Open Access. Powered by Scholars. Published by Universities.®

Public Health Commons™

Open Access. Powered by Scholars. Published by Universities.®

Epidemiology

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1291 - 1320 of 5751

Full-Text Articles in Public Health

Determinan Kematian Bayi Ditinjau Dari Perilaku Kesehatan Ibu: Tinjauan Literatur, Imelda Aliska, Ade Suzana Eka Putri, Amir Su’Udi Jun 2023

Determinan Kematian Bayi Ditinjau Dari Perilaku Kesehatan Ibu: Tinjauan Literatur, Imelda Aliska, Ade Suzana Eka Putri, Amir Su’Udi

Jurnal Epidemiologi Kesehatan Indonesia

Angka Kematian Bayi (AKB) di Indonesia masih belum mencapai target SDGS tahun 2030 dan RPJMN tahun 2020-2024 pada bidang kesehatan. AKB perlu diperhatikan karena merupakan indikator sensitif untuk mengukur keberhasilan pencapaian pembangunan kesehatan dan juga mengukur pencapaian indeks modal manusia. Tujuan dari penelitian ini adalah untuk mereview determinan perilaku kesehatan ibu terhadap kejadian kematian bayi dengan metode literature review. Penelusuran literature dilakukan di database PubMed, Portal Garuda, Semantic Scholar, dan Google Scholar. Kriteria inklusi pada penelitian ini adalah artikel penelitian yang terbit pada 2016-2022, menggunakan bahasa Indonesia dan bahasa Inggris, serta menggunakan desain studi observasional.Hasil akhir dari proses pencarian studi …


Analisis Survival: Hubungan Konversi Sputum Dengan Keberhasilan Pengobatan Pasien Tuberkulosis Resistan Obat Di Indonesia, Shena Masyita Deviernur, Nurhayati Adnan Jun 2023

Analisis Survival: Hubungan Konversi Sputum Dengan Keberhasilan Pengobatan Pasien Tuberkulosis Resistan Obat Di Indonesia, Shena Masyita Deviernur, Nurhayati Adnan

Jurnal Epidemiologi Kesehatan Indonesia

Angka keberhasilan pengobatan Tuberkulosis Resistan Obat (TB RO) di Indonesia masih rendah. Konversi sputum dapat menjadi monitoring awal untuk memantau keberhasilan pengobatan. Penelitian ini bertujuan untuk melihat hubungan antara konversi sputum <3 bulan dengan keberhasilan pengobatan. Penelitian ini menggunakan desain studi kohort retrospektif dengan data yang bersumber dari sistem informasi tuberkulosis Kementerian Kesehatan RI. Populasi pada penelitian ini adalah pasien TB RO yang memulai pengobatan tahun 2020-2021 di Indonesia dengan jumlah sampel sebanyak 8.025 kasus dan participation rate sebesar 88,6%. Kurva Kaplan Meier dengan uji log-rank dibuat untuk analisis deskriptif, sedangkan analisis regresi Cox digunakan untuk melihat hubungan antara konversi sputum dengan keberhasilan pengobatan. Hasil analisis menunjukkan bahwa 45,9% pasien konversi sputum < 3 bulan pengobatan dengan 74,6% memiliki keberhasilan pengobatan. Secara keseluruhan median time untuk keberhasilan pengobatan berdasarkan konversi sputum < 3 bulan adalah bulan ke-18. Hasil analisis multivariat menunjukkan konversi sputum < 3 bulan 1,25 (95% CI 1,18-1,34) lebih tinggi peluangnya untuk mencapai keberhasilan pengobatan dibandingkan pasien yang tidak konversi < 3 bulan setelah dikontrol oleh status HIV dan paduan pengobatan. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa monitoring konversi sputum dapat menjadi cara untuk melakukan monitoring keberhasilan pengobatan sedini mungkin. Konversi sputum merupakan standar yang dilakukan untuk pemantauan pengobatan pasien TB RO. Namun jumlah laboratorium yang dapat melakukan pemeriksaan untuk konversi pada pasien TB RO masih terbatas. Perlu adanya perluasan layanan dan peningkatan mutu layanan untuk melakukan pemeriksaan konversi sputum pada pasien TB RO.


