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2022

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Articles 1171 - 1200 of 4420

Full-Text Articles in Public Health

Food Insecurity Among Low-Income Households With Children Participating In A School-Based Fruit And Vegetable Co-Op, Allison N Marshall, Ru-Jye Chuang, Joanne Chow, Nalini Ranjit, Jayna M Dave, Mallika Mathur, Christine Markham, Shreela V Sharma Aug 2022

Food Insecurity Among Low-Income Households With Children Participating In A School-Based Fruit And Vegetable Co-Op, Allison N Marshall, Ru-Jye Chuang, Joanne Chow, Nalini Ranjit, Jayna M Dave, Mallika Mathur, Christine Markham, Shreela V Sharma

Faculty, Staff and Student Publications

The purpose of this study was to evaluate the impact of a nutrition intervention on food insecurity among low-income households with children. Data were collected from 371 parent−child dyads in a quasi-experimental evaluation study of a 1-year intervention (n = 6 intervention schools receiving Brighter Bites, n = 6 wait-list control schools), and longitudinal follow-up of the intervention group 2 years post-intervention in Houston, Texas. Data were collected at three timepoints: at baseline and 1 year for all participants, and at 2 year follow-up for the intervention group (the wait-list control group received the intervention during that time). At baseline, …


Barriers And Facilitators To Exclusive Breastfeeding In Rural Pakistan: A Qualitative Exploratory Study, Atif Riaz, Shelina Bhamani, Sheraz Ahmed, Fayyaz Umrani, Sadaf Jakhro, Abdul Khaliq Qureshi, Syed Asad Ali Aug 2022

Barriers And Facilitators To Exclusive Breastfeeding In Rural Pakistan: A Qualitative Exploratory Study, Atif Riaz, Shelina Bhamani, Sheraz Ahmed, Fayyaz Umrani, Sadaf Jakhro, Abdul Khaliq Qureshi, Syed Asad Ali

Department of Paediatrics and Child Health

Background: Exclusive breastfeeding (EBF) of children until six months of age is considered one of the most critical interventions in tackling childhood undernutrition. EBF rates are suboptimal in Pakistan, particularly in rural areas where child undernutrition is most prevalent. This study aimed to explore barriers to EBF in a rural context of Pakistan.
Methods: The study was conducted in the rural district Matiari of Sindh, Pakistan, during Jan-March 2020. We used a qualitative exploratory study design and conducted 36 focus group discussions (FGDs). Participants were purposively selected mothers who had not practiced EBF during their previous childbirth, their spouses and …


Omicron Spike Function And Neutralizing Activity Elicited By A Comprehensive Panel Of Vaccines, John E. Bowen, Amin Addetia, Ha V Dang, Cameron Stewart, Jack T. Brown, William K. Sharkey, Kaitlin R. Sprouse, Kumail Ahmed, Asefa Shariq Ansari, Najeeha Talat Iqbal Aug 2022

Omicron Spike Function And Neutralizing Activity Elicited By A Comprehensive Panel Of Vaccines, John E. Bowen, Amin Addetia, Ha V Dang, Cameron Stewart, Jack T. Brown, William K. Sharkey, Kaitlin R. Sprouse, Kumail Ahmed, Asefa Shariq Ansari, Najeeha Talat Iqbal

Department of Paediatrics and Child Health

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and …


2022-08-18_Michiganoverview_Misc, Michigan Department Of Health & Human Services Aug 2022

2022-08-18_Michiganoverview_Misc, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

The MIS-C Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/mis-c-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by health care providers and local health departments. Data is updated on the first and third Thursdays of the month.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, …


Nutritional Cooking Program With Girls Inc., Taunton, Ma, Chantel Almanzar Aug 2022

Nutritional Cooking Program With Girls Inc., Taunton, Ma, Chantel Almanzar

Honors Program Theses and Projects

As a member of the Institutional Review Board-approved research team comprised of Dr. Maura Rosenthal, Dr. Angela Bailey, and Christina Elderbee, I led a six-week community-based health program that included cooking lessons for girls aged 10 to 13. I taught girls how to prepare healthful foods that they may cook with their family and friends at home. The larger project, Building Equity Through Collaboration with Girl's Inc., aims to study the outcomes of girls’ participation in after school and summer camp programs in 2021 and 2022. One part of this research, which intends to learn more about girls' current and …


