Psychiatry and Psychology Commons^™

Word-List Intrusion Errors Predict Progression To Mild Cognitive Impairment, Kelsey R Thomas, Joel Eppig, Emily C Edmonds, Diane M Jacobs, David J Libon, Rhoda Au, David P Salmon, Mark W Bondi, Alzheimer’S Disease Neuroimaging Initiative

Rowan-Virtua School of Osteopathic Medicine Departmental Research

OBJECTIVE: Preclinical Alzheimer's disease (AD) defined by a positive AD biomarker in the presence of normal cognition is presumed to precede mild cognitive impairment (MCI). Subtle cognitive deficits and cognitive inefficiencies in preclinical AD may be detected through process and error scores on neuropsychological tests in those at risk for progression to MCI.

METHOD: Cognitively normal participants (n = 525) from the Alzheimer's Disease Neuroimaging Initiative were followed for up to 5 years and classified as either stable normal (n = 305) or progressed to MCI (n = 220). Cox regressions were used to determine whether baseline process scores on …

Memory In Memoir & Biography: Science, Place, And Agency, Johnathan E. Longo

Dissertations, Theses, and Capstone Projects

This thesis explores modern scientific understanding of memory in humans and how it affects works of life writing. Scientific research shows that memory is unreliable and often misunderstood by the general public, and this has implications for different forms of life writing. This paper uses biographies, memoirs, and hybrid forms of life writing to explore how memory, with all its limitations, is used in service of a life story. How do writers of these sub-genres use memory and why are those strategies different from one another? Questions of agency and authority over written and spoken material make the issues still …

Assessing Working Memory In Mild Cognitive Impairment With Serial Order Recall., Sheina Emrani, David J Libon, Melissa Lamar, Catherine C Price, Angela L Jefferson, Katherine A Gifford, Timothy J Hohman, Daniel A Nation, Lisa Delano-Wood, Amy Jak, Katherine J Bangen, Mark W Bondi, Adam M Brickman, Jennifer Manly, Rodney Swenson, Rhoda Au, Consortium For Clinical And Epidemiological Neuropsychological Data Analysis (Cenda)

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Working memory (WM) is often assessed with serial order tests such as repeating digits backward. In prior dementia research using the Backward Digit Span Test (BDT), only aggregate test performance was examined.

OBJECTIVE: The current research tallied primacy/recency effects, out-of-sequence transposition errors, perseverations, and omissions to assess WM deficits in patients with mild cognitive impairment (MCI).

METHODS: Memory clinic patients (n = 66) were classified into three groups: single domain amnestic MCI (aMCI), combined mixed domain/dysexecutive MCI (mixed/dys MCI), and non-MCI where patients did not meet criteria for MCI. Serial order/WM ability was assessed by asking participants to repeat …

Development Of Ethologically-Based Inhibitory Avoidance Models Of Fear Memory, Savannah Dalrymple

USF Tampa Graduate Theses and Dissertations

Translational research provides a unique opportunity to investigate innate and conditioned fear to develop an integrated understanding of anxiety disorders, ultimately improving treatment for those afflicted. Many fear conditioning paradigms use physically aversive stimuli to induce fear but ethological stimuli may better represent psychological disorders from a translational standpoint. Natural predators and immobilization have been successful in inducing both innate and contextually conditioned fear in rodents but an inhibitory avoidance paradigm that uses ethologically relevant stimuli has yet to be developed. To expand the use of these stimuli into inhibitory avoidance conditioning, an inhibitory avoidance paradigm was developed to include …

Sensation Seeking Impact On Skin Conductance Measures Of Deception And Memory, Andrew David Manson, Suzanna Lagerroos, Phillip Janz, Adam Lawson, Jonathan Gore

EKU Faculty and Staff Scholarship

We sought to determine whether sensation seeking would differentially predict measures of memory and deception (concealing information) as indexed by behavioral (response time, accuracy) and autonomic (skin conductance level) markers in a sample of college students. Participants were randomly assigned to a mock-crime group or an innocent-errand group. Both groups were trained to complete a task requiring the copying of documents from a secure location; the difference was the mock-crime group broke into the office whereas the errand group was given permission to enter the room and access the documents. After being trained to perform the crime or errand task, …