Prediktor Kepuasan Mahasiswa Profesi Kesehatan Dalam Melaksanakan Praktik Klinik Selama Pandemi Covid-19 Di Rsd Mangusada : Studi Potong Lintang, I Nengah Suarmayasa, I Ketut Swarjana Jun 2023

Prediktor Kepuasan Mahasiswa Profesi Kesehatan Dalam Melaksanakan Praktik Klinik Selama Pandemi Covid-19 Di Rsd Mangusada : Studi Potong Lintang, I Nengah Suarmayasa, I Ketut Swarjana

Jurnal Epidemiologi Kesehatan Indonesia

Pandemi coronavirus disease 2019 (COVID-19) tidak hanya berdampak pada ekonomi dan kesehatan, tetapi juga aspek pendidikan termasuk praktek klinik mahasiswa profesi kesehatan di rumah sakit. Berbagai perubahan dan penyesuaian jumlah mahasiswa yang melaksanakan praktik klinik, peralatan praktik dan juga metode bimbingan dapat berpengaruh terhadap kepuasan mahasiswa. Penelitian ini bertujuan untuk mengidentifikasi kepuasan mahasiswa profesi kesehatan dan prediktornya dalam melaksanakan praktik klinik selama pandemi COVID-19 di Rumah Sakit Daerah (RSD) Mangusada, Kabupaten Badung. Penelitian ini adalah sebuah studi potong lintang yang melibatkan 341 mahasiswa profesi kesehatan (Mahasiswa Koas, Profesi Ners, Profesi Bidan dan Profesi Fisioterapis) yang melaksanakan praktik klinik di RSD …


Sindrom Metabolik Dan Kejadian Stroke Pada Penduduk Berusia > 15 Tahun Di Indonesia: Analisis Data Riskesdas 2018, Muhammad Farhan Dwi Yulianto, Tri Yunis Miko Wahyono, Helda Helda Jun 2023

Sindrom Metabolik Dan Kejadian Stroke Pada Penduduk Berusia > 15 Tahun Di Indonesia: Analisis Data Riskesdas 2018, Muhammad Farhan Dwi Yulianto, Tri Yunis Miko Wahyono, Helda Helda

Jurnal Epidemiologi Kesehatan Indonesia

Prevalensi global stroke dan sindrom metabolik, sebagai kumpulan faktor risiko utama yang mempengaruhi stroke terus mengalami peningkatan. Penelitian ini bertujuan melihat hubungan antara sindrom metabolik dan kejadian stroke di Indonesia. Desain studi ini adalah cross-sectional dan menggunakan data survei skala nasional. Responden berusia >15 tahun yang mengalami stroke dengan data lengkap terkait pengukuran lingkar perut, tekanan darah, kadar glukosa darah, trigliserida, dan kadar high-density lipoprotein akan masuk dalam studi ini. Model regresi logistik digunakan dalam analisis kami. Dari 24.451 responden, studi kami menunjukkan mayoritas berusia <55 tahun (73,9%), perempuan (62,2%), dengan proporsi penderita stroke serta proporsi sindrom metabolik adalah 1,2%, dan 24,4%. Studi ini memperlihatkan adanya hubungan antara sindrom metabolik dan kejadian stroke (adj POR: 2,4; 95% CI: 1,9-3,1). Dengan menangani sindrom metabolik pada penduduk > 15 tahun di Indonesia, diharapkan pengendalian stroke dapat optimal


The Effects Of Covid-19 Lockdown On Social Connectedness And Psychological Distress In Us Adults With Chronic Diseases, Ben King, Omolola E Adepoju, Lechauncy Woodard, Abiodun O Oluyomi, Xiaotao Zhang, Christopher I Amos, Hoda Badr Jun 2023

The Effects Of Covid-19 Lockdown On Social Connectedness And Psychological Distress In Us Adults With Chronic Diseases, Ben King, Omolola E Adepoju, Lechauncy Woodard, Abiodun O Oluyomi, Xiaotao Zhang, Christopher I Amos, Hoda Badr

Faculty, Staff and Students Publications

Lockdown measures enacted in 2020 to control the spread of COVID-19 led to increases in the prevalence of mental health problems. Due to their high-risk status, individuals with chronic diseases may be at increased risk and disproportionately adversely affected by the COVID-19 pandemic. The investigators examined associations between having a high-risk chronic condition, social connectedness, and general distress and COVID-19-specific distress among U.S. adults during the COVID-19 lockdown. Baseline measures of a longitudinal survey collected at the beginning of the pandemic (April to June 2020) were analyzed to identify factors associated with loss of social connectedness from pre- to post-lockdown. …


A Healthcare Claims Investigation Of Parasomnia Epidemiology, Associations With Attention Deficit/Hyperactivity Disorder, And Rem Sleep Behavior Disorder Correlates, Anh Thy Ha Nguyen Jun 2023

