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Articles 2191 - 2220 of 2337
Full-Text Articles in Public Health
Population-Based Analysis Of Synergistic Effects Of Functional Disability And Comorbidities On Retention In Hiv Care Among People With Hiv, Charles Darkoh
Population-Based Analysis Of Synergistic Effects Of Functional Disability And Comorbidities On Retention In Hiv Care Among People With Hiv, Charles Darkoh
Faculty, Staff and Student Publications
Objective: This cross-sectional study examined how types of disability and comorbidities influence retention in care (RIC) among people with HIV (PWH) in Houston/Harris County, Texas, USA.
Methods: Data from 1142 participants in the Houston Medical Monitoring Project (2015–2021) were analyzed. Descriptive statistics, bivariate analyses, and multivariable logistic regression were used to evaluate factors associated with RIC.
Results: Approximately 74.9% of participants were retained in care. Compared to PWH without specific comorbidities, those with dyslipidemia and kidney disease had higher odds of RIC (AOR: 2.66; 95% CI: 1.40–5.03 and AOR: 14.08; 95% CI: 1.44–138.12, respectively). PWH reporting only mobility disability had …
Technological Interventions For Reducing Climate Change Impacts On Health: An Overview Of Future Possibilities, Sujatha Alla, Vijay Kumar Chattu, Bawa Singh
Technological Interventions For Reducing Climate Change Impacts On Health: An Overview Of Future Possibilities, Sujatha Alla, Vijay Kumar Chattu, Bawa Singh
Engineering Management & Systems Engineering Faculty Publications
Globally, over five million deaths annually are attributed to extreme weather events exacerbated by climate change, such as heatwaves, hurricanes, wildfires, droughts, and floods, which create health crises and economic losses. The 2015 Paris Declaration emphasized climate technology mechanisms, including research and development, to enhance resilience and reduce greenhouse gas emissions. Biotechnological advancements have mitigated about 20% of economic losses since the 1960s, highlighting technology’s potential to address climate-induced health risks.
A Cross-Sectional Study Investigating The Relationship Between The Fto Gene Polymorphism In Relation To Obesity Traits And Vitamin D Status In Adolescence, Ahmad Al-Serri, Rabeah A. Al-Temaimi, Abdullah Al-Taiar, Lemia Shaban, Reem Al-Sabah, Abdur Rahman, Ali H. Ziyab
A Cross-Sectional Study Investigating The Relationship Between The Fto Gene Polymorphism In Relation To Obesity Traits And Vitamin D Status In Adolescence, Ahmad Al-Serri, Rabeah A. Al-Temaimi, Abdullah Al-Taiar, Lemia Shaban, Reem Al-Sabah, Abdur Rahman, Ali H. Ziyab
Epidemiology, Biostatistics, & Environmental Health Faculty Publications
Background and Objective: Obesity affects 18%-25% of adolescents globally and represents a major public health challenge. Genetic factors contribute to obesity susceptibility, with the FTO gene variant rs9939609 consistently associated with obesity in adults; however, evidence in adolescents is limited. This study examined the association between FTO and obesity traits in adolescents and explored potential interactions with vitamin D status.
Methods: In this cross-sectional study, 509 adolescents aged 10-15 years were genotyped for FTO rs9939609. Obesity traits, including BMI, BMI z-score, and waist circumference, were assessed. Associations with genotype were analyzed using an additive genetic model, and potential interactions with …
Spectral Frequency And Broadband Noise Analysis Of The Firefighter Environment: Potential Implications For Cardiac Health, James Blando, Catherine Reed, Amya Turner
Spectral Frequency And Broadband Noise Analysis Of The Firefighter Environment: Potential Implications For Cardiac Health, James Blando, Catherine Reed, Amya Turner
Epidemiology, Biostatistics, & Environmental Health Faculty Publications
Firefighters are well known to have elevated risk of adverse health outcomes across a wide range of diseases and injuries, including cancer, hearing loss, fatal cardiac events, post-traumatic stress disorder (PTSD), sleep disorders, and many other adverse outcomes. It has been speculated that the noise environment is a significant risk factor for several of these diseases. In particular, the impact of noise on cardiac outcomes has recently been identified. An environmental survey of noise that included spectral and broadband analysis was conducted across all 14 firehouses in a southeastern city in the United States as a first step to investigate …
Examining The Association Of Maternal Oral Health Experiences With Adverse Birth Outcomes: Findings From Virginia's Prams Survey, May Salama, Abdullah Al-Taiar, Denise C. Mckinney, Li-Wu Chen, Anwar T. Merchant
Examining The Association Of Maternal Oral Health Experiences With Adverse Birth Outcomes: Findings From Virginia's Prams Survey, May Salama, Abdullah Al-Taiar, Denise C. Mckinney, Li-Wu Chen, Anwar T. Merchant
Epidemiology, Biostatistics, & Environmental Health Faculty Publications
Background
Preterm birth (PTB) and low birth weight (LBW) are significant public health challenges globally, contributing to neonatal morbidity, mortality, and long-term complications. Maternal oral health has been increasingly recognized as a potential contributor to PTB and LBW, yet there is inconclusive evidence about the effectiveness of dental cleaning in preventing PTB and LBW. This study examined the association between dental cleaning during pregnancy and the prevalence of PTB and LBW using data from the Virginia Pregnancy Risk Assessment Monitoring System (PRAMS).
