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Full-Text Articles in Other Psychiatry and Psychology

Social Media Use And Mental Health: An Educational Intervention To Reduce Depression And Anxiety In Adolescents, Natalie Catlett Jan 2022

Social Media Use And Mental Health: An Educational Intervention To Reduce Depression And Anxiety In Adolescents, Natalie Catlett

DNP Projects

Background: Most adolescents spend a great deal of their time using various social media platforms. However, excessive and maladaptive social media use is correlated with worsening symptoms of depression and anxiety among adolescents.

Objective: This project aimed to determine whether an educational intervention could help decrease overall time spent using social media and improve mood and mental health outcomes among adolescents with depression or anxiety disorders.

Methods: This was a quasi-experiment with a pretest and posttest design. An educational intervention about the relationship between social media use and symptoms of depression and anxiety among adolescents and strategies to minimize risk …


An Examination Of The Relationship Between Fear Of Evaluation, Social Anxiety, And Depression, Michelle Ingraffia Jan 2022

An Examination Of The Relationship Between Fear Of Evaluation, Social Anxiety, And Depression, Michelle Ingraffia

Masters Theses

This study explores fear of negative evaluation (FNE) and fear of positive evaluation (FPE) across social anxiety and depression. The following assessment tools were used to measure fear of positive evaluation, fear of negative evaluation, social anxiety, and depression: Fear of Positive Evaluation Scale, Brief Fear of Negative Evaluation - Straightforward, Liebowitz Social Anxiety Scale – Self Report, The Center for Epidemiological Studies Depression Scale – Revised. A sample of two hundred and thirty-one participants completed forms online via Amazon Mechanical Turk. Social anxiety was correlated positively with both FNE and FPE; likewise, depression was correlated positively with both FNE …


Ketamine As A Treatment Modality For Treatment-Resistant Depression, Tracy Wulff, Shen Cao Dec 2021

Ketamine As A Treatment Modality For Treatment-Resistant Depression, Tracy Wulff, Shen Cao

Physician Assistant Capstones, 2020-current

Many recent studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to produce antidepressant effects that may be effective in helping reduce treatment-resistant major depression. In particular, three double-blinded randomized control trials have been conducted to assess the viability and effectiveness of this medication for treatment. This systematic literature review will analyze these studies and determine if the overall research indicates that ketamine is useful in improving depression as measured by the Montgomery–Asberg Depression Rating Scale (MADRS)1.

Objective: Assess the effectiveness of IV Ketamine in reducing treatment-resistant major depressive disorder as measured by the Montgomery–Asberg …


Depression As A Moderator Of The Relationship Between Perceived Injustice And Neuropsychological Performance Validity Among Individuals Previously Diagnosed With A Concussion, Jeremiah Lum Dec 2021

Depression As A Moderator Of The Relationship Between Perceived Injustice And Neuropsychological Performance Validity Among Individuals Previously Diagnosed With A Concussion, Jeremiah Lum

Clinical Psychology Dissertations

Concussion is one of the most common conditions seen within rehabilitation and neuropsychology. Given that many concussions are diagnosed following litigation-associated injuries, it is unsurprising that malingered neurocognitive deficit (i.e., deliberate underperformance on cognitive instruments in the interest of secondary gain) has dominated the concussion literature. Although the identification of malingering is essential to ethical assessment, its presence or absence is not the sole determinant of performance validity as a whole. Rather, performance validity is a broad construct involving effort, which refers to examinees’ investment in performing at capacity levels; emerging research suggests this can be affected by psychological factors …


The Acute And Persisting Impact Of Covid-19 On Trajectories Of Adolescent Depression: Sex Differences And Social Connectedness, Sabrina R. Liu, Elyssia Poggi Davis, Anton M. Palma, Curt A. Sandman, Laura M. Glynn Nov 2021

The Acute And Persisting Impact Of Covid-19 On Trajectories Of Adolescent Depression: Sex Differences And Social Connectedness, Sabrina R. Liu, Elyssia Poggi Davis, Anton M. Palma, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Background

The COVID-19 era is a time of unprecedented stress, and there is widespread concern regarding its short- and long-term mental health impact. Adolescence is a sensitive period for the emergence of latent psychopathology vulnerabilities, often activated by environmental stressors. The present study examined COVID-19′s impact on adolescent depression and possible influences of different domains of social connectedness (loneliness, social media use, social video game time, degree of social activity participation).

