Public Health Commons^™

Evaluating Fda Generic Approval After 2017 Agency Initiatives, Kuo Jiao

Public Health Theses

Importance: Generic drugs play an essential role in the US healthcare system, providing less costly alternatives to branded drugs that are equally effective and safe. The US Food and Drug Administration (FDA) regulatory policies influence the standards for generic drug approval. In 2017, the FDA instituted several initiatives to promote generic drug approval, particularly focused on those with limited competition.

Objective: To determine whether the initiatives begun by FDA in 2017 were associated with greater numbers of approvals of generic drugs with limited generic competition and histories of drug shortage.

Study Sample and Design: We conducted a cross-sectional study of …

Eating Insects: A Community Action Toolkit, Lily X. Chumrau, Charlotte Langner, Freya Sargent, Ellen Sears, Mary Mccormick

Undergraduate Theses, Professional Papers, and Capstone Artifacts

The world’s human population has risen exponentially over the last 100 years and is expected to reach nine billion by 2050. Ensuring food security and resource sustainability is of global concern. The United Nations Food and Agriculture Organization endorses insect farming as an alternative to cattle, pork, sheep, and poultry industries because of their higher food conversion rate. Insect farming requires less arable land, less water, and produces less greenhouse gases than traditional livestock. The practice of eating insects, known as entomophagy, is not a new idea as two billion people around the world include insects in their diets. Unfortunately, …

A Qualitative Research Synthesis Of Contextual Factors Contributing To Female Overweight And Obesity Over The Life Course In Sub-Saharan Africa, Ifeoma Ozodiegwu, Mary Ann Littleton, Christian Nwabueze, Oluwaseun Famojuro, Megan Quinn, Rick L. Wallace, Hadii M. Mamudu

ETSU Faculty Works

Objective: Adult women are disproportionately affected by overweight and obesity in Sub-Saharan African (SSA) countries. Existing evidence on the sociocultural context remains unconsolidated. In this qualitative research synthesis, we aggregate research literature on contextual factors that potentially predispose adult women and adolescent girls to overweight and obesity to inform research, policies and programs over the life course.

Methods: PubMed, CINAHL, PsychInfo, ProQuest Central, EMBASE, and Web of Science were searched to locate qualitative research articles conducted in SSA countries beginning in the year 2000. After assessment for eligibility and critical appraisal, 17 studies were included in the synthesis. Textual data …

Adventist Healthcare: A Qualitative Study Of 19th Century Founding Governing Principles In 21st Century Adventist Hospitals, Cesiah Yareth Pimentel Melendez

Dissertations

Problem and Purpose

Founding values and principles can help organizations stay focused on fulfilling their mission. This is especially true in faith-based organizations that seek to continue their founding principles as a governing commitment to their core identity. This study identified Adventist healthcare founding principles in Ellen G. White's early health visions and explored how Adventist healthcare leaders perceived these principles as governing principles applied to current Adventist healthcare practices.

Conceptual Framework and Research Design

Two metaphors and three areas of literature review guided my approach of this qualitative study of Adventist healthcare founding principles. My first metaphor of DNA …

Differential Abundance And Clustering Analysis With Empirical Bayes Shrinkage Estimation Of Variance (Dasev) For Proteomics And Metabolomics Data, Zhengyan Huang

Theses and Dissertations--Epidemiology and Biostatistics

Mass spectrometry (MS) is widely used for proteomic and metabolomic profiling of biological samples. Data obtained by MS are often zero-inflated. Those zero values are called point mass values (PMVs). Zero values can be further grouped into biological PMVs and technical PMVs. The former type is caused by the absence of components and the latter type is caused by detection limit. There is no simple solution to separate those two types of PMVs. Mixture models were developed to separate the two types of zeros apart and to perform the differential abundance analysis. However, we notice that the mixture model can …

Bold Leadership Is Needed For Transforming Health Care., Dora Barilla, Huma Shah, Rick Rawson

Articles, Abstracts, and Reports

Health care in the United States is going through significant changes and is at the forefront of the political landscape. While the health care debate rages on, leaders need to forge ahead and continue to work towards population-based health care and investing in their communities in a fiscally conscious way. Many innovations are happening but more needs to be done, especially in upstream services improving the health of the community. Research shows that investing in social care services and community-based investments results in lower health care expenditures and better health outcomes. Efforts should be placed on exploring a blended medical/social …