A Healthcare Claims Investigation Of Parasomnia Epidemiology, Associations With Attention Deficit/Hyperactivity Disorder, And Rem Sleep Behavior Disorder Correlates, Anh Thy Ha Nguyen

USF Tampa Graduate Theses and Dissertations

Parasomnias, such as sleepwalking and nightmare disorder, are abnormal behaviors and emotions emanating from sleep or wake to sleep transitions. Parasomnias can lead to significant adverse outcomes – sleepwalking can result in injuries and hospitalizations, frequent nightmares are associated with self-harm and suicidal thoughts, and rapid-eye movement (REM) sleep behavior disorder (RBD) is linked to neurodegeneration. Despite a history of fascination with abnormal sleep behaviors in the general and medical communities, epidemiologic understanding of parasomnias remains limited, in part due to their amnestic nature and presumption that they are benign childhood problems. This work used the MarketScan® Commercial Claims and …


The Impact Of Sars-Cov-2 On The Consolidated Meatpacking System In The United States, Judith R. Solomon Jun 2023

The Impact Of Sars-Cov-2 On The Consolidated Meatpacking System In The United States, Judith R. Solomon

Anthós

The Sars-Cov-2 virus has had a particularly intense impact on the meatpacking industry in the United States. In this paper I provide a brief introduction to the social, economic, and political realities that lead to mass deaths of meatpacking workers from COVID, and the impact of a consolidated meatpacking system on disease mitigation. These workers are considered expendable due to a lack of power.


Predicting Chemotherapy Benefit Across Different Races In Early-Stage Breast Cancer Patients Using The Oncotype Dx Score, Vikram R Shaw, Christopher I Amos, Chao Cheng Jun 2023

Predicting Chemotherapy Benefit Across Different Races In Early-Stage Breast Cancer Patients Using The Oncotype Dx Score, Vikram R Shaw, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Background: Oncotype DX assay, a multigene molecular test, has been widely used to stratify relapse risk and guide chemotherapy treatment in breast cancer. However, the optimal threshold of the Oncotype DX score in predicting chemotherapy benefit and its racial variation has not been investigated.

Methods: In this study, we apply a random forest survival model to the SEER-Oncotype cohort data (Surveillance, Epidemiology, and End Results with Oncotype DX test information for breast cancer patients) and determine chemotherapy benefit thresholds in early-stage, estrogen-receptor-positive (ER+), and HER2-negative (HER2-) patients of different races.

Results: Our results indicate that early-stage ER+, HER2-, and LN-/LN+ …


Exposure Levels Of Airborne Fungi, Bacteria, And Antibiotic Resistance Genes In Cotton Farms During Cotton Harvesting And Evaluations Of N95 Respirators Against These Bioaerosols, Atin Adhikari, Pratik Banerjee, Taylor Thornton, Daleniece Higgins, Caleb Adeoye, Sonam Sherpa Jun 2023

Exposure Levels Of Airborne Fungi, Bacteria, And Antibiotic Resistance Genes In Cotton Farms During Cotton Harvesting And Evaluations Of N95 Respirators Against These Bioaerosols, Atin Adhikari, Pratik Banerjee, Taylor Thornton, Daleniece Higgins, Caleb Adeoye, Sonam Sherpa

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

The USA is the third-leading cotton-producing country worldwide and cotton farming is common in the state of Georgia. Cotton harvest can be a significant contributor to airborne microbial exposures to farmers and nearby rural communities. The use of respirators or masks is one of the viable options for reducing organic dust and bioaerosol exposures among farmers. Unfortunately, the OSHA Respiratory Protection Standard (29 CFR Part 1910.134) does not apply to agricultural workplaces and the filtration efficiency of N95 respirators was never field-tested against airborne microorganisms and antibiotic resistance genes (ARGs) during cotton harvesting. This study addressed these two information gaps. …


Childhood Asthma-Management Practices In Rural Nigeria: Exploring The Knowledge, Attitude, And Practice Of Caregivers In Oyo State, Oyindamola Akinso, Atin Adhikari, Jingjing Yin, Joanne Chopak-Foss, Gulzar H. Shah Jun 2023

Childhood Asthma-Management Practices In Rural Nigeria: Exploring The Knowledge, Attitude, And Practice Of Caregivers In Oyo State, Oyindamola Akinso, Atin Adhikari, Jingjing Yin, Joanne Chopak-Foss, Gulzar H. Shah