Functional Human Grin2b Promoter Polymorphism And Variation Of Mental Processing Speed In Older Adults, Yang Jiang, Ming Kuan Lin, Gregory A. Jicha, Xiuhua Ding, Sabrina L. Mcilwrath, David W. Fardo, Lucas S. Broster, Frederick A. Schmitt, Richard J. Kryscio, Robert H. Lipsky

Behavioral Science Faculty Publications

We investigated the role of a single nucleotide polymorphism rs3764030 (G > A) within the human GRIN2B promoter in mental processing speed in healthy, cognitively intact, older adults. In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels. We tested the hypothesis that individuals with A allele will have better memory performance (i.e. faster reaction times) in older age. Twenty-eight older adults (ages 65-86) from a well-characterized longitudinal cohort were recruited and performed a modified delayed match-to-sample task. The rs3764030 polymorphism was …

Prevention Of Recurrent Affective Episodes Using Extinction Training In The Reconsolidation Window: A Testable Psychotherapeutic Strategy., Robert M Post, Robert Kegan

Psychiatry and Behavioral Sciences Faculty Publications

Stressors may initially precipitate affective episodes, but with sufficient numbers of recurrences, episodes can occur more autonomously. It is postulated the memory engram for these recurrent depressions moves from the conscious representational memory system to the unconscious habit memory system encoded in the striatum. If this were the case, cognitive behavior therapy targeted toward extinction of habit memories could be an effective maneuver for helping reverse the automaticity of affective episode recurrence. Extinction training in the reconsolidation window (which opens about 5 min to 1 h after active memory recall) can revise, reverse, or eliminate the long term memories associated …

A Cognitive Electrophysiological Signature Differentiates Amnestic Mild Cognitive Impairment From Normal Aging, Juan Li, Lucas S. Broster, Gregory A. Jicha, Nancy B. Munro, Frederick A. Schmitt, Erin L. Abner, Richard J. Kryscio, Charles D. Smith, Yang Jiang

Behavioral Science Faculty Publications

Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer’s disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.

Methods: Eighteen NC, 17 subjects with aMCI, and 13 subjects with AD performed a delayed match-to-sample task specially designed not only to be …

The Effects Of Abilify On Memory, Coordination, And Stereotypy In Cd-1 Mice, Jostein Andersen

Undergraduate Honors College Theses 2016-

The atypical antipsychotic Abilify is the second most popular treatment for schizophrenia and other related disorders. Its popularity and wide use is due to its unique pharmacological profile, working differently at dopamine and serotonin receptors compared to other antipsychotics. Schizophrenia is an infamous mental dysfunction involving cognitive impairment, positive symptoms, and negative symptoms. The current study investigated Abilify’s effect in a dose-dependent manner on memory, coordination and stereotypic movement. The sample consisted of 15 male and 15 female CD-1 mice. Memory was tested in a cognitive maze, the Rota-Rod series 8 model measured coordination, and the Coulbourn Tru-Scan Activity Box …

Construct Validity For The Poreh Nonverbal Memory Test On Participants With Right, Left, And Bilateral Temporal Lobe Epilepsy, Sarah E. Tolfo

ETD Archive

The present study examined the construct validity of a novel nonverbal memory measure, the Poreh Nonverbal Memory Test (PNMT), using a heterogeneous sample of patients with epilepsy. Results from this study shows that the PNMT differentially correlated with existing memory measures. Namely, the PNMT delay scores significantly correlated with ROCF delay scores, and RAVLT delay and ROCF delay scores were significantly correlated with each other. However, the PNMT did not significantly correlate with RAVLT, which was hypothesized. PNMT and RAVLT learning trials produced logarithmic learning curves that indicate both are good measures of learning. When controlling for gender, education, and …

How Best To Study For A Test: A Comparison Of Practice Retrieval And Self-Explanation, Casey Fortney

Mahurin Honors College Capstone Experience/Thesis Projects

Students often struggle to prepare for their exams, perhaps as a result of using an unhelpful study method. This study compared the effects of using three study methods: rereading, practice retrieval, and self-explanation. 79 college students studied a short science text passage and were tested with both verbatim and inference questions one week later. Students who reread the information did not perform differently from those who practiced retrieving or self-explained the information. Students who self-explained the information performed better on verbatim test questions than those who practiced retrieving the information. Possible explanations for these findings and implications are discussed.