Effects Of Caffeine, Methylliberine, And Theacrine On Vigilance, Marksmanship, And Hemodynamic Responses In Tactical Personnel: A Double-Blind, Randomized, Placebo-Controlled Trial, Harry P. Cintineo, Marissa L. Bello, Alexa J. Chandler, Thomas D. Cardaci, Bridget A. Mcfadden, Shawn M. Arent Aug 2022

Effects Of Caffeine, Methylliberine, And Theacrine On Vigilance, Marksmanship, And Hemodynamic Responses In Tactical Personnel: A Double-Blind, Randomized, Placebo-Controlled Trial, Harry P. Cintineo, Marissa L. Bello, Alexa J. Chandler, Thomas D. Cardaci, Bridget A. Mcfadden, Shawn M. Arent

Faculty Publications

Background

Tactical athletes require fast reaction times (RT) along with high levels of vigilance and marksmanship performance. Caffeine has been shown to improve these measures but also results in increased blood pressure and jitteriness. Research on other purine alkaloids, such as methylliberine and theacrine, has suggested they do not increase blood pressure or jitteriness to the same extent, but their impact on tactical performance is unknown.

Methods

A between-subjects, randomized, placebo-controlled design was used to test the effects of placebo (PLA), 300 mg caffeine (CAF), and a combination of 150 mg caffeine, 100 mg methylliberine, and 50 mg theacrine (CMT) …


Leveraging Clinical Digitized Data To Understand Temporal Characteristics And Outcomes Of Acute Myocardial Infarctions At A Tertiary Care Medical Centre In Pakistan From 1988-2018 - Methods And Results, Zainab Samad, Ali Aahil Noorali, Awais Farhad, Safia Awan, Nada Qaiser Qureshi, Mushyada Ali, Laiba Masood, Ghurfan Adnan, Zulfiqar Ahmed Bhutta, Javed Tai Aug 2022

Leveraging Clinical Digitized Data To Understand Temporal Characteristics And Outcomes Of Acute Myocardial Infarctions At A Tertiary Care Medical Centre In Pakistan From 1988-2018 - Methods And Results, Zainab Samad, Ali Aahil Noorali, Awais Farhad, Safia Awan, Nada Qaiser Qureshi, Mushyada Ali, Laiba Masood, Ghurfan Adnan, Zulfiqar Ahmed Bhutta, Javed Tai

Section of Cardiology

Background and objective: Few data exist on trends in acute myocardial infarction (AMI) patterns spanning recent epidemiological shifts in low middle-income countries (LMICs). To understand temporal disease patterns of AMI characteristics and outcomes between 1988-2018, we used digitized legacy clinical data at a large tertiary care centre in Pakistan.
Methods: We reviewed digital health information capture systems maintained across the Aga Khan University Hospital and obtained structured elements to create a master dataset. We included index admissions of patients >18 years that were discharged between January 1, 1988, and December 31, 2018, with a primary discharge diagnosis of AMI (using …


Covid-19 Youth Ambassador Corp, A Community-Based Program To Address Vaccine Hesitancy, Atoosa Azarang Aug 2022

Covid-19 Youth Ambassador Corp, A Community-Based Program To Address Vaccine Hesitancy, Atoosa Azarang

Master's Projects and Capstones

With over one million confirmed deaths from COVID-19, the United States (U.S.) continues to battle the public health crisis arising from the spread of the SARS-CoV-2 virus. The COVID-19 pandemic has had a devastating impact on our economic, social, and health systems. Social distancing efforts and other precautionary measures such as mask-wearing have not sufficiently reduced morbidity and mortality from COVID-19; thus, COVID-19 vaccinations are an important tool for substantially alleviating the effects of the pandemic. Although COVID-19 vaccines are available to all Americans aged six months and older, many individuals are hesitant to receive vaccines. The two most common …


Statistical Analysis Methods Applied To Early Outpatient Covid-19 Treatment Case Series Data, Eleftherios Gkioulekas, Peter A. Mccullough, Vladimir Zelenko Aug 2022

Statistical Analysis Methods Applied To Early Outpatient Covid-19 Treatment Case Series Data, Eleftherios Gkioulekas, Peter A. Mccullough, Vladimir Zelenko

School of Mathematical & Statistical Sciences Faculty Publications

When confronted with a public health emergency, significant innovative treatment protocols can sometimes be discovered by medical doctors at the front lines based on repurposed medications. We propose a statistical framework for analyzing the case series of patients treated with such new protocols, that enables a comparison with our prior knowledge of expected outcomes, in the absence of treatment. The goal of the proposed methodology is not to provide a precise measurement of treatment efficacy, but to establish the existence of treatment efficacy, in order to facilitate the binary decision of whether the treatment protocol should be adopted on an …