Methods

A community sample of 175 adolescents (51% boys, mean age = 16.01 years) completed questionnaires once before and twice during the COVID-19 pandemic. Piecewise growth modeling examined the …


A Blue Christmas? Celebrating With Those Who Are Suffering Loss, Pain And Isolation., Chris Kan Nov 2021

A Blue Christmas? Celebrating With Those Who Are Suffering Loss, Pain And Isolation., Chris Kan

Pastoral Liturgy

No abstract provided.


Breaking Down The Impact Of Resilience On Mental Health: An Analysis Utilizing The Resilience Scale For Adults, Sydney K. Cook Oct 2021

Breaking Down The Impact Of Resilience On Mental Health: An Analysis Utilizing The Resilience Scale For Adults, Sydney K. Cook

The Journal of Purdue Undergraduate Research

Resilience is the capacity to recover quickly from difficulties, and previous studies have determined that resilience has a relationship with mental health. However, the association of each aspect of resilience on mental health, depression, and adverse childhood events (ACEs) have not been closely examined. Discerning which aspects of resilience are associated with mental health issues, depression, and ACEs can help psychiatric nurses determine effective treatments and interventions for at-risk patients.

One hundred ninety-five community-dwelling participants (ages 18 to 89) were invited to Purdue University in Indiana and Scripps College in California for the study. Participants completed the Resilience Scale for …


Does Feminine Gender Role Stress Moderate The Relationship Between Disordered Eating And Depression?, Paige Nichols Jul 2021

Does Feminine Gender Role Stress Moderate The Relationship Between Disordered Eating And Depression?, Paige Nichols

Masters Theses & Specialist Projects

The purpose of this investigation was to examine the moderating effect of feminine gender role stress on disordered eating behaviors and depression. It was hypothesized that feminine gender role stress would significantly moderate the relationship between disordered eating and depression, such that disordered eating behaviors would be more strongly associated with depression when FGRS total and subscale scores were high. These hypotheses were tested by surveying a sample of 334 university students (mean age = 20.54 years), all of whom were cisgender women. Participants completed self-report measures including the Eating Attitudes Test-26, Beck Depression Inventory, Feminine Gender Role Stress Scale, …


Music As A Gateway To Healing Speech Disorders And Mental Health Holistically In The Patient With Aphasia: A Literature Review, Susan Warren May 2021

Music As A Gateway To Healing Speech Disorders And Mental Health Holistically In The Patient With Aphasia: A Literature Review, Susan Warren

Expressive Therapies Capstone Theses

People with some types of post-stroke aphasia often experience depression as well as loss of speech. Music therapy has unique properties that allow it to be used therapeutically to treat both speech impairment and depression yet it is rarely used to treat both disorders. This literature review seeks to examine the underlying causes for this discrepancy, review methods used by practitioners to treat both disorders and suggest future directions for additional research and implications for the treatment of patients with aphasia who have both language impairment and depression.


Assessment Of Major Depressive Disorders Through Neuroimaging Studies And Their Treatment Methods, Jevetha Vijayadasan, Diksha Raghunathan, Sivakumar Rajagopal, Rahul Soangra Feb 2021

Assessment Of Major Depressive Disorders Through Neuroimaging Studies And Their Treatment Methods, Jevetha Vijayadasan, Diksha Raghunathan, Sivakumar Rajagopal, Rahul Soangra

Physical Therapy Faculty Articles and Research

Many mental disorders are caused due to improper regulation of the brain and depression is one such. It affects both children and adults and is very common among teenagers. There are many challenges clinicians face regarding the management of this disease. These challenges have prompted the development of various neuroimaging techniques that effectively diagnose the condition. The main techniques are Magnetic resonance imaging (MRI) and Positron emission tomography (PET) which have gained momentum over the years. Advanced MRI techniques help study certain regions of the brain such as hippocampus and amygdala. Effective treatments for depression include antidepressant medications and brain …


Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar Jan 2021

Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar

Pharmacy Faculty Articles and Research

Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the …


A Predictable Home Environment May Protect Child Mental Health During The Covid-19 Pandemic, Laura M. Glynn, Elyssia Poggi Davis, Joan L. Luby, Tallie Z. Baram, Curt A. Sandman Jan 2021