Harm Reduction Policy : Biopower, Race & Stigma At The Heart Of The 'Opioid Crisis', Cole Charles Melby

Legacy Theses & Dissertations (2009 - 2024)

Across the U.S., concerns regarding substance abuse, addiction, and treatment are coming to the forefront of public discourse, due to increased media coverage of the popularly dubbed ‘opioid crisis.’ As overdose rates increase, particularly in rural and suburban white communities, so have debates about the ethics and efficacy of harm reduction services. Through a review of existing literature and reflections on interviews from key informants at New York State Department of Health, grassroots harm reduction organizations, and a ‘mainstream’ addiction clinic, this thesis will critically examine the history of drug user stigmatization in the U.S. and how it has influenced …

Environmental Influences On Rates Of Osteo- And Rheumatoid Arthritis, Azad Abdulrahman Mohammed

Legacy Theses & Dissertations (2009 - 2024)

Abstract

Epidemiology Of Self-Reported Maternal Depression During Pregnancy And Association With Adverse Birth Outcomes In New York State, 2012-2017, Solita Julianna Jones

Legacy Theses & Dissertations (2009 - 2024)

Background

The Aids Volcano : Narratives Of Hiv/Aids In The Iranian Public Sphere, Elham Pourtaher

Legacy Theses & Dissertations (2009 - 2024)

Broadly construed, this thesis will examine the transformations in the socio-cultural construction of HIV/AIDS in Iran from the joint perspectives of media and medical sociology. Until recently, official public narratives in Iran primarily regarded AIDS to be a drug-related disease. However, beginning from the early 2010s, a new narrative frame (often called as “the third wave”) introduces a significant “alarming” collective shift in the transmissions modes of the disease toward sexual pathways. Having observed the rather rapid transformation of the public AIDS framing, this research began with an empirical question: considering the fact that the shift implied the prevalence of …

Impact Evaluation Of The Church Environment As An Enabler Of Physical Activity Among Church-Going African Americans In New York City, Moses Mansu

Legacy Theses & Dissertations (2009 - 2024)

Background: While African Americans in NYC are more likely to have sedentary lifestyles than other racial groups, it is known that regular moderate to vigorous physical activity (PA) reduces their risks of chronic diseases. Recognizing that the church has a deep reach in the African American community, the NYCDOHMH in 2015 initiated a PA program in70 houses of worship, among which were 49 African American churches. Free exercise equipment and the services of paid fitness instructors were donated to participating organizations to conduct exercise classes.

Climate Change And Salmonella, New York State, Kevin Taylor Welch

Legacy Theses & Dissertations (2009 - 2024)

A study of climate change and Salmonella was conducted, serving as the evidence-based results for action to mitigate adverse Salmonella outcomes for the population of New York State (NYS), and to facilitate dissemination of findings in regard to validated approaches for broader use to mitigate climate change and adverse communicable disease outcomes in a variety of other settings. This study bolsters understanding of dynamic exposures and outcomes for improved and targeted public health approaches to localized climate change and communicable disease outcomes. The approach was developed and refined through continuously validated and calibrated methodology for the enhancement of disease control …

Anxiety Among Women Living With Hiv In Kazakhstan, Kathryn Emily Mishkin

Legacy Theses & Dissertations (2009 - 2024)

Research shows that mental illness has an impact on the health and quality of life of women living with HIV. As a result, many countries have adopted integrated care models to provide holistic treatment to women living with HIV. However, some countries, where the HIV burden is particularly high, have been ineffective at addressing the mental health needs of these women, primarily because of a compartmentalized health care structure that limits interaction among sectors. By describing the prevalence of anxiety and comorbid anxiety-depression among women living with HIV in affected areas, there is an opportunity for effective policies to be …

Pregnant Women's Knowledge And Use Of Evidence-Based Practices During Labor And Childbirth After Participating In A Health Education Intervention : Senses Of Birth, Luisa Da Matta Machado Fernandes

Legacy Theses & Dissertations (2009 - 2024)

Background: Senses of Birth (SoB) is a health education intervention in Brazil that addresses reproductive rights, the benefits and risks of normal birth and cesarean, and use of evidence-based practices (EBP) during labor and childbirth, aiming to reduce unnecessary cesareans in the country. This mixed-method study had three objectives: 1) evaluate the impact of the SoB intervention on pregnant women’s perceived knowledge about normal birth, cesarean, and use of EBP in childbirth; 2) identify socio-demographic factors, obstetric characteristics, and aspects of women’s perceived knowledge that influence women’s use of EBP; and 3) analyze the outcomes, barriers and facilitators/strategies to use …

