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Full-Text Articles in Other Psychiatry and Psychology
Relationship Between Sensory Sensitivities And Cognitive And Adaptive Abilities In Children With Autism Spectrum Disorders, Laura Pendergast
Relationship Between Sensory Sensitivities And Cognitive And Adaptive Abilities In Children With Autism Spectrum Disorders, Laura Pendergast
Honors Scholar Theses
Sensory sensitivities are widely reported among individuals with ASD. These sensory sensitivities can be classified as over-responsivity, under-responsivity, or seeking of sensory stimulation. Following recent changes in the diagnostic criteria, sensory sensitivities are considered a key feature of the behavioral phenotype of ASDs. Despite their significance, sensory sensitivities have been largely underestimated. Therefore, more research in this area may reveal important information about the influence of sensitivities on functioning, as well as the underlying causes of the symptoms. This study investigated a possible relationship between sensory sensitivities and cognitive and adaptive abilities in children with ASD. The sample included 29 …
An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins
An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins
Honors Scholar Theses
Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …
Restoring Effort-Related Functions In Models Of Depression Symptoms: Reversing Fatigue Symptoms Induced By Catecholamine Depleting Agent Tetrabenazine With The Adenosine A2a Antagonist Msx-3, Charlotte Freeland
Honors Scholar Theses
Motivational symptoms related to effort expenditure have been associated with major depression and other disorders that afflict millions of individuals worldwide. In an effort to identify potential therapeutic agents and characterize the underlying biochemical mechanisms related to these behaviors, recent research has utilized animal models to study and characterize such behavior. Previous work in the Salamone lab produced evidence that rats with impaired dopamine (DA) transmission show changes in response allocation in tasks that measure effort-related choice behavior, which are characterized by a decrease in selection of the high-effort choice but increased selection of the low-effort alternative. The present work …
History Of Maltreatment And Psychiatric Impairment In Children In Outpatient Psychiatric Treatment, Kerry Gagnon
History Of Maltreatment And Psychiatric Impairment In Children In Outpatient Psychiatric Treatment, Kerry Gagnon
Honors Scholar Theses
There is increasing evidence that childhood victimization and attachment disruptions impact a child’s development. In this study, children and adolescents from an outpatient psychiatric clinic were assessed, measuring history of trauma, history of out-of-home placement, initial diagnoses, and CBCL internalizing and externalizing problem scores. Multiple regression analyses showed that both violent abuse trauma (physical/sexual abuse) and victim trauma (physical abuse/sexual abuse/witnessing domestic violence/witnessing community violence) are prevalent among patients with externalizing severity problems; concluding that diagnosis alone may not account for a history of victimization, but externalizing problem severity does. Overall, the study is consistent with past literature that it …