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Articles 961 - 990 of 4420
Full-Text Articles in Public Health
New Coyote Stories
The International Journal of Ecopsychology (IJE)
No abstract provided.
Book Review Vol. 5 (1) 2022
The International Journal of Ecopsychology (IJE)
No abstract provided.
Table Of Contents (Vol. 5.1): Foundations Ii, Editorial Board
Table Of Contents (Vol. 5.1): Foundations Ii, Editorial Board
The International Journal of Ecopsychology (IJE)
No abstract provided.
Book Recommendation Vol. 5 (1)
Book Recommendation Vol. 5 (1)
The International Journal of Ecopsychology (IJE)
No abstract provided.
Loving Truly: An Epistemic Approach To The Doxastic Norms Of Love
Loving Truly: An Epistemic Approach To The Doxastic Norms Of Love
The International Journal of Ecopsychology (IJE)
If you love someone, is it good to believe better of her than epistemic norms allow? The partiality view says that it is: love, on this view, issues norms of belief that clash with epistemic norms. The partiality view is supposedly supported by an analogy between beliefs and actions, by the phenomenology of love, and by the idea that love commits us to the loved one’s good character. I argue that the partiality view is false, and defend what I call the epistemic view. On the epistemic view, love also issues norms of belief. But these say simply (and …
Beating “Love” To Death: Emotion Junkies, The Unnatural Affectations Of “Loving Earth,” And Other Ghostly Infatuations
The International Journal of Ecopsychology (IJE)
If the sentiment, or more precisely, an emotion that one identifies as ‘love’ becomes the protagonist of and footnote to almost everything we do, that is, if that thing ‘love’ reigns supreme and is definitive of what most humans do or want, then grinding and packing everything else into the same ‘love’ sausage casing becomes commonplace if only to add provenance to ‘our feelings’ – in order to, unnecessarily perhaps, validate them. When we beat ‘love’ to death (virtual signalling) it is more likely, it seems, that we are in the shadows of its scarcity. In its clamoring we know …
Proximate And Ultimate Perspectives On Romantic Love
Proximate And Ultimate Perspectives On Romantic Love
The International Journal of Ecopsychology (IJE)
Romantic love is a phenomenon of immense interest to the general public as well as to scholars in several disciplines. It is known to be present in almost all human societies and has been studied from a number of perspectives. In this integrative review, we bring together what is known about romantic love using Tinbergen’s “four questions” framework originating from evolutionary biology. Under the first question, related to mechanisms, we show that it is caused by social, psychological mate choice, genetic, neural, and endocrine mechanisms. The mechanisms regulating psychopathology, cognitive biases, and animal models provide further insights into the mechanisms …
American Artists: Craig Albright
American Artists: Craig Albright
The International Journal of Ecopsychology (IJE)
No abstract provided.
A Review Of The Effectiveness, Feasibility, And Acceptability Of Art Therapy For Children And Adolescents During The Covid-19 Pandemic, Minh Ngoc Le Vu, Anh Linh Do, Laurent Boyer, Quy Chi Tran, Stefan Kohler, Syed Ishtiaque Ahmed, Andreea Molnar, Tung Son Vu, Nhan Trong Huynh Vo, Linh Mai Vu Nguyen, Linh Gia Vu, Vu Anh Trong Dam, Thomy Duong, Dan Linh Nguyen Do, Ngoc Minh Do, Roger S Mclntyre, Carl Latkin, Roger Chun Man Ho, Cyrus Su Hui Ho
A Review Of The Effectiveness, Feasibility, And Acceptability Of Art Therapy For Children And Adolescents During The Covid-19 Pandemic, Minh Ngoc Le Vu, Anh Linh Do, Laurent Boyer, Quy Chi Tran, Stefan Kohler, Syed Ishtiaque Ahmed, Andreea Molnar, Tung Son Vu, Nhan Trong Huynh Vo, Linh Mai Vu Nguyen, Linh Gia Vu, Vu Anh Trong Dam, Thomy Duong, Dan Linh Nguyen Do, Ngoc Minh Do, Roger S Mclntyre, Carl Latkin, Roger Chun Man Ho, Cyrus Su Hui Ho
Faculty, Staff and Student Publications
Art therapy has been widely offered to reduce symptoms of psychological disturbance. Pooled evidence about its effectiveness in epidemic contexts, particularly during the COVID-19 pandemic, has not been yet established. This study reviewed the effectiveness, feasibility, and acceptability of art therapy on children and adolescents during the COVID-19 pandemic and past epidemics. We searched PubMed/Medline, PsycINFO, CENTRAL (Cochrane Library), and CINAHL for articles on art therapy during COVID-19. Included studies reported improvements in measures of mental health, sleep quality, and psychological well-being in children with or without disabilities in the epidemic context. Results also showed that art therapy was highly …
