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Articles 5071 - 5100 of 6880

Full-Text Articles in Public Health

In Vitro Secretion Of Peptides Of The Calcitonin Family: Calcitonin, Katacalcin, And Calcitonin Gene-Related Peptide, Friedhelm Raue, Hubert Serve, Eckard Rix, Reinhard Ziegler Jun 1987

In Vitro Secretion Of Peptides Of The Calcitonin Family: Calcitonin, Katacalcin, And Calcitonin Gene-Related Peptide, Friedhelm Raue, Hubert Serve, Eckard Rix, Reinhard Ziegler

Henry Ford Hospital Medical Journal

A tissue culture explant and a primary cell culture of malignant C-cells have been estabUshed to study the secretion pattern of calcitonin (CT), katacalcin (KC), and CT gene-related peptide (CGRP) in vitro under different conditions. Within the first five days of culture the spontaneous secretion of the peptides in both systems dropped to and remained at a constant level. With increasing calcium (Ca) concentration in the medium, a dose dependent release of CT, KC and, in cell culture, of CGRP was observed. BAY-K-8644. an analog of the Ca channel blocker nifedipine, enhanced the CT secretion to the same extent as …

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Localization Of A Radiolabeled Monoclonal Antibody To Calcitonin In Rat Medullary Thyroid Carcinoma Allografts, Naguib A. Samaan, Kuo-Pao Yang Jun 1987

Localization Of A Radiolabeled Monoclonal Antibody To Calcitonin In Rat Medullary Thyroid Carcinoma Allografts, Naguib A. Samaan, Kuo-Pao Yang

Henry Ford Hospital Medical Journal

A radiolabeled anticalcitonin monoclonal antibody (MoAb) was testedfor tumor-localizing capability in WAG/Rij rats allografted with cultured medullary thyroid carcinoma cells (line 44-2). 131I-labeled anticalcitonin IgG was taken up by the tumors in a time-dependent and dose-dependent manner. Tumor tissue uptake of the injected MoAb was 0.7 to 1.3%/g of tumor tissue when tested with a dose range of 40 lo 250 μg/kg of body weight. Distribution ratios of the radiolabeled MoAb were 1.2:1 for tumor-to-blood and 2-20:1 for tumor-to-organs. In rats injected with control IgG, disiribution ratios of radioactivity were 0.4:1 for tumor-to-blood, and 0.6-2:1 for tumor-to-organs. These results suggested …

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Studies Of Multiple Endocrine Neoplasia Type 2a Syndrome: Linkage Analyses And Comparison Of Constitutional And Tumor Genotypes, Hideo Tateishi, Shin-Ichiro Takai, Isamu Nishisho, Tetsuro Miki, Kazuyoshi Motomura, Makoto Okazaki, Akira Miyauchi, Tatsuro Ikeuchi, Kohtaro Yamamoto, Tatsuo Hattori, Yuichi Kumahara, Hideo Matsumoto, Tasuko Honjo, Takesada Mori Jun 1987

Studies Of Multiple Endocrine Neoplasia Type 2a Syndrome: Linkage Analyses And Comparison Of Constitutional And Tumor Genotypes, Hideo Tateishi, Shin-Ichiro Takai, Isamu Nishisho, Tetsuro Miki, Kazuyoshi Motomura, Makoto Okazaki, Akira Miyauchi, Tatsuro Ikeuchi, Kohtaro Yamamoto, Tatsuo Hattori, Yuichi Kumahara, Hideo Matsumoto, Tasuko Honjo, Takesada Mori

Henry Ford Hospital Medical Journal

Linkage analyses were carried out in nine Japanese kindreds with multiple endocrine neoplasia type 2A (MEN-2A) using polymorphic classical markers and DNA markers. We excluded close linkage of the MEN-2A gene (MEN2A) locus with Gm, JK, PGMl, and a DNA segment, D20S5, which is assigned to band 12 of the short arm of chromosome 20 (20p12.2). Assuming that MEN2A is recessive at the cellular level as in retinoblastoma (RB) and Wilms' tumor (WT). comparison of constitutional and tumor genotypes may be useful in the search for the MEN2A locus. When DNA samples from 12 patients with medullary thyroid carcinoma (MTC) …

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Where Is The Locus For Multiple Endocrine Neoplasia Type 2a?, Nancy E. Simpson, Kenneth K. Kidd Jun 1987

Where Is The Locus For Multiple Endocrine Neoplasia Type 2a?, Nancy E. Simpson, Kenneth K. Kidd

