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Articles 1 - 13 of 13
Full-Text Articles in Mental Disorders
Addressing Healthcare Disparities Faced By Aging Down Syndrome Populations, Rhea Mistry
Addressing Healthcare Disparities Faced By Aging Down Syndrome Populations, Rhea Mistry
Pitzer Senior Theses
Down syndrome (DS) is a chromosomal genetic condition that impacts the development of the body and brain. The life expectancy of individuals with DS has drastically improved over the decades, increasing from 9 years in 1929 to 25 years in 1983 and further reaching 60 years by 2002. Individuals with DS face a variety of prominent co-occurring health conditions that are subject to change over time, including cognitive, visual, and hearing impairments, sleep apnea, cardiovascular defects, Down syndrome regression disorder, and dementia. Despite this increase in life span, DS is still most familiar to pediatric care providers, resulting in healthcare …
Synthetic Neuroactive Steroids Targeting Gaba-A Receptors As A Potential Therapy For Contraceptive-Associated Mood Disorders, Alexandria A. Davis
Synthetic Neuroactive Steroids Targeting Gaba-A Receptors As A Potential Therapy For Contraceptive-Associated Mood Disorders, Alexandria A. Davis
Scripps Senior Theses
4-10% of women who use hormonal oral contraceptives (HOCs) discontinue use after experiencing symptoms of anxiety, irritability, and depression in the first 3 months of administration. Previous studies have acknowledged a relationship between HOCs and emotional dysregulation but have not identified mechanisms by which HOCs have this effect. As a result, effective treatment options for HOC-induced mood disorders are lacking. Current theories implicate combined-HOCs, particularly those containing ethinyl estradiol and levonorgestrel (EE-LNG), in reducing neuroactive steroid levels. Specifically, HOC users show decreases in allopregnanolone, a positive allosteric modulator associated with neuronal inhibition and emotional regulation. The objective of this study …
Mental Health Stigma In South Asians With Crohn’S Disease, Bansi Patel
Mental Health Stigma In South Asians With Crohn’S Disease, Bansi Patel
Scripps Senior Theses
Chronically ill individuals often face comorbid mental illnesses. Mental illness symptoms can cause their chronic illness symptoms to worsen; the converse is also true. Such is the case with Crohn’s disease (CD) patients. The present literature lacks research on the relationship between CD and mental illness symptoms. Additionally, the literature lacks chronically ill participants who are South Asian Americans (SAA). SAA often face more mental health stigma than their white peers which can worsen one’s mental illness symptoms. This study examines the impact that mental health symptoms have on the psychological distress faced by SAA who are diagnosed with CD. …
Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece
Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece
CMC Senior Theses
Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …
The Roles Of Gsk3 And Reelin In The Modulation Of Behavioral Phenotypes Related To Bipolar Disorder: Implications For The Etiology And Treatment Of Neuropsychiatric Disorders, Angel Sherpa
Pitzer Senior Theses
Deficiency of Reelin, an extracellular glycoprotein, and overactivity of GSK3, a kinase downstream of Reelin, in the brain have been associated with bipolar disorder (BD). Overexpression of Reelin inhibits GSK3 activity by phosphorylation. However, it is unclear if the inhibition of GSK3 in the forebrain is a crucial element of Reelin signaling modulating bipolar-like behaviors. To fill this gap in our understanding, my first experiment proposes to examine if Reelin-deficient mice with reduced activity of GSK3 exhibit BD-like behaviors. If inhibition of GSK3 is indeed a crucial element of Reelin signaling modulating BD-like behaviors, then Reelin-deficient mice with decreased activity …
Viability Of Physiologically Timed Relaxation Interventions In Children With Asd, Nicholas Mendez
Viability Of Physiologically Timed Relaxation Interventions In Children With Asd, Nicholas Mendez
CMC Senior Theses
Autism Spectrum Disorder (ASD) is an increasingly common developmental disorder that changes how people experience the world and affects individuals’ social interactions and often leads to many adverse behaviors. Current literature dictates that a primary contributor to these adverse behaviors is that those with ASD have difficulty determining their own emotional states and determining the physiological signals that their body sends them. A study by Dr. Sarabadani et al. determined that it was possible to monitor the physiology of an individual with ASD and correlate certain signals to emotions, such as stress. These findings indicate the feasibility of establishing a …
Exploring The Covid-19 Experience Of Young Adult Latinos In Rural California: Insights Into Mental Health & The Immigrant Health Paradox, Vivianna Plancarte
Exploring The Covid-19 Experience Of Young Adult Latinos In Rural California: Insights Into Mental Health & The Immigrant Health Paradox, Vivianna Plancarte
Pomona Senior Theses
This study expands the COVID-19 and Latino Immigrants in Rural California (CLIMA) Study at UC Merced by exploring how the mental health of young adult Latinos in rural CA has been affected by the COVID-19 pandemic and comparing the experiences of US-born Latinos to those of Latino immigrants to investigate an Immigrant Health Paradox. A convergent mixed methods design was first employed whereby qualitative and quantitative data was collected concurrently, and then merged. Then, the data collected from young adult Latinos was compared to that from Latino immigrants collected by CLIMA Study to explore the Immigrant Health Paradox in the …
