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Articles 301 - 330 of 519

Full-Text Articles in Public Health

A Community Of Isolation: An Ethnographic Examination Of Mothering In Poverty And Its Impact On Food Security In Pinellas County, Florida, Amanda M. Terry Sep 2015

A Community Of Isolation: An Ethnographic Examination Of Mothering In Poverty And Its Impact On Food Security In Pinellas County, Florida, Amanda M. Terry

USF Tampa Graduate Theses and Dissertations

The objective of this dissertation is to document the lived experience of mothering in poverty and the unique challenges the role of mother presents to maintaining food security. Millions of households in the United States are struggling to put food on the table, a problem made worse by the current economic recession and high food prices. Among them, households with children and specifically, single mothers, report the highest prevalence of food insecurity. While Federal food assistance programs are available to help alleviate this issue, the continued problem of hunger is a very real and pervasive concern for millions of American …


Health Infor[M-Ed]: Black College Females Discuss A Virtual Reality (Vr) Platform For Sexual Health Education And Training, Henry Arnett Ross Sep 2015

Health Infor[M-Ed]: Black College Females Discuss A Virtual Reality (Vr) Platform For Sexual Health Education And Training, Henry Arnett Ross

USF Tampa Graduate Theses and Dissertations

Background: College settings are likely environments for Black women to contract STIs (including HIV) or experience unintentional/unwanted pregnancies. Effective prevention strategies for this population include dialogue and activities that focus on gender, maturity, cultural barriers, personal strength, and information needs. However, technological advancements (including virtual reality) and innovation are limited in prevention efforts.

Methods: Four 90-minute focus group sessions were conducted in a convenience sample of Black college females (ages 18 years or older) and a research-intensive public institution in the southeast. A series of surveys were distributed during each audio-recorded focus group session. A mixed-method approach to data analysis …


Effect Of Timely Treatment On Malaria Gametocytemia In Esmeraldas, Ecuador, Miguel Reina-Ortiz Sep 2015

Effect Of Timely Treatment On Malaria Gametocytemia In Esmeraldas, Ecuador, Miguel Reina-Ortiz

USF Tampa Graduate Theses and Dissertations

Malaria is a disease that causes great burden in public health worldwide. It was estimated that in 2011 there were 3.3 billion people at risk of acquiring malaria. According to data from the Ministry of Public Health of Ecuador, malaria incidence has shown a 99.9% steady decrease since year 2000. This study evaluated the effect of timely treatment on circulating gametocyte and malaria incidence rates. All cases reported in the province of Esmeraldas, Ecuador from July 2012 to March 2015 and to the national headquarters between February 2012 and December 2014 were studied. The effect of early treatment on: 1) …


Assessment Of Soil Transmitted Helminth Infection (Sthi) In School Children, Risk Factors, Interactions And Environmental Control In El Salvador., Sharad Suryakant Malavade Sep 2015

Assessment Of Soil Transmitted Helminth Infection (Sthi) In School Children, Risk Factors, Interactions And Environmental Control In El Salvador., Sharad Suryakant Malavade

USF Tampa Graduate Theses and Dissertations

Background:

Soil transmitted helminth infections (STHI) are important Neglected Tropical Diseases (NTD). The three main STHI are infections with Ascaris lumbricoides, Trichuris trichiura and hookworms. STHI have a significant effect on the growth and development of children. A national survey for STHI in El Salvador by Pan American Health Organization and Ministry of Health in 2012 in school children aged 8years to 10 years. The survey collected data on age, gender, behavioral habits, and source of drinking water, type of toilet facility used and ecological zone of residence.