Analysis Of An Seir Model With The Vertical Transmission On Transmission And Spread Of Hepatitis B In Ghana, Kwaafo Akoto Awuah-Mensah, Ute Mueller, Steven Richardson
Analysis Of An Seir Model With The Vertical Transmission On Transmission And Spread Of Hepatitis B In Ghana, Kwaafo Akoto Awuah-Mensah, Ute Mueller, Steven Richardson
Research outputs 2022 to 2026
Lack of good quality information about hepatitis B (HB) is a major hindrance to policy direction and comprehensive implementation of interventions to prevent and control the disease in the endemic region of Sub- Saharan Africa (SSA), particularly Ghana. A SEIR deterministic compartmental model which incorporates latent period and vertical transmission, and applied to HB incidence data was used to examine the transmission and spread of HB in order to inform policy decision on prevention and control of the disease in a population. The model parameters were estimated by a unique hybrid optimisation method involving Genetic Algorithm and Levenberg Marquardt Algorithm …
Impact Evaluation Of A Central Australian Aboriginal Cultural Awareness Training Program For Health Professionals And Students, Chris Rissel, Lynette Liddle, Courtney Ryder, Annabelle Wilson, Madeleine Bower, Barbara Richards
Impact Evaluation Of A Central Australian Aboriginal Cultural Awareness Training Program For Health Professionals And Students, Chris Rissel, Lynette Liddle, Courtney Ryder, Annabelle Wilson, Madeleine Bower, Barbara Richards
Journal of the Australian Indigenous HealthInfoNet
The aim of this study was to prospectively evaluate the impact of a Central Australian cultural awareness training program for health care staff. A mixed methods approach was used. Program participants completed a baseline and post-program questionnaire, which included an attitude scale assessing cultural safety, critical thinking and transformative unlearning, and open-ended questions. An online follow-up survey two months later repeated these questions. Mean scale scores were compared using paired and unpaired t-tests. Qualitative data were analysed thematically. Baseline scale mean was 45.7. At post-program it had statistically significantly increased to 47.3, using both the paired (p=< 0.01) and unpaired t-test (p=< 0.03). At the two-month follow-up it had decreased to 42.2. This was not statistically different from the baseline score with a paired (n=11) t-test (p=< 0.37), however the difference was statistically significant with an unpaired t-test (p=< 0.01) which included an additional eight respondents. Qualitative feedback was consistently positive. Many respondents learnt new information about the negative effects of colonisation on Aboriginal and/or Torres Strait Islander people, and how this continues to affect current health. Learning about Aboriginal and/or Torres Strait Islander cultures, kinship relationships and systems, and communication styles was identified as directly relevant to work practices. A cultural education program produced positive short-term changes in attitudes and was highly valued by participants. However, it is unclear if these changes are maintained in the medium term.
Assessing The Validity Of A Culturally Modified Drinking Motives Questionnaire For Use In Aboriginal Communities, David Tucker, Martyn Symons, Elaine Clifton, Margaret Ramirez, James P. Fitzpatrick, Roz Walker, Glenn Pearson, Michelle Gray, Gary Kirby, Nyanda Mcbride
Assessing The Validity Of A Culturally Modified Drinking Motives Questionnaire For Use In Aboriginal Communities, David Tucker, Martyn Symons, Elaine Clifton, Margaret Ramirez, James P. Fitzpatrick, Roz Walker, Glenn Pearson, Michelle Gray, Gary Kirby, Nyanda Mcbride
Journal of the Australian Indigenous HealthInfoNet
Alcohol related harms disproportionately affect Aboriginal people in Australia. Motives to drink have been identified as the most proximal factor to alcohol consumption.The aim of this study is to assess the validity of a culturally modified Drinking Motives Questionnaire-Revised (DMQ-R) (Cooper, 1994) with Aboriginal participants. The study was cross sectional, utilising data collected via face-to-face surveys with a sample of adult Aboriginal participants. A convenience sample of 135 Aboriginal men (n=41) and women (n=94) from the Pilbara Region of Western Australia, who had consumed alcohol in the preceding 12 months. The Culturally modified DMQ-R (CDMQ-R) developed in consultation with Aboriginal …