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Background: Caregivers of asthmatic children have a poor knowledge of proper asthma-management practices in Nigeria. This study examined the knowledge, attitudes, and practice behaviors of caregivers in the management of asthma in children under 5 years of age in Oyo State, Nigeria. Methods: While a mixed method was used in the original research, this brief describes the quantitative method used in this study to evaluate caregivers’ asthma-management practices. A 55-item questionnaire on childhood asthma knowledge, attitude, and practice was administered during child welfare-clinic visits to 118 caregivers. Data were analyzed using the IBM SPSS Version 25.0. Statistical significance was set …


An Audit Of Diabetes-Dependent Quality Of Life And Glycemic Control Among Type 2 Diabetes Patients In A Tertiary Hospital In Bangkok: A Hospital-Based Cross-Sectional Study, Nattaya Tungsirikoon, Nopporn Howteerakul, Nawarat Suwannapong, Petch Rawdaree Jun 2023

An Audit Of Diabetes-Dependent Quality Of Life And Glycemic Control Among Type 2 Diabetes Patients In A Tertiary Hospital In Bangkok: A Hospital-Based Cross-Sectional Study, Nattaya Tungsirikoon, Nopporn Howteerakul, Nawarat Suwannapong, Petch Rawdaree

Journal of Health Research

Background: This hospital-based cross-sectional study aimed to examine the association between diabetes-specific quality of life (QoL), diabetes-related clinical characteristics and glycemic control among type 2 diabetes (T2DM) patients.

Methods: 335 T2DM patients receiving treatment at the diabetes clinic of a tertiary hospital in Bangkok, Thailand, were recruited into the study. The Audit of Diabetes-Dependent Quality of Life (ADDQoL19) was used to assess QoL. The ADDQoL scores were split into two groups using quartiles. The group in the lower quartile was considered as “having low QoL.” Hemoglobin A1c (A1C) was used as an index of glycemic control.

Results: 67.8% of participants …


Parental Characteristics And Experience Of Intimate Partner Violence Among Young Women In Ibadan, Nigeria, Omowumi O. Okedare, Mobolaji M. Salawu, Olufunmilayo I. Fawole Jun 2023

Parental Characteristics And Experience Of Intimate Partner Violence Among Young Women In Ibadan, Nigeria, Omowumi O. Okedare, Mobolaji M. Salawu, Olufunmilayo I. Fawole

Journal of Health Research

Background: Intimate Partner Violence (IPV) is a global public health problem. This study examined the influence of parental background on the experience of IPV by young women in Ibadan, Nigeria.

Method: A cross-sectional survey was conducted in the five Local Government Areas of Ibadan metropolis. One thousand and fifty young women aged between 18 and 24 years were selected using a multistage sampling method to participate in the study. Data was collected using a 28-item semi-structured questionnaire. The independent variables were the parents’ education, marital status, occupation, and mother’s experience of victimization. The dependent variable was previous experience of physical, …


Improving Microbiome Research Through Enhanced Reporting And Modeling The Effects Of Antibiotic Usage, Chloe A. Mirzayi Jun 2023

Improving Microbiome Research Through Enhanced Reporting And Modeling The Effects Of Antibiotic Usage, Chloe A. Mirzayi

Dissertations and Theses

I consider two key areas in the growing field of human microbiome research: improving the quality of study reporting and the impact of antibiotics on participants in human gut microbiome research studies. In the first chapter, a team of evaluators used the Strengthening the Organization and Reporting of Microbiome Studies (STORMS) checklist to assess recently published microbiome literature. I found moderate agreement and reliability between evaluators, identified several items in STORMS that could be improved, and confirmed that the STORMS checklist can serve as a tool for assessing the reporting quality of published microbiome study. The next chapter considers pre-exposure …


Sex Differences In The Clinical Presentation Of Early Psychosis In A Primary Care Setting, Brooke Carter, Rebecca Rodrigues, Jennifer Reid, Suzanne Archie, Amanda L Terry, Lena Palaniyappan, Arlene G Macdougall, Aristotle Voineskos, Saadia Hameed Jan, Liisa Jaakkimainen, Branson Chen, Neo Sawh, Kelly K. Anderson Jun 2023

Sex Differences In The Clinical Presentation Of Early Psychosis In A Primary Care Setting, Brooke Carter, Rebecca Rodrigues, Jennifer Reid, Suzanne Archie, Amanda L Terry, Lena Palaniyappan, Arlene G Macdougall, Aristotle Voineskos, Saadia Hameed Jan, Liisa Jaakkimainen, Branson Chen, Neo Sawh, Kelly K. Anderson