Methods
We analyzed data from Virginia PRAMS Phases 7 and 8, spanning a 10-year period from 2012 to …
Characteristics Of Women Who Fast During Pregnancy: Findings From The Kuwait Birth Cohort Study, Abdullah Al-Taiar, Ali H. Ziyab, Reem Al Sabah, Ahmed N. Albatineh, James Blando, Majeda S. Hammoud
Characteristics Of Women Who Fast During Pregnancy: Findings From The Kuwait Birth Cohort Study, Abdullah Al-Taiar, Ali H. Ziyab, Reem Al Sabah, Ahmed N. Albatineh, James Blando, Majeda S. Hammoud
Epidemiology, Biostatistics, & Environmental Health Faculty Publications
Fasting during pregnancy is a widespread practice in Muslim communities, yet its health implications remain poorly understood. A lack of conceptual frameworks and limited understanding of the characteristics of women who fast during pregnancy have hindered research in this area. This study examines the differences in several nutritional biomarkers between women who fasted and those who did not and identifies factors associated with fasting behaviour. We analysed data from the Kuwait Birth Cohort in which information on fasting, sociodemographic characteristics and health behaviours was collected via structured interviews between 2017 and 2021. Clinical and laboratory data were extracted from medical …
Systematic Review And Meta‑Analysis Of United States Childhood Obesity Public Policy Interventions, Marilyn Frenn, Maharaj Singh, Julia A. Snethen, Leigh Small, Nancy Browne, Cindy Smith Greenberg, Emily Horner, Sharon Y. Irving, Eric A. Hodges
Systematic Review And Meta‑Analysis Of United States Childhood Obesity Public Policy Interventions, Marilyn Frenn, Maharaj Singh, Julia A. Snethen, Leigh Small, Nancy Browne, Cindy Smith Greenberg, Emily Horner, Sharon Y. Irving, Eric A. Hodges
College of Nursing Data
No abstract provided.
Meta-Analysis Of The Health Effects Of Gas Cooking In Homes, P. Jacob Bueno De Mesquita, Núria Casquero-Modrego, Erik Pontes
Meta-Analysis Of The Health Effects Of Gas Cooking In Homes, P. Jacob Bueno De Mesquita, Núria Casquero-Modrego, Erik Pontes
Arts & Sciences Faculty Publications
Background: Given existing evidence linking indoor gas combustion with potential health effects, we aimed to quantify from epidemiologic field studies the health impacts associated with residential gas cooking and unvented heating.
Methods: We evaluated and synthesized results from peer-reviewed epidemiologic studies that isolated associations between exposure to residential gas cooking and/or unvented heating and an unrestricted range of health outcomes. We focused on studies conducted since 2000 that cited at least one of five, well-regarded studies. We evaluated relevant studies and computed pooled effect estimates, where at least three studies contributed data, using random effect meta-analysis models with inverse-variance weighting. …
A Quantitative Analysis Of Barriers To College Students’ Seasonal Vaccination Intentions And Behaviors, Kelly S. Clemens, John Matkovic
A Quantitative Analysis Of Barriers To College Students’ Seasonal Vaccination Intentions And Behaviors, Kelly S. Clemens, John Matkovic
Faculty Publications – Health Sciences
Objective
Vaccination is crucial to college student health, but quantitative analyses of barriers in this population are limited. The present study expands the work of Su and Chen to determine the relative influence of structural, psychological, and social vaccination barriers.
Participants
Participants were 650 students from a large, midwestern university during the 2024 vaccination season.
Methods
Participants were recruited from a college campus and randomized to respond to items assessing their barriers to, intentions to receive, and uptake of the COVID-19 or influenza vaccination.