Changes In Fish Consumption Patterns And Knowledge Pre-/Post-Fish Consumption Education By Race In The Capital District Of New York State, Donghong Gao

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Examining The Association Between Toxocara Infection And Lung Function In A Nationally Representative Sample Of U.S. Adults Aged 18-79 Years, Tejaswini Chakravarthy

Legacy Theses & Dissertations (2009 - 2024)

Introduction:

Descriptive And Risk Factor Analysis Of Infantile Cataracts, Marine Nalbandyan

Legacy Theses & Dissertations (2009 - 2024)

Infantile cataract is a lens opacity diagnosed by 12 months of age. It is a major cause of childhood blindness, with about 200,000 children worldwide being blind because of bilateral cataracts. Blindness has a negative impact on the quality of a child’s life and is associated with increased healthcare costs. While reduction/elimination of childhood blindness is a priority issue in public health, risk factors remain unknown for about two-thirds of infantile cataract cases. The primary aims of this dissertation were to (1) identify, evaluate, and summarize observational studies investigating non-genetic risk factors for infantile cataracts, (2) estimate birth prevalence and …

Association Of Serum Pcsk9 With Carotid Artery Thickness And Carotid Lesions In Women With Hiv And Hepatitis C Virus, Michael Patrick Searles

Legacy Theses & Dissertations (2009 - 2024)

Background: Increase in risk for coronary artery disease (CAD) is a well-documented for HIV-infected (HIV+) populations. A precursor of cardiovascular events in HIV+ populations are non-calcified plaque (lesion) formations and can be associated with arterial inflammation, monocyte aggregation and dendritic cell activation. PCSK9 a known modulator of LDL cholesterol, has also been shown to contribute to inflammation, dendritic cell activation, monocyte aggregation and potentially plaque formations.

The Clinical Laboratory Workforce In New York State : A Study Of Supply And Demand, Stephanie H. Shulman

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

The Effect Of Anthropogenic Environmental Modifications On Malaria Vectors In Amazonian Peru And Brazil, Catharine Prussing

Legacy Theses & Dissertations (2009 - 2024)

Malaria is the most deadly vector borne disease, causing substantial morbidity and hundreds of thousands of deaths worldwide each year. In the Americas, the incidence of malaria has increased steadily since 2014. The factors driving continued malaria transmission are complex and highly variable across endemic areas. These factors include inadequate access and financial commitment to prevention, diagnosis, and treatment, and a failure to target interventions to heterogeneous malaria transmission patterns and vector populations. Nyssorhynchus darlingi (formerly Anopheles darlingi), the predominant malaria vector in Latin America, is known for behavioral, phenotypic, and genetic variability across its range, which allow it to …

The Effect Of Maternal Dietary Habits During Pregnancy On Neonate Leptin Methylation Patterns And Gestational Age, Sean Fitzpatrick

Legacy Theses & Dissertations (2009 - 2024)

The health of a newborn baby is inextricably linked to the health status of its mother and in turn the mother’s diet during pregnancy. Leptin (LEP) is an adipokine hormone involved in metabolism regulation and has been linked fetal development through the hypothalamic-pituitary-adrenal axis (HPA). Prior work suggests that gestational epigenetic alterations the LEP gene may be sensitive to adverse exposures during pregnancy, which in turn could explain variation in neonate outcomes. However, no prior work has examined this possibility explicitly. The objective of this study was to investigate the association between dietary patterns of mothers during pregnancy and their …

Behavioral And Socio-Ecological Determinants Of Depression At Different Stages Of The Life Course, Xiao Cong

Legacy Theses & Dissertations (2009 - 2024)

Background:

Assessing The Sustainability Of Collaborations Between Local Health Departments And Nonprofit Hospitals For Population Health, Christopher Mierow Maylahn

Legacy Theses & Dissertations (2009 - 2024)

In 2008, New York’s health commissioner asked LHDs and nonprofit hospitals to collaborate with community partners to conduct community health needs assessments, identify two or three health priorities to focus on, and implement evidence-based strategies to address them. The actions taken as part of the New York State Prevention Agenda mirrored the IRS rules and PHAB recommendations that followed. The dearth of published studies on public health-hospital collaborations and the momentum to understand how communities in New York have responded to the IRS rules and PHAB standards are the impetus for this research.

