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Articles 61 - 90 of 400
Full-Text Articles in Public Health
Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page
Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page
All ETDs from UAB
ationale: Prone positioning is one of the few interventions shown in a robust, randomized, controlled clinical trial to reduce mortality in severe ARDS. Ideal duration of prone positioning is unknown. A 16-hour prone positioning period has been studied and is considered standard, although longer duration may be beneficial. Objectives: Determine if a prolonged prone positioning strategy for patients with COVID-19-induced ARDS is feasible and safe. Methods: We performed a pilot, randomized, parallel-arm feasibility study in patients with COVID-19-induced ARDS. Patients were randomized to either a prolonged 24-hour or a traditional 16-hour prone positioning strategy. Measurements & Main Results: 52 patients …
Photothermal Desorption Of Volatile Organic Compounds From Buckypaper Sorbents, For Occupational Exposure Assessment, Jacob S. Shedd
Photothermal Desorption Of Volatile Organic Compounds From Buckypaper Sorbents, For Occupational Exposure Assessment, Jacob S. Shedd
All ETDs from UAB
Volatile organic compounds (VOCs) are a common source of occupational exposures. To prevent adverse health effects in employees, industrial hygienists must regularly conduct occupational air sampling to ensure exposures remain below regulatory limits. As such, the need for sensitive and reliable exposure assessment methodologies becomes apparent. Currently, diffusive sampling is popular and well-established exposure assessment method amongst professionals. However, its reliance on diffusion-driven mass uptake and chemical extraction, results in limited analytical sensitivity. In response to this, a pre-analytical technology, known as photothermal desorption (PTD), has been in development over the past decade. PTD uses pulses of high-energy light to …
Filtration And Adsorption Performance Of Activated Carbon Fiber: Applications For Respiratory Protection, Margaret C. Summers
Filtration And Adsorption Performance Of Activated Carbon Fiber: Applications For Respiratory Protection, Margaret C. Summers
All ETDs from UAB
Activated Carbon Fiber (ACF) is an adsorbent material that can be used to re-move volatile organic compounds (VOCs) from the air. Unlike granular adsorbents that are currently used in organic vapor respirators, ACF is a self-supporting fiber structure that can be tailored into non-woven forms and can potentially be used to support particu-late filtration. While ACF-containing respirators first appear in patent literature in the 1980s, the use of ACF in respiratory protection has not been widely considered in the PPE market in the intervening years. To develop the concept of an ACF-containing N95 that offers particulate filtration in addition to …
Non-Mean Ambulatory Blood Pressure Monitoring Parameters And Left Ventricular Hypertrophy: Analysis Of Pooled Population- And Community-Based Studies, Swati Sakhuja
All ETDs from UAB
High mean blood pressure (BP) on ambulatory BP monitoring (ABPM) is a strong risk factor for left ventricular hypertrophy (LVH), an early manifestation of hypertension-related cardiovascular disease (CVD). Typically, 48-72 systolic and diastolic BP (SBP and DBP) readings are obtained on a 24-hour ABPM recording. The large number of readings from ABPM allows for the estimation of parameters beyond mean BP that capture level and fluctuation in BP over 24-hours, which may be useful for identifying individuals at high risk for CVD. The measures of BP level other than mean BP obtained from ABPM recording include BP load (percentage of …
Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson
Power And Sample Size Calculations For Linear Mixed Models Of Longitudinal Data Using The Kenward-Roger Adjusted Wald Test, Tarrant Oliver Mcpherson
All ETDs from UAB
The linear mixed model has become a popular technique for the analysis of longitudinal data, but Wald test statistics of fixed effects for these models frequently lack well defined distributions. A common approach to this problem uses the Kenward-Roger adjustment, which attempts to approximate the distribution of the Wald statistic by matching its moments obtained via Taylor expansion to those of an F distribution. However, this approach only matches moments obtained under the null hypothesis of no effect and cannot currently be used to approximate the distribution of the test statistic under some alternative hypothesis. This limitation prevents a straightforward …
Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman
Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman
All ETDs from UAB
Introduction: Chlamydia is the most common bacterial sexually transmitted infection (STI) worldwide and it disproportionally affects young people and those living in the Southern United States. If left untreated chlamydia infections can lead to complications such as infertility and pelvic inflammatory disease. Currently, chlamydia vaccines are being development. A successful chlamydia immunization program would require adolescents to be vaccinated before engagement in sexual activity and would require parental approval and recommendations from healthcare providers. Therefore, this project aims to explore parent and healthcare provider opinions about chlamydia vaccines to identify potential barriers and facilitators to uptake. Because the COVID-19 pandemic …