Results
Structural, psychological, and social barriers were differentially important to vaccinations and to intentions vs. uptake …
Enhancing Military Health System Organizational Efficiency And Quality Of Care Through A Social-Ecological Framework, Eric L. Peipelman
Enhancing Military Health System Organizational Efficiency And Quality Of Care Through A Social-Ecological Framework, Eric L. Peipelman
College of Graduate Studies: Theses & Dissertations
Timely and fair adjudication of incivility-related actions within the Department of Defense (DoD) and Military Health System (MHS) is increasingly crucial for maintaining accountability, mission readiness, and quality of care. Ongoing delays in resolving workplace complaints and inefficiencies in resource-heavy adjudications highlight the need to shift from reactive complaint handling toward proactive civility promotion and transparent decision-making. This Integrated Learning Experience (ILE) introduces the Peipelman Civility Discussion and Assessment Toolkit (PCDAT)—a comprehensive, evidence-based framework designed to improve civility, optimize resources, and enhance communication, even in the MHS. Based on the Social-Ecological Model (SEM) and adapted from the Workplace Power and …
Exploring Psychological Safety And Workforce Experiences Among Employees In Recovery Community Organizations In The Southern United States: A Qualitative Study, Claire-Lorentz Ugo-Ike
Exploring Psychological Safety And Workforce Experiences Among Employees In Recovery Community Organizations In The Southern United States: A Qualitative Study, Claire-Lorentz Ugo-Ike
College of Graduate Studies: Theses & Dissertations
This qualitative study explored how employees in Recovery Community Organizations (RCOs) in the Southern United States experience psychological safety and how these experiences shape employee well-being and their intentions to stay or leave their organizations. Guided by Edmondson’s Psychological Safety Theory and the Job Demands-Resources (JD-R) model, the study examined how leadership practices, workplace culture, and the emotional demands of recovery support work shape employees’ perception of safety, support, and sustainability in the workforce. Semi-structured interviews were conducted with 19 RCO employees working in various peer support roles. Thematic analysis identified five major themes: (1) leadership behaviors shape psychological safety …
Trends Among Suspected Opioid Overdose Emergency Medical Service (Ems) Incidents In Georgia From 2019-2023, Ashton Harris
Trends Among Suspected Opioid Overdose Emergency Medical Service (Ems) Incidents In Georgia From 2019-2023, Ashton Harris
College of Graduate Studies: Theses & Dissertations
Opioid overdoses remain a problem in the United States, underscoring the need for additional surveillance tools to monitor trends in opioid overdoses. Emergency Medical Services (EMS) data is a timely surveillance method that captures more potential overdoses than hospitals by representing the pre-hospital setting. Research questions in the study assess EMS responses to suspect opioid overdose incidents from 2019-2023 in Georgia to encompass the following characteristics: timeframe (pre, during, post-pandemic), urban versus rural counties, race/ethnicity, categorical type of first responder, mean dosage of naloxone in milligrams administered, and death. 84,359 records meeting the inclusion criteria were initially retrieved from the …
From Vision To Impact: Strategic Planning For The South Health District, Jason D. Butler Jr
From Vision To Impact: Strategic Planning For The South Health District, Jason D. Butler Jr
College of Graduate Studies: Theses & Dissertations
This study presents a community health assessment and strategic planning process for the South Health District (SHD), a rural, multi-county public health district. Using a mixed-methods approach, quantitative surveys and qualitative data from County Nurse Managers, County Boards of Health, and internal staff were integrated with secondary sources to identify community health priorities and organizational gaps. Broad stakeholder engagement through surveys, SWOT workshops, and town-hall meetings ensured credibility and contextual relevance.
Findings revealed challenges in behavioral health, substance abuse, chronic disease, access to preventive services, transportation, workforce capacity, communication, and infrastructure. Four strategic issues—Communication, Workforce Development and Retention, Purpose-Driven District, …
Body Image Perception In African American Women, Ages 20-55 Years, Trina Suttles
Body Image Perception In African American Women, Ages 20-55 Years, Trina Suttles
College of Graduate Studies: Theses & Dissertations
This qualitative study explored the factors that influence body image perception among African American women in the metropolitan Atlanta, Georgia area and examined how these perceptions shape physical activity and dietary behaviors. Body image perception is a critical psychocultural factor influencing obesity-related behaviors, particularly among African American women who navigate culturally specific beauty standards and health beliefs. Guided by the Socioecological Model, this study addressed three research questions: (1) how African American women perceive their body image, (2) how these perceptions influence health behaviors, and (3) what multilevel factors shape body image perceptions. This study employed consensual qualitative research (CQR) …
Sociodemographic Differences In Sepsis-Related Medicare Hospitalizations: A State-Level Analysis Of Diagnosis-Related Groups For Severe Sepsis In 2019 And 2022, Alba Kuqi
College of Graduate Studies: Theses & Dissertations
Introduction: This state-level ecological repeated cross-sectional study examined sociodemographic differences in sepsis-related Medicare hospitalizations assigned to Medicare Severity Diagnosis-Related Groups (MS-DRGs) 871 and 872 in 2019 and 2022.
Objective: The study focused on three outcomes: changes in sepsis-related Medicare discharge volume, changes in average Medicare payment per sepsis discharge, and changes in the proportion of MS-DRG 871 discharges relative to MS-DRG 872 discharges.