Apolipoprotein E And Clusterin Can Magnify Effects Of Personality Vulnerability On Declarative Memory Performance In Non‐Demented Older Adults, Sharaddha Sapkota, Sandra A. Wiebe, Brent J. Small, Roger A. Dixon

Aging Studies Faculty Publications

Objectives: Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative‐related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross‐domain risk interactions (magnification effects).

Methods: Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality …

Sex Differences In Hiv Effects On Visual Memory Among Substance-Dependent Individuals, Michael K. Keutmann, Raul Gonzalez, Pauline M. Maki, Leah H. Rubin, Jasmin Vassileva, Eileen M. Martin

Psychiatry Publications

HIV’s effects on episodic memory have not been compared systematically between male and female substance-dependent individuals. We administered the Brief Visuospatial Memory Test–Revised (BVMT–R) to 280 substance-dependent HIV+ and HIV– men and women. Groups were comparable on demographic, substance use, and comorbid characteristics. There were no significant main effects of sex or HIV serostatus on BVMT–R performance, but HIV+ women performed significantly more poorly on delayed recall. This effect was most prominent among cocaine-dependent HIV+ women. Our findings are consistent with recent speculation that memory impairment may be more common among HIV+ women, particularly those with a history of cocaine …

An Integrative Neurological Model For Basic Observable Human Behavior, Ryan M. Francis

Calvert Undergraduate Research Awards

The scientific method uncovers information from the natural world in small increments. This spurs the design of models to explain how the pieces fit together and to identify future targets of research. This is especially the case in psychology, where visualizing concepts is an advantageous practice. One all too common criticism of cognitive and behavioral models in psychology is the lack of a biological basis. This paper aims to alleviate part of this issue by integrating currently understood biological and neurological mechanisms that drive psychological phenomena into a predictive and descriptive model for basic human behavior. To accomplish this task, …

Effect Of Sensory Cues On Hand Hygiene Habits Among A Diverse Workforce In Food Service, Robert Pellegrino

Graduate Theses and Dissertations

Poor hand hygiene is a leading cause of foodborne illnesses in the foodservice industry. A series of complex motivational interventions must be employed to permanently change the behavior of workers, to increase their compliance and sustain appropriate levels of proper hand hygiene. Unlike the healthcare industry, which uses large, costly multi-modal behavior modification strategies, the foodservice industry must deploy rapid, cost-efficient strategies that are focus on accommodating these goals with the constraints of high employee turnover rates and diverse demographics. This research was twofold, 1) examining differences in emotions and hand hygiene behavior among participants of two cultures when handling …

Hoarding And Emotional Reactivity: The Link Between Negative Emotional Reactions And Hoarding Symptomatology, A. M. Shaw, K. R. Timpano, G. Steketee, D. F. Tolin, Randy O. Frost

Psychology: Faculty Publications

Hoarding disorder (HD) is characterized by difficulty discarding, clutter, and frequently excessive acquiring. Theories have pointed to intense negative emotional reactions (e.g., sadness) as one factor that may play a critical role in HD's etiology. Preliminary work with an analogue sample indicated that more intense negative emotions following emotional films were linked with greater hoarding symptoms. Symptom provocation imaging studies with HD patients have also found evidence for excessive activation in brain regions implicated in processing emotions. The current study utilized a sample with self-reported serious hoarding difficulties to examine how hoarding symptoms related to both general and hoarding-related emotional …

How Insomnia Reduces Declarative And Non-Declarative Memory Sonsolidation, Kseniya Chumachenko

A with Honors Projects

Insomnia has many negative effects on those who suffer from it, both physical and mental. Memory consolidation is also affected by insomnia, because it depends on reaching REM sleep and deep wave sleep, which are both impaired by insomnia.

Deficits In Retrospective And Prospective Components Underlying Prospective Memory Tasks In Amnestic Mild Cognitive Impairment, Ting Zhou, Lucas S. Broster, Yang Jiang, Feng Bao, Huali Wang, Juan Li

Behavioral Science Faculty Publications

OBJECTIVES: By use of purer indices of PM and RM components than previous studies and adoption of three PM task types, the present study aimed to investigate the deficits of these two components underlying global impairment at a PM task in individuals with amnestic mild cognitive impairment (aMCI).