History Of Allergy, Atopy, Infectious And Autoimmune Disease And Risk Of Multiple Myeloma, Tony B. Zbysinski
History Of Allergy, Atopy, Infectious And Autoimmune Disease And Risk Of Multiple Myeloma, Tony B. Zbysinski
All ETDs from UAB
Multiple Myeloma (MM) is a plasma cell malignancy, which is defined in part by antibodies and complexes of immunoglobulin (Ig) heavy and light chains (IgH and IgL). Previous associations of immune-stimulating conditions such as allergic, autoimmune, and infectious conditions and the risk of multiple myeloma (MM) are inconsistent. However, these studies were conducted in populations of European ancestry, leaving the possibility that these conditions may contribute to the excess risk of plasma cell proliferative disorders observed among Black Americans. Therefore, we assessed MGUS, a precursor condition to myeloma, and MM risk related to a history of allergy, atopy, infections and …
Analysis Of Excess Mortality At The County Level In Alabama By Socioeconomic Factors, Abigail Jo Tucker
Analysis Of Excess Mortality At The County Level In Alabama By Socioeconomic Factors, Abigail Jo Tucker
All ETDs from UAB
Objective: Analyze county level socioeconomic factors and their association with Covid-19 excess mortality in Alabama.Methods: Linear regression analyses were used to evaluate the association between potential risk factors assessed using the American Community survey (n = 40 counties and county clusters) and excess mortality in 2020 per 100,000 population. Excess mortality came from a previously published paper by Ackley et al. Results: Median household income (per 1,000 dollars); an average county median household income that 1,000 dollars higher was associated with 6 per 100,000 lower excess mortality (β= -5.953 p-value
Effects Of Covid-19 On Ventilator Associated Events (Vaes) Due To Multi-Drug Resistant Organisms (Mdros), Jeffery Asiedu
Effects Of Covid-19 On Ventilator Associated Events (Vaes) Due To Multi-Drug Resistant Organisms (Mdros), Jeffery Asiedu
All ETDs from UAB
The aim of this study was to assess the association between the coronavirus disease (COVID-19) and the odds of ventilator associated events (VAEs). Retrospective analysis on prospectively collected data from 11,307 patients admitted to the intensive care unit (ICU) at the University of Alabama at Birmingham hospital between January 2018 and June 2022 was used. Outcomes considered were Any VAE, IVAC/PVAP, PVAP and MDRO PVAP. Crude and adjusted logistic regression models were used to evaluate the association between COVID-19 and the outcome variables. When a patient has Prior COVID-19, the odds of getting any VAE during the delta period is …
The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron
The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron
All ETDs from UAB
A major obstacle to the advancement of our understanding of the metabolically healthy obesity (MHO) phenotype is the inconsistent definition of metabolic health and obesity among studies. A harmonized definition of MHO in adults has been proposed based on the diagnosis of obesity (BMI > 30 k/m2) and meeting the cardio-metabolic criteria for triglycerides, high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), no antihypertensive treatment, fasting blood glucose, and no drug treatment with glucose-lowering agents. In addition, waist circumference can be associated with increased disease risk when WC is >94 cm in men and >80 cm in …
Child Schooling And Other Factors Associated With Covid-19 Vaccine Hesitancy Among Adults That Had Not Been Vaccinated In The Fall Of 2021, Ryan M. Fischer
Child Schooling And Other Factors Associated With Covid-19 Vaccine Hesitancy Among Adults That Had Not Been Vaccinated In The Fall Of 2021, Ryan M. Fischer
All ETDs from UAB
Although COVID-19 vaccine hesitancy decreased noticeably over time during the first months of 2021, there was still a high degree of vaccine hesitancy in the United States at the time that the vaccine first became available to adolescents. Data from Phase 3.2 of the U.S. Census Bureau’s Household Pulse Survey (July 21 – October 11th, 2021) was used to conduct an ecological study on COVID-19 vaccine hesitancy that investigated associations between vaccine hesitancy and socio-demographic characteristics as well as child school type (public school, private school, homeschool). Subjects that had not received a vaccine at the time of survey data …
Adverse Childhood Experiences: Connecting The Dots Between Early Life Stress And Asthma Aming Children And Adolescents With Sickle Cell Disease, Brandi Mcclain Pernell
Adverse Childhood Experiences: Connecting The Dots Between Early Life Stress And Asthma Aming Children And Adolescents With Sickle Cell Disease, Brandi Mcclain Pernell
All ETDs from UAB