Methods: Publicly available Medicare inpatient hospital data and state-level demographic data were used to evaluate whether age, race, gender composition, and median household income were associated with these changes across the 50 U.S. states and …
Hs 6000 Food Systems And Health, Shannon Caravello
Hs 6000 Food Systems And Health, Shannon Caravello
Open Educational Resources
Within the context of the US food system, students will examine the role of urban agriculture and its impact on local communities. Students will gain the ability to critically analyze current trends in urban agriculture and apply them to societal; cultural and health issues associated with the US food system as well as develop strategies to implement healthy eating in their own lives. Issues of food justice and insecurity will be addressed. Demonstrations and workshops on the KCC Community Farm and Garden may be included.
Precision Prevention For Health: The Global Alliance Framework For The Promotion Of Physical Activity, Jürgen M. Steinacker, Willem Van Mechelen, Lars Engebretsen, Evert Verhagen, Mats Börjesson, Marcela González-Gross, Mark R. Hutchinson, Petra Zupet, Herbert Löllgen, Dina C. Janse Van Rensburg, Norbert Bachl, Sergio Migliorini, Pieter D‘Hooghe, Christian Schneider, Jiao Jiao, Ka Ki Wong, Jeroen Swart, Leigh Gordon, Victoria Badtieva, Borja Muniz-Pardos, Tony Lei Shi, Li Xiangchen, Feng Qiang, Guoping Li, Minhao Xie, Xia Zhang, Uğur Erdener, Federica Fagnani, Fabio Pigozzi, Chiara Fossati, Luigi Di Luigi, Francisco Arroyo, Jean-François Kaux, Camille Tooth, Shulin Cheng, Xiuqiang Wang, Emin Ergen, Bülent Ülkar, Frederic Dutheil, Ruediger Reer, Theodora Papadopoulou, Clea Papaellina, Demitri Constantinou, Jason Constantinou, Merling Phaswana, Mamosilo Lichaba, Philippe Gradidge, Mandisa Simamane, Georgia Torres, Natalia Neophytou, Elelwani D. Nevhufumba, Bernhard Schwaab, José Antonio Casajús Mallen, Martin Halle, Martine Duclos, Daniel Neunhaeuserer, Andrea Ermolao, Francesca Battista, Federica Duregon, Julio Motta-Pensabene, Yiannis Koutedakis, Wilhelm Bloch, Nicolaas P. Pronk, Anastasia Fischer, Lisset Pantoja-Arévalo, Ana V. Cintrón, Adewale S. Adebero, Jill Borresen, Johannes Zwerver, Diana M. Ramos-Caballero, Erica M. Mancera-Soto, Pedro Manonelles, Benedict Tan, Ingrid Burrowes, Carl Ward, Kim R. Quimby, Christina Howitt, Robert Clive Landis, Hans Hauner, Mikio Hiura, Luz Divina De La Cruz Lastre, Gunnar Treff, Fotini Tsofliou, José Kawazoe Lazzoli, Umutcan Kayıkçı, Mourad Ghrairi, Vincent Onywera, Robert Ojiambo, Robert Sallis, Sophia Papamichalopoulos, Maher Zahar, Christine Joisten, Bernd Wolfarth, Sandra Rozenstoka, Hashel Al Tunaiji, Kiera Wason, Felix Drummond, Wolfgang Schobersberger, Vahur Ööpik, Eve Unt, Anna Jegier, Stéphane Doutreleau, Seung Hoon Han, Jörg F. Debatin, Nils Schumacher, Luís B. Sardinha, Lenka Dienstbach-Wech, Tuba Melekoğlu, Sheng Zeng, Maurizio Casasco, Kristy Howells, Eva-Maria Klinkisch, James Bilzon, Gregory Heath, Thomas Horstmann, Eduardo H. De Rose, Nick Webborn, Klaus-Michael Braumann, Li Jing, Xiao Xu, Elizabeth Moxley, Yi Zheng, Alison V. September, Malcolm Collins, Olena Andrieieva, Svitlana Drozdovska, Andreas Michael Nieß, Rikke Helene Moe, Carolin Knoke, Silvano Zanuso, Francesco Zanatta, Veronika Všetíčková, Spyridon Zormpas, Christoforos D. Giannaki, Brian P. Carson, Matthew P. Herring, Ciara Mccormack, Marco Vecchiato, Thomas Yvert, Makro Korenjak, Benjamin Billet, Andréia Lópes Azevedo, Naama Constantini, Sigmund Loland, Aaron Leigh Baggish, Luis Monteiro, Nuray Yazihan, Yannis P. Pitsiladis
Precision Prevention For Health: The Global Alliance Framework For The Promotion Of Physical Activity, Jürgen M. Steinacker, Willem Van Mechelen, Lars Engebretsen, Evert Verhagen, Mats Börjesson, Marcela González-Gross, Mark R. Hutchinson, Petra Zupet, Herbert Löllgen, Dina C. Janse Van Rensburg, Norbert Bachl, Sergio Migliorini, Pieter D‘Hooghe, Christian Schneider, Jiao Jiao, Ka Ki Wong, Jeroen Swart, Leigh Gordon, Victoria Badtieva, Borja Muniz-Pardos, Tony Lei Shi, Li Xiangchen, Feng Qiang, Guoping Li, Minhao Xie, Xia Zhang, Uğur Erdener, Federica Fagnani, Fabio Pigozzi, Chiara Fossati, Luigi Di Luigi, Francisco Arroyo, Jean-François Kaux, Camille Tooth, Shulin Cheng, Xiuqiang Wang, Emin Ergen, Bülent Ülkar, Frederic Dutheil, Ruediger Reer, Theodora