Mental Disorders Commons^™

Reward Deficits In Co-Occurring Social Anxiety And Depression: The Roles Of Anhedonia, Boredom, Loneliness, And Covid-19 Social Restriction, Nathan M. Hager, Alicia L. Milam, Hannah C. Hamrick, Benjamin Swanson, Matt R. Judah

Psychology Faculty Publications

Prior research points toward reward deficits as crucial to the link between social anxiety disorder and major depressive disorder. However, studies have not explored specific types of reward deficits or how social-environmental factors may impact them. The current study examined whether the indirect effects of three reward deficits (anhedonia, boredom, and loneliness) accounted for the connection between social anxiety and depression. Questionnaires were collected in a sample of college students (N = 523) during the first year of the COVID-19 pandemic, allowing examination of environmental stressors (i.e., remote learning and current friend network size) on reward deficits. Indirect effect models …

Substitution Of Cannabis For Prescribed Medications In The Management Of Anxiety And Depression Among Midlife Women: A Cross-Sectional Study, Jocelyn Mueller, Jamia Sapp, Jennifer Attonito, Aditya Chakraborty, Karina Villalba

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background and Aims

Given the rising prevalence of cannabis use as an alternative strategy for managing mental health symptoms, there is a crucial need to understand the determinants of substitution behavior, particularly among midlife women who may experience distinct psychosocial and clinical profiles. This study examined the predictors of cannabis substitution among midlife women by comparing profiles of women who substituted cannabis for antidepressant medications versus those who substituted for anxiolytic medications.

Methods

A cross-sectional survey of 172 women who reported substituting cannabis for either anxiety or depression medications was conducted. Measures included the PHQ-8, OASIS, AUDIT, and ACEs. Logistic …

From Molecules To Minds: Integrative Multi-Omics In Psychiatry, Hossein Abbasi, Sage E. Hawn, Arash Javanbakht, Soraya Seedat, Kyle Bourassa, Sinead M. Sinnott, Antonia V. Seligowski, Sian Hemmings, Nathan A. Kimbrel, Alicia K. Smith, Leslie Brick, Divya Mehta

Psychology Faculty Publications

Psychiatric disorders are biologically complex conditions arising from interactions across genomic, epigenomic, transcriptomic, proteomic, metabolomic, and metagenomic layers. Single-omics approaches rarely capture more than a fraction of the variance in complex conditions, underscoring the importance of integrative multi-omics frameworks. This mini-review summarizes key methodologies and their application in psychiatric research, with a focus on systems-level integration of genomic risk scores, transcriptomic networks, and neuroimaging data to advance biological understanding of disorders such as depression, schizophrenia, and Alzheimer’s disease. We also outline the infrastructural requirements for effective multi-omics research, including standardized biobanking, Laboratory Information Management Systems, adherence to FAIR data principles, …

A Real-Time Examination And Comparison Of Differentiation Among Suicidal Thinking And Affect Items In An Adolescent Sample, Elizabeth A. Edershile, Kinjal K. Patel, Annabelle M. Mournet, Richard T. Liu, Catherine R. Glenn, Evan M. Kleiman

Psychology Faculty Publications

Suicide risk assessments require individuals to differentiate among types of suicidal thoughts (e.g., passive vs. active); yet most research relies on aggregate metrics that obscure this differentiation. Indeed, more severe forms of suicidal thinking are thought to involve the simultaneous experience of multiple forms of thoughts at high intensities. The present study draws on concepts from the affect differentiation literature to (a) examine different ways to operationalize differentiation in suicidal thinking and (b) compare differentiation in suicidal thinking with differentiation in affect. Adolescents (N = 200) recently hospitalized for suicidal thoughts and behaviors completed a 28-day ecological momentary assessment …

Prenatal Exposure To Nicotine And Postpartum Depression: A Systematic Review And Meta-Analysis, Reem Sharaf-Alddin, May Salama, Denise Mckinney, George Saade, Qi Zhang

Health Behavior, Policy & Management Faculty Publications

Purpose: Postpartum Depression (PPD) is the most common mental health complication of childbirth, and has short-term and long-term consequences for mother, child, and the entire family. PPD is a function of several factors. Prenatal exposure to nicotine (PEN) by Active Tobacco Smoking (ATS), Secondhand Smoking (SHS), or Electronic Nicotine Products (ENPs) is a major potential risk factor. This systematic review and meta-analysis aim to summarize and evaluate all evidence regarding the association between PEN and PPD.