A) We did an analyses of the data with an aim to …


Energy Production And Effluent Quality In Tubular Digesters Treating Livestock Waste In Rural Costa Rica, Maureen Njoki Kinyua Sep 2015

Energy Production And Effluent Quality In Tubular Digesters Treating Livestock Waste In Rural Costa Rica, Maureen Njoki Kinyua

USF Tampa Graduate Theses and Dissertations

Use of tubular anaerobic digesters to treat livestock waste in developing countries has energy, agricultural, health, social and environmental benefits. However, careful use of digester effluent as a soil amendment is required due to the potential presence of protozoan parasites Cryptosporidium parvum and Giardia lamblia. This research investigated the performance of four tubular digesters in the Monteverde region of Costa Rica. High (>75%) volatile solids and BOD5 removal efficiencies were observed, which was attributed to the formation of a biologically active floccular sludge layer. Computational fluid dynamics (CFD) and bioprocess models were developed to evaluate the transport and transformation …


Race/Ethnic Disparities In Treatment Patterns Among Newly Diagnosed Primary Prostate Cancer Patients In Florida, Vonetta L. Williams Apr 2015

Race/Ethnic Disparities In Treatment Patterns Among Newly Diagnosed Primary Prostate Cancer Patients In Florida, Vonetta L. Williams

USF Tampa Graduate Theses and Dissertations

Study Purpose: The purpose of this study was to examine whether there were differences in patterns of care between African American (AA) and Non-Hispanic White (NHW) men newly diagnosed with prostate cancer in Florida, and how the treatment patterns compare with the National Comprehensive Cancer Network (NCCN) initial treatment recommendations.

Materials and Methods: This retrospective cohort study utilized data from the Florida Cancer Data System (FCDS), to identify incident cases of prostate cancer diagnosed between 1982 and 2012. The variables of interest included: race/ethnicity, marital status, age at diagnosis, stage at diagnosis, tumor grade, year of diagnosis, and treatment modality …


Slope Settlement And Post-Disaster Health Needs Of Urban Displacement In La Paz, Bolivia, James Steven Arango Apr 2015

Slope Settlement And Post-Disaster Health Needs Of Urban Displacement In La Paz, Bolivia, James Steven Arango

USF Tampa Graduate Theses and Dissertations

In 2011, a landslide displaced approximately six thousand people from the urbanized mountain slopes of La Paz, Bolivia. The municipal government of La Paz (GAMLP) managed the displacement by housing thousands of people in displacement camps throughout the city. By 2013, residents were attempting to return to still damaged lands. This research used participant observation and interviews with residents over eight weeks in 2013 to address the following questions: 1) What social, cultural, economic or historic factors influence the settling and then resettling of at-risk slope neighborhoods in La Paz, Bolivia? 2) What are the most pressing health needs of …


The Impact Of The Veterans Health Administration's Home Based Primary Care On Health Services Use, Expenditures, And Mortality, Melissa Castora-Binkley Mar 2015

The Impact Of The Veterans Health Administration's Home Based Primary Care On Health Services Use, Expenditures, And Mortality, Melissa Castora-Binkley

USF Tampa Graduate Theses and Dissertations

Background: Among patients with multiple chronic conditions, care coordination and integration remains one of the major challenges facing the U.S. health care system. A home-based, patient-centered primary care program has been offered through the Veterans Health Administration (VHA) since the 1970s for frail veterans who have difficulty accessing VHA clinics. The VHA Home Based Primary Care (VHA HBPC) aims to integrate primary care, rehabilitation, disease management, palliative care, and coordination of care for frail individuals with complex, chronic diseases within their homes. Early research suggested that VHA HBPC was associated with positive outcomes (e.g., reduced resource use and patient satisfaction). …


Gene Expression Analysis Of Upregulated Genes By 20-Oh Ecdysone In Brugia Malayi, Monica Lazaro Mar 2015

Gene Expression Analysis Of Upregulated Genes By 20-Oh Ecdysone In Brugia Malayi, Monica Lazaro

USF Tampa Graduate Theses and Dissertations

Brugia malayi is a filarial nematode causing lymphatic filariasis in humans characterized by swelling of the lower extremities. The aim of this study was to conduct a real time PCR (qRT-PCR) to verify gene expression levels of Brugia malayi nematodes treated with 20 hydroxyecdysone. Transcriptome analysis was previously performed resulting in the identification of 44 genes that were upregulated by exposure to 20-hydroxyecdysone. Based on transcriptome results, known GO Terms and functions, four genes and one endogenous housekeeping gene were chosen for validation by RT-PCR. Induced samples showed a mean increase of microfilarie by 2.2 fold. Induced wells exhibited a …


