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Articles 271 - 300 of 2166
Full-Text Articles in Public Health
Early Detection Of Hereditary Medullary Thyroid Cancer With Polymorphic Dna Probes, Steven A. Narod, Hagay Sobol, Isabelle Schuffenecker, R. Alan B. Ezekowitz, Gilbert M. Lenoir
Early Detection Of Hereditary Medullary Thyroid Cancer With Polymorphic Dna Probes, Steven A. Narod, Hagay Sobol, Isabelle Schuffenecker, R. Alan B. Ezekowitz, Gilbert M. Lenoir
Henry Ford Hospital Medical Journal
We have performed linkage analysis on 32 families with hereditary medullary thyroid cancer (MTC) wilh seven polymorphic DNA probes situated near the centromere of chromosome 10. Nineteen of these families were affected with multiple endocrine neoplasia type 2A (MEN 2A), and the remainder had MTC without pheochromocytoma. There were no instances of recombination between the MEN 2 A susceptibility gene and the IRBP.H4 marker. Two other probes, TBM.34 and MCK2, are also tightly linked(θ = 0.00 and θ = 0.02. respectively). Because TBM.34 and IRBP.H4/MCK2 are situated on opposite sides of the MEN 2A gene, screening with flanking DNA markers …
Genetic Mechanisms Of Neoplasia In Men 2, Charles E. Jackson, Robert A. Norum
Genetic Mechanisms Of Neoplasia In Men 2, Charles E. Jackson, Robert A. Norum
Henry Ford Hospital Medical Journal
Several possible mechanisms for the initiation and progression of tumors in multiple endocrine neoplasia type 2 (MEN 2) merit consideration. Localization of MEN2A to the pericentromeric area of chromosome 10 indicates the site of the initial mutagenic event but does not explain the tissue specificity observed. The consistency of tissue involvement within families, despite the variability between families, suggests that the tumors result from separate but contiguous tissue-specific genes arranged in a particular linear order. Linkage studies in MEN 2A and 2B families are compatible with this contiguous gene theory. Data suggest that Knudson's two-mutational-event theory is applicable in MEN2, …
Improvement In Left Ventricular Systolic Function After Pericardiocentesis: Case Report, Gary S. Salem, Robert A. Genovese, Mohsin Alam, Mihai Gheorghiade
Improvement In Left Ventricular Systolic Function After Pericardiocentesis: Case Report, Gary S. Salem, Robert A. Genovese, Mohsin Alam, Mihai Gheorghiade
Henry Ford Hospital Medical Journal
No abstract provided.
Screening For Adenocarcinoma Of The Prostate, Brian J. Miles
Screening For Adenocarcinoma Of The Prostate, Brian J. Miles
Henry Ford Hospital Medical Journal
No abstract provided.
Primary Fibrinolysis In Acute Monocytic Leukemia, Ellis J. Van Slyck, Sundara B. K. Raman, Nalini Janakiraman
Primary Fibrinolysis In Acute Monocytic Leukemia, Ellis J. Van Slyck, Sundara B. K. Raman, Nalini Janakiraman
Henry Ford Hospital Medical Journal
We present the case of a young man with acute monocytic leukemia (French-American-British classification:M5) and systemic hyperfibrinolysis with severe bleeding. Although fibrinolysis is usually mild and secorulary to disseminated intravascular coagulation, its role as a primary and dominant factor in rare cases of leukemia warrants that its presence be sought as a cause of abnormal bleeding. Decreased serum plasminogen and increased serum plasmin determined by synthetic substrate assay and a negative protamine paracoagulation test are crucial findings. Use of high-dose epsilon-aminocaproic acid was effective in treating this complication. A transient increase in fibrinolytic activity coincident with the early effect of …
Pleural Effusion In Michigan Caused By Coccidioides Immitis After Travel To An Endemic Area, Christopher M. Hughes, Paul A. Kvale
Pleural Effusion In Michigan Caused By Coccidioides Immitis After Travel To An Endemic Area, Christopher M. Hughes, Paul A. Kvale
Henry Ford Hospital Medical Journal
Primary coccidioidal disease is rarely diagnosed in the midwest in the nonimmunocompromised host. Since coast-to-coast travel is common today, many patients may become exposed to Coccidioides immitis while traveling in endemic areas. We present a case of acute coccidioidal pleural effusion in a Michigan woman who had recently visited northeastern Arizona. Her travel history was the single most important factor in the eventual diagnosis of coccidioidal pleural effusion.