First-Stage Development Of The Pitjantjatjara Translation Of The World Health Organization’S Alcohol, Smoking And Substance Involvement Screening Test (Assist), Matthew Wr Stevens, Dom Barry, Sue Bertossa, Mark Thompson, Robert Ali
First-Stage Development Of The Pitjantjatjara Translation Of The World Health Organization’S Alcohol, Smoking And Substance Involvement Screening Test (Assist), Matthew Wr Stevens, Dom Barry, Sue Bertossa, Mark Thompson, Robert Ali
Journal of the Australian Indigenous HealthInfoNet
Substance use is a leading contributor to global disease, illness and death. Compared with non-Indigenous Australians, Aboriginal and Torres Strait Islander Australians are at an increased risk of substance-related harms due to the experience of additional social, cultural, and economic factors. While preventive approaches, including screening and early interventions are promising, currently there are limited options available to healthcare workers that are culturally appropriate for use in Aboriginal and Torres Strait Islander populations. Therefore, the aim of this research was to translate and culturally adapt the World Health Organization endorsed, Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) into Pitjantjatjara. …
Patterns And Determinants Of Hiv Postexposure Prophylaxis In A Tertiary Health Facility In Nigeria, Onyinye H. Chime, Edmund O Ndibuagu, Wilfred O. Okenwa
Patterns And Determinants Of Hiv Postexposure Prophylaxis In A Tertiary Health Facility In Nigeria, Onyinye H. Chime, Edmund O Ndibuagu, Wilfred O. Okenwa
International Journal of Health and Allied Sciences
Background: One of the targets of HIV prevention strategy is to ensure that 95% of the population access prevention services by 2030 with the aspiration of ending the AIDS epidemic by 2030. Methods: This is a record-based cross-sectional review. Data was extracted from the PEP registers and treatment folders from January 2017 to December 2021. Results: Non-occupational exposure (82.5%) was reported more than occupational (17.5%). Majority of cases (442) resulted from rape. Only 9.1% of the clients returned for follow-up and all were negative. Conclusion: Behavioral interventions designed to promote HIV risk reduction and protective behaviors should be promoted.
Development Of Tlc Fingerprinting Profile Of Shadanga Paniya – An Ayurvedic Formulation To Treat Symptoms Of Covid-19, Mehta D. Mehul, Kunal M. Gohil, Krunal A. Doshi
Development Of Tlc Fingerprinting Profile Of Shadanga Paniya – An Ayurvedic Formulation To Treat Symptoms Of Covid-19, Mehta D. Mehul, Kunal M. Gohil, Krunal A. Doshi
International Journal of Health and Allied Sciences
BACKGROUND: Shadanga Paniya is a compound Ayurvedic formulation that contains six ingredients. Ayurvedic Physicians have been using Shadanga Paniya to treat fever for ages. Symptoms of COVID-19 are also being treated by Shadanga Paniya. However, the Shadanga Paniya has not reported standardisation.
AIMS: To prepare Shadanga Paniya as per the standard classical protocol. To carry out qualitative tests, standardisation and TLC profile development for Shadanga Paniya.
MATERIALS AND METHODS: All the ingredients of Shadanga Paniya wiz. Nagarmotha, Pittapapada, Khasa, Lal Chandana, Sugandhbala and Sunthi were taken in equal amounts. All these ingredients are heated over mild heat with water. The …
Public Health Liberation – An Emerging Transdiscipline To Elucidate And Transform The Public Health Economy, Christopher Williams Mph, Joy Birungi Msc, Melody Brown Mph, Mhsa, James Deutsch Md, Phd, Felecia Williams Phd, Mpa, P.S. Perkins Ma, Patricia Bishop, Dena Walker, Ebony Moody, Rhonda Hamilton Ma, Jehan El-Bayoumi Md
Public Health Liberation – An Emerging Transdiscipline To Elucidate And Transform The Public Health Economy, Christopher Williams Mph, Joy Birungi Msc, Melody Brown Mph, Mhsa, James Deutsch Md, Phd, Felecia Williams Phd, Mpa, P.S. Perkins Ma, Patricia Bishop, Dena Walker, Ebony Moody, Rhonda Hamilton Ma, Jehan El-Bayoumi Md
Advances in Clinical Medical Research and Healthcare Delivery
Public Health Liberation (PHL) is an innovative general theory of public health aimed at accelerating health equity. This paper provides a rich synthesis of philosophical traditions, novel theories, and approaches to establish the basis for a new public health transdiscipline. The authors argue that the "public health economy" as a single analytic lens elucidates the contradictions and tensions that reproduce vast health inequity. Authored by a majority of Black women, community experiences and perspectives are a major strength of this paper because they draw upon leadership experiences with contemporary issues.