Food Insecurity And Hunger Experiences And Their Impact On Food Pantry Clients In The Tampa Bay, Nora Brickhouse Arriola Mar 2015

Food Insecurity And Hunger Experiences And Their Impact On Food Pantry Clients In The Tampa Bay, Nora Brickhouse Arriola

USF Tampa Graduate Theses and Dissertations

Since 1999, there has been a significant increase in the number of food insecure individuals in the United States. The Great Recession (2007-2009) and slow economic recovery has led to additional increases in rates of food insecurity and the usage of emergency food assistance programs. Thirty qualitative interviews with individuals seeking emergency food assistance at a Tampa Bay food pantry were conducted. Interviews focused on collecting the life experiences of participants, the barriers they face in having food security, their strategies to cope with limited food budgets, and how food insecurity impacts their household's overall health and wellbeing. Recommendations for …


Melding Data Collection Methodology With Community Assistance: Benefits To Both Researchers And The Indigenous Groups They Study, Douglas S. London Mar 2015

Melding Data Collection Methodology With Community Assistance: Benefits To Both Researchers And The Indigenous Groups They Study, Douglas S. London

Journal of Ecological Anthropology

I present a description of a model of melding data collection with community aid in the form of health educator training that emerged in the process of research collaboration during 2009-2011 with the Kawymeno Waorani foragers of Amazonian Ecuador. Some guidelines are suggested as to how benefits to both parties might be achieved when collecting data with indigenous populations. In this article I describe some of the advantages and pitfalls of melding data collection and community aid with research when collaborating with vulnerable indigenous groups.


Reproductive Health Seeking Behaviors Among Female University Students: An Action Oriented Exploratory Study, Robin Emily Mowson Feb 2015

Reproductive Health Seeking Behaviors Among Female University Students: An Action Oriented Exploratory Study, Robin Emily Mowson

USF Tampa Graduate Theses and Dissertations

The focus of this research was to: 1) study the perceptions of female students attending the university Student Health Center, concerning available services, 2) learn how they describe their decisions to obtain care, and 3) identify perceived barriers to reproductive health care and contraception. This exploratory study used a mixed-methods approach that included clinic public-space observations, interviews with health care providers and staff at Student Health Services (SHS), surveys distributed to clients of the campus clinic, and in-depth interviews to contextualize emergent themes. Topics addressed included sexual health behaviors and perceptions, influence of peers and partners, the propagation of health …


Basic Epidemiology, Center For Leadership In Public Health Practice Jan 2015

Basic Epidemiology, Center For Leadership In Public Health Practice

Preparedness and Emergency Response Learning Center

Basic Epidemiology, a training course from the USF Center for Leadership in Public Health Practice, develops the awareness and knowledge of public health workers who may be deployed on Field Epidemiology strike teams. It is designed to help them assist local, regional, state, and national epidemiology staff in disease investigations during surge capacity. Basic Epidemiology is a required prerequisite for the IFIRST and IFIRST-2 programs.


Documenting Perceived Effectiveness Of Community-Based Health Promotion Coalitions: A Grounded Theory Approach, Alyssa Brooke Mayer Jan 2015

Documenting Perceived Effectiveness Of Community-Based Health Promotion Coalitions: A Grounded Theory Approach, Alyssa Brooke Mayer

USF Tampa Graduate Theses and Dissertations

Introduction: Community coalitions with public health-related missions are formal, semi-permanent, action-oriented partnerships comprised of community members, representatives of government agencies, policymakers, and academic partners. Despite their potential to promote sustainable change, coalitions have had mixed success in effecting long-term improvements in community health. There is a need to assist them in developing strategies for improving and sustaining their functionality. The purpose of this study was to improve understanding of the elements of coalition success and sustainability that are vital to health-related community-based participatory research.