Henry Ford Hospital Medical Journal

Attempts to map the locus of the gene (MEN2A) for the multiple endocrine neoplasia type 2A (MEN-2A) syndrome over the past II years are reviewed. Lod scores from family linkage studies of polymorphisms for 26 proteins and 64 DNA markers (restriction fragment length polymorphisms or RFLPs) were pooled from the published literature and the authors' unpublished data. The pooled data excluded 32% of the genome as possible sites for the MEN2A locus. This represents a considerable increase in the area of exclusion over that of the 6% reported at the first workshop. Linkage studies of RFLPs recognized by DNA sequences …

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Back Matter Jun 1987

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Health Care Policy Issues Related To Aids: Lessons Learned From The Henry Ford Hospital Experience, David W. Benfer Mar 1987

Health Care Policy Issues Related To Aids: Lessons Learned From The Henry Ford Hospital Experience, David W. Benfer

Henry Ford Hospital Medical Journal

No abstract provided.

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Extensive Morphea-Form Basal Cell Carcinoma Invasion Of The Iris And The Orbital Content, David Barsky, William J. Vasileff Mar 1987

Extensive Morphea-Form Basal Cell Carcinoma Invasion Of The Iris And The Orbital Content, David Barsky, William J. Vasileff

Henry Ford Hospital Medical Journal

No abstract provided.

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Multiple Small Bowel Perforations Secondary To Cytomegalovirus In A Patient With Acquired Immunodeficiency Syndrome, Herman P. Houin, James C. Gruenberg, Evelyn J. Fisher, Eugene Mezger Mar 1987

Multiple Small Bowel Perforations Secondary To Cytomegalovirus In A Patient With Acquired Immunodeficiency Syndrome, Herman P. Houin, James C. Gruenberg, Evelyn J. Fisher, Eugene Mezger

Henry Ford Hospital Medical Journal

Cytomegalovirus gastroenteritis can be a life-threatening infection in patients with the acquired immunodeficiency syndrome. Although gastrointestinal ulcerations from cytomegalovirus have been widely reported, our patient is only the second case reported with actual perforations in the small bowel.

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Clinical Review Of Epidemic Kaposi's Sarcoma With Focus On Treatment Modalities, Judie Goodman, Robert Chapman, Eyal Meiri Mar 1987

Clinical Review Of Epidemic Kaposi's Sarcoma With Focus On Treatment Modalities, Judie Goodman, Robert Chapman, Eyal Meiri

Henry Ford Hospital Medical Journal

No abstract provided.

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Book Review: Osteosclerosis, Hyperostosis And Related Disorders, Malachi J. Mckenna Mar 1987

Book Review: Osteosclerosis, Hyperostosis And Related Disorders, Malachi J. Mckenna

Henry Ford Hospital Medical Journal

No abstract provided.

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T-Lymphocyte Subset Studies To Monitor Patients With Aids And Aids-Related Complex, Hajime Hayashi, Eugene Mezger, Michael J. Deegan, Evelyn J. Fisher, Norman Markowitz Mar 1987

T-Lymphocyte Subset Studies To Monitor Patients With Aids And Aids-Related Complex, Hajime Hayashi, Eugene Mezger, Michael J. Deegan, Evelyn J. Fisher, Norman Markowitz

Henry Ford Hospital Medical Journal

Multiple specimens from 124 patients from our clinic were evaluated for T4/T8 cell ratio over three to 28 months. Twenty-nine of 30 patients with the acquired immunodeficiency syndrome (AIDS), 58 of 71 patients with AIDS-related complex (ARC), and four of 23 patients at risk showed initial T4/T8 cell ratios of less than 0.8. which either remained unchanged or decreased. Seventeen of 23 AIDS patients and two of 20 ARC patients with a consistently low ratio (0.3 or less) died during the follow-up period. This indicated that the severity of disease could be predicted by periodical T4/T8 cell ratio studies. These …

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Gastrointestinal Complications Of Aids: Radiologic Findings, Marc A. Bernstein, Jeremy J. Hollerman, Peter J. Feczko Mar 1987

Gastrointestinal Complications Of Aids: Radiologic Findings, Marc A. Bernstein, Jeremy J. Hollerman, Peter J. Feczko

Henry Ford Hospital Medical Journal

The acquired immunodeficiency syndrome (AIDS) is a significant health problem. Patients with this disease develop unusual infections and neoplasms, many within the gastrointestinal tract. Of the 66 AIDS patients seen over a three-year period at Henry Ford Hospital, 25 patients had AIDS-related gastrointestinal disease, with one death attributed to this cause. The radiologic findings and pathologic correlation of this experience are presented.