METHODS: Nineteen aMCI patients and 22 normal controls were examined on event-, time- and activity-based PM tasks. Separate scores were obtained for initiation of intentions (i.e. PM component) and for the content of the intentions (i.e. RM component).

RESULTS: Individuals with aMCI achieved lower PM component (but not RM component) scores than …

Norepinephrine Involvement In The Intermittent Swim Stress-Induced Deficit In Spatial Learning And Memory, Emily Elgert

Honors Theses and Capstones

Learning and memory impairments are often caused by stress disorders including depression. The present study investigated the involvement of norepinephrine in the swim stress-induced deficits of spatial learning and memory. Exposure to intermittent swim stress (ISS) followed by learning and memory tests in the Morris water maze (MWM) were used to investigate this relationship. The ISS paradigm consists of intermittent exposure to cold water, producing stress responses in rats. Reboxetine, a norepinephrine selective reuptake inhibitor (NSRI), was employed to investigate whether this compound reverses the ISS-induced deficit. In other words, rats exposed to the ISS, were hypothesized to experience impaired …

Construct And Criterion Validity Of The Rey Auditory Verbal Learning Test-Spanish Version In Adults With Traumatic Brain Injury, Cristobal Neblina

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Rey Auditory Verbal Learning Test (RAVLT) is among the most commonly used English-language neuropsychological tests of verbal learning and memory. Previous research supports the validity and clinical utility of adaptations of the RAVLT into many diverse languages. In the United States, Hispanics represent the largest and fastest-growing ethnic minority group. As the Hispanic populace continues to grow, so does the need for empirically validated Spanish-language neuropsychological measures. In 2002, a Spanish adaptation of the RAVLT was developed in Puerto Rico (Acevedo-Vargas, 2002). However, validation studies have not been undertaken with clinical samples, and little is known regarding its psychometric …

Affect Identification And Interpersonal Skills: An In-Depth Evaluation Of Social Cognition In Schizophrenia, Griffin Pollock Sutton

UNLV Theses, Dissertations, Professional Papers, and Capstones

The presence of deficits in various sub-domains of social cognition has been investigated to a degree in individuals with schizophrenia. Some of the most commonly researched and documented deficits have included impairments in the identification of affect portrayed in faces. Research has indicated that the performance of individuals with schizophrenia on such tasks is generally impaired as compared to normal controls. However, some have questioned the generalizability of such findings to real-world situations, as day-to-day interactions generally necessitate a constant, fluid assessment of the thoughts and feelings of others and are rarely, if ever, limited to still images of others. …

Neurological Soft Signs In Persons With Amnestic Mild Cognitive Impairment And The Relationships To Neuropsychological Functions, Hui-Jie Li, Peng-Yun Wang, Yang Jiang, Raymond C.K. Chan, Hua-Li Wang, Juan Li

Behavioral Science Faculty Publications

BACKGROUND: Neurological abnormalities have been reported in people with amnestic mild cognitive impairment (aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group and to examine the relationship of NSS to other neuropsychological performances.

METHODS: Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all the participants.

RESULTS: People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS …

Linguistic Devices, Emotionality, And Memorability Of Computer Mediated Communication, Angela M. Mion

Undergraduate Honors Thesis Collection

I examined whether college students use shortcuts, pragmatics, and errors in text messages differently depending on their gender and the emotionality of the message. Results indicate that the prevalence of particular shortcuts differed across happy, sad, and angry messages, but gender did not influence use of linguistic devices. In a second study, I examined the emotionality and memorability of text messages versus voicemails. Results indicate that texts may be remembered better than voicemails, and happy, sad, and angry messages may be remembered differently by men and women.