Child Health In Darfur, Sudan: Addressing The Effects Of Armed Conflict On Children's Health In Darfur, Judith Natukunda Aug 2022

Child Health In Darfur, Sudan: Addressing The Effects Of Armed Conflict On Children's Health In Darfur, Judith Natukunda

Master's Projects and Capstones

ABSTRACT

Background: For 19 years, the Darfur region of Sudan has experienced unending civil unrest and war, resulting in more than 2 million deaths and over 4 million displaced persons. The war led to severe food insecurity, clean and safe drinking water shortages, high disease prevalence, destruction of infrastructure, and a broken health care system. Despite the interventions by the global community and various humanitarian agencies, over 2.8 million people are still displaced and living in IDP camps across Darfur. Over 300,000 children are living in neighboring Chad. The armed conflict led to high levels of child malnutrition, a high …


Standardizing Perinatal Mental Health Interventions: A Guide For The U.S., Maile Lauren Robles Aug 2022

Standardizing Perinatal Mental Health Interventions: A Guide For The U.S., Maile Lauren Robles

Master's Projects and Capstones

The term perinatal individual refers to women and other individuals who are pregnant or who have been pregnant within the last 12 months. Every year, in the United States there are 700 pregnancy-related deaths and 10% are due to mental health causes including death by suicide. Mental health conditions including but not limited to anxiety, depression, substance use disorders, and post-traumatic stress disorder affect one in five perinatal individuals throughout the United States. This increases perinatal morbidity, hospitalization costs, and economic burden nationwide.

After 43 days postpartum, mental health conditions are the second leading cause of death. The United States …


2022-08-17_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services Aug 2022

2022-08-17_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.


2022-08-17_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services Aug 2022

2022-08-17_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …


Release Of Vocs, Gasses, And Bacteria From Contaminated Landings And Creeks Of Ogeechee River Basin, Victoria A. Clower, Melanie Sparrow, Atin Adhikari Aug 2022

Release Of Vocs, Gasses, And Bacteria From Contaminated Landings And Creeks Of Ogeechee River Basin, Victoria A. Clower, Melanie Sparrow, Atin Adhikari

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

River landings are common public grounds, visited by many people every day. The aftermath of visiting these places may be unsettling since much trash is left behind and scattered throughout. The litter collects and with each rain or high wind, it has a better chance of ending up in our streams, rivers, creeks, and eventually our oceans. The main purpose of this study was to measure both air and water quality throughout the Ogeechee River basin in South Georgia to determine how each was impacted by trash. Ammonia, methane, and volatile organic compounds (VOCs) along with temperature and humidity were …


2022-08-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Aug 2022

2022-08-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …


2022-08-16_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services Aug 2022

2022-08-16_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …


2022-08-16_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Aug 2022

2022-08-16_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …


2022-08-16_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services Aug 2022

2022-08-16_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.


Covid-19 Newsletter (Vol. 132), Center For Disaster Medicine, New York Medical College Aug 2022

Covid-19 Newsletter (Vol. 132), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.


The Global Network Socioeconomic Status Index As A Predictor Of Stillbirths, Perinatal Mortality, And Neonatal Mortality In Rural Communities In Low And Lower Middle Income Country Sites Of The Global Network For Women's And Children's Health Research, Archana B. Patel, Carla M. Bann, Cherryl S. Kolhe, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Lester Figueroa, Nancy F. Krebs, Fabian Esamai, Sarah Saleem Aug 2022

The Global Network Socioeconomic Status Index As A Predictor Of Stillbirths, Perinatal Mortality, And Neonatal Mortality In Rural Communities In Low And Lower Middle Income Country Sites Of The Global Network For Women's And Children's Health Research, Archana B. Patel, Carla M. Bann, Cherryl S. Kolhe, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Lester Figueroa, Nancy F. Krebs, Fabian Esamai, Sarah Saleem

Community Health Sciences

Background: Globally, socioeconomic status (SES) is an important health determinant across a range of health conditions and diseases. However, measuring SES within low- and middle-income countries (LMICs) can be particularly challenging given the variation and diversity of LMIC populations.
Objective: The current study investigates whether maternal SES as assessed by the newly developed Global Network-SES Index is associated with pregnancy outcomes (stillbirths, perinatal mortality, and neonatal mortality) in six LMICs: Democratic Republic of the Congo, Guatemala, India, Kenya, Pakistan, and Zambia.
Methods: The analysis included data from 87,923 women enrolled in the Maternal and Newborn Health Registry of the NICHD-funded …