Methods: We searched the following databases, PubMed, Medline, Cochrane, EMBASE, and CINHAL, for studies published between Jan.1st ,2000&Sep.19th ,2024, with the outcome PPD. Studies …

Anhedonia Links Sleep Problems And Suicidal Thoughts: An Intensive Longitudinal Study In High-Risk Adolescents, Kinjal K. Patel, Jaclyn C. Kearns, Dan Foti, Wilfred R. Pigeon, Evan M. Kleiman, Catherine R. Glenn

Psychology Faculty Publications

Growing research indicates that sleep problems are a robust independent risk factor for suicidal thoughts and behaviors among youth. However, relatively little is known about how this risk is conferred. This study used an intensive longitudinal design to investigate anhedonia as a mechanism linking sleep problems and next-day suicidal thoughts in a clinically high-risk sample of adolescents. Adolescents (N = 48; M_age=14.96; 77.1% white, 64.6% female) completed an ecological momentary assessment (EMA) study design for 28 days following discharge from acute psychiatric care for suicide risk. Daily sleep diaries were used to assess prior night total sleep …

A Multilevel Framework For The Promotion Of Maternal Mental Health And Well-Being During The Perinatal Period, Jenn A. Leiferman, Jessica Walls Wilson, Charlotte V. Farewell, Chelsea Walker-Mao, James F. Paulson

Psychology Faculty Publications

Background: Depression and anxiety are prevalent in the perinatal period and may contribute to adverse maternal and child health outcomes. A focus on multilevel protective factors may be effective in promoting well-being and increasing quality of life (QOL) in the perinatal period while simultaneously reducing or preventing depression and anxiety symptoms. We tested a conceptual model that posits specific personal, social, and community factors affecting depression, anxiety, and QOL among pregnant and postpartum individuals.

Methods: Four hundred and thirty-eight pregnant or postpartum individuals completed a 121-item cross-sectional survey composed of validated tools that assessed multilevel protective factors, health behaviors, and …

Unlocking Adolescent Mental Health: Exploring Social Determinants And Depression With The Social Ecological Model, Lauren B. Robins, Danielle Rodgers, Yusuf Barburoglu, Jasmine Griffith, Cearra L. Arnold

Counseling & Human Services Faculty Publications

Employing the robust framework of the Social Ecological Model (SEM) and drawing insights from the Social Determinants of Health (SDOH), this research sought to uncover the interplay between SDOH and mental health among adolescents. With a focus on depression, the study unraveled how various social determinants, both individually and collectively, shape the mental well-being of adolescents, leveraging the rich dataset provided by the National Survey of Children’s Health 2018. Utilizing advanced statistical techniques, the study revealed the predictive power of SDOH in understanding adolescent mental health. Results illuminate the significant influence of social determinants on depression, underscoring the imperative for …

Mental Workload Modulates The Effects Of Baroreceptor Afferents On Sensorimotor Processing, Xiao Yang, Katie Herberlein, Anthony Reid, Dongfang Jiao, Fang Fang

Psychology Faculty Publications

The heart–brain interaction is the main mechanism for maintaining normative physiological processes, and its dysregulation underlies the somatic symptoms of various mental disorders. Cortical inhibition, triggered by afferent signals from baroreceptor activation, induces systematic variations in sensorimotor responses within a cardiac cycle, with reaction times (RTs) slower at cardiac systole compared to diastole (known as cardiac cycle time effects). However, recent data suggest that baroreceptor afferents not only inhibit simple responses but also facilitate complex sensorimotor responses during cardiac systole. The mental workload that is implicated in complex responses may modulate the cardiac cycle time effects. The current study aimed …

Insights Into Child Abuse And Neglect: Findings From The Minnesota Longitudinal Study Of Risk And Adaptation, Marissa D. Nivison, Madelyn H. Labella, K. Lee Raby, Jenalee R. Doom, Jodi Martin, William F. Johnson, Osnat Zamir, Michelle M. Englund, Jeffry A. Simpson, Elizabeth A. Carlson, Glennn I. Roisman

Psychology Faculty Publications

The Minnesota Longitudinal Study of Risk and Adaptation (MLSRA) is a landmark prospective, longitudinal study of human development focused on a sample of mothers experiencing poverty and their firstborn children. Although the MLSRA pioneered a number of important topics in the area of social and emotional development, it began with the more specific goal of examining the antecedents of child maltreatment. From that foundation and for more than 40 years, the study has produced a significant body of research on the origins, sequelae, and measurement of childhood abuse and neglect. The principal objectives of this report are to document the …

Neuroticism Mediates The Association Between Autistic Traits And Choice Reaction Time Among Young Adults, Kassandra De Jesus Cintron, Xiao Yang

Psychology Faculty Publications

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that influences an individual’s cognitive functions and social interaction. While most studies have focused on children and adolescents diagnosed with ASD, elevated levels of autistic traits in subclinical populations may also influence individuals’ daily functioning. Autistic traits are also linked to the Big Five personality. In particular, neuroticism (emotion instability) has been shown to be positively associated with autistic traits, which may contribute to behavioral symptoms of autistic traits. The present study aimed to investigate the association between autistic symptoms and sensorimotor processing among a subclinical population. One hundred young adults (M …