Histopathologic Diagnosis And Classification Of Prostate Adenocarcinoma: Biologic Significance, Jill M. Peters, John D. Crissman
Histopathologic Diagnosis And Classification Of Prostate Adenocarcinoma: Biologic Significance, Jill M. Peters, John D. Crissman
Henry Ford Hospital Medical Journal
Early diagnosis and accurate, biologically meaningful classification of prostate neoplasia remain important goals. The relation of evolving clinicopathologic concepts of histologic appearances to potential tumor progression is a major advance in classification of prostatic neoplasia. The criteria for recognizing incidental or "occult" stage A-l adenocarcinomas remain problematic in diagnosis, and focal neoplasms with little or no propensity to progression must be differentiated from cancers with a high likelihood of aggressive behavior. Current histologic grading systems in classifying prostate adenocarcinoma accurately identify two cancer subsets: 1) focal well differentiated tumors which rarely progress, and 2) diffuse poorly differentiated tumors which invariably …
Staging Carcinoma Of The Prostate, Joseph C. Cerny
Staging Carcinoma Of The Prostate, Joseph C. Cerny
Henry Ford Hospital Medical Journal
No abstract provided.
Hormonal Management Of Advanced Adenocarcinoma Of The Prostate, Brian J. Miles
Hormonal Management Of Advanced Adenocarcinoma Of The Prostate, Brian J. Miles
Henry Ford Hospital Medical Journal
No abstract provided.
Advances In The Diagnosis Of Urothelial Neoplasia, John D. Crissman, Richard J. Zarbo, Terri Johnson, V. Ramesh Babu, Fazlul H. Sarkar, Brian J. Miles, Joseph C. Cerny
Advances In The Diagnosis Of Urothelial Neoplasia, John D. Crissman, Richard J. Zarbo, Terri Johnson, V. Ramesh Babu, Fazlul H. Sarkar, Brian J. Miles, Joseph C. Cerny
Henry Ford Hospital Medical Journal
Urothelial neoplasia is a unique cancer in that it consists of a spectrum of tumors with different biologic behaviors. The most common urothelial neoplasm is the low grade superficial papillary carcinoma or papilloma which may recur numerous times but does not result in significant morbidity or mortality. A variant of the superficial papillary carcinoma, which represents approximately 10% of the tumors, is the noninvasive papillary neoplasm which progresses to a less differentiated invasive transitional cell carcinoma (TCC). Considerable effort has been directed at identifying which of the superficial well differentiated papillary tumors will persist, recur and progress to invasive cancer …
Effect Of Cyclosporine On The Rate Of Renal Function Recovery After Renal Transplantation, Francis Dumler
Effect Of Cyclosporine On The Rate Of Renal Function Recovery After Renal Transplantation, Francis Dumler
Henry Ford Hospital Medical Journal
To assess the effect of cyclosporine therapy on the rate of renal function recovery after renal transplantation, patients with no clinical evidence of rejection and who were treated with either cyclosporine or azathioprine in addition to steroid therapy were studied (n = 74). Of the patients with immediate renal function (n = 57), those receiving organs from living, related donors had a faster recovery rate of glomerular filtration than patients with cadaveric grafts (azathioprine, 15 ± 2 versus 7 ± 1 mL/min/day, P = 0.0001; cyclosporine, 14 ± 3 versus 6 ± 1 mL/min/day, P = 0.001). Recipients of cadaveric …
Quinidine-Induced Immune Thrombocytopenia, Mansoor N. Saleh, Nadhav Dhodaphar, Karen Allen, Albert F. Lobuglio
Quinidine-Induced Immune Thrombocytopenia, Mansoor N. Saleh, Nadhav Dhodaphar, Karen Allen, Albert F. Lobuglio
Henry Ford Hospital Medical Journal
We have identified six cases of quinidine-induced immune thrombocytopenia based on clinical evidence and in association with elevated amounts of platelet surface IgG. The degree of thrombocytopenia did not correlate with severity of clinical symptoms, nor did it predict the amount of IgG on the platelet surface. Three of the patients recovered promptly after drug discontinuation alone whereas the other patients received additional corticosteroid therapy. The clinical presentation, mode of diagnosis, and therapeutic considerations in the treatment of drug-induced thrombocytopenia are discussed.