Tobacco Policy Reform: Ending The Youth And Young Adult Tobacco Epidemic, Rocio Arjon Aug 2022

Tobacco Policy Reform: Ending The Youth And Young Adult Tobacco Epidemic, Rocio Arjon

Master's Projects and Capstones

Tobacco has been accessible to communities all over the world since 6,000 BC. Overtime, the tobacco industry adapted its products to become more modern and look like technology or taste like common foods and candy. In 1989 the California Department of Public Health organized the California Control Tobacco Program (CTCP) which funds many local jurisdictions in California to provide tobacco education to community members and pass local ordinance to protect the health of their community. This paper is examining the existing policies in Hollister to protect our children and young adults, end the tobacco epidemic, advocate for more comprehensive tobacco …


A One Health Approach: Addressing The Overuse Of Antibiotics In Agriculture, Abby Erin Anderson Aug 2022

A One Health Approach: Addressing The Overuse Of Antibiotics In Agriculture, Abby Erin Anderson

Master's Projects and Capstones

Antimicrobial resistance (AMR) has emerged as one of the leading public health threats of the 21st century (Naghavi, 2022). AMR occurs due to an evolution of bacteria, making treatments of bacterial infections less effective (Naghavi, 2022). In recent years, several publications began identifying a linkage between antibiotic use in agriculture to humans. Roughly 70% of all antibiotics in the United States are being used in animal feed (Cable, 2018). More than 2.8 million antibiotic-resistance infections occur in the United States every year- which results in roughly 35,000 deaths (CDC, 2019). A comprehensive analysis estimated nearly 1.27 million deaths globally …


Serious Hazards Of Transfusion: Evaluating The Dangers Of A Wrong Patient Autologous Salvaged Blood In Cardiac Surgery., Masashi Uramatsu, Hideyuki Maeda, Shiro Mishima, Megumi Takahashi, Jun Wada, Kagehiro Amano, Paul Barach, Tamotsu Miki Aug 2022

Serious Hazards Of Transfusion: Evaluating The Dangers Of A Wrong Patient Autologous Salvaged Blood In Cardiac Surgery., Masashi Uramatsu, Hideyuki Maeda, Shiro Mishima, Megumi Takahashi, Jun Wada, Kagehiro Amano, Paul Barach, Tamotsu Miki

College of Population Health Faculty Papers

BACKGROUND: The past half century has seen the near eradication of transfusion-associated hazards. Intraoperative cell salvage while widely used still poses significant risks and hazards due to human error. We report on a case in which blood collected from a patient with lung cancer was mistakenly administered to a patient undergoing cardiac surgery who should have received his own collected blood. The initial investigation found that the cause of the patient harm was violations of procedures by hospital personnel. A detailed investigation revealed that not only violations were the cause, but also that the underlying causes included haphazard organizational policies, …


Cross-Sector Decision Landscape In Response To Covid-19: A Qualitative Network Mapping Analysis Of North Carolina Decision-Makers, Caitlin B Biddell, Karl T Johnson, Mehul D Patel, Raymond L Smith, Hillary K Hecht, Julie L Swann, Maria E Mayorga, Kristen Hassmiller Lich Aug 2022

Cross-Sector Decision Landscape In Response To Covid-19: A Qualitative Network Mapping Analysis Of North Carolina Decision-Makers, Caitlin B Biddell, Karl T Johnson, Mehul D Patel, Raymond L Smith, Hillary K Hecht, Julie L Swann, Maria E Mayorga, Kristen Hassmiller Lich

Faculty, Staff and Student Publications

INTRODUCTION: The COVID-19 pandemic response has demonstrated the interconnectedness of individuals, organizations, and other entities jointly contributing to the production of community health. This response has involved stakeholders from numerous sectors who have been faced with new decisions, objectives, and constraints. We examined the cross-sector organizational decision landscape that formed in response to the COVID-19 pandemic in North Carolina.