Epidemiology and Biostatistics Publications

Primary care is an important part of the help-seeking pathway for young people experiencing early psychosis, but sex differences in clinical presentation in these settings are unexplored. We aimed to identify sex differences in clinical presentation to primary care services in the 1-year period prior to a first diagnosis of psychotic disorder. We identified first-onset cases of non-affective psychotic disorder over a 10-year period (2005-2015) using health administrative data linked with electronic medical records (EMRs) from primary care (n = 465). Detailed information on encounters in the year prior to first diagnosis was abstracted, including psychiatric symptoms, other relevant behaviours, …


Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease, Dylan Thibaut, Ryan A. Witcher, Anitha Kunnath, James Toldi Jun 2023

Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease, Dylan Thibaut, Ryan A. Witcher, Anitha Kunnath, James Toldi

Advances in Clinical Medical Research and Healthcare Delivery

Abstract

Introduction: Pigeon Breeder’s Pneumonitis (PBP) results due to a complex pathophysiology that includes exposure to avian antigens. Susceptibility has been linked to human leukocyte antigen (HLA) class II, though consensus has not been reached. The goal of this systematic review is to further elucidate the association between PBP and HLA-DR subtypes.

Methods: Databases utilized included PubMed, Google Scholar, ScienceDirect, and Cochrane Library. Inclusion required a minimum of three studies in English presenting HLA-DR alleles of PBP and control subgroups. Exclusion was due to insufficient data or non-feasible control groups. Forest plots were created for HLA-DR subtypes’ association …


(R2032) Modeling The Effect Of Sanitation Effort On The Spread Of Carrier-Dependent Infectious Diseases Due To Environmental Degradation, Ram Naresh, Sandhya Rani Verma, J. B. Shukla, Manju Agarwal Jun 2023

(R2032) Modeling The Effect Of Sanitation Effort On The Spread Of Carrier-Dependent Infectious Diseases Due To Environmental Degradation, Ram Naresh, Sandhya Rani Verma, J. B. Shukla, Manju Agarwal

Applications and Applied Mathematics: An International Journal (AAM)

In this present study, an SIS model is proposed and analyzed to study the effect of sanitation effort in controlling the spread of carrier-dependent infectious disease in a human habitat due to environmental degradation. The dynamics of the model consist of six dependent variables, the susceptible population density, infective population density, carrier population density, cumulative density of environmental degradation and the density of sanitation effort applied on carrier population and degraded environment. In the modeling process, the carrier population density and sanitation effort are modeled logistically and the degradation of the environment is assumed to be directly proportional to the …


Trends Of Ovarian Cancer Incidence And Mortality In Mississippi Between 2003 And 2020, Angel Walker Jun 2023

Trends Of Ovarian Cancer Incidence And Mortality In Mississippi Between 2003 And 2020, Angel Walker

Honors Theses

Ovarian cancer is the fifth leading cause of cancer deaths in women, accounting for more deaths than any other gynecologic cancer (Arora et al., 2023). Over the past few decades, there have been several advancements in treating the disease. However, improvements in survival rates for ovarian cancer are not seen equally among women. For White women, the five-year survival rate for ovarian cancer has improved, while for Black women, it has worsened (Karanth et al., 2019). To further understand how ovarian cancer affects women, we aim to describe the trends of ovarian cancer incidence and mortality for White and Black …


Stool-Based Tests Mitigate Impacts Of Covid-19 On Colorectal Cancer Screening, Po-Hong Liu, Amit G Singal, Caitlin C Murphy Jun 2023

Stool-Based Tests Mitigate Impacts Of Covid-19 On Colorectal Cancer Screening, Po-Hong Liu, Amit G Singal, Caitlin C Murphy

Faculty, Staff and Student Publications

No abstract provided.


Implementation Of Post-Covid Conditions Management Utilizing Interprofessional Collaboration In A Multi-Facility Healthcare Organization, Jocelin Friedman, Christina Dhesi-Bawa, Kathleen Kennedy, Stephen Lee, Leona Hidalgo Jun 2023

Implementation Of Post-Covid Conditions Management Utilizing Interprofessional Collaboration In A Multi-Facility Healthcare Organization, Jocelin Friedman, Christina Dhesi-Bawa, Kathleen Kennedy, Stephen Lee, Leona Hidalgo

Physical Therapy Faculty Articles and Research

Background: The prevalence of Post-Covid Conditions (PCC) is estimated to affect 10-35% of infected individuals, with upwards of 85% of previously hospitalized individuals reporting prolonged effects. Literature indicates deficiencies in communication between healthcare providers which can negatively affect patients. Due to limited interprofessional communication, there was a scarcity of individuals with PCC receiving comprehensive therapy treatment on an outpatient basis. The multi-system nature of PCC was an indication for interprofessional collaboration and the development of workflows facilitating access to care.