Evaluating Interpersonal Problems In Anorexia Nervosa Through The Lens Of Polyvagal Theory, Marika Morelan
Evaluating Interpersonal Problems In Anorexia Nervosa Through The Lens Of Polyvagal Theory, Marika Morelan
CMC Senior Theses
Eating disorders are an increasingly prevalent issue, especially among young women. While they aren’t a new phenomenon, they are historically under-researched, and remain widely misunderstood. Without understanding the causes underlying these disorders or the mechanisms working to maintain them, treating them successfully has proved to be incredibly difficult. This is especially the case with Anorexia Nervosa. Out of the six eating disorders in the DSM-5, it has the lowest treatment success rate and an alarmingly high relapse rate. Treating the disorder through weight restoration and the extinction of compensatory behaviors alone does not fully resolve the disordered pathology; interpersonal problems …
An Analysis And Critique Of Mental Health Treatment In American State Prisons And Proposal For Improved Care, Shelby Hayne
An Analysis And Critique Of Mental Health Treatment In American State Prisons And Proposal For Improved Care, Shelby Hayne
Scripps Senior Theses
Mental health treatment in state prisons is revealed to be highly variable, under-funded, and systematically inadequate. Existing literature exposes this injustice but fails to provide a comprehensive proposal for reform. This paper attempts to fill that gap, outlining a cost-effective, evidence-based treatment proposal, directly addressing the deficits in care revealed through analysis of our current system. In addition, this paper provides historical overviews of the prison system and mental health treatment, utilizing theoretical perspectives to contextualize this proposal in the present state of affairs. Lastly, the evidence is provided to emphasize the potential economic and social benefits of improving mental …
Investigating Neurogenesis As A Veritable Epigenetic Endophenotype For Alzheimer's Disease, Layne Wells
Investigating Neurogenesis As A Veritable Epigenetic Endophenotype For Alzheimer's Disease, Layne Wells
Scripps Senior Theses
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by progressive amyloid plaque aggregation, neurofibrillary tangles, and cortical tissue death. As the prevalence of AD is projected to climb in coming years, there is a vested interest in identifying endophenotypes by which to improve diagnostics and direct clinical interventions. The risk for complex disorders, such as AD, is influenced by multiple genetic, environmental, and lifestyle factors. Significant strides have been made in identifying genetic variants linked to AD through the genome-wide association study (GWAS). It has been estimated in more recent years, however, that GWAS-identified variants account for limited …
Into The Wild: Factors Mediating The Positive Outcomes Of Wilderness Based Therapy, Layla Moehring
Into The Wild: Factors Mediating The Positive Outcomes Of Wilderness Based Therapy, Layla Moehring
Scripps Senior Theses
Wildnerness therapy is becoming increasingly popular as a treatment for adolescents. It has been established as an efficacious treatment in previous literature, but the mechanisms as to why have thus far remained a mystery. This research is looking at the connection between wilderness therapy and DBT, another evidence-based treatment. This study will examine 156 adolescents, comparing the efficacy of wilderness therapy to traditional inpatient and intensive outpatient. Pre-treatment assessments of suicidal ideation, emotional regulation, and distress tolerance will be taken. It is expected that there will be main effects for each of the treatments, but that wilderness therapy will be …
Saving Our Heroes: A Longitudinal Study Of Mental Disorders Within The Fire Service, Bailee Pelham
Saving Our Heroes: A Longitudinal Study Of Mental Disorders Within The Fire Service, Bailee Pelham
Scripps Senior Theses
Previous research on the mental health of firefighters has shown that they are at a greater risk than the majority of the population to develop various mental disorders, such as depression, anxiety, alcohol abuse, suicidal ideation, and post-traumatic stress disorder. However, very little research has been done on the repetitive cumulative exposure to trauma that is associated with their career, which may lead to elevated levels of mental disorders that may not be detected in one testing. In this study, a series of assessments will be given to a sample of urban firefighters every year for the entirety of their …
The Silhouettes Of Autism, Chloe J. Dobbert
The Silhouettes Of Autism, Chloe J. Dobbert
CMC Senior Theses
My passion as a student at the Claremont Colleges is to help children with Autism Spectrum Disorder grow and learn as normal children and to help prepare them for life outside the Autism Center at Claremont McKenna College. In my thesis project, I am exploring the concept of silhouettes through photography and my perceptions of the stories told to me by the children I teach. Esthetically, I am inspired by Kara Walker’s installation of large cutout silhouettes but I am using different mediums to accomplish my project: Artistically, I am inspired by the detailed descriptions of the obsessive stories and …