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Mechanical Ventilation: New Modes, Old Modes, John Popovich Jr. Mar 1987

Mechanical Ventilation: New Modes, Old Modes, John Popovich Jr.

Henry Ford Hospital Medical Journal

No abstract provided.

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The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson Mar 1987

The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson

Henry Ford Hospital Medical Journal

Creutzfeldt-Jakob disease, a transmissible, rapidly progressive dementia of unknown etiology, mimics Alzheimer's disease, presents in middle life, and affects many central nervous system structures. The disease progresses in three distinct stages, culminating in death. Its occurrence is sporadic and its distribution worldwide. Pathological changes are varied, but spongy degeneration of the neuropil is classic. Research on scrapie, the animal model of Creutzfeldt-Jakob disease, has demonstrated that this unconventional, slow disease is transmitted via a small (less than 50,000 mW) particle, which is composed principally of protein. How this infectious particle, variably named prion, virino, or slow virus, invokes disease or …

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Renal Involvement In The Acquired Immunodeficiency Syndrome: Presentation, Clinical Course, And Therapy, Robert Provenzano, Warren Kupin, Godofredo C. Santiago Mar 1987

Renal Involvement In The Acquired Immunodeficiency Syndrome: Presentation, Clinical Course, And Therapy, Robert Provenzano, Warren Kupin, Godofredo C. Santiago

Henry Ford Hospital Medical Journal

Acute renal failure developing during the clinical course of the acquired immunodeficiency syndrome (AIDS) has been related to complications of sepsis, nephrotoxic antibiotics, and recently to the development of glomerular lesions. Of 114 AIDS patients admitted to our hospital between January 1985 and June 1986. II patients (9.6%) developed acute renal failure. None of these II patients had a history of intravenous drug abuse or hypertension. All patients were male with an average age of 35 years old, 81% were black, and all were bisexual or homosexual. Renal failure was attributed to AIDS-related focal glomerulosclerosis (five cases), prerenal azotemia (one …

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A Tribute To C. Leslie Mitchell, Md, David Mitchell Mar 1987

A Tribute To C. Leslie Mitchell, Md, David Mitchell

Henry Ford Hospital Medical Journal

No abstract provided.

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Front Matter Mar 1987

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Aids Update, Evelyn J. Fisher Mar 1987

Aids Update, Evelyn J. Fisher

Henry Ford Hospital Medical Journal

No abstract provided.

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Primary Neurologic Complications Of The Acquired Immunodeficiency Syndrome, Stuart N. Kieran Mar 1987

Primary Neurologic Complications Of The Acquired Immunodeficiency Syndrome, Stuart N. Kieran

Henry Ford Hospital Medical Journal

No abstract provided.

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Pulmonary Complications Of Aids: Henry Ford Hospital Experience Between January 1984 And July 1986, Barry Lesser, Joan Price, Phillip Bruno, Evelyn J. Fisher, John Popovich Jr., Michael S. Eichenhorn Mar 1987

Pulmonary Complications Of Aids: Henry Ford Hospital Experience Between January 1984 And July 1986, Barry Lesser, Joan Price, Phillip Bruno, Evelyn J. Fisher, John Popovich Jr., Michael S. Eichenhorn

Henry Ford Hospital Medical Journal

We have retrospectively reviewed our bronchoscopic experience in patients with suspected pulmonary complications of the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex at Henry Ford Hospital between 1984 and 1986. The charts of 52 patients, representing a total of 87 bronchoscopic examinations, were available for review. The bronchoscopic findings as well as correlative chest roentgenograms and arterial blood gases are reviewed, and implications for therapy are discussed.

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The Aids Challenge: A Psychosocial Perspective, Madelyn S. Plotkin, Margaret Dietz Domanski Mar 1987

The Aids Challenge: A Psychosocial Perspective, Madelyn S. Plotkin, Margaret Dietz Domanski

Henry Ford Hospital Medical Journal

No abstract provided.

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Ultrasonic Evaluation In The Management Of Postpartum Infection, Chang Y. Lee, Beatrice L. Madrazo, Sheryl Parks, Michael Sandler Mar 1987

Ultrasonic Evaluation In The Management Of Postpartum Infection, Chang Y. Lee, Beatrice L. Madrazo, Sheryl Parks, Michael Sandler

Henry Ford Hospital Medical Journal

To evaluate the effectiveness of ultrasound in the management of postpartum problems, ultrasonographic examination was performed on 98 patients with suspected postpartum infection. The study includes only those patients who did not respond to antibiotic treatment for at least 48 hours and those patients who were readmitted to the hospital with suspected postpartum infection. Echogenic tissue was found in the uterine cavity in 12 patients, and significant fluid collection was found in 24 patients. Gas collection appeared in the uterine cavity in five patients and around the uterine incision in four patients. Fluid collection was found around the uterine incision …

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Bilateral Anterior Cerebral Artery Occlusion In An Alcohol Abuser With Sickle-Cell Trait, Thomas H. Swanson, John L. Zinkel, Patti L. Peterson Mar 1987

Bilateral Anterior Cerebral Artery Occlusion In An Alcohol Abuser With Sickle-Cell Trait, Thomas H. Swanson, John L. Zinkel, Patti L. Peterson

Henry Ford Hospital Medical Journal

The contribution of ethanol ingestion to brain infarction is unclear, although many studies suggest that the two may be causally related. We report an unusual case of bilateral anterior cerebral artery occlusion in a young female ethanol abuser with sickle-cell trait whose platelets showed hyperaggregability during epinephrine and adenosine diphosphate-induced aggregation experiments. It is concluded that ethanol withdrawal and dehydration along with direct effects of ethanol on platelet aggregation may result in cerebral artery thrombosis. Sickling of red blood cells in the distal circulation also may be a compounding factor, but this is not proven.

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Back Matter Mar 1987

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Biotechnology In The Conquest Of Infectious Diseases, Ashley T. Haase Jan 1987

Biotechnology In The Conquest Of Infectious Diseases, Ashley T. Haase

Journal of the Minnesota Academy of Science

No abstract provided.

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Forest Conservation In Nepal: Encouraging Women's Participation, Augusta Molnar Jan 1987

Forest Conservation In Nepal: Encouraging Women's Participation, Augusta Molnar

Poverty, Gender, and Youth

This issue of SEEDS focuses on ways in which women have been involved in a government forest conservation and restoration program in Nepal. As is common with many large-scale projects with a general impact, women were not a direct focus of the project's original design. As activities got underway, however, both the Nepali staff and their expatriate colleagues quickly realized that the direct involvement of women was crucial to the success of the project's participatory strategy. Over the initial five years, 1980 to 1985, a number of approaches to addressing women's needs and generating their active participation were tried. The …

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Helminth Remains From Prehistoric Indian Coprolites On The Colorado Plateau, Karl J. Reinhard, Richard H. Hevly, Glenn A. Anderson Jan 1987

Helminth Remains From Prehistoric Indian Coprolites On The Colorado Plateau, Karl J. Reinhard, Richard H. Hevly, Glenn A. Anderson

Karl Reinhard Publications

Examination of coprolites excavated from archaeological sites in the Americas demonstrates excellent preservation of helminth eggs and, in some cases, larvae. To gain an understanding of helminth parasitism in prehistory on the Colorado Plateau of Arizona, New Mexico, and Utah, 319 coprolites from 5 archaeological sites were analyzed. Helminth eggs and larvae were recovered after the coprolites were rehydrated, screened, and sedimented. At a sixth site, soils excavated from 5 rooms used as latrine areas were processed with palynological techniques. The results indicate that all but 1 of the prehistoric populations examined were infected with intestinal worms. The helminths implicated …

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Use Of A "Permission Giving" Patient Checklist In Identification Of Social And Sexual Problems, William B. Anderson Dec 1986

Use Of A "Permission Giving" Patient Checklist In Identification Of Social And Sexual Problems, William B. Anderson

Henry Ford Hospital Medical Journal

A checklist derived from the ACOG bulletin entitled "Communication of Sexual Problems in Office Gynecology" was given to 614 women. The findings demonstrate that social and sexual concerns are encountered frequently in the practice of clinical gynecology and that a checklist is effective in identifying these concerns.

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The Ambulatory Care "Gold Rush?", Michael A. Slubowski Dec 1986

The Ambulatory Care "Gold Rush?", Michael A. Slubowski

Henry Ford Hospital Medical Journal

No abstract provided.

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Letters To The Editor Dec 1986

Letters To The Editor

Henry Ford Hospital Medical Journal

No abstract provided.

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