Purpose: This qualitative study investigates the Post-COVID-19 Rehabilitation Program (PCRP) at a California, USA multi-facility healthcare system. The …


Methylation Of Nonessential Genes In Cutaneous Melanoma – Rule Out Hypothesis, Ivan P Gorlov, Kathleen Conway, Sharon N Edmiston, Eloise A Parrish, Honglin Hao, Christopher I Amos, Spiridon Tsavachidis, Olga Y Gorlova, Colin Begg, Eva Hernando, Chao Cheng, Ronglai Shen, Irene Orlow, Li Luo, Marc S Ernstoff, Pei Fen Kuan, David W Ollila, Yihsuan S Tsai, Marianne Berwick, Nancy E Thomas Jun 2023

Methylation Of Nonessential Genes In Cutaneous Melanoma – Rule Out Hypothesis, Ivan P Gorlov, Kathleen Conway, Sharon N Edmiston, Eloise A Parrish, Honglin Hao, Christopher I Amos, Spiridon Tsavachidis, Olga Y Gorlova, Colin Begg, Eva Hernando, Chao Cheng, Ronglai Shen, Irene Orlow, Li Luo, Marc S Ernstoff, Pei Fen Kuan, David W Ollila, Yihsuan S Tsai, Marianne Berwick, Nancy E Thomas

Faculty, Staff and Students Publications

Differential methylation plays an important role in melanoma development and is associated with survival, progression and response to treatment. However, the mechanisms by which methylation promotes melanoma development are poorly understood. The traditional explanation of selective advantage provided by differential methylation postulates that hypermethylation of regulatory 5'-cytosine-phosphate-guanine-3' dinucleotides (CpGs) downregulates the expression of tumor suppressor genes and therefore promotes tumorigenesis. We believe that other (not necessarily alternative) explanations of the selective advantages of methylation are also possible. Here, we hypothesize that melanoma cells use methylation to shut down transcription of nonessential genes - those not required for cell survival and …


Racial/Ethnic Disparities In Cervical Cancer Stage At Diagnosis: Mediating Effects Of Neighborhood-Level Socioeconomic Deprivation, Itunu O Sokale, Abiodun O Oluyomi, Jane R Montealegre, Aaron P Thrift Jun 2023

Racial/Ethnic Disparities In Cervical Cancer Stage At Diagnosis: Mediating Effects Of Neighborhood-Level Socioeconomic Deprivation, Itunu O Sokale, Abiodun O Oluyomi, Jane R Montealegre, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Mortality from cervical cancer has declined steadily in the United States over the past several decades due to widespread screening for precancerous and early-stage cervical cancer (ECC), which are significantly easier to treat compared with late-stage cervical cancer (LCC). Unequal screening access continues to cause significant racial/ethnic disparities in cervical cancer diagnosis stage. This study examined the underlying role of neighborhood-level socioeconomic disadvantage as a potential mediator of the association between race/ethnicity and cervical cancer diagnosis stage.

METHODS: We analyzed Texas Cancer Registry data for cervical cancer cases diagnosed among women ages 18 or older from 2010 to 2018. …


Genetic Studies Of Paired Metabolomes Reveal Enzymatic And Transport Processes At The Interface Of Plasma And Urine, Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram Akilesh, Gckd Investigators, Miriam Schmidts, Matthias A Hediger, Ulla T Schultheiss, Kai-Uwe Eckardt, Peter J Oefner, Peggy Sekula, Yong Li, Anna Köttgen Jun 2023

Genetic Studies Of Paired Metabolomes Reveal Enzymatic And Transport Processes At The Interface Of Plasma And Urine, Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulça Uluvar, Matthias Wuttke, Yurong Cheng, Arif B Ekici, Gergely Gyimesi, Edward D Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F Gomez, Bing Yu, Morgan E Grams, Josef Coresh, Eric Boerwinkle, Michael Köttgen, Florian Kronenberg, Heike Meiselbach, Robert P Mohney, Shreeram Akilesh, Gckd Investigators, Miriam Schmidts, Matthias A Hediger, Ulla T Schultheiss, Kai-Uwe Eckardt, Peter J Oefner, Peggy Sekula, Yong Li, Anna Köttgen