Sickle cell disease (SCD) is an inherited red blood cell disorder plagued by increased morbidity and premature mortality. Asthma disproportionally affects individuals with SCD and is strongly associated with an increased incidence of pain, acute lung complications and death among this high-risk population. Psychological stress is a well-established contributor and trigger for asthma development and exacerbations. Adverse Childhood Experiences (ACEs) are defined as traumatic experiences occurring before 18 years of age. ACEs occur at the individual, familial (Original-ACEs) and community level (Expanded-ACEs) and can accumulate with time. Chronic exposure to ACEs leads to toxic stress, widespread inflammation and risk for …
Characterizing Occupational Status History And Assessing Occupational Status As A Social Determinant Of Health In The Deceased Organ Donor Population, Nicole F. Pelletier
Characterizing Occupational Status History And Assessing Occupational Status As A Social Determinant Of Health In The Deceased Organ Donor Population, Nicole F. Pelletier
All ETDs from UAB
Transplant physicians review clinical data ranging from laboratory values to substance use history and use prediction models combining these factors, along with previous recipient outcomes, to evaluate deceased organ donors for organ suitability. Factors such as social determinants of health (SDOH) are not currently included in prediction models, despite evidence of relationships between SDOH and health outcomes in the general population. Occupational status is a SDOH routinely collected at the time of donation and stored in DonorNet, but not yet characterized in the deceased donor population. Despite well-documented relationships between occupational status and health outcomes in the general population, these …
Development Of A Fit-Matching App: Validation Of 3-D Scanning Applications, Jasna Rosser Williams
Development Of A Fit-Matching App: Validation Of 3-D Scanning Applications, Jasna Rosser Williams
All ETDs from UAB
According to the National Institute of Occupational Health and Safety (NIOSH), each day nearly 2,000 workers sustain a job-related eye injury that requires medical treatment. It has been reported that the cause of these eye injuries is frequently due to workers not wearing eye protection because it does not fit properly on their faces. To improve the fit of eye protection, we are aiming to develop a fit matching application (app) which will identify the wearers’ better-fitting safety eyewear using 3D technology. We have successfully tested the feasibility of the use of commercially available 3D scanning apps using a mannequin …
Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang
Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang
All ETDs from UAB
Background: The food truck industry in the U.S. has rapidly expanded, with an average growth of 7.9 % from 2017 to 2022. Food truck workers are potentially exposed to harmful airborne contaminants such as particulate matter (PM) and aldehydes produced during cooking process. Kitchen exhaust hoods are designed to capture the cooking emissions, but it is not well understood whether the commercial kitchen exhaust hoods in food trucks are properly, efficiently operated to reduce the workers' exposure to such harmful contaminants. The purpose of the study was to evaluate food truck workers' exposure to respirable particulates generated from cooking process …
Early Detection Of Acute Kidney Injury In Neonates After Cardiopulmonary Bypass, Tennille N. Webb
Early Detection Of Acute Kidney Injury In Neonates After Cardiopulmonary Bypass, Tennille N. Webb
All ETDs from UAB
Prophylactic peritoneal dialysis (PD) in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB) has proven to be safe and improve outcomes. Understanding which neonates would most benefit from prophylactic PD is needed to optimize care. Objective: We sought to validate patient-specific characteristics associated with the need for PD in neonates requiring CPB. We hypothesized serum creatinine (SCr), pre-operative weight, or open chest post-operatively are associated with the need for PD. Methods: We evaluated neonates in the cardiac ICU requiring cardiac surgery with CPB from March 2019 through March 2021 with our new protocol for PD catheter placement. Neonates were classified …
Guided Exploration Of Military Servicewomen's Healthcare Experiences And Related Outcomes (Gems Hero), Princess Victoria Jane Nash
Guided Exploration Of Military Servicewomen's Healthcare Experiences And Related Outcomes (Gems Hero), Princess Victoria Jane Nash
All ETDs from UAB
Purpose: This study focuses on factors related to healthcare seeking behaviors and utilization of Veterans Affairs primary care services by female African American Veterans. The purpose of this mixed methods study is to assess what factors influence seeking care at VA healthcare facilities. Research Design: This study used a modified explanatory sequential mixed methods design to assess health services utilization and healthcare experiences of African American female Veterans. This research utilized items from the Health Belief model as a guiding framework to highlight factors that could impact VA healthcare utilization. Methodology: Health services utilization analysis used national data from the …
Evaluation Of A Living Shoreline Technique On A Southeastern United States Reservoir, Eric V. Muth
Evaluation Of A Living Shoreline Technique On A Southeastern United States Reservoir, Eric V. Muth
All ETDs from UAB