Papadopoulou, Clea Papaellina, Demitri Constantinou, Jason Constantinou, Merling Phaswana, Mamosilo Lichaba, Philippe Gradidge, Mandisa Simamane, Georgia Torres, Natalia Neophytou, Elelwani D. Nevhufumba, Bernhard Schwaab, José Antonio Casajús Mallen, Martin Halle, Martine Duclos, Daniel Neunhaeuserer, Andrea Ermolao, Francesca Battista, Federica Duregon, Julio Motta-Pensabene, Yiannis Koutedakis, Wilhelm Bloch, Nicolaas P. Pronk, Anastasia Fischer, Lisset Pantoja-Arévalo, Ana V. Cintrón, Adewale S. Adebero, Jill Borresen, Johannes Zwerver, Diana M. Ramos-Caballero, Erica M. Mancera-Soto, Pedro Manonelles, Benedict Tan, Ingrid Burrowes, Carl Ward, Kim R. Quimby, Christina Howitt, Robert Clive Landis, Hans Hauner, Mikio Hiura, Luz Divina De La Cruz Lastre, Gunnar Treff, Fotini Tsofliou, José Kawazoe Lazzoli, Umutcan Kayıkçı, Mourad Ghrairi, Vincent Onywera, Robert Ojiambo, Robert Sallis, Sophia Papamichalopoulos, Maher Zahar, Christine Joisten, Bernd Wolfarth, Sandra Rozenstoka, Hashel Al Tunaiji, Kiera Wason, Felix Drummond, Wolfgang Schobersberger, Vahur Ööpik, Eve Unt, Anna Jegier, Stéphane Doutreleau, Seung Hoon Han, Jörg F. Debatin, Nils Schumacher, Luís B. Sardinha, Lenka Dienstbach-Wech, Tuba Melekoğlu, Sheng Zeng, Maurizio Casasco, Kristy Howells, Eva-Maria Klinkisch, James Bilzon, Gregory Heath, Thomas Horstmann, Eduardo H. De Rose, Nick Webborn, Klaus-Michael Braumann, Li Jing, Xiao Xu, Elizabeth Moxley, Yi Zheng, Alison V. September, Malcolm Collins, Olena Andrieieva, Svitlana Drozdovska, Andreas Michael Nieß, Rikke Helene Moe, Carolin Knoke, Silvano Zanuso, Francesco Zanatta, Veronika Všetíčková, Spyridon Zormpas, Christoforos D. Giannaki, Brian P. Carson, Matthew P. Herring, Ciara Mccormack, Marco Vecchiato, Thomas Yvert, Makro Korenjak, Benjamin Billet, Andréia Lópes Azevedo, Naama Constantini, Sigmund Loland, Aaron Leigh Baggish, Luis Monteiro, Nuray Yazihan, Yannis P. Pitsiladis
Research outputs 2022 to 2026
This conceptual, implementation-oriented paper proposes a framework for precision prevention centred on physical activity promotion and early risk mitigation, aiming to support a shift from reactive disease management toward proactive prevention. The proposed framework focuses on the early identification of risk trajectories by integrating biological, environmental, and social determinants of health through systems thinking, multi-omics technologies, digital health, and behavioural science. It aims to inform tailored, context-sensitive interventions that will help to mitigate chronic non-communicable diseases (NCDs), while supporting lifelong resilience. Within this framework, physical activity is positioned as the central, modifiable anchor behaviour through which personalised prevention strategies may …
Multi-Omics Integration Reveals Vaccine-Specific Molecular Signatures And Temporal Dynamics Of Covid-19 Immune Responses, Anne H. Klein, David J. Beale, Thao V. Nquyen, Jian-Wei Liu, Petrus Jansen Van Vuren, Nagendrakumar B. Singanallur, Carol Lee, Andrew C. Boomer, Jennifer A. Juno, Stephen J. Kent, Adam K. Wheatley, Gough G. Au, Seshadri S. Vasan, Laurence Wilson, Alexander J. Mcauley
Multi-Omics Integration Reveals Vaccine-Specific Molecular Signatures And Temporal Dynamics Of Covid-19 Immune Responses, Anne H. Klein, David J. Beale, Thao V. Nquyen, Jian-Wei Liu, Petrus Jansen Van Vuren, Nagendrakumar B. Singanallur, Carol Lee, Andrew C. Boomer, Jennifer A. Juno, Stephen J. Kent, Adam K. Wheatley, Gough G. Au, Seshadri S. Vasan, Laurence Wilson, Alexander J. Mcauley
Research outputs 2022 to 2026
Vaccination elicits systemic immune responses that extend beyond antibody and lymphocyte activation, engaging coordinated metabolic and lipid pathways that modulate immune function. Nevertheless, how systemic molecular responses differ across COVID-19 vaccine platforms, including closely related mRNA platforms, remains poorly understood. Here, we performed integrated plasma proteomic, lipidomic, and metabolomic profiling of 53 SARS-CoV-2–naïve adults vaccinated with Pfizer-BioNTech, Moderna, or AstraZeneca COVID-19 vaccines. Samples were analysed across multiple timepoints using differential analysis and DIABLO-based multi-omics integration. Our findings reveal distinct platform-associated multi-omic molecular signatures not captured by unsupervised analyses alone. Pfizer-BioNTech vaccination was associated with widespread increases in immunoglobulin and complement …
