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2025

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Articles 391 - 420 of 698

Full-Text Articles in Psychiatry and Psychology

Reliability And Validity Of The Brief Emotional Experience Scale (Bees) As A Measure Of Emotional Well-Being, Shane L. Rogers, Nicole Brown, Matthew Goulding, Kathryn Campbell, Brennen Mills, Ross Hollett, Travis Cruickshank, Kazunori Nosaka May 2025

Reliability And Validity Of The Brief Emotional Experience Scale (Bees) As A Measure Of Emotional Well-Being, Shane L. Rogers, Nicole Brown, Matthew Goulding, Kathryn Campbell, Brennen Mills, Ross Hollett, Travis Cruickshank, Kazunori Nosaka

Research outputs 2022 to 2026

This study presents initial reliability and validity evidence for the Brief Emotional Experience Scale (BEES) as a measure of emotional well-being. Using ordinal confirmatory factor analysis across three cross-sectional samples, Australian university students (n = 1239), the general public (n = 5631), and school students from Australia and the UK (n = 767). A correlated two-factor structure was supported. In the university sample, the BEES demonstrated strong convergent validity with other well-being measures and was linked to the lowest levels of reported distress when completing the survey. Preliminary cut-offs for high emotional distress were developed via comparison with the Kessler …


Hands-On Healing: The Role Of Creative Art And Clay In Happiness And Stress Reduction, Aria Mokhtari, Mahdi Ghasemi, Melika Eshaghian, Kat Bishop, Brittany Turner, Ryan Golshir, Ana De Faria Lima, Kaylee Stone, Soojin Lee, Jennifer Cooper Apr 2025

Hands-On Healing: The Role Of Creative Art And Clay In Happiness And Stress Reduction, Aria Mokhtari, Mahdi Ghasemi, Melika Eshaghian, Kat Bishop, Brittany Turner, Ryan Golshir, Ana De Faria Lima, Kaylee Stone, Soojin Lee, Jennifer Cooper

Symposium of Student Scholars

Stress and mental health concerns are increasing among students at Kennesaw State University. Creativity has gained recognition for their therapeutic benefits. This research investigated the impact of clay sculpting on stress reduction and emotional well-being. Through qualitative and quantitative assessments, we analyzed participants' self-reported stress levels before and after participating in clay sculpting. A pre-and post-event survey measured the impact of engagement in these activities. After evaluating feedback and statistical trends, this study can provide evidence supporting clay sculpting as an effective tool for enhancing mental well-being among students. Stress levels were assessed using numerical rating scales (a form of …


Evaluating Referral Rates For Positive Postpartum Depression Screenings At Telehealth And Well-Child Visits: A Scoping Review, Rachel Macklin Barber, Mph, Bsn, Rn, Damaris Amber Brooks, Bsn, Rn, Ashli-Emeria Gary, Bsn, Rn, Margaret Harvey, Phd, Acnp-Bc, Chfn, Kate Fouquier Phd, Aprn, Cnm, Pmh-C, Facnm Apr 2025

Evaluating Referral Rates For Positive Postpartum Depression Screenings At Telehealth And Well-Child Visits: A Scoping Review, Rachel Macklin Barber, Mph, Bsn, Rn, Damaris Amber Brooks, Bsn, Rn, Ashli-Emeria Gary, Bsn, Rn, Margaret Harvey, Phd, Acnp-Bc, Chfn, Kate Fouquier Phd, Aprn, Cnm, Pmh-C, Facnm

Doctor of Nursing Practice Projects

Purpose/Background

Postpartum depression (PPD) affects one in nine women. It has distressing impacts, including behavioral and attachment issues and toveruse of healthcare services. PPD occurs within 4 weeks to 12 months postpartum. A scoping review was conducted to compare referral rates to mental health providers after PPD screenings were conducted via telehealth versus those completed at well-child visits.