Faculty, Staff and Students Publications

The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the …


The Impact Of Covid-19 On A Large Pragmatic Clinical Trial Embedded In Primary Care, Sarah M Leatherman, Cynthia Hau, Alison Klint, Peter A Glassman, Addison A Taylor, Ryan E Ferguson, William C Cushman, Areef Ishani Jun 2023

The Impact Of Covid-19 On A Large Pragmatic Clinical Trial Embedded In Primary Care, Sarah M Leatherman, Cynthia Hau, Alison Klint, Peter A Glassman, Addison A Taylor, Ryan E Ferguson, William C Cushman, Areef Ishani

Faculty, Staff and Students Publications

INTRODUCTION: The COVID-19 pandemic had significant impact on clinical care and clinical trial operations, but the impact on decentralized pragmatic trials is unclear. The Diuretic Comparison Project (DCP) is a Point-of Care (POC) pragmatic trial testing whether chlorthalidone is superior to hydrochlorothiazide in preventing major cardiovascular (CV) events and non-cancer death. DCP utilized telephone consent, data collection from the electronic health record and Medicare, forwent study visits, and limited provider commitment beyond usual care. We assessed the impact of COVID-19 on recruitment, follow-up, data collection, and outcome ascertainment in DCP.

METHODS: We compared data from two 8-month periods: Pre-Pandemic (July …


Pulse Oximetry And Arterial Saturation Difference In Pediatric Covid-19 Patients: Retrospective Analysis By Race, Fabio Savorgnan, Adel Hassan, Nirica Borges, Sebastian Acosta Jun 2023

Pulse Oximetry And Arterial Saturation Difference In Pediatric Covid-19 Patients: Retrospective Analysis By Race, Fabio Savorgnan, Adel Hassan, Nirica Borges, Sebastian Acosta

Faculty, Staff and Students Publications

OBJECTIVES: Pulse oximetry (Sp o2 ) may overestimate arterial oxygen saturation (Sa o2 ) in blood laboratory testing. This study aimed to assess Sp o2 -Sa o2 difference in relation to race (i.e., patient self-reporting as Black or White), occult hypoxemia, and length of stay (LOS) in pediatric patients with COVID-19.

DESIGN: Single-center retrospective study in pediatric COVID-19 patients. We used multivariable linear regressions to examine the association between race and oximetry measurements and between occult hypoxemia and LOS. Oximetry bias was defined using Sp o2 and Sa o2 data according to approved comparisons. Occult hypoxemia was defined as Sp …


Covid-19 Vaccines And The Pandemic: Lessons Learnt For Other Neglected Diseases And Future Threats, Peter J Hotez, Sarah Gilbert, Melanie Saville, Lois Privor-Dumm, Salim Abdool-Karim, Didi Thompson, Jean-Louis Excler, Jerome H Kim Jun 2023

Covid-19 Vaccines And The Pandemic: Lessons Learnt For Other Neglected Diseases And Future Threats, Peter J Hotez, Sarah Gilbert, Melanie Saville, Lois Privor-Dumm, Salim Abdool-Karim, Didi Thompson, Jean-Louis Excler, Jerome H Kim

Faculty, Staff and Students Publications

Through the experiences gained by accelerating new vaccines for both Ebola virus infection and COVID-19 in a public health emergency, vaccine development has benefited from a 'multiple shots on goal' approach to new vaccine targets. This approach embraces simultaneous development of candidates with differing technologies, including, when feasible, vesicular stomatitis virus or adenovirus vectors, messenger RNA (mRNA), whole inactivated virus, nanoparticle and recombinant protein technologies, which led to multiple effective COVID-19 vaccines. The challenge of COVID-19 vaccine inequity, as COVID-19 spread globally, created a situation where cutting-edge mRNA technologies were preferentially supplied by multinational pharmaceutical companies to high-income countries while …


Dietary Changes Among Normal And High Blood Pressure Adolescents During The Covid-19 Pandemic, Bernadette Victoria, Ratu Ayu Dewi Sartika, Rizti Millva Putri May 2023

Dietary Changes Among Normal And High Blood Pressure Adolescents During The Covid-19 Pandemic, Bernadette Victoria, Ratu Ayu Dewi Sartika, Rizti Millva Putri

Kesmas

The COVID-19 pandemic has significantly impacted adolescents' unhealthy eating habits and sedentary lifestyles, leading to an increase in blood pressure and obesity rate. High blood pressure among adolescents is an early indicator of adult hypertension, but this condition has received less attention recently. Therefore, this study aimed to determine the differences in dietary changes among high school students with normal and high blood pressure before and during the COVID-19 pandemic in West Lampung District, Indonesia. A cross-sectional design was used, and the sample population consisted of 167 students aged 14-19 years. The results showed that 43 participants had elevated blood …