Development Of A Semi-Mechanistic Population Pharmacokinetic Model For Predicting Tenofovir Disoproxil Fumarate And Tenofovir Alafenamide Exposure In Plasma And Cellular Matrices During Pregnancy And Postpartum, Yifan Yu, Kristina M. Brooks, Gustavo F. Doncel, Brookie M. Best, Mark A. Marzinke, Mark Mirochnick, Peter Anderson, Landon Myer, Connie Celum, Renee Heffron, Jenell Coleman, Dvora Joseph Davey, Craig W. Hendrix, Jeremiah D. Momper, Robert Bies, Rachel K. Scott
Development Of A Semi-Mechanistic Population Pharmacokinetic Model For Predicting Tenofovir Disoproxil Fumarate And Tenofovir Alafenamide Exposure In Plasma And Cellular Matrices During Pregnancy And Postpartum, Yifan Yu, Kristina M. Brooks, Gustavo F. Doncel, Brookie M. Best, Mark A. Marzinke, Mark Mirochnick, Peter Anderson, Landon Myer, Connie Celum, Renee Heffron, Jenell Coleman, Dvora Joseph Davey, Craig W. Hendrix, Jeremiah D. Momper, Robert Bies, Rachel K. Scott
CONRAD Publications
Background and Objective
Tenofovir (TFV)-based regimens are backbones of both HIV treatment and pre-exposure prophylaxis during pregnancy. Multiple studies have shown up to one-third decreases in dried blood spot tenofovir-diphosphate concentrations during pregnancy among participants taking tenofovir disoproxil fumarate (TDF). Currently, there are no mechanism-based models describing the pharmacokinetics of tenofovir diphosphate (the active anabolite) in peripheral blood mononuclear cells (PBMCs) of pregnant individuals receiving TDF or tenofovir alafenamide (TAF), and the mechanisms behind observed differences between dried blood spots and PBMCs remain unclear.
Methods
To address this gap, we developed a semi-mechanistic model to simultaneously describe the pharmacokinetics of …
Artificial Intelligence And Machine Learning In Smart Vaginal Formulation Development, Deborah A. Ogundemuren, Vivek Agrahari, Andrew P. Wong, Carolina Herrera, Margaret O. Ilomuanya, Gustavo F. Doncel
Artificial Intelligence And Machine Learning In Smart Vaginal Formulation Development, Deborah A. Ogundemuren, Vivek Agrahari, Andrew P. Wong, Carolina Herrera, Margaret O. Ilomuanya, Gustavo F. Doncel
CONRAD Publications
Vaginal drug delivery in women's health remains underutilized and insufficiently studied, largely due to the complexity and dynamic nature of the vaginal microenvironment. Variations in vaginal pH, hormonal levels, and microbiota composition introduce significant biological variability, complicating formulation design and contributing to inconsistent therapeutic outcomes and poor patient adherence. Conventional vaginal formulations often fail to account for these individual differences, highlighting the need for more adaptive and predictive approaches. Emerging advances in artificial intelligence (AI) and machine learning (ML) offer promising strategies to address these challenges by enabling multi-parameter, data-driven formulation development that explicitly considers biological variability. Despite their transformative …
Micrornas Regulated By Pregnancy Target Antiviral And Cancer Immunity Overlapping With The Hiv Interactome, Paula F. T. Cezar-De-Mello, Jonathan M. Dreyfuss, Pai-Lien Chen, Hidemi Yamamoto, Xiaoming Gao, Hui Pan, Charles Morrison, Gustavo F. Doncel, Robert L. Barbieri, Raina N. Fichorova
Micrornas Regulated By Pregnancy Target Antiviral And Cancer Immunity Overlapping With The Hiv Interactome, Paula F. T. Cezar-De-Mello, Jonathan M. Dreyfuss, Pai-Lien Chen, Hidemi Yamamoto, Xiaoming Gao, Hui Pan, Charles Morrison, Gustavo F. Doncel, Robert L. Barbieri, Raina N. Fichorova
CONRAD Publications
Innate immunity predictors of HIV-1 risk and pathogenesis vary with reproductive hormones, pregnancy, and lactation, yet the underlying mechanisms remain unclear. We hypothesized that pregnancy-associated physiological adaptations alter systemic microRNA (miRNA) expression, thereby regulating immunity, pathogenesis and susceptibility to infection. We analyzed 174 serum samples from 88 participants in a longitudinal cohort from Uganda and Zimbabwe across pre-pregnancy (PP), pregnancy (P), and postpartum breastfeeding (BF). Cell-free peripheral blood miRNAs (n = 2083) were profiled using HTG EdgeSeq. Pregnancy-specific miRNAs were identified by intersecting differentially expressed (DE) miRNAs from P vs. PP and P vs. BF comparisons. miRNA targets and pathways …