A Predictable Home Environment May Protect Child Mental Health During The Covid-19 Pandemic, Laura M. Glynn, Elyssia Poggi Davis, Joan L. Luby, Tallie Z. Baram, Curt A. Sandman

Psychology Faculty Articles and Research

Objective

Information about the adverse effects of the COVID-19 pandemic on adolescent and adult mental health is growing, yet the impacts on preschool children are only emerging. Importantly, environmental factors that augment or protect from the multidimensional and stressful influences of the pandemic on emotional development of young children are poorly understood.

Methods

Depressive symptoms in 169 preschool children (mean age 4.1 years) were assessed with the Preschool Feelings Checklist during a state-wide stay-at-home order in Southern California. Mothers (46% Latinx) also reported on externalizing behaviors with the Strengths & Difficulties Questionnaire. To assess the role of environmental factors in …


Characterizing Prenatal Maternal Distress With Unique Prenatal Cortisol Trajectories, Gage Peterson, Emma V. Espel, Elyssia Poggi Davis, Curt A. Sandman, Laura M. Glynn Nov 2020

Characterizing Prenatal Maternal Distress With Unique Prenatal Cortisol Trajectories, Gage Peterson, Emma V. Espel, Elyssia Poggi Davis, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Objective: It is widely assumed that glucocorticoids represent a primary mechanism through which exposure to adversity and maternal psychological distress shape prenatal developmental trajectories of both mother and fetus. However, despite repeated investigations and the fact that prenatal cortisol has been reliably linked to developmental outcomes, the empirical evidence supporting an association between prenatal cortisol and maternal distress is scarce. In this study, a novel approach to assessing links between maternal prenatal psychological distress and gestational cortisol profiles, general growth mixture modeling (GGMM), was applied. Method: Measures of pregnancy anxiety, perceived stress, and state anxiety and depressive symptoms as well …


Mental Health Screening For Low Income Adolescents: An Evidence-Based Project, Allison Bryden May 2020

Mental Health Screening For Low Income Adolescents: An Evidence-Based Project, Allison Bryden

Doctor of Nursing Practice Final Manuscripts

Abstract

TITLE: Mental Health Screening For Low-Income Adolescents

BACKGROUND: Nearly 80% of adolescents in the United States will suffer from a mental illness and not receive evaluation or services. Children from low socio-economic backgrounds have an increased risk of mental health disorders which permeate into adulthood, leading to additional negative sequel and lower quality of life. Among adolescent mental health conditions, depression and anxiety are the most common. Literature has suggested provider intuition alone has low sensitivity and specificity for detecting mental illness and that screening tools are indicated.

PURPOSE: The aim of this project is to implement standardized routine …


An Exploratory Study Of How Millennials Approach And Communicate Mental Health In The Workplace, Johanna I. Seitenbach Dec 2019

An Exploratory Study Of How Millennials Approach And Communicate Mental Health In The Workplace, Johanna I. Seitenbach

Student Theses and Dissertations

Depression is the leading cause of disability worldwide, affecting more than 300 million people. As more millennials take on leadership positions, it is important to understand how companies are currently addressing mental health in the workplace and compare this to how millennials approach the subject. The quantitative analysis completed through this study helped to determine what a mentally healthy workplace looks and feels like for millennials. Companies are increasingly investing in mental health initiatives for several reasons: to increase brand recognition, to improve company culture, to mitigate potential lawsuits, and to increase employee engagement and retention. This survey assessed how …


Identifying Depression In The National Health And Nutrition Examination Survey Data Using A Deep Learning Algorithm, Jihoon Oh, Kyongsik Yun, Uri Maoz, Tae-Suk Kim, Jeong-Ho Chae Jul 2019

Identifying Depression In The National Health And Nutrition Examination Survey Data Using A Deep Learning Algorithm, Jihoon Oh, Kyongsik Yun, Uri Maoz, Tae-Suk Kim, Jeong-Ho Chae

Psychology Faculty Articles and Research

Background

As depression is the leading cause of disability worldwide, large-scale surveys have been conducted to establish the occurrence and risk factors of depression. However, accurately estimating epidemiological factors leading up to depression has remained challenging. Deep-learning algorithms can be applied to assess the factors leading up to prevalence and clinical manifestations of depression.

