up With Young Individuals Recently Diagnosed With Hiv, Brock Bradley, Pranally Desai, Nathan Li, Eve Sherbin, Jeremy Taigman, Zachary Vaishampayan

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Five Easy Ways To Stick To Your Perinatal Hiv Treatment Plan, Simran Brar, Gabrielle Cowen, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Kassim Salami, Zachary Vaishampayan Sep 2023

Chronic Illness Education 2023: Five Easy Ways To Stick To Your Perinatal Hiv Treatment Plan, Simran Brar, Gabrielle Cowen, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Kassim Salami, Zachary Vaishampayan

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Don’T Be Salty About Ckd: How To Watch Your Sodium Intake, Anthony Bally, Sarah Chamdin, Yousif Jafar, Petar Martinovski, Manahil Shaikh, Nadeen Sukhon, Arnulfo Cazares Sep 2023

Chronic Illness Education 2023: Don’T Be Salty About Ckd: How To Watch Your Sodium Intake, Anthony Bally, Sarah Chamdin, Yousif Jafar, Petar Martinovski, Manahil Shaikh, Nadeen Sukhon, Arnulfo Cazares

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Hiv Treatment Accessibility & Access To Clinics (Ages 18+) In Detroit, Brennan Burrows, Gabriella Cascio, Tiffany Chu, Samantha Odeesho, Sumeet Saini, Nickolas Vinokurov, Zachary Vaishampayan Sep 2023

Chronic Illness Education 2023: Hiv Treatment Accessibility & Access To Clinics (Ages 18+) In Detroit, Brennan Burrows, Gabriella Cascio, Tiffany Chu, Samantha Odeesho, Sumeet Saini, Nickolas Vinokurov, Zachary Vaishampayan

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Nontraditional Factors That Affect Blood Glucose: Things Diabetic Should Know, Hazem Alata, Rebecca Cameron, Desiree Duncan, Kyle O'Hollaren, Nicole Oska, Kyriacos Vlachos, Trey Vanaken Sep 2023

Chronic Illness Education 2023: Nontraditional Factors That Affect Blood Glucose: Things Diabetic Should Know, Hazem Alata, Rebecca Cameron, Desiree Duncan, Kyle O'Hollaren, Nicole Oska, Kyriacos Vlachos, Trey Vanaken

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Providing Resources For Wsusom Students Exhibiting Major Depressive Symptoms, Ece Erder, Zunaira Imran, Parsa Kamalipour, Deni Peterson, John Pum, Kishwar Basith Sep 2023

Chronic Illness Education 2023: Providing Resources For Wsusom Students Exhibiting Major Depressive Symptoms, Ece Erder, Zunaira Imran, Parsa Kamalipour, Deni Peterson, John Pum, Kishwar Basith

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Available Mental Health Resources For Students With Anxiety And Depression, Carline Dugue, Lauren Fleckenstein, Ethan Mathew, Alexander Minos, Katherine Sommers, Peter Zakaria, Anna Kang Sep 2023

Chronic Illness Education 2023: Available Mental Health Resources For Students With Anxiety And Depression, Carline Dugue, Lauren Fleckenstein, Ethan Mathew, Alexander Minos, Katherine Sommers, Peter Zakaria, Anna Kang

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Glycemic Index And Diabetes, Michelle Chung, Olivia Decker, Nevil Khurana, Breanna Ramsey, Riley Wistrom, Sinyu Yang, Jacqueline Townshend Sep 2023

Chronic Illness Education 2023: Glycemic Index And Diabetes, Michelle Chung, Olivia Decker, Nevil Khurana, Breanna Ramsey, Riley Wistrom, Sinyu Yang, Jacqueline Townshend

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Recognizing And Managing Anxiety And Depression In Medical Students, Angie Achkar, Brandon Doan, Abigail Jaczkowski, Julian Johnson, Diana Mcmahon, Kevin Tran, Anna Kang Sep 2023