Surgical Management Of Spinal Epidural Disease: An Update, Jack P. Rock, Dale V. Hoekstra, Henry H. Schmidek
Surgical Management Of Spinal Epidural Disease: An Update, Jack P. Rock, Dale V. Hoekstra, Henry H. Schmidek
Henry Ford Hospital Medical Journal
Management of spinal cord compression from metastatic malignant disease remains unsatisfactory. Results of surgical decompression are at best less than those of radiation therapy alone. However, new surgical approaches now focus on removing the anterior-situated tumor tissue which produces neural compression in about 85% of the cases. The results of these procedures that allow removal of the ventrally compressing tumor show significant improvement in the management of patients with spinal epidural disease. We review the surgical strategy of these new approaches and the attendant results.
Echo-Doppler Features Of Pulmonary Valve Endocarditis, Jihad Bitar, Mohsin Alam
Echo-Doppler Features Of Pulmonary Valve Endocarditis, Jihad Bitar, Mohsin Alam
Henry Ford Hospital Medical Journal
Three patients with fever and pneumonitis were found to have pulmonary valve vegetations by echocardiography. Pulsed and color flow Doppler studies demonstrated mild to moderate pulmonary valve insufficiency in these patients. All patients responded to the appropriate antibiotics without requiring valve surgery. Echocardiography is of value in diagnosing pulmonary valve endocarditis and should be considered in every patient with recurrent pneumonitis.
Digitalis Intoxication Or Intrinsic Conduction System Disease, Hooman Mahdyoon, Howard S. Rosman, Demetrios N. Mermiges, Mihai Gheorghiade
Digitalis Intoxication Or Intrinsic Conduction System Disease, Hooman Mahdyoon, Howard S. Rosman, Demetrios N. Mermiges, Mihai Gheorghiade
Henry Ford Hospital Medical Journal
No abstract provided.
Cerebral Infarction Associated With Cocaine Use, Iliana Meza, Carlos A. Estrada, Justo A. Montalvo, Walter N. Hidalgo, Jennie Andresen
Cerebral Infarction Associated With Cocaine Use, Iliana Meza, Carlos A. Estrada, Justo A. Montalvo, Walter N. Hidalgo, Jennie Andresen
Henry Ford Hospital Medical Journal
We report the case of a young man with an acute infarction of the left putamen and caudate nucleus, whose symptoms appeared six hours after intranasal use of approximately 0.5 g of cocaine hydrochloride. It seems probable that in this patient cocaine consumption played a role in the development of stroke.
Adenocarcinoma Of The Prostate: An Overview, Brian J. Miles, Robert Chapman, Joseph C. Cerny
Adenocarcinoma Of The Prostate: An Overview, Brian J. Miles, Robert Chapman, Joseph C. Cerny
Henry Ford Hospital Medical Journal
No abstract provided.
Bladder Catheter Knotting: A Case Report, Mark G. Goetting
Bladder Catheter Knotting: A Case Report, Mark G. Goetting
Henry Ford Hospital Medical Journal
No abstract provided.
Prevalence Of Respiratory Symptoms And Allergic Sensitivity In Multiply Handicapped Children, Dennis R. Ownby, Mary Logan, Ruth Ann Belfi
Prevalence Of Respiratory Symptoms And Allergic Sensitivity In Multiply Handicapped Children, Dennis R. Ownby, Mary Logan, Ruth Ann Belfi
Henry Ford Hospital Medical Journal
Among the many challenges of providing care for children with multiple physical and developmental handicaps is the proper management of their respiratory difficulties. This study was designed to evaluate the prevalence of respiratory symptoms in children attending a multidisciplinary clinic for handicapped children. We also used several methods to estimate the prevalence of allergic sensitivity in children with respiratory complaints. Questionnaires concerning respiratory symptoms were completed by the parents of 104 patients. The most frequent complaint reported was snoring in 41% of the children. Of the 39% who had multiple respiratory symptoms, 85% had detectable allergen- specific IgE to cat, …
Attention Deficit Disorder: An Overview, Wiley C. Rasbury
Attention Deficit Disorder: An Overview, Wiley C. Rasbury
Henry Ford Hospital Medical Journal
No abstract provided.