Prenatal Exposure To Nicotine And Postpartum Depression: A Systematic Review And Meta-Analysis, Reem Sharaf-Alddin, May Salama, Denise Mckinney, George Saade, Qi Zhang
Prenatal Exposure To Nicotine And Postpartum Depression: A Systematic Review And Meta-Analysis, Reem Sharaf-Alddin, May Salama, Denise Mckinney, George Saade, Qi Zhang
Health Behavior, Policy & Management Faculty Publications
Purpose: Postpartum Depression (PPD) is the most common mental health complication of childbirth, and has short-term and long-term consequences for mother, child, and the entire family. PPD is a function of several factors. Prenatal exposure to nicotine (PEN) by Active Tobacco Smoking (ATS), Secondhand Smoking (SHS), or Electronic Nicotine Products (ENPs) is a major potential risk factor. This systematic review and meta-analysis aim to summarize and evaluate all evidence regarding the association between PEN and PPD.
Methods: We searched the following databases, PubMed, Medline, Cochrane, EMBASE, and CINHAL, for studies published between Jan.1st ,2000&Sep.19th ,2024, with the outcome PPD. Studies …
A Scoping Review To Conceptualize Social Privilege For Studying Patients' Health Outcomes And Health Disparities, Elizabeth A. Brown, Priyanka Patel, Esther May B. Sarino, Vladimir Markovic, Carles Muntaner
A Scoping Review To Conceptualize Social Privilege For Studying Patients' Health Outcomes And Health Disparities, Elizabeth A. Brown, Priyanka Patel, Esther May B. Sarino, Vladimir Markovic, Carles Muntaner
Health Behavior, Policy & Management Faculty Publications
Background
The continued reliance on single-category self-reported demographic data (e.g., race/ethnicity) reflects conceptual limitations that hinder the study and understanding of health outcomes research. There is a pressing need for more precise measures of social privilege that conceptualize privilege and oppression while enabling the examination of their effects on health outcomes in the United States (US) healthcare system.
Objective
The purpose of this scoping review was to review the literature, determine how researchers have measured aspects of privilege and oppression, and develop a conceptual framework to study patients' social privilege in the US healthcare system and public health research.
Methods …
Large Language Model-Assisted Research Question Development In Public Health: A Case Study In The Special Supplemental Nutrition Program For Women, Infants, And Children (Wic), Qi Zhang, Bidusha Neupane, Priyanka Patel, Futun N. Alkhalifah, Yi He, Leslie Hodges
Large Language Model-Assisted Research Question Development In Public Health: A Case Study In The Special Supplemental Nutrition Program For Women, Infants, And Children (Wic), Qi Zhang, Bidusha Neupane, Priyanka Patel, Futun N. Alkhalifah, Yi He, Leslie Hodges
Health Behavior, Policy & Management Faculty Publications
Objective:
To assess the feasibility of using large language models (LLMs) to develop research questions about changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) food packages.
Design:
We conducted a controlled experiment using ChatGPT-4 and its plugin, MixerBox Scholarly, to generate research questions based on a section of the USDA summary of the final public comments on the WIC revision. Five questions weekly for three weeks were generated using LLMs under two conditions: fed with or without relevant literature. The experiment generated 90 questions, which were evaluated using the FINER criteria (Feasibility, Innovation, Novelty, Ethics, …
Vitamin D Status During Pregnancy Modulates The Effect Of Pre-Pregnancy Obesity On Gestational Diabetes Mellitus Risk: A Birth Cohort Study, Ali H. Ziyab, Abdullah Al-Taiar, Reem Al-Sabah, Majeda S. Hammoud, Saeed Akhtar
Vitamin D Status During Pregnancy Modulates The Effect Of Pre-Pregnancy Obesity On Gestational Diabetes Mellitus Risk: A Birth Cohort Study, Ali H. Ziyab, Abdullah Al-Taiar, Reem Al-Sabah, Majeda S. Hammoud, Saeed Akhtar
Epidemiology, Biostatistics, & Environmental Health Faculty Publications
Objective:
To determine whether gestational vitamin D status modulates the effect of pre-pregnancy obesity on gestational diabetes mellitus (GDM) risk while stratifying by maternal age.