Chronic Illness Education 2023: Recognizing And Managing Anxiety And Depression In Medical Students, Angie Achkar, Brandon Doan, Abigail Jaczkowski, Julian Johnson, Diana Mcmahon, Kevin Tran, Anna Kang

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: Healthy Living With Diabetes: How To Use And Understand Continuous Glucose Monitor (Cgm), Hussein Bazzi, Emma Breukink, Ranganath Kathawate, Ron Lukose, Vikram Rajan, Noor Sulaiman, Anneliese Rademacher Sep 2023

Chronic Illness Education 2023: Healthy Living With Diabetes: How To Use And Understand Continuous Glucose Monitor (Cgm), Hussein Bazzi, Emma Breukink, Ranganath Kathawate, Ron Lukose, Vikram Rajan, Noor Sulaiman, Anneliese Rademacher

Patient Education Projects

No abstract provided.


Chronic Illness Education 2023: The Impact Of Food Deserts On Adult Diabetes Mellitus, Stephanie Barna, Blaise Deschamps, Jack Mao, Armaan Naghdi, Anjani Raja, Noor Sulieman, Anneliese Rademacher Sep 2023

Chronic Illness Education 2023: The Impact Of Food Deserts On Adult Diabetes Mellitus, Stephanie Barna, Blaise Deschamps, Jack Mao, Armaan Naghdi, Anjani Raja, Noor Sulieman, Anneliese Rademacher

Patient Education Projects

No abstract provided.


Prevalence Of Symptoms ≤12 Months After Acute Illness, By Covid-19 Testing Status Among Adults — United States, December 2020–March 2023, Juan Carlos C Montoy, James Ford, Huihui Yu, Michael Gottlieb, Dana Morse, Michelle Santangelo, Kelli N O'Laughlin, Kevin Schaeffer, Pamela Logan, Kristin Rising, Mandy J Hill, Lauren E Wisk, Wafah Salah, Ahamed H Idris, Ryan M Huebinger, Erica S Spatz, Robert M Rodriguez, Robin E Klabbers, Kristyn Gatling, Ralph C Wang, Joann G Elmore, Samuel A Mcdonald, Kari A Stephens, Robert A Weinstein, Arjun K Venkatesh, Sharon Saydah, Innovative Support For Patients With Sars-Cov-2 Infections Registry (Inspire) Group Aug 2023

Prevalence Of Symptoms ≤12 Months After Acute Illness, By Covid-19 Testing Status Among Adults — United States, December 2020–March 2023, Juan Carlos C Montoy, James Ford, Huihui Yu, Michael Gottlieb, Dana Morse, Michelle Santangelo, Kelli N O'Laughlin, Kevin Schaeffer, Pamela Logan, Kristin Rising, Mandy J Hill, Lauren E Wisk, Wafah Salah, Ahamed H Idris, Ryan M Huebinger, Erica S Spatz, Robert M Rodriguez, Robin E Klabbers, Kristyn Gatling, Ralph C Wang, Joann G Elmore, Samuel A Mcdonald, Kari A Stephens, Robert A Weinstein, Arjun K Venkatesh, Sharon Saydah, Innovative Support For Patients With Sars-Cov-2 Infections Registry (Inspire) Group

Faculty, Staff and Student Publications

To further the understanding of post-COVID conditions, and provide a more nuanced description of symptom progression, resolution, emergence, and reemergence after SARS-CoV-2 infection or COVID-like illness, analysts examined data from the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a prospective multicenter cohort study. This report includes analysis of data on self-reported symptoms collected from 1,296 adults with COVID-like illness who were tested for SARS-CoV-2 using a Food and Drug Administration-approved polymerase chain reaction or antigen test at the time of enrollment and reported symptoms at 3-month intervals for 12 months. Prevalence of any symptom decreased substantially between baseline …