Human Service Student's Preparedness For Assessing Suicidality: Recommendations For Human Services Education, Narketta Sparkman-Key, Jeffrey Moe, Bianca Augustine, T'Airra Belcher

Counseling & Human Services Faculty Publications

Suicide continues to be a public health concern, with suicide rates increasing. Human service professionals are among the helping professions tasked with assessing and addressing suicidality. Despite the well-documented benefits of suicide assessment and training for those within the helping professions, there remains a dearth of literature specific to suicide prevention in the preparation of human services students. To address this gap, the current study used the SIRI-2 to assess the preparedness of human services students (n = 98) to assess and address client suicidality. Findings indicated that participants’ responses were less competent than area experts. Furthermore, student participants’ responses …

Genetic Associations Between Alcohol Phenotypes And Life Satisfaction: A Genomic Structural Equation Modeling Approach, Kaitlin E. Bountress, Shannon E. Cusack, Sage E. Hawn, Andrew Grotzinger, Daniel Bustamante, Robert M. Kirkpatrick, Howard J. Edenberg, Ananda B. Amstadter

Psychology Faculty Publications

Alcohol use (i.e., quantity, frequency) and alcohol use disorder (AUD) are common, associated with adverse outcomes, and genetically-influenced. Genome-wide association studies (GWAS) identified genetic loci associated with both. AUD is positively genetically associated with psychopathology, while alcohol use (e.g., drinks per week) is negatively associated or NS related to psychopathology. We wanted to test if these genetic associations extended to life satisfaction, as there is an interest in understanding the associations between psychopathology-related traits and constructs that are not just the absence of psychopathology, but positive outcomes (e.g., well-being variables). Thus, we used Genomic Structural Equation Modeling (gSEM) to analyze …

The Prevalence Of And Factors Associated With Anxiety And Depression Among Working-Age Adults In Mainland China At The Early Remission Stage Of The Coronavirus 2019 Pandemic, Haixia Xie, Xiaowei Huang, Qi Zhang, Yan Wei, Xuheng Zeng, Fengshui Chang, Shuyin Wu

Community & Environmental Health Faculty Publications

Background: The Coronavirus 2019 (COVID-19) outbreak has led to a considerable proportion of adverse psychological symptoms in different subpopulations. This study aimed to investigate the status of anxiety and depression and their associated factors in the adult, working-age population in Mainland China at the early remission stage of the COVID-19 pandemic.

Methods: An online study was conducted among 1,863 participants in 29 provinces in Mainland China from March 23 to 31, 2020. Their mental health was evaluated by the generalized anxiety disorder scale (GAD-7) and the patient health questionnaire (PHQ-9). Descriptive analysis, Chi-square, and multiple logistic regressions were applied.

Results: …

Family Structure And Maternal Depressive Symptoms: A Cross-National Comparison Of Australia, The United Kingdom, And The United States, Kirsten Rasmussen, Elizabeth K. Sigler, Sadie A. Slighting, Jonathan A. Jarvis, Mikaela J. Dufur, Shana Pribesh

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study is to understand the relationship between family structure and maternal depressive symptoms (MDS) in Australia, the United Kingdom, and the United States. Family structures that involve transitions across life's course, such as divorce, can alter access to resources and introduce new stressors into family systems. Using the stress process model, we examine the links between family structure, stress, resources, and MDS. Using nationally representative data from Australia, the United Kingdom, and the United States and cross-sectional models for each country, we find that family structure may influence MDS differently in the UK than it does …

Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice

Computational Modeling & Simulation Engineering Faculty Publications

Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at …

Factor Analysis Of The Borderline Personality Inventory Using Item Response Theory, Courtney Mozo

Psychology Theses & Dissertations

The current study used a sample of 251 undergraduate females &om Old Dominion University to assess the item properties of the Borderline Personality Inventory (BPI). The BPI is a true/false self-report instrument used to measure borderline personality disorder. The BPI was created using classical test theory techniques, and traditional methods were used to assess the scale's properties (Leichsenring, 1999). Due to the dichotomous nature of the BPI, traditional classical test theory techniques are not ideal. The current study used Item Response Theory (IRT) to characterize the scale and item properties. The study was conducted using an online survey that also …

How Individuals Understand Depression: Attributions, Stigma, And Treatment Recommendations, Erin A. Pladsen

Psychology Theses & Dissertations

This study examined participants' beliefs/attributions about depression, their help seeking recommendations for depressed individuals, and the stigma associated with depression. Participants were asked to read a vignette that described a target person who is suffering from depression, and they were asked to complete various questionnaires based upon the vignette. Overall, the results indicated that individuals did not possess negative attitudes toward mental illness, that individuals more strongly recommended professional mental health assistance, and that individuals did not tend to stigmatize depressed individuals. Results did indicate that the label of depression and the gender of the target person affected provider type …