Methods

Peer-reviewed articles published within five years before the initial search, beginning September 2022 and ending November 2024, were selected. Articles were sourced from several publications using an online library database with various MeSH terms and Boolean operators. Search results were narrowed …


Assessing Healthcare Students’ Self-Efficacy In Disaster Response: A Cross-Sectional Analysis, Aydın Şenol, Abdülkerim Adıyaman, Canan Birimoglu Okuyan Apr 2025

Assessing Healthcare Students’ Self-Efficacy In Disaster Response: A Cross-Sectional Analysis, Aydın Şenol, Abdülkerim Adıyaman, Canan Birimoglu Okuyan

Makara Journal of Health Research

Background: Assessing healthcare students’ self-efficacy in disaster response is crucial for preparing them to effectively manage real-world disaster situations. This study aimed to assess the self-efficacy status of healthcare students in disaster response.

Methods: The data for this cross-sectional analysis were gathered from 498 healthcare students between November 18, 2023, and February 14, 2024, using an individual diagnostic form and the disaster-response self-efficacy (DRSE) scale. This scale is used to assess an individual’s self-efficacy in responding effectively to disasters, including on-site rescue competency, disaster psychological nursing competency, disaster role quality, and adaptation competency.

Results: The mean age …


Expediting Tool-Use Learning: Effects Of Non-Invasive Neurostimulation Of The Left Anterior Supramarginal Gyrus, Kamila Haliru Apr 2025

Expediting Tool-Use Learning: Effects Of Non-Invasive Neurostimulation Of The Left Anterior Supramarginal Gyrus, Kamila Haliru

Honors Thesis

The left anterior supramarginal gyrus (aSMG) has been implicated as an important brain region in tool use. While anodal transcranial Direct Current Stimulation (atDCS) over the primary motor cortex (M1) has been shown to facilitate skilled tool use, the effects of aSMG stimulation remain largely unexplored. Using a chopstick-marble paradigm, this thesis examined whether atDCS to the left aSMG would enhance tool-use learning. Electroencephalography (EEG) was concurrently recorded to assess atDCS-dependent changes to the beta and gamma frequency bands. Our results demonstrated that atDCS over the left aSMG significantly expedited tool-use learning and was associated with increased gamma band activity …


Evaluation Of Depression Screening Tools For Utilization In Adolescents: A Scoping Review, Helen Whitaker Bsn, Rn, Jade Bray Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C, Jacqueline Sharp Dnp, Aprn, Pmhp-Bc, Sharon Little Dnp, Fnp-Bc Apr 2025

Evaluation Of Depression Screening Tools For Utilization In Adolescents: A Scoping Review, Helen Whitaker Bsn, Rn, Jade Bray Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C, Jacqueline Sharp Dnp, Aprn, Pmhp-Bc, Sharon Little Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Anxiety and depression are prevalent mood disorders among the adolescent population with significant impacts on academic performance, social interactions, and mental well-being. With depression rates continuing to rise and suicide among the leading causes of death in adolescents, there is an urgent need for effective screening and intervention. While depression screening is recommended in the primary care setting, many adolescents do not have regular access to healthcare, complicating early identification and treatment. The purpose of this scoping review is to compare the effectiveness of two depression screening tools, the Patient Health Questionnaire (PHQ-9) and the Beck Depression Inventory (BDI), …


The Dialogue Dilemma: The Role Of Patient-Clinician Communication For Low-Income People Who Smoke And Manage Multiple Conditions, Monique T. Cano, Michael R. Lindstrom, Ricardo F. Muñoz Apr 2025

The Dialogue Dilemma: The Role Of Patient-Clinician Communication For Low-Income People Who Smoke And Manage Multiple Conditions, Monique T. Cano, Michael R. Lindstrom, Ricardo F. Muñoz