Methods: Although the literature describes coalition functions for effecting sustainable programs and policies, most research reports …


Women’S Use Of And Decision‐Making Regarding Geo‐Social Networking Applications To Arrange Sexual Experiences, Shireen Mary Noble Jan 2015

Women’S Use Of And Decision‐Making Regarding Geo‐Social Networking Applications To Arrange Sexual Experiences, Shireen Mary Noble

USF Tampa Graduate Theses and Dissertations

The purpose of this thesis was to learn more about geo-social networking applications and how they are used by women to meet sexual partners. Currently, there are no known studies that have looked at heterosexually-oriented geo-social networking applications or at the way women have used these apps for heterosexual sexual encounters. This thesis attempts to begin to bridge this gap in the literature.

For the first study, apps were selected based on their appearance in popular media articles about dating applications. Results generally related to online safety concerns, while occasional features were related to sexual safety concerns. Communication options were …


Assessment Of The Impact Of Attention Deficit Hyperactivity Disorder On Type 1 Diabetes, Kellee Miller Jan 2015

Assessment Of The Impact Of Attention Deficit Hyperactivity Disorder On Type 1 Diabetes, Kellee Miller

USF Tampa Graduate Theses and Dissertations

Individual day-to-day management and effective control of type 1 diabetes (T1D) is ultimately driven by decisions made by the individual. Individuals with attention deficit hyperactivity disorder (ADHD) have a higher tendency to be inattentive, impulsive, and hyperactive. Attention deficits and impulsivity among adolescents and adults with T1D could result in poor diabetes management through infrequent self-monitoring of blood glucose and inadequate insulin dosing – key components of achieving optimal glycemic control.

This study included 7,380 adolescents and young adults, ages 13-25 years, participating in the T1D Exchange clinic registry (median age 17.4 years, duration 7.7 yrs, 50% female, 81% white). …


Sound Attenuation Performance Of Fiber-Reinforced Polymer Composite Circumaural Hearing Protection Devices, Steven Christopher Augustine Jan 2015

Sound Attenuation Performance Of Fiber-Reinforced Polymer Composite Circumaural Hearing Protection Devices, Steven Christopher Augustine

USF Tampa Graduate Theses and Dissertations

Personnel who work on the flight deck of an aircraft carrier are exposed to extreme levels of jet engine noise often in excess of 140 decibels (dB). The current circumaural hearing protective devices (CAHPD) employed by flight deck crewmen are inadequate for the level of protection required for these extreme levels of noise. Fiber-reinforced thermoset polymer composite (FRPC) materials such as aramid fibers used in body armor, have high theoretical values of acoustic impedance due to a fundamentally high modulus of elasticity and may offer a superior level of hearing protection over original equipment (OE) thermoplastic CAHPDs. The objective of …


Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck Jan 2015

Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck

USF Tampa Graduate Theses and Dissertations

Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …


Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo Jan 2015

Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo

USF Tampa Graduate Theses and Dissertations

Latino immigrants encounter an entanglement of rights and policies after occupational injury or illness. In collaboration with an immigrant worker center, ethnographic research and a survey are used to analyze injured workers’ experiences. The center uses survey results to identify common threads and systematic problems, and to explore potential direct action. Through interviews with workers and medical and legal professionals, I investigate the barriers Latino immigrants face following occupational injury or illness, how their lived experiences relate to the greater medicolegal frameworks that demarcate most formal processes of compensation and treatment, and the experiences of professionals who mediate these structures. …


Effects Of Occupational Stressors On Nurses’ Safety Performance And Well-Being: A Within-Individual Study, Xinxuan Che Jan 2015

Effects Of Occupational Stressors On Nurses’ Safety Performance And Well-Being: A Within-Individual Study, Xinxuan Che

USF Tampa Graduate Theses and Dissertations

Occupational stressors have been extensively studied as predictors of safety performance and employee well-being in previous research. However, many newly introduced organizational constructs that have the characteristics of an occupational stressor have rarely been studied as such, especially from a within-person perspective. The current study focused on three occupational stressors in relation to safety performance. Based on previous literature, I proposed that within individuals, compulsory citizenship behavior, illegitimate tasks, and interpersonal conflict at work as occupational stressors would have negative effects on employees well-being and safety performance through negative emotions (anger), job attitudes (job satisfaction and organizational commitment) and role …