The authors begin by describing their background in public health …
2022-09-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-09-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
2022-09-14_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
2022-09-14_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
Michigan COVID-19 Vaccine Data
The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.
First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.
Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.
This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).
The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …
2022-09-14_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services
2022-09-14_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services
Michigan COVID-19 Confirmed Cases by Date of Onset Data
Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/stats.
Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.
Pre Covid-19 Pandemic Use Of Telemedicine For Adherence Promotion In Patients With Psychotic Disorders: A Literature Review, Alyssa M. Edwards, Jordan C. Petitt, Sanjana Kumar, Jennifer B. Levin, Martha Sajatovic
Pre Covid-19 Pandemic Use Of Telemedicine For Adherence Promotion In Patients With Psychotic Disorders: A Literature Review, Alyssa M. Edwards, Jordan C. Petitt, Sanjana Kumar, Jennifer B. Levin, Martha Sajatovic
Faculty Scholarship
Introduction: Given the increasing use of telepsychiatry and to serve as a reference point informing future research, our team evaluated the literature on the use of telepsychiatry for medication adherence promotion prior to the COVID-19 pandemic among patients with psychotic disorders. Methods: A search of PubMed, Cochrane, Web of Science, CINAHL, and PsycINFO was conducted using PRISMA guidelines to identify telepsychiatry interventions to enhance medication adherence in patients with primary psychotic disorders. Both quantitative and qualitative data were extracted from the identified articles including study characteristics, interventions, and outcomes. Results: In total, 230 articles were obtained through electronic literature search, …
2022-09-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
2022-09-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
Michigan COVID-19 Long Term Care Data
The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.
This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.
The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …
2022-09-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2022-09-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …
Mesures À Haute Sensibilité Du Passage De Contaminants Nanométriques À Travers Les Gants De Protection Par Imagerie Médicale, Mahmoud Mohamed Omar, Amélie Augé, Myriam Laprise-Pelletier, Ludovic Tuduri, Marc-André Fortin
Mesures À Haute Sensibilité Du Passage De Contaminants Nanométriques À Travers Les Gants De Protection Par Imagerie Médicale, Mahmoud Mohamed Omar, Amélie Augé, Myriam Laprise-Pelletier, Ludovic Tuduri, Marc-André Fortin
Rapports de recherche scientifique
Les gants de polymère sont utilisés comme équipements de protection individuels dans de nombreux secteurs d’activité professionnelle où les risques chimiques sont présents. Leur efficacité à bloquer le passage de certains contaminants doit être mesurée par des méthodes d’essais précises et standardisées. Les mesures de résistance chimique sont généralement effectuées en utilisant une cellule de perméation, un petit appareil contenant deux réservoirs séparés par la membrane dont on veut mesurer le potentiel-barrière : l’un contient le contaminant, l’autre contient un milieu collectant le contaminant après que celui-ci ait passé à travers la membrane. Au fur et à mesure de l’expérience, …
Effect Of Body Mass Index, Testosterone, And Insulin On Breast Cancer: A Mendelian Randomization Study And Investigation Of Selection Bias, Kezhen Fei
Dissertations and Theses
BACKGROUND: Female breast cancer is the most studied cancer, and the second leading cause of cancer death in women, whose aetiology is still not completely clear. The parallel increase of incident obesity and breast cancer in women worldwide raises the question of the role of adiposity, measured by body mass index (BMI), and of major anabolic hormones, such as insulin and testosterone, on breast cancer. Observational studies are open to confounding making it difficult to clearly demonstrate causal effects. Several mendelian randomization (MR) studies have shown inverse association of BMI with breast cancer. To assess selection bias in MR …
Delineating Covid-19 Immunological Features Using Single-Cell Rna Sequencing, Wendao Liu, Johnathan Jia, Yulin Dai, Wenhao Chen, Guangsheng Pei, Qiheng Yan, Zhongming Zhao
Delineating Covid-19 Immunological Features Using Single-Cell Rna Sequencing, Wendao Liu, Johnathan Jia, Yulin Dai, Wenhao Chen, Guangsheng Pei, Qiheng Yan, Zhongming Zhao
Faculty, Staff and Student Publications
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response toward COVID-19 in multiple tissues and organs. Here, we review the applications and findings from over 80 original COVID-19 single-cell RNA sequencing studies as well as many secondary analysis studies. We describe that single-cell RNA sequencing reveals multiple features of COVID-19 patients with different severity, including cell populations with proportional alteration, COVID-19-induced genes and pathways, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in single cells, and adaptation …
Curating A Knowledge Base For Individuals With Coinfection Of Hiv And Sars-Cov-2: A Study Protocol Of Ehr-Based Data Mining And Clinical Implementation, Chen Liang, Sharon Weissman, Bankole Olatosi, Eric G. Poon, Michael E. Yarrington, Xiaoming Li Ph.D.