A Multicenter, Controlled Human Infection Study Of Influenza A(H1n1)Pdm09 In Healthy Adults, Justin R Ortiz, David I Bernstein, Daniel F Hoft, Christopher W Woods, Micah T Mcclain, Sharon E Frey, Rebecca C Brady, Christopher Bryant, Ashley Wegel, Robert W Frenck, Emmanuel B Walter, Getahun Abate, Sarah R Williams, Robert L Atmar, Wendy A Keitel, Nadine Rouphael, Mathew J Memoli, Mamodikoe K Makhene, Paul C Roberts, Kathleen M Neuzil Aug 2023

A Multicenter, Controlled Human Infection Study Of Influenza A(H1n1)Pdm09 In Healthy Adults, Justin R Ortiz, David I Bernstein, Daniel F Hoft, Christopher W Woods, Micah T Mcclain, Sharon E Frey, Rebecca C Brady, Christopher Bryant, Ashley Wegel, Robert W Frenck, Emmanuel B Walter, Getahun Abate, Sarah R Williams, Robert L Atmar, Wendy A Keitel, Nadine Rouphael, Mathew J Memoli, Mamodikoe K Makhene, Paul C Roberts, Kathleen M Neuzil

Faculty, Staff and Students Publications

BACKGROUND: We evaluated the associations between baseline influenza virus-specific hemagglutination inhibition (HAI) and microneutralization (MN) titers and subsequent symptomatic influenza virus infection in a controlled human infection study.

METHODS: We inoculated unvaccinated healthy adults aged 18-49 years with an influenza A/California/04/2009/H1N1pdm-like virus (NCT04044352). We collected serial safety labs, serum for HAI and MN, and nasopharyngeal swabs for reverse-transcription polymerase chain reaction (RT-PCR) testing. Analyses used the putative seroprotective titer of ≥40 for HAI and MN. The primary clinical outcome was mild-to-moderate influenza disease (MMID), defined as ≥1 postchallenge positive qualitative RT-PCR test with a qualifying symptom/clinical finding.

RESULTS: Of 76 …


The Influence Of Political Ideology On Awareness Of Hpv And Hpv Vaccine Among Adults In The United States, Onyema Greg Chido-Amajuoyi, Henry Onyeaka, Hermioni Amonoo, Sanjay Shete Aug 2023

The Influence Of Political Ideology On Awareness Of Hpv And Hpv Vaccine Among Adults In The United States, Onyema Greg Chido-Amajuoyi, Henry Onyeaka, Hermioni Amonoo, Sanjay Shete

Faculty, Staff and Student Publications

This study aimed to investigate the association between political ideology and awareness of HPV and HPV vaccine among US adults. Study data were derived from Health Information National Trends Survey 5 Cycle 4, a 2020 cross-sectional survey of US adults. Multivariable logistic regressions were conducted to examine the association between political ideology with HPV and HPV vaccine awareness. A total of 3418 adults participated in the study, with the majority being non-Hispanic White individuals and women. The results showed that 66.1% and 62.3% of the participants were aware of HPV and HPV vaccine, respectively. A total of 36.9%, 29.7% and …


The Importance Of Acculturation Orientation In Understaanding The Impact Of Pre- And Post-Migration Stressors On Behavioral Health: Evidence From A Crisis Migrant Sample, Christopher P Salas-Wright, Michael G Vaughn, Mildred M Maldonado-Molina, Melissa Bates, Eric C Brown, María F García, José Rodríguez, Seth J Schwartz Aug 2023

The Importance Of Acculturation Orientation In Understaanding The Impact Of Pre- And Post-Migration Stressors On Behavioral Health: Evidence From A Crisis Migrant Sample, Christopher P Salas-Wright, Michael G Vaughn, Mildred M Maldonado-Molina, Melissa Bates, Eric C Brown, María F García, José Rodríguez, Seth J Schwartz

Faculty, Staff and Student Publications

OBJECTIVE: We examine the interplay of acculturation orientation, cultural stress, and hurricane trauma exposure with behavioral health among Puerto Rican crisis migrants who relocated to the US mainland after Hurricane Maria.