Maternal Stress, Breastmilk Igf-1, And Offspring Growth Among Breastfeeding Mothers-Infant Pairs In The Tampa Bay Area, Lauren Michelle Gottfredson Jan 2015

Maternal Stress, Breastmilk Igf-1, And Offspring Growth Among Breastfeeding Mothers-Infant Pairs In The Tampa Bay Area, Lauren Michelle Gottfredson

USF Tampa Graduate Theses and Dissertations

Background: Maternal stress during utero has been shown to have negative health consequences on the offspring, including low birth weight and increased risk of adult disease. Variation in breastmilk may act as an environmental cue of maternal stress and continue to program the infant during early life. This research aimed to explore the role of breastmilk on developmental programming of the infant. Specifically, to examine how breastmilk may act as a medium for the exposure of stress between the mother and the offspring, and see if variation in insulin like growth factor-1 (IGF-1) a potential mechanism for the relationship.

Methods: …


Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic Jan 2015

Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic

USF Tampa Graduate Theses and Dissertations

The causative agent of malignant tertian malaria, Plasmodium falciparum undergoes an arrested growth phenotype of its erythrocytic stage when under drug-stress. Recent artemisinin treatment failures seem to be indicative of such induction followed by recrudescence rather than actual therapeutic failure. Likewise, P. vivax hypnozoites are the prototypic dormants and the latent infections for which they are responsible prove most difficult to treat. Dihydroartemisinin, an artemisinin-derivative, can be used to exploit this mechanism by inducing a dormant state in ring-stage P. falciparum parasites and in turn, their recovery may be used as a screening period for compounds that inhibit or foster …


Immunological Characterization Of Duffy Binding Protein Of Plasmodium Vivax, Miriam Thankam George Jan 2015

Immunological Characterization Of Duffy Binding Protein Of Plasmodium Vivax, Miriam Thankam George

USF Tampa Graduate Theses and Dissertations

Plasmodium vivax Duffy binding protein (DBP) is an essential ligand for reticulocyte invasion making it a premier asexual blood stage vaccine candidate. However, strain-specific immunity due to DBPII allelic variation may complicate vaccine efficacy, suggesting that an effective DBPII vaccine needs to target immune responses to conserved epitopes that are potential targets of strain-transcending neutralizing immunity. Anti DBPII monoclonal antibodies, which were previously characterized by COS7 cell binding assay as inhibitory and non-inhibitory to DBPII-erythrocyte binding, were mapped to DBPII gene fragment libraries using phage display. Inhibitory mAb 3C9 binds to a conserved conformation-dependent epitope in subdomain 3 while non-inhibitory …


Theoretically Guided Examination Of Caregiver Strain And Its Relationship With School-Based Mental Health Services Utilization And Parent Engagement In Services, Amy Lynn Green Jan 2015

Theoretically Guided Examination Of Caregiver Strain And Its Relationship With School-Based Mental Health Services Utilization And Parent Engagement In Services, Amy Lynn Green

USF Tampa Graduate Theses and Dissertations

Broadly, the purpose of this study was to address the gaps in the knowledge base of caregiver strain through an examination of this and other theoretically related constructs in a sample of parents of high-risk youth. In the last two decades, a growing body of research has pointed to the significance of strain that can result from this caregiving experience, particularly as it relates to patterns of mental health services utilization. Despite the fact that the majority of children who receive mental health receive them from the school, few studies have examined caregiver strain in the context of school-based mental …


Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy Jan 2015

Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy

USF Tampa Graduate Theses and Dissertations

In the United States, concerns about adolescent childbearing and its perceived corollaries – negative health outcomes for mother and child, the disintegration of the nuclear family, and “over-dependence” on public resources – began to circulate widely in policy spheres and popular media in the 1970’s, resulting in a proliferation of policies, programs, and services designed to address its prevention. Although national birth rates among adolescents are currently at their lowest since peaking in the early 1990’s, this decline masks persistent and significant disparities between groups of young people by race, ethnicity, geography, and poverty level. The concomitant existence of social …