Curating A Knowledge Base For Individuals With Coinfection Of Hiv And Sars-Cov-2: A Study Protocol Of Ehr-Based Data Mining And Clinical Implementation, Chen Liang, Sharon Weissman, Bankole Olatosi, Eric G. Poon, Michael E. Yarrington, Xiaoming Li Ph.D.
Faculty Publications
Introduction Despite a higher risk of severe COVID-19 disease in individuals with HIV, the interactions between SARS-CoV-2 and HIV infections remain unclear. To delineate these interactions, multicentre Electronic Health Records (EHR) hold existing promise to provide fullspectrum and longitudinal clinical data, demographics and sociobehavioural data at individual level. Presently, a comprehensive EHR-based cohort for the HIV/SARS-CoV-2 coinfection has not been established; EHR integration and data mining methods tailored for studying the coinfection are urgently needed yet remain underdeveloped. Methods and analysis The overarching goal of this exploratory/developmental study is to establish an EHR-based cohort for individuals with HIV/SARS-CoV-2 coinfection and …
Exploring Ghanaian Immigrants' Healthcare Access And Utilization Of The U.S. Health System, Kweku J. Agyeman
Exploring Ghanaian Immigrants' Healthcare Access And Utilization Of The U.S. Health System, Kweku J. Agyeman
Seton Hall University Dissertations and Theses (ETDs)
ABSTRACT
EXPLORING THE GHANAIAN IMMIGRANTS’ HEALTHCARE ACCESS AND
HEALTHCARE UTILIZATION OF U.S. HEALTHCARE SYSTEM
BY
Kweku J. Agyeman
Background and Purpose of the Study: Healthcare access and utilization in the U.S. continue to pose serious challenges to immigrants. Although the U.S. spends the most on healthcare ($3.8 trillion) among developed countries, accessing and utilizing the U.S. healthcare has become an illusion to most immigrants living in the U.S. including Ghanaians. To date, little is known specifically about Ghanaian immigrants’ access and utilization of the U.S. Healthcare system. For Ghanaians and other immigrants to fully understand the complex U.S. Healthcare …
2022-09-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-09-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
Clonal Hematopoiesis Of Indeterminate Potential, Dna Methylation, And Risk For Coronary Artery Disease, M D Mesbah Uddin, Ngoc Quynh H Nguyen, Bing Yu, Jennifer A Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S Weinstock, Michael C Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K Griffin, Varuna Chander, Richard A Gibbs, Jerome I Rotter, Chunyu Liu, Andrea A Baccarelli, Daniel I Chasman, Eric A Whitsel, Douglas P Kiel, Joanne M Murabito, Eric Boerwinkle, Benjamin L Ebert, Siddhartha Jaiswal, James S Floyd, Alexander G Bick, Christie M Ballantyne, Bruce M Psaty, Pradeep Natarajan, Karen N Conneely
Clonal Hematopoiesis Of Indeterminate Potential, Dna Methylation, And Risk For Coronary Artery Disease, M D Mesbah Uddin, Ngoc Quynh H Nguyen, Bing Yu, Jennifer A Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S Weinstock, Michael C Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K Griffin, Varuna Chander, Richard A Gibbs, Jerome I Rotter, Chunyu Liu, Andrea A Baccarelli, Daniel I Chasman, Eric A Whitsel, Douglas P Kiel, Joanne M Murabito, Eric Boerwinkle, Benjamin L Ebert, Siddhartha Jaiswal, James S Floyd, Alexander G Bick, Christie M Ballantyne, Bruce M Psaty, Pradeep Natarajan, Karen N Conneely
Faculty, Staff and Student Publications
Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic mutations in hematopoietic stem cells (HSCs), is associated with blood cancer and coronary artery disease (CAD). Epigenetic regulators DNMT3A and TET2 are the two most frequently mutated CHIP genes. Here, we present results from an epigenome-wide association study for CHIP in 582 Cardiovascular Health Study (CHS) participants, with replication in 2655 Atherosclerosis Risk in Communities (ARIC) Study participants. We show that DNMT3A and TET2 CHIP have distinct and directionally opposing genome-wide …