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: Adults from low-income backgrounds who smoke face significant health disparities related to tobacco use, often at disproportionately high rates. These individuals are more likely to endure multiple mental and physical (MP) health conditions, which can negatively influence their self-rated health (SRH). The quality and effectiveness of patient-clinician communication (PCC) can influence how patients perceive their own health. Understanding how PCC influences SRH among low-income adults who smoke and suffer from multiple MP conditions is essential for clinical care as multimorbidity is on the rise. This study examines how PCC may influence the health perceptions of low-income adults who smoke …


Factors Influence Homeless People’S Psychological Well-Being And Suicidal Ideation, Pi-Ming Yeh Apr 2025

Factors Influence Homeless People’S Psychological Well-Being And Suicidal Ideation, Pi-Ming Yeh

Epsilon Sigma at-Large Research Conference

Introduction/Significance: About 582,462 individuals are experiencing homelessness in America. Homelessness is devastating, regardless of age. But for children, it can have serious physical, emotional, and psychological implications.

Purpose: The purpose of this study was to examine the influences of spiritual well-being, coping strategies, family interaction, and personality on psychological well-being, and suicidal ideation among people with homelessness.

Methods: Sixty people with homelessness were recruited in the Eastern Tennessee Downtown Day Center, USA. IRB was approved. This was a cross-sectional descriptive research design. Questionnaires were used to do data collection. SPSS 28.0 was used to do the data analysis. Descriptive …


The Use Of Person-Centered Language In Scientific Research Articles Focused On Psychosis, Zach Monahan, Tanner Stone, Vinay Swami, Kelly Dunn, Micah Hartwell Apr 2025

The Use Of Person-Centered Language In Scientific Research Articles Focused On Psychosis, Zach Monahan, Tanner Stone, Vinay Swami, Kelly Dunn, Micah Hartwell

Journal of Patient-Centered Research and Reviews

Purpose: Societal stigma of psychosis leads to delayed treatment for individuals experiencing early symptoms, for fear of being labeled “crazy” or “psychotic.” Delayed treatment can worsen the prognosis of individuals with psychosis. Proper adherence to person-centered language (PCL) guidelines can curb the widely held stigmatized preconceptions about psychotic conditions.

Methods: Our meta-epidemiological analysis began with a systematic search of literature in PubMed discussing psychosis from 2020-2022. From the 14,522 results, we randomly selected 500 articles in journals with at least 20 articles on psychosis (n = 9,775), of which 241 articles met the inclusion criteria. These papers were screened for …


Is Love A “Pathological Condition Of The Soul”? Joyce Carol Oates's Beasts And Rape: A Love Story, Nicolas P. Boileau Apr 2025

Is Love A “Pathological Condition Of The Soul”? Joyce Carol Oates's Beasts And Rape: A Love Story, Nicolas P. Boileau

Bearing Witness: Joyce Carol Oates Studies

This paper seeks to address the question of Oates’s relation to feminist and gender theories by looking at two novellas published consecutively, Beasts and Rape: A Love Story in the beginning of the 2000s. The short texts share a common storyline based on rape, which is far from uncommon in Oates’s fiction. However, I argue that there is something very specific in these two novellas in the way Oates chooses to handle the testimony of the rape, both overtly and covertly, both in graphic details and in repressed forms of expression, giving way to a reflection on women’s vulnerable position …


Neural Patterns Of Self-Efficacy And Resulting Changes After Cognitive Rehabilitation In Mild Traumatic Brain Injury, Emma N. Tribbey Apr 2025

Neural Patterns Of Self-Efficacy And Resulting Changes After Cognitive Rehabilitation In Mild Traumatic Brain Injury, Emma N. Tribbey

Theses

Mild traumatic brain injury (mTBI) often leads to cognitive impairments, which can significantly affect recovery outcomes. Although there are many different interventions available for individuals with mTBI, evidence-based research has indicated that cognitive rehabilitation programs can lead to significant improvement in psychological symptoms as well as psychosocial and vocational functioning in mTBI. Additionally, clinical research has identified a construct, self-efficacy, or the belief in one's capacity to achieve goals, that may play a critical role in further improving cognitive rehabilitation outcomes. Current research examining self-efficacy