Effects Of Solids Retention Time And Feeding Frequency On Performance And Pathogen Fate In Semi-Continuous Mesophilic Anaerobic Digesters, Nathan Daniel Manser Jan 2015

Effects Of Solids Retention Time And Feeding Frequency On Performance And Pathogen Fate In Semi-Continuous Mesophilic Anaerobic Digesters, Nathan Daniel Manser

USF Tampa Graduate Theses and Dissertations

Anaerobic digestion is a biochemical process in which organic carbon is biodegraded in an oxygen free environment through a microbial consortium. Engineered biological systems used for resource recovery often utilize anaerobic digestion to treat anthropogenic organic wastes by reclaiming the carbon as energy (methane gas) and a soil amendment (biosolids). Small-scale, or household, semi-continuous anaerobic digesters have been used in developed and developing countries for many decades to produce biogas from human and livestock waste, which is used for heating, lighting, and cooking. This application has been shown to improve the quality of life of the user. Although there is …


An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis Jan 2015

An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis

USF Tampa Graduate Theses and Dissertations

Research misconduct has been generally considered a limited issue, occurring in a small percentage of research studies. Studies of the number of article retractions use retraction percentages to perpetuate the idea that research misconduct is not a common event, and use information in the retraction notice to quantify types of research misconduct and types or research error. However, retractions appear to be the wrong variable with which to assess misconduct rates and characteristics. Using final misconduct findings in hard science research from the Office of Research Integrity (ORI) for investigations closed from 1993 through 2013, the number of publications and …


Assessment Of Public Health Risks Associated With Petrochemical Emissions Surrounding An Oil Refinery, Erin L. Pulster Jan 2015

Assessment Of Public Health Risks Associated With Petrochemical Emissions Surrounding An Oil Refinery, Erin L. Pulster

USF Tampa Graduate Theses and Dissertations

Refinery operations have been associated with a wide variety of atmospheric emissions consisting of criteria air pollutants, volatile organic components, hazardous air pollutants as well as other pollutants. With approximately 100 oil refineries in the Wider Caribbean region (WCR), hydrocarbons in this region pose significant environmental and human health risks. One of the oldest and largest refineries in the WCR is the Isla Refineriá, which is located on the island of Curaçao, and has been the basis of historical debates and conflict between the public and the local government over the environmental and human health risks. This research aims to …


Southern Chivalry: Perception Of Health & Environmental Justice In A Small Southern Neighborhood, Brian S. Brijbag Jan 2015

Southern Chivalry: Perception Of Health & Environmental Justice In A Small Southern Neighborhood, Brian S. Brijbag

USF Tampa Graduate Theses and Dissertations

This paper analyzes heath risk and how it is communicated to, and understood within, a predominantly African American neighborhood in central Florida. Residents accuse the county department of public works of purposeful contamination and discrimination over a period of 30 years. I raise the questions of how risk is perceived and what roles race or class may play. I also developed a model for risk communication that includes all stakeholders. Finally, I expand the conversation of health disparities to include issues of widening gaps in perceptions of health.

This was examined by looking at the following:

1. The lack of …


The Characterization Of The Neuropathological Consequences Of Plac1 Ablation In A Mutant Mouse Model, Jacob Robert Bourgeois Jan 2015

The Characterization Of The Neuropathological Consequences Of Plac1 Ablation In A Mutant Mouse Model, Jacob Robert Bourgeois

USF Tampa Graduate Theses and Dissertations

Placenta-specific 1 (Plac1) is an X-linked gene that is essential for normal placental development. Previous studies have shown that Plac1 is also expressed in the fetal brain and paternally imprinted. Its expression in the fetal brain is markedly downregulated immediately after birth. Plac1 ablation predisposes Plac1-null males and Xm-X Hets (inactive maternal allele) to an increased risk of developing lethal postnatal hydrocephalus suggesting a functional role for Plac1 during embryonic development. The objective of this study was to characterize the effect of Plac1 on brain development and postnatal function. In order to address this, a …