Right Size Me : Policy Responses To The Obesity Eidemic And Behavioral Change, Wenhui Feng

Legacy Theses & Dissertations (2009 - 2024)

Obesity is a critical health and social concern. Almost 40% of American adults are obese, creating more than $300 billion dollars in annual medical costs. While obesity is a public concern that has been on the policy agenda for some time, obesity policies have proven difficult to formulate, adopt and implement in practice. In this dissertation, I explore three obesity-related policies – adoption of obesity prevention policies by local health department, calorie labeling on restaurant menus and food assistance benefits – and find the importance of ideological and political considerations for obesity policies at different stages in the policy process …

Endogenous Policy Design In Healthcare : A Case Study Of Emergency Department Crowding, Katrina Alexandra Hull

Legacy Theses & Dissertations (2009 - 2024)

The United States’ health care system has faced growing per capita use, and subsequent crowding, of the emergency department since the 1990’s, evidenced by longer wait times and the institution of ambulance diversions. Emergency departments are but one element of a complex system, with difficulties which persist despite policy efforts.

Depression, Sensation-Seeking Behavior And Violence As Mediators Of The Association Between Childhood Adversity And Substance Use Disorder, Calvin Wong

Legacy Theses & Dissertations (2009 - 2024)

Background:

Risk Factors For Gestational Diabetes In Upstate New York Women & Implications For Practice, Margaret Versteegen

Legacy Theses & Dissertations (2009 - 2024)

Gestational diabetes mellitus (GDM) is a form of diabetes, or abnormal blood glucose (sugar) metabolism, diagnosed during pregnancy. Pregnant, non-diabetic women who are initially noted to experience high blood glucose levels during their pregnancy are considered to have GDM (ADA, 2016b). GDM has significant implications for infant and maternal morbidity and mortality, with adverse pregnancy outcomes such as infant macrosomia, difficult birth requiring cesarean section, and postpartum hemorrhage (Kamana, Shakya, & Zhang, 2015). In the majority of cases, GDM goes away once the baby is born, but around 5-10% of women with GDM go on to have type 2 diabetes …

Response To "From A Polemic Paradox To A Proper Perspective Of Job Burnout And Job Satisfaction, Eric Laurent, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

Juárez García and colleagues considered that “part of the conceptual and empirical problem of burnout is that many researchers force it into a biomedical disease model despite its being a psychosocial one.” Problematically, these authors’ scholastic argument a priori excludes biological or bodily factors from psychological conceptualizations. Scientists usually face considerable difficulties when trying to describe complex processes. If the understanding of biological processes sheds light on the complex processes that bear on burnout, then there is no reason to exclude research on those processes.

Evaluating The Impacts Of Antidepressant Use On The Risk Of Dementia, Ran Duan

Theses and Dissertations--Epidemiology and Biostatistics

Dementia is a clinical syndrome caused by neurodegeneration or cerebrovascular injury. Patients with dementia suffer from deterioration in memory, thinking, behavior and the ability to perform everyday activities. Since there are no cures or disease-modifying therapies for dementia, there is much interest in identifying modifiable risk factors that may help prevent or slow the progression of cognitive decline. Medications are a common focus of this type of research.

Importantly, according to a report from the Centers for Disease Control and Prevention (CDC), 19.1% of the population aged 60 and over report taking antidepressants during 2011-2014, and this number tends to …

Autonomy, Intimate Partner Violence, And Maternal Health-Seeking Behavior: Findings From Mixed-Methods Analysis In Kenya, Charlotte E. Warren, Pooja Sripad, Charity Ndwiga

Reproductive Health

Gendered norms and discriminatory practices often limit women’s decision-making power, which over time can lead to social norms that systematically disadvantage women. Aspects of empowerment were explored in a global evaluation of Demographic and Health Survey data that measured how gendered social norms influenced maternal health-seeking behaviors. Analysis specifically explored associations of women’s autonomy and acceptability of intimate partner violence against women (IPVAW) on antenatal care use and facility delivery in 63 low- and middle-income countries. Service utilization is positively associated with increased autonomy and negatively associated with increased acceptability of IPVAW, but variability exists across countries and regions. In …