Methods

Customized deep-neural-network and machine-learning classifiers were assessed using survey data from 19,725 participants from the NHANES database (from 1999 through 2014) and 4949 from the South Korea NHANES (K-NHANES) database in 2014.

Results

A deep-learning algorithm showed area under the receiver operating characteristic curve (AUCs) …


The Influence Of Unpredictable, Fragmented Parental Signals On The Developing Brain, Laura M. Glynn, Tallie Z. Baram Jan 2019

The Influence Of Unpredictable, Fragmented Parental Signals On The Developing Brain, Laura M. Glynn, Tallie Z. Baram

Psychology Faculty Articles and Research

Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children’s mental health. Existing literature on maternal signals has focused almost exclusively on their quality and valence (e.g. maternal depression, sensitivity). Here we identify a novel dimension of maternal signals: their patterns and especially their predictability/unpredictability, as an important determinant of children’s neurodevelopment. We find that unpredictable maternal mood and behavior presage risk for child and adolescent psychopathology. In experimental models, fragmented/unpredictable …


Music As A Catalyst For Altered States Of Consciousness And Peak Experiences In The Treatment Of Depression, Anxiety, And Ptsd, Paul Battles May 2018

Music As A Catalyst For Altered States Of Consciousness And Peak Experiences In The Treatment Of Depression, Anxiety, And Ptsd, Paul Battles

Expressive Therapies Capstone Theses

Abstract This paper investigates the therapeutic uses of altered states of consciousness (ASC) and peak experiences (PE) for the treatment of depression, anxiety, and post-traumatic stress disorder (PTSD), and the ways in which music can be used to facilitate or enhance these experiences. ASC’s and PE’s can help uncover hidden or repressed unconscious material and potentially change the way an individual views and interacts with his or her world. In cases of people suffering from depression, anxiety, and post-traumatic stress disorder (PTSD), these emotional, cognitive, and perceptual changes have been shown to have sometimes profound and long- lasting therapeutic effects, …


Economic And Health Predictors Of National Postpartum Depression Prevalence: A Systematic Review, Meta-Analysis And Meta-Regression Of 308 Studies From 56 Countries, Jennifer Hahn-Holbrook, Taylor Cornwell-Hinrichs, Itzel Anaya Feb 2018

Economic And Health Predictors Of National Postpartum Depression Prevalence: A Systematic Review, Meta-Analysis And Meta-Regression Of 308 Studies From 56 Countries, Jennifer Hahn-Holbrook, Taylor Cornwell-Hinrichs, Itzel Anaya

Psychology Faculty Articles and Research

Background: Postpartum depression (PPD) poses a major global public health challenge. PPD is the most common complication associated with childbirth and exerts harmful effects on children. Although hundreds of PPD studies have been published, we lack accurate global or national PPD prevalence estimates and have no clear account of why PPD appears to vary so dramatically between nations. Accordingly, we conducted a meta-analysis to estimate the global and national prevalence of PPD and a meta-regression to identify economic, health, social, or policy factors associated with national PPD prevalence.

Methods: We conducted a systematic review of all papers reporting …


An Examination Of The Relationships Between Attributional Style, Reappraisal, And Depression Risk In Arab Americans, Khadeja Najjar Jan 2018

An Examination Of The Relationships Between Attributional Style, Reappraisal, And Depression Risk In Arab Americans, Khadeja Najjar

ETD Archive

While depression is a cross-cultural phenomenon, much of the literature that examines risk factors and mechanisms for its occurrence is examined from a Western perspective. As cultural background and level of acculturation to the host culture is known to shape the expression of depressive disorders, as well as their risk factors, this study examined whether cultural factors influence the relationship between two cognitive emotion regulation processes and depression symptoms. Specifically, this study examined whether the relationship between internal, stable, and global causal attributions for negative events (negative attributional style) and depression is mediated by one’s tendency to reframe the meaning …


Decreasing Stigma Against Depression In Chinese International Students, Elizabeth Trader Jan 2018

Decreasing Stigma Against Depression In Chinese International Students, Elizabeth Trader