The impoundment of rivers in the southeastern United States has led to the creation of reservoirs that have seen the riparian zone become heavily developed with residential real estate. As the hybrid river/lake systems started forming new shorelines, property owners reacted by attempting to reduce their losses. This has been done in a variety of ways, with the majority falling into the bulkhead category. The use of vertical hard armament has resulted in a loss of ecological function and an increase in erosion of the lakebed at the toe or escarpment. In response to this, the idea was proposed by …
Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown
Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown
All ETDs from UAB
espite the strong evidence of physical activity benefits, the prevalence of physical inactivity and associated obesity continues to increase. Rural and cancer survivor populations with obesity, in particular, remain highly inactive and are at increased risk of comorbidities. Thus, physical activity interventions are needed to promote active lifestyles. However, before developing or adapting existing multi-level physical activity interventions, more research is needed to understand the necessary components to meet the needs and preferences of these unique populations. Therefore, this project involved identifying the gaps in literature followed by three studies to investigate the multilevel influences on physical activity in rural …
Statistical Methods For Evaluating Confounding In Nutritional Epidemiology: Examining The Association Of Dietary Measures And Incident Type 2 Diabetes, Stephanie E. Tison
Statistical Methods For Evaluating Confounding In Nutritional Epidemiology: Examining The Association Of Dietary Measures And Incident Type 2 Diabetes, Stephanie E. Tison
All ETDs from UAB
Nutrition is a key factor in the development of noncommunicable diseases (NCDs) such as cardiovascular disease, diabetes, obesity, and cancer, which are continuing to increase globally. Research on dietary patterns is crucial for informing what aspects of diet are most critical for preventing and possibly reversing chronic disease. Dietary patterns focus on the types of food that are consumed which reflects the complexity and cultural aspects of diet rather than focusing on a single food or nutrient. Observational cohort studies are able to observe typical dietary intake and thus better reflect the real association between diet and chronic disease. In …
Pain Among Older Adults With Cancer-Results From The Cancer And Aging Resilience Evaluation (Care) Registry, Mustafa Al Obaidi
Pain Among Older Adults With Cancer-Results From The Cancer And Aging Resilience Evaluation (Care) Registry, Mustafa Al Obaidi
All ETDs from UAB
Purpose: The impact of pain on functional status and mental health among older adults with cancer is a relevant, yet understudied issue. Our aim of this study sought to identify prevalence of pain at diagnosis in older adults with cancer and evaluate the association with functional status limitations, cognition, and mental health issues. Methods: This study included patients diagnosed with cancer at age ≥60 enrolled in the CARE Registry at University of Alabama at Birmingham. Patients completed a patient-reported geriatric assessment at the time of their initial visit with a medical oncologist. Pain measured in numeric rating scale from 0-10. …
Statistical Methodology For Mendelian Randomiztion Analysis, Phillip Hunter Allman
Statistical Methodology For Mendelian Randomiztion Analysis, Phillip Hunter Allman
All ETDs from UAB
Instrumental variable (IV) methods are causal analysis techniques used on observational data to address confounding, provided that certain assumptions are met. In the usual observational setting, some exposure of interest �� is associated with some outcome of interest ��, but confounders �� could distort the measure of the association between �� and ��. A valid IV is a proxy of sorts for �� which behaves in a very specific way, in that the IV operates analogously to the treatment group assignment seen in randomized trials. Finding a valid IV is no trivial task, but if one exists and we identify …
The Association Between Post-Stroke Delirium And Mortality Among Stroke Patients In Long-Term Facilities, Nuo Xu
All ETDs from UAB
Delirium is a common neurobehavioral complication following a stroke. Patients who have post-stroke delirium (PSD) are more likely to have severe prognoses, such as physical function decline, high mortality and an increased need for long-term care. Nursing home residents as one of the fragile and special populations sharing the attributes of old age, and high prevalence of chronic diseases and limited mobility. However, there only a few studies have investigated the association between PSD and mortality among individuals admitted to a long-term care facility. This retrospective cohort study aimed to examine the association between PSD and mortality among the participants …
Nutritional And Metabolic Effects Of Elexacaftor/Tezacaftor/Ivacaftor In Adults And Adolescents With Cystic Fibrosis, Julianna Bailey
Nutritional And Metabolic Effects Of Elexacaftor/Tezacaftor/Ivacaftor In Adults And Adolescents With Cystic Fibrosis, Julianna Bailey
All ETDs from UAB