Design:
Birth cohort.
Setting:
A major maternity hospital in Kuwait.
Participants:
Pregnant women in their second/third trimester of gestation were enrolled. Pre-pregnancy body mass index (BMI, kg/m²) was categorized as under/normal weight (< 25.0), overweight (25.0 to < 30.0), and obesity (≥30.0). Gestational 25-hydroxyvitamin D concentrations were categorized as deficiency (< 50 nmol/L) or insufficiency/sufficiency (≥50 nmol/L). GDM status was ascertained according to international guidelines. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were estimated using logistic regression.
Results:
Data from 957 pregnant women were analyzed, with GDM affecting 166 (17.4%) pregnancies. Pre-pregnancy obesity and gestational vitamin D deficiency was ascertained in 275 (28.7%) and 533 (55.7%) pregnant women, respectively. The association between pre-pregnancy obesity and GDM risk differed according …
Low Burden Of Clinically Relevant Anaemia And Thrombocytopenia Among Adolescents Living With Hiv Receiving Tenofovir/Lamivudine Plus Dolutegravir: The Cipher-Adola Study In Cameroon, Nadine Nguendjoung Fainguem, Yagai Bouba, Rachel Kamgaing, Jeremiah Efakika Gabisa, Aude Christelle Ka’E, Michel Carlos Tommo Tchouaket, Alex Durand Nka, Cynthia Ayafor, Lum Forgwei, Upal Roy
Low Burden Of Clinically Relevant Anaemia And Thrombocytopenia Among Adolescents Living With Hiv Receiving Tenofovir/Lamivudine Plus Dolutegravir: The Cipher-Adola Study In Cameroon, Nadine Nguendjoung Fainguem, Yagai Bouba, Rachel Kamgaing, Jeremiah Efakika Gabisa, Aude Christelle Ka’E, Michel Carlos Tommo Tchouaket, Alex Durand Nka, Cynthia Ayafor, Lum Forgwei, Upal Roy
Health & Biomedical Sciences Faculty Publications
Background: Anaemia and thrombocytopenia adversely affect adolescent HIV outcomes, yet adolescent-specific data from the tenofovir/lamivudine/dolutegravir (TLD) era remain scarce, and access to full blood count (FBC) testing is limited in Cameroon. We evaluated the prevalence, severity, and factors associated with these cytopenias among adolescents living with HIV (ADLHIV) in the TLD era.
Methods: Multicentre cross-sectional study was conducted among ADLHIV (10-19 years) receiving TLD in the CIPHER-ADOLA cohort in Cameroon. Full blood count, viral load (VL) and CD4-count were performed. Factors associated with anaemia and thrombocytopenia were ascertained.
Results: A total of 252 ADLHIV was enrolled (50.8% male, 83.3% were …
Facilitating Shared Reading Exposure To Promote Health Outcomes In A Rural Pediatric Primary Care Clinic, Meredith L. Longino
Facilitating Shared Reading Exposure To Promote Health Outcomes In A Rural Pediatric Primary Care Clinic, Meredith L. Longino
Doctor of Nursing Practice Final Project Abstract
Purpose
The purpose of this scholarly project was to address a gap in early literacy promotion for rural children by incorporating the Reach Out and Read program. This program bolsters foundational literacy by providing a book and anticipatory guidance at every well-child visit from birth through age 5. This project was expected to decrease no-show well-child attendance rates and improve provider morale.
Background
The project was implemented in an established rural pediatric primary care clinic in Northeast Texas.
Methodology
Process implementation was measured through books distributed and EHR documentation of the intervention. Process objectives were measured by no-show rates for …
Higher Nurse-To-Patient Staffing Ratios Affect Patient Safety Outcomes: An Integrative Research Review (Irr), Kimberly Everard Martinez
Higher Nurse-To-Patient Staffing Ratios Affect Patient Safety Outcomes: An Integrative Research Review (Irr), Kimberly Everard Martinez
Covenant Nurses Week 2026
No abstract provided.
No Pass Culture Lowers Patient Fall Incidence, Marie Camille Austria
No Pass Culture Lowers Patient Fall Incidence, Marie Camille Austria
Covenant Nurses Week 2026
No abstract provided.
Improving Patient Outcomes Through Structured Nursing Safety Huddles In Acute Care Settings: An Integrative Research Review (Irr), Brandon Everard Thomas
Improving Patient Outcomes Through Structured Nursing Safety Huddles In Acute Care Settings: An Integrative Research Review (Irr), Brandon Everard Thomas
Covenant Nurses Week 2026
No abstract provided.