Mahurin Honors College Capstone Experience/Thesis Projects

Higher levels of stress and a shift in support systems during the transition to another culture can put international students at risk for mood disorders like depression. Previous research supports there is also a higher level of depression stigma within Eastern cultures in comparison to Western cultures (Rao, Feinglass, & Corrigan, 2007). This may account for the strikingly low numbers from the Chinese population that seek and maintain professional counseling services while studying in the U.S. (Yakushko, Davidson, & Sandford-Martens, 2008). The present study sought to determine whether two self-produced Chinese videos regarding information about stigma, symptoms, and treatment of …


Mental Health In Commercial Aviation - Depression & Anxiety Of Pilots, Maurice C. Dehoff, Stephen K. Cusick Jan 2018

Mental Health In Commercial Aviation - Depression & Anxiety Of Pilots, Maurice C. Dehoff, Stephen K. Cusick

International Journal of Aviation, Aeronautics, and Aerospace

Two landmark accidents invigorated the discussion regarding pilot mental health. Other incidents may also have a mental health component that is related to, but not the direct cause of, the event. It is suspected that these “other incidents” are much more commonplace and while not catastrophic, erode safety. Depression and anxiety are two commonly occurring mental health concerns. Research indicates that a considerable portion of the U. S. population suffers from some form of mental health issue. Most go undiagnosed and untreated. A similar rate of occurrence appears to be found within the airline pilot population. The stigma of mental …


The Mobius Strip Of Total Health: Manipulation Of Thinking Prior To Exercise Activity, Joseph A. Schenk Jan 2017

The Mobius Strip Of Total Health: Manipulation Of Thinking Prior To Exercise Activity, Joseph A. Schenk

Honors College Theses

Research shows mental and physical health are interdependent. We sought to test various methods of external motivation to effect change in the physical performance and mental health of students enrolled in walking classes. We hypothesized that if there was a correlation between physical exercise and mental health and we could motivate individuals to exercise, then that motivation would in turn result in better mental health. Participants, 19 in the pilot and 320 in the main study, were randomly assigned into three groups to receive messages prior to conducting physical activity: those who received neutral messages about exercise, those who received …


Male Psychological Adaptation To Unsuccessful Medically Assisted Reproduction Treatments: A Systematic Review, Mariana Veloso Martins, Miguel Basto-Pereira, Juliana Pedro, Brennan Peterson, Vasco Almeida, Lone Schmidt, Maria Emília Costa Mar 2016

Male Psychological Adaptation To Unsuccessful Medically Assisted Reproduction Treatments: A Systematic Review, Mariana Veloso Martins, Miguel Basto-Pereira, Juliana Pedro, Brennan Peterson, Vasco Almeida, Lone Schmidt, Maria Emília Costa

Marriage and Family Therapy Faculty Articles and Research

BACKGROUND Similarly to women, men suffer from engaging in fertility treatments, both physically and psychologically. Although there is a vast body of evidence on the emotional adjustment of women to infertility, there are no systematic reviews focusing on men's psychological adaptation to infertility and related treatments.

OBJECTIVE AND RATIONALE The main research questions addressed in this review were ‘Does male psychological adaptation to unsuccessful medically assisted reproduction (MAR) treatment vary over time?’ and ‘Which psychosocial variables act as protective or risk factors for psychological maladaptation?’

SEARCH METHODS A literature search was conducted from inception to September 2015 on five databases …


Relationship Of Optimism And Suicidal Ideation In Three Groups Of Patients At Varying Levels Of Suicide Risk, Jeff C. Huffman, Julia K. Boehm, Scott R. Beach, Eleanor E. Beale, Christina M. Dubois, Brian C. Healy Mar 2016

Relationship Of Optimism And Suicidal Ideation In Three Groups Of Patients At Varying Levels Of Suicide Risk, Jeff C. Huffman, Julia K. Boehm, Scott R. Beach, Eleanor E. Beale, Christina M. Dubois, Brian C. Healy

Psychology Faculty Articles and Research

Optimism has been associated with reduced suicidal ideation, but there have been few studies in patients at high suicide risk. We analyzed data from three study populations (total N=319) with elevated risk of suicide: (1) patients with a recent acute cardiovascular event, (2) patients hospitalized for heart disease who had depression or an anxiety disorder, and (3) patients psychiatrically hospitalized for suicidal ideation or following a suicide attempt. For each study we analyzed the association between optimism (measured by the Life-Orientation Test-Revised) and suicidal ideation, and then completed an exploratory random effects meta-analysis of the findings to synthesize this data. …