Covid-19 Prevention In People Living With Hiv/Aids: Entering The Endemic Phase, Imelda F E Manurung, Afrona E L Takaeb, Jermias Da Cruz May 2023

Covid-19 Prevention In People Living With Hiv/Aids: Entering The Endemic Phase, Imelda F E Manurung, Afrona E L Takaeb, Jermias Da Cruz

Kesmas

The mortality and severity risks due to COVID-19 infection are higher in people living with HIV/AIDS (PLWHA) than those with no such condition. This study aimed to analyze the relationship between health literacy, social support, and the health belief model in PLWHA in preventing COVID-19 from entering the endemic phase. An analytic observational study with a cross-sectional design was conducted in October 2021 among 94 PLWHA selected by purposive sampling in Kupang City, Indonesia. The bivariate data analysis used the Chi-square, and the multivariate data analysis used the binomial logistic regression test. The results showed that 88.3% of the participants …


Extremely Hot Ambient Temperature And Injury-Related Mortality, Mien T N Nguyen, Man V M Nguyen, Huong V T Le, Hoai Viet Nguyen, Vu Anh Nguyen, Ngoan Tran Le May 2023

Extremely Hot Ambient Temperature And Injury-Related Mortality, Mien T N Nguyen, Man V M Nguyen, Huong V T Le, Hoai Viet Nguyen, Vu Anh Nguyen, Ngoan Tran Le

Kesmas

This pilot study aimed to evaluate the effects of extremely hot ambient temperatures on the total number of fatal injuries. Data were collected from a population-based mortality registry of Thanh Hoa, a province in the North Central region of Vietnam. This study qualified the distributed lag non-linear model and calculated the RR and 95% CI adjusted for long-term trend and absolute humidity. For the entire study population with 3,949 registered deaths due to injuries collected during 2005-2007, after the onset of extremely hot ambient temperatures, an increased risk of death was observed on the 9th day RR (95% CI) = …


Assessment Of Rabies Control Attitudes During The Covid-19 Pandemic Through Partial Least Square-Structural Equation Modeling, Sang Gede Purnama, Ni Wayan Arya Utami, Made Subrata, Putu Erma Pradnyani, Karang Agustina, Ibn Swacita May 2023

Assessment Of Rabies Control Attitudes During The Covid-19 Pandemic Through Partial Least Square-Structural Equation Modeling, Sang Gede Purnama, Ni Wayan Arya Utami, Made Subrata, Putu Erma Pradnyani, Karang Agustina, Ibn Swacita

Kesmas

The COVID-19 pandemic disrupts rabies control activities in the community. A new approach is needed to control rabies during the COVID-19 pandemic through digital health interventions by conducting digital surveillance and education. This study aimed to determine key attitude indicators in controlling rabies during the COVID-19 pandemic. A cross-sectional study on 166 participants in Denpasar City with a total of 31 indicators measuring five variables: perceptions of the benefits of rabies control (6 indicators), perceptions of rabies risk (6 indicators), perceptions of obstacles to rabies control (5 indicators), perceptions of the need for technology (7 indicators), and attitudes toward rabies …


Evaluation Of A Place-Based Asthma Reduction Initiative On Asthma-Related Morbidity Among Children In East Harlem And The Impact Of The Covid-19 Pandemic On Health Care Utilization And Medication Adherence Among Medicaid-Enrolled Children, Sarah C. Walters May 2023

Evaluation Of A Place-Based Asthma Reduction Initiative On Asthma-Related Morbidity Among Children In East Harlem And The Impact Of The Covid-19 Pandemic On Health Care Utilization And Medication Adherence Among Medicaid-Enrolled Children, Sarah C. Walters

Dissertations and Theses

Background: In New York City, asthma continues to be the leading cause of hospitalizations and emergency department (ED) visits among children, and disproportionally burdens Black and Latino children in low-income neighborhoods. Place-based, or geographically targeted, programs offer upstream strategies for addressing public health issues in these underserved neighborhoods, and given their targeted nature, quasi-experimental or other observational methods are needed to rigorously evaluate their impact. This dissertation uses multiple methodological approaches to assess the impact of the East Harlem Asthma Center of Excellence (EHACE) – an equity-focused, multi-faceted, place-based asthma mitigation initiative in the East Harlem neighborhood of a New …