METHOD: Participants were 319 adult (Mage = 39 years; 71% female; 90% arriving in 2017-2018) Hurricane Maria survivors surveyed on the US mainland. Latent profile analysis was used to model acculturation subtypes. In turn, ordinary least squares regression was executed to examine the associations of cultural stress and hurricane trauma exposure with behavioral health while stratifying by acculturation subtype.

RESULTS: Five acculturation orientation subtypes were modeled, three of which-Separated …


Integrative Prognostic Machine Learning Models In Mantle Cell Lymphoma, Holly A Hill, Preetesh Jain, Chi Young Ok, Koji Sasaki, Han Chen, Michael L Wang, Ken Chen Aug 2023

Integrative Prognostic Machine Learning Models In Mantle Cell Lymphoma, Holly A Hill, Preetesh Jain, Chi Young Ok, Koji Sasaki, Han Chen, Michael L Wang, Ken Chen

Faculty, Staff and Student Publications

Patients with mantle cell lymphoma (MCL), an incurable B-cell malignancy, benefit from accurate pretreatment disease stratification. We curated an extensive database of 862 patients diagnosed between 2014 and 2022. A machine learning (ML) gradient-boosted model incorporated baseline features from clinicopathologic, cytogenetic, and genomic data with high predictive power discriminating between patients with indolent or responsive MCL and those with aggressive disease (AUC ROC = 0.83). In addition, we utilized the gradient-boosted framework as a robust feature selection method for multivariate logistic and survival modeling. The best ML models incorporated features from clinical and genomic data types highlighting the need for …


Polypharmacy And Prescription Medication Use In A Population-Based Sample Of Adolescent And Young Adult Cancer Survivors, Andrea C Betts, Caitlin C Murphy, L Aubree Shay, Bijal A Balasubramanian, Christine Markham, Marlyn Allicock Aug 2023

Polypharmacy And Prescription Medication Use In A Population-Based Sample Of Adolescent And Young Adult Cancer Survivors, Andrea C Betts, Caitlin C Murphy, L Aubree Shay, Bijal A Balasubramanian, Christine Markham, Marlyn Allicock

Faculty, Staff and Student Publications

PURPOSE: We examined prescription medication use and identified correlates of polypharmacy-taking multiple medications-in adolescent and young adult cancer survivors (AYAs), who experience early-onset chronic conditions.

METHODS: Our cross-sectional study pooled data (2008-2017) from the national Medical Expenditure Panel Survey. We estimated prevalence of polypharmacy (≥ 5 unique prescription medications over an approximate 1-year period) in AYAs (age 18-39 years with a history of cancer) and age- and sex-matched controls, overall and by sociodemographics, clinical factors, and health indicators. We compared survivors' and controls' medication use across therapeutic classes. To identify correlates of polypharmacy among AYAs, we included factors with p …


Communication Of Patients’ And Family Members’ Ethical Concerns To Their Healthcare Providers, Mariam Noorulhuda, Christine Grady, Paul Wakim, Talia Bernhard, Hae Lin Cho, Marion Danis Jul 2023

Communication Of Patients’ And Family Members’ Ethical Concerns To Their Healthcare Providers, Mariam Noorulhuda, Christine Grady, Paul Wakim, Talia Bernhard, Hae Lin Cho, Marion Danis

Student Papers, Posters & Projects

BACKGROUND: Little is known about communication between patients, families, and healthcare providers regarding ethical concerns that patients and families experience in the course of illness and medical care. To address this gap in the literature, we surveyed patients and family members to learn about their ethical concerns and the extent to which they discussed them with their healthcare providers.

METHODS: We surveyed adult, English-speaking patients and family members receiving inpatient care in five hospitals in the Washington DC-Baltimore metropolitan area from July 2017 to March 2020. Descriptive statistics were used to determine the frequency, comfortableness, and helpfulness of discussions regarding …


Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly Jul 2023

Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly

Faculty, Staff and Student Publications

IMPORTANCE: Immune dysregulation contributes to poorer outcomes in COVID-19.

OBJECTIVE: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.

DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and …