Improved Self-Control Associated With Using Relatively Large Amounts Of Glucose: Learning Self-Control Is Metabolically Expensive, Matthew T. Gailliot

Faculty Publications

The current study examined whether changes in glucose during a self-control task would predict changes in self-control performance later on. Participants attended two experimental sessions, spaced two weeks apart. During each session, they had their glucose measured, completed the Stroop task as a measure of self-control, and then had their glucose measured again. Larger decreases in glucose (from before to after the Stroop task) during the first session predicted larger increases in improvement on the Stroop task during the second session, in the form of increased speed. Learning self-control might benefit from using larger amounts of glucose. Learning self-control is …

The Role Of Sleep In The Enhancement And Impedance Of Episodic Emotional Memories, Rafael De Jesus

Dissertations and Theses

"The current study examined whether sleep enhances the retention of emotionally arousing memories, and whether an emotional memory can be blocked with a single night of sleep deprivation. Using a modified version of a slide show varying in emotionality with respect to the narrative (participants' acting as either a mother or father experiencing the tragic death of their imagined child), 100 (healthy young adult student volunteer) subjects following the experience were randomly assigned to either a normal night of sleep or were variously sleep deprived (in laboratory). After having experienced the emotional event followed immediately by a night of sleep …

Interaction Of Long- And Short-Term Memory On Selective Attention During Timbre Discrimination, Eva Garcia

Dissertations and Theses

The present study investigated the effects of short- and long-term memory on processes of selective attention during timbre discrimination. Pitch served as the distractor dimension, held constant on standard trials and deviating from the standard frequency on distractor trials. Short-term memory was operationalized as levels of covariate context: Within a block of trials, pitch deviants (p=.28) were either absent (baseline condition), varied orthogonally (filtering condition) or systematically (positive and perfect conditions) with timbre values. Long-term memory was operationalized as levels of psychophysical context: Within a block of trials, the range of pitch change was psychophysically equated with timbre change in …

The Effects Of Circadian Rhythm-Related Mood On Recognition And Recall Memory For Emotional Images, Priya Puliyampet

Dissertations and Theses

"Studies have proposed that sleep following the presentation of emotional information aids in the consolidation of memory for the emotional elements of the stimuli. Some of these studies have used a paradigm that may have been affected by the confounding influence of circadian factors. Mood may follow a circadian rhythm and research suggests that mood at the time of recall can influence the content of the memory recalled. This study was meant to determine whether the enhanced memory for emotional stimuli in the morning following a night of sleep is a function of the circadian rhythm of mood. Better recall …

Forgetting Constrains The Emergence Of Cooperative Decision Strategies, Jeffrey R. Stevens, Jenny Volstorf, Lael J. Schooler, Jörg Rieskamp

Department of Psychology: Faculty Publications

Theoretical studies of cooperative behavior have focused on decision strategies that depend on a partner’s last choices. The findings from this work assume that players accurately remember past actions. The kind of memory that these strategies employ, however, does not reflect what we know about memory. Here, we show that human memory may not meet the requirements needed to use these strategies. When asked to recall the previous behavior of simulated partners in a cooperative memory task, participants performed poorly, making errors in 10–24% of the trials. Participants made more errors when required to track more partners. We conducted agent-based …

The Development Of Attribute Dominance In The Knowledge Base, Marc A. Lindberg Ph.D.

Psychology Faculty Research

Two cuing, free-recall studies were conducted to test Bach and Underwood's (1970) hypothesis that acoustic encoding is dominant among second graders and semantic encoding is dominant among sixth graders. When retrieval cues were presented with to-be-remembered items at both input and output (Experiment 1), and when cues were presented only at output (Experiment 2), semantic cues were more efficient in elevating recall than were acoustic cues for both second and sixth graders. When these and other results generally found using recognition, sorting, incidental learning, and free-recall experimental designs are compared, it seems plausible that item presentation and memory-testing formats interact …

Environmental Familiarization In Rats: Differential Effects Of Acute And Chronic Nicotine, Rick A. Bevins, Jana Koznarova, Tracy J. Armiger

Department of Psychology: Faculty Publications

If an environment is familiar, rats will interact more with a novel object than if the environment is unfamiliar. In two experiments we used this behavioral tendency to assess the effects of nicotine on environmental familiarization (i.e., an elevated platform). As expected, rats given 2 min of exposure to the platform on 2 consecutive days (familiarization phase) interacted more with a novel object in a subsequent test than rats that had not experienced the platform until the test day. During the familiarization phase acute pretreatment with nicotine (0.6 and 1.8 mg/kg, subcutaneous) 10 min before platform exposure interfered with familiarization …