METHODS: We conducted virtual semi-structured interviews with 44 organizational decision-makers representing nine sectors in North Carolina between October 2020 and January 2021 to understand the decision-making landscape within the first year of the COVID-19 pandemic. In line with a complexity/systems thinking …


The Rationale For The Utilization Of Under Desk Bikes In Office Settings, Danielle Little Aug 2022

The Rationale For The Utilization Of Under Desk Bikes In Office Settings, Danielle Little

Masters Theses, 2020-current

Inactivity and sedentary behavior are major health concerns, exacerbated by the amount of time individuals spend at work. Purpose: To examine if 30-60 minutes of daily under-the-desk bicycle (UDB) use while working for 8 weeks helped sedentary and physically inactive adults reach the U.S. physical activity guidelines (PAG) and improve perceptions of wellness and job satisfaction. Methods: Subjects (n=22, average age=45.3 yrs, average BMI=30.2 kg/m2) cycled for 30-60 minutes on workdays for 8-weeks at a self-selected intensity level of 2 or 3 out of 8 total levels. Participants were advised not to engage in additional physical activity outside the study …


Poziotinib Inhibits Her2-Mutant-Driven Therapeutic Resistance And Multiorgan Metastasis In Breast Cancer, Rashi Kalra, Ching Hui Chen, Junkai Wang, Ahmad Bin Salam, Lacey E Dobrolecki, Alaina Lewis, Christina Sallas, Clayton C Yates, Carolina Gutierrez, Balasubramanyam Karanam, Meenakshi Anurag, Bora Lim, Matthew J Ellis, Shyam M Kavuri Aug 2022

Poziotinib Inhibits Her2-Mutant-Driven Therapeutic Resistance And Multiorgan Metastasis In Breast Cancer, Rashi Kalra, Ching Hui Chen, Junkai Wang, Ahmad Bin Salam, Lacey E Dobrolecki, Alaina Lewis, Christina Sallas, Clayton C Yates, Carolina Gutierrez, Balasubramanyam Karanam, Meenakshi Anurag, Bora Lim, Matthew J Ellis, Shyam M Kavuri

Faculty, Staff and Student Publications

The pan-HER tyrosine kinase inhibitor (TKI) neratinib is therapeutically active against metastatic breast cancers harboring activating HER2 mutations, but responses are variable and often not durable. Here we demonstrate that recurrent HER2 mutations have differential effects on endocrine therapy responsiveness, metastasis, and pan-HER TKI therapeutic sensitivity. The prevalence and prognostic significance may also depend on whether the HER2 mutant has arisen in the context of lobular versus ductal histology. The most highly recurrent HER2 mutant, L755S, was particularly resistant to neratinib but sensitive to the pan-HER TKI poziotinib, alone or in combination with fulvestrant. Poziotinib reduced tumor growth, diminished multiorgan …


2022-08-15_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services Aug 2022

2022-08-15_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …


The Cost Of Child Support: Policy Design And Father Identity, Lara Markovitz Aug 2022

The Cost Of Child Support: Policy Design And Father Identity, Lara Markovitz

Brown School Graduate Student Theses and Dissertations

Child support policy is one of the key forces in the lives of families in the U.S., where 1 in 4 children and half of African American children live apart from their fathers (Carlson et al., 2017; Grall, 2020; U.S. Census Bureau, 2014). Most unmarried fathers of newborns express a strong desire and commitment to their children (Carlson & McLanahan, 2002; England & Edin, 2007). However, by the time their children turn five, fathers'; involvement (caregiving and time, provision of child support) diminishes greatly (Turner & Waller, 2017). This decrease in father involvement among low-income NRFs is thought to be …


The Vulnerability Of A Poor Urban Neighborhood To Extreme Weather Disasters And The Role Of Ecosocial Work: The Case Of Tongja-Dong Jjokbang-Chon In Seoul, South Korea, Joonmo Kang Aug 2022

The Vulnerability Of A Poor Urban Neighborhood To Extreme Weather Disasters And The Role Of Ecosocial Work: The Case Of Tongja-Dong Jjokbang-Chon In Seoul, South Korea, Joonmo Kang

Brown School Graduate Student Theses and Dissertations

his study is an inquiry into the vulnerability of poor older adults living in the Tongja-dong jjokbang-chon, one of the last remaining informal settlements in Seoul, South Korea, to climate change-related disasters, particularly heat waves and cold waves; climate change’s impact on their livelihoods; and the role of social work in responding to these challenges. Even though the harsh living conditions and the sufferings of those living in jjokbang-chon residents during extreme weather is constantly highlighted in the media, there is a dearth of empirical research focusing on the vulnerabilities of marginalized communities living in jjokbang-chon to extreme weather and …


2022-08-15_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services Aug 2022

2022-08-15_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.