Background: Since malnutrition is a main clinical consequence of CF, a high-calorie, high-fat diet is recommended. Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators promote improved growth and weight gain in subsets of the CF population. Recently Elexacaftor/Tezacaftor/Ivacaftor (ETI) was approved for use in up to 90% of people with CF. Our single center open-label observational cohort study aimed to explore the changes in dietary and metabolic outcomes with use of ETI. Methods: Participants underwent baseline (V1) measurements prior to taking their first dose of ETI. Follow-up measurements were obtained at 28 days (V2) on ETI and > 6 months …
Cardiovascular Disease Risk In Head Neck Squamous Cell Carcinoma Patients: Using Electronic Medical Records Data, Amrita Mukherjee
Cardiovascular Disease Risk In Head Neck Squamous Cell Carcinoma Patients: Using Electronic Medical Records Data, Amrita Mukherjee
All ETDs from UAB
The objective of my dissertation research was to assess burden of cardiovascular disease (CVD) risk factors in Head Neck Squamous Cell Carcinoma (HNSCC) patients and to determine the association of traditional CVD risk factors and HNSCC-related factors with incident CVD outcomes. For this clinical cohort study, I analyzed electronic medical records (EMR) and tumor registry data on HNSCC patients diagnosed between January 2012 and December 2018 at UAB hospital and O’Neal Comprehensive Cancer Center. First, I assessed prevalence and incidence of traditional CVD risk factors at HNSCC diagnosis (baseline) and at one-year post HNSCC diagnosis, respectively. Then I determined the …
Likelihood Based Inferential Methods To Analyze Trials Incorporating Patient's Treatment Choice, Rouba A. Chahine
Likelihood Based Inferential Methods To Analyze Trials Incorporating Patient's Treatment Choice, Rouba A. Chahine
All ETDs from UAB
Randomized clinical trials (RCT) are the gold standards for clinical trials as they reduce bias and minimize variability between different arms of a study. One of the drawbacks of these designs is their lack of flexibility to incorporate patient’s preference, which may reduce recruitment rates and/or reduce patient’s tolerance if they receive a non-preferred treatment. Designs incorporating choice allow a subset of participants to choose a preferred treatment. Some of these designs are Zelen’s (1979), Brewin’s (1989), and Rucker’s (Two-Stage RCT, 1989). Current methods to analyze two-stage RCT are based on an analysis of variance (ANOVA) approach that do not …
Mental Health And Chronic Disease Management: Examining The Association Between Depression And Multiple Sclerosis (Ms) Outcomes, Christina J. Glenn
Mental Health And Chronic Disease Management: Examining The Association Between Depression And Multiple Sclerosis (Ms) Outcomes, Christina J. Glenn
All ETDs from UAB
The aim of this dissertation is to determine whether depression is associated with clinical (relapses and disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary data analysis of the CombiRx clinical trial. Psychiatric comorbidities, including depression are common in people living with MS (PwMS), often underreported, and contribute to reduced quality of life and mortality associated with the disease. Most clinical studies that have examined the relationship between depression, depression medication usage, and MS outcomes have been small, excluded participants with relapsing-remitting subtypes and severe depressive symptoms, and had relatively short study periods—all shortcomings this thesis …
Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim
All ETDs from UAB
Background: Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. Methods: We included 11,617 black and white participants (mean age 63.0 + 8.4 years) from the REGARDS (REasons for Geographic and Racial Differences in Stroke) national cohort study who were free of AF at baseline between 2003 and 2007, and completed a follow-up exam between 2013 and 2016 with assessment of AF. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval of incident AF associated with …
Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains
Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains
All ETDs from UAB
Objectives: Delirium affects 7-17% of older Emergency Department (ED) patients. Inadequate pain control and opioid pain management have been reported to increase risk for delirium. The aim of this study was to evaluate the association between pain severity, opioid exposure, and delirium among older ED patients.Methods: A single-center retrospective cohort study was conducted in an academic Geriatric ED. Patients aged ≥65 years with an Identification of Seniors at Risk (ISAR) score ≥2 and an Emergency Severity Index (ESI) level 3 were enrolled into the Geriatric ED Pathway. Those who received a delirium screening using the Nursing Delirium Screening Scale (NuDESC) …
Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan
Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan
All ETDs from UAB
A 2017 World Health Organization (WHO) data brief included suicide in the top 20 causes of death worldwide. The WHO also listed suicide as the second leading cause of death for those aged 15 – 29 worldwide. In the US, suicide is the leading cause of violent death and has been consistently ranked as the 10th leading cause of death among all age groups in the US since 2008. In Alabama, the CDC reports suicide as the 11th leading cause of death in the state and the second leading cause of death for those aged 15 – 34. This study …