Impact Of Caregiving Role In The Quality Of Life Of Family Caregivers For Persons With Alzheimer's Disease, Supriya Sarkar Jan 2015

Impact Of Caregiving Role In The Quality Of Life Of Family Caregivers For Persons With Alzheimer's Disease, Supriya Sarkar

All Graduate Theses, Dissertations, and Other Capstone Projects

This study investigated quality of life of family caregivers of persons with Alzheimer's disease (AD). Caregiving is a strenuous and challenging job. Family caregivers experience poor quality of life after they take the role of caregiving which might be related to depression. Purpose of this study was to find if caregiving duration and depression has any role in affecting family caregivers' emotional, physical, and general health.

Data for this study were collected through electronic and mailed survey methods. The questionnaires completed by subjects: Medical Outcomes Study Short Form 36 (MOS-36) and Center for Epidemiologic Studies Depression Scale (CES-D). Descriptive statistics …


An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins May 2014

An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins

Honors Scholar Theses

Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …


Follow-Up Evaluation Of Treatment For Anxiety And Depression Provided In A University-Based Primary Care Clinic, Renée M. Grinnell Jan 2014

Follow-Up Evaluation Of Treatment For Anxiety And Depression Provided In A University-Based Primary Care Clinic, Renée M. Grinnell

Theses and Dissertations

Although integrated primary care psychology services are becoming increasingly common, the literature lacks adequate research support for the longitudinal durability of treatment effects following the conclusion of brief primary care interventions. This study served as a follow-up program evaluation of psychological services for depression and anxiety provided at the Medical College of Virginia’s Ambulatory Care Center in Richmond, Virginia. Data were collected on 47 adult primary care patients who received treatment for depression and/or anxiety between six and 18 months prior to the follow-up telephone call. Data were collected on the trajectory of depression scores throughout and following treatment, treatment …


Restoring Effort-Related Functions In Models Of Depression Symptoms: Reversing Fatigue Symptoms Induced By Catecholamine Depleting Agent Tetrabenazine With The Adenosine A2a Antagonist Msx-3, Charlotte Freeland May 2013

Restoring Effort-Related Functions In Models Of Depression Symptoms: Reversing Fatigue Symptoms Induced By Catecholamine Depleting Agent Tetrabenazine With The Adenosine A2a Antagonist Msx-3, Charlotte Freeland

Honors Scholar Theses

Motivational symptoms related to effort expenditure have been associated with major depression and other disorders that afflict millions of individuals worldwide. In an effort to identify potential therapeutic agents and characterize the underlying biochemical mechanisms related to these behaviors, recent research has utilized animal models to study and characterize such behavior. Previous work in the Salamone lab produced evidence that rats with impaired dopamine (DA) transmission show changes in response allocation in tasks that measure effort-related choice behavior, which are characterized by a decrease in selection of the high-effort choice but increased selection of the low-effort alternative. The present work …


Gene X Environment Effects Of Serotonin Transporter, Dopamine Receptor D4, And Monoamine Oxidase A Genes With Contextual And Parenting Risk Factors On Symptoms Of Oppositional Defiant Disorder, Anxiety, And Depression In A Community Sample Of 4-Year-Old Children, John V. Lavigne, Laura B.K. Herzing, Edwin H. Cook, Susan A. Lebailly, Karen R. Gouze, Joyce Hopkins, Fred B. Bryant Jan 2013

Gene X Environment Effects Of Serotonin Transporter, Dopamine Receptor D4, And Monoamine Oxidase A Genes With Contextual And Parenting Risk Factors On Symptoms Of Oppositional Defiant Disorder, Anxiety, And Depression In A Community Sample Of 4-Year-Old Children, John V. Lavigne, Laura B.K. Herzing, Edwin H. Cook, Susan A. Lebailly, Karen R. Gouze, Joyce Hopkins, Fred B. Bryant

Psychology: Faculty Publications and Other Works

Genetic factors can play a role in the multiple level of analyses approach to understanding the development of child psychology. The present study examined gene-environment correlations and Gene x Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine reactor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter …