Public Health Commons^™

Electron Microscopic Examination Of Various Types Of Ancient Specimens, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

No abstract provided.

Dr Frank J. Sladen: The Osler Connection, Richmond W. Smith Jr.

Henry Ford Hospital Medical Journal

No abstract provided.

In Defense Of The Pickwickian Syndrome, Howard Markel

Henry Ford Hospital Medical Journal

No abstract provided.

Playing With Medicine: A Historical Perspective, William H. Beierwaltes

Henry Ford Hospital Medical Journal

No abstract provided.

A Graphical Aid To Medical Decision Making, William A. Benish

Henry Ford Hospital Medical Journal

Given knowledge of a test's sensitivity and specificity, physicians may use Bayes' theorem to appropriately modify their initial assessment of the likelihood of disease subsequent to obtaining a positive or negative test result. A graphical representation of Bayes' theorem was constructed in order to provide a simple tool to aid in the selection and interpretation of diagnostic tests.

Diagnosis Of Hepatic Portal Venous Gas By Computed Tomography: Role Of Intravenous Contrast Material, Allan M. Haggar, Michael A. Sandler, Martin L. Gross, Beatrice L. Madrazo

Henry Ford Hospital Medical Journal

We describe a case of hepatic portal venous (HPV) gas. The diagnosis was assisted by findings of computed tomography (CT). The HPV gas resulted from a diverticular abscess in a patient who had a stable clinical course. If the possibility of HPV gas exists, scanning without intravenous administration of contrast material should be performed. If postcontrast scans alone are obtained, the opacified portal blood may mask small amounts of HPV gas, as was true in this case. Also, postcontrast scans can easily distinguish HPV gas from air within the biliary tree if findings of precontrast scans are equivocal.

Metastatic Bronchogenic Carcinoma Simulating Osteoarthritis, David Wendt, Paul Kvale

Henry Ford Hospital Medical Journal

No abstract provided.

Leiomyosarcoma Of The Heart: A Twenty-Year Cure, Gerald Fine, B. Usha Raju

Henry Ford Hospital Medical Journal

Excision of a predominantly intracavitary right atrial tumor, which mimicked a number ofother clinical disorders, effected a 20-year cure. Microscopic, ultrastructural, and immunocytochemical characteristics of the tumor were those of smooth muscle; cellular anaplasia, mitotic activity and tumor infiltration of the auricular myocardium indicated malignant neoplasia, a leiomyosarcoma. Distribution of the tumor was consistent with its origin from the auricular endocardium.

The Invalidity Of Monitoring Transcutaneous Oxygen Tension In Patients Who Have Chronic Renal Failure, John R. Armstrong, Thomas W. Kreps, William A. Conway, Francis Dumler, John Popovich Jr.

Henry Ford Hospital Medical Journal

We assessed accuracy of monitoring transcutaneous oxygen tension (PtcO2) in patients with chronic renal failure (CRF). Sixteen stable individuals undergoing chronic maintenance hemodialysis were studied. Correlations between simultaneously determined PtcO2 and arterial oxygen tension (PaO2) were made both before and during dialysis. Comparisons were made with a group of 22 consecutive patients in whom respiration was mechanically assisted, who were hemodynamically stable (urine output greater than 30 mL/hour, pulse less than 130 beats/min, and mean arterial blood pressure greater than 80 mm Hg in the absence of pressor agents), and who had normal renal function.

Among CRF patients, the correlation …

Editorial: In Defense Of Historians, Conrad R. Lam

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner

Henry Ford Hospital Medical Journal

A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large …

The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson

Henry Ford Hospital Medical Journal

No abstract provided.

Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander

Henry Ford Hospital Medical Journal

We evaluated the effects of screening for multiple endocrine neoplasia type 2A (MEN-2A) in 12 families. Genealogical studies going back to 1730 show a common ancestry for seven Swedish families and one American family. The total number of patients included 105 individuals, 68 of whom were diagnosed by our screening program. Our screening methods for medullary carcinoma of the thyroid (MTC) had an optimal sensitivity and specificity. The frequency of gene carriers detected in MEN-2A families was 55%. Screening will lead to early diagnosis and early therapy, which in turn, will significantly decrease morbidity, incidence of surgical complications, and mortality …

Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten

Henry Ford Hospital Medical Journal

No abstract provided.

Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson

Henry Ford Hospital Medical Journal

In 19 patients from nine MEN-2A families, high-resolution C-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.

Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill

Henry Ford Hospital Medical Journal

Progress in understanding the single gene, cytogenetic, and multifactorial traits that predispose to human cancer suggests possible new directions for research in the multiple endocrine neoplasia (MEN) syndromes. Among the other 200 or so monogenic disorders associated with human neoplasia, advances have come from further delineation of syndromes by various clinical specialists, the recognition of subtypes of syndromes previously thought to be homogeneous, the search for in vitro manifestations of the mutant gene in fibroblasts, and the establishment of cell, tissue and patient registries and of voluntary lay organizations to serve as advocates for the disease. With regard to cytogenetics, …

Book Review: Medical Meanings, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple

Henry Ford Hospital Medical Journal

No abstract provided.

The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin

Henry Ford Hospital Medical Journal

No abstract provided.

Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder

Henry Ford Hospital Medical Journal

A collaborative group for the study of multiple endocrine neoplasia type 2 (MEN-2) syndromes comprised of clinicians and laboratory scientists has been set up in the United Kingdom. Its aims are 1) to provide a basis for collaborative work on MEN-2; 2) to establish a register of patients; 3) and specifically to conduct studies aimed at defining the best policy for screening the families of apparently sporadic patients, to establish radioimmunoassays for family screening, and to identify large kindreds for genetic linkage studies using DNA polymorphisms.

Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen

Henry Ford Hospital Medical Journal

Screening of first-degree relatives of patients with medullary thyroid cancer (MTC) gave normal values of pentagastrin-stimulated serum calcitonin and 24-hour urinary catecholamine levels in the relatives of 18 of 22 patients. This result is considered to be valid evidence for sporadic MTC. Absence of C-cell hyperplasia maybe another indication of sporadic MTC. Four hereditary MTCs were represented by one fully expressed MEN-2B patient without affected relatives, one fully expressed MEN-2A case in one family, and two first cousins with MTC as the only MEN-2A lesion in another family. Fourteen relatives of the MEN-2A patients had elevated serum calcitonin levels, and …

Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara

Henry Ford Hospital Medical Journal

Through nationwide surveys, we collected and analyzed 242 patients of medullary thyroid carcinoma (MTC). Included were 40 patients with multiple endocrine neoplasia type 2A (MEN-2A), six patients with MEN-2B, and 36 patients with only MTC having a positive family history (82 total patients in the hereditary group). Ten-year survival rates were 81.5% for all cases, and 97.5% and 76.1% for the hereditary and the sporadic group, respectively. Epinephrine/norepinephrine ratio in the urine was found to be a good indicator of the adrenomedullary hyperfunction in patients with hereditary MTC. At least one patient in each family with hereditary MTC had overt …

A French Canadian Family With Multiple Endocrine Neoplasia Type 2 Syndromes, Maurice B. Verdy, Marcel Cadotte, Walter Schurch, William C. Sturtridge, Jacques Cantin, Andrée M. Weber, André Lacroix, Cynthia Forster-Gibson

Henry Ford Hospital Medical Journal

No abstract provided.

Scintigraphy With 1-131 Mibg As An Aid To The Treatment Of Pheochromocytomas In Patients With The Multiple Endocrine Neoplasia Type 2 Syndromes, James C. Sisson, Brahm Shapiro, William H. Beierwaltes

Henry Ford Hospital Medical Journal

We reviewed the scintigraphic images made after injections of 1-131 metaiodobenzylguanidine (MIBG) or 1-123 MIBG in patients with multiple endocrine neoplasia (MEN) types 2A and 2B. The information we obtained was applied to three questions about the treatment of pheochromocytoma in patients affected with these syndromes. Our first question "When should adrenal gland(s) be removed?" was not directly answered. However, adrenalectomy generally should not be contemplated unless distinct abnormalities are present in the scintigraphic images. With experience it may be possible to approximate, from the stage of pheochromocytoma depicted by scintigraphy, how many years will elapse before symptoms or hypertension …

The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz

Henry Ford Hospital Medical Journal

Using recombinant DNA techniques, we analyzed the structure of human calcitonin (CT)-encoding DNA. The sequence of nucleotides derived from the messenger RNA (mRNA) predict the amino acid sequence of the entire human CT precursor protein. The complete CT gene could be isolated from a DNA library of the human genome. The CT precursor encoding sequences (exons) as well as the noncoding intervening sequences (introns) could be identified. Another sequence, called human calcitonin gene-related peptide (hCCRP), could be located near this CT-encoding DNA. A genomic fragment encoding hCCRP was used as a probe to detect and isolate the corresponding mRNA in …

Genetic Studies Of Multiple Endocrine Neoplasia Type 2 Syndromes: A Workshop Commentary, Nancy E. Simpson

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.