Child Life: Meeting The Psychosocial Needs Of Children And Families In The Hospital, Christine O. Newman, Carol G. Klingbeil, Roberta B. Abrams
Child Life: Meeting The Psychosocial Needs Of Children And Families In The Hospital, Christine O. Newman, Carol G. Klingbeil, Roberta B. Abrams
Henry Ford Hospital Medical Journal
No abstract provided.
The Expanding Spectrum Of Pediatric Practice, Jeffrey M. Devries
The Expanding Spectrum Of Pediatric Practice, Jeffrey M. Devries
Henry Ford Hospital Medical Journal
No abstract provided.
Perinatal Idiopathic Hemochromatosis, Usha B. Raju, Sudhakar Ezhuthachan, Chan K. Ma
Perinatal Idiopathic Hemochromatosis, Usha B. Raju, Sudhakar Ezhuthachan, Chan K. Ma
Henry Ford Hospital Medical Journal
We report the clinicopathologic features of an infant who died of a rare form of perinatal cirrhosis associated with idiopathic hepatic and extrahepatic parenchymal siderosis. The infant appeared normal at birth but soon became severely ill, following a progressively downhill course associated with hypoglycemia, metabolic acidosis, bleeding diathesis, jaundice, and shock. The infant died at 7 days of age. The manifestations were those of hepatic failure but mimicked sepsis and disseminated intravascular coagulation. Cirrhosis, giant cell transformation, and parenchymal iron deposition characteristic of perinatal idiopathic hemochromatosis, a recently emerging clinicopathologic entity of unknown etiology, were present in this infant. These …
Ovarian Failure In A Chromosomally Competent Adolescent Female: A Case Report, T. Jann Caison-Sorey
Ovarian Failure In A Chromosomally Competent Adolescent Female: A Case Report, T. Jann Caison-Sorey
Henry Ford Hospital Medical Journal
Primary ovarian failure in adolescence is uncommon. This report depicts such a case in a 17 1/2-year old girl whose investigation revealed elevations in the follicle-stimulating hormone and luteinizing hormone levels in association with a low estrogen level. The blood leukocyte chromosome analysis with Giemsa banding revealed a 46,XX chromosomal complement. Pelvic ultrasound disclosed a rudimentary uterus and a small left ovary. Hormonal replacement has resulted in advancement of secondary sexual characteristics and monthly withdrawal bleeding.
A Practical Approach To Infantile Apnea, Gregory Preston
A Practical Approach To Infantile Apnea, Gregory Preston
Henry Ford Hospital Medical Journal
No abstract provided.
Validation Of Electronic Rectal Thermometry, Mark G. Goetting, Karen Stratton
Validation Of Electronic Rectal Thermometry, Mark G. Goetting, Karen Stratton
Henry Ford Hospital Medical Journal
Electronic rectal thermometry is performed routinely in most medical centers. While electronic thermometry has been validated at the oral site, rectal measurement has not. We performed a controlled study on 84 children comparing mercury-in-glass and electronic thermometry at the rectal site. No significant difference occurred in temperatures between the two methods. We conclude that the electronic thermometer is a valid instrument to measure rectal temperature.
Pediatric Emergency Care: A Survey Of Michigan Emergency Departments, David J. Treloar, Gregory Preston, Fred Lamb
Pediatric Emergency Care: A Survey Of Michigan Emergency Departments, David J. Treloar, Gregory Preston, Fred Lamb
Henry Ford Hospital Medical Journal
Recent studies suggest a lack of preparation in emergency medical systems for pediatric patients. Michigan emergency departments were surveyed to determine their degree of preparedness regarding equipment, space, and pediatric on-call coverage. More than 50% of responding emergency departments did not have a pediatrician on call and lacked a pediatric "crash cart," and 34% had to send their personnel to other areas in the hospital to obtain pediatric equipment during resuscitations. This survey suggests a lack of preparation for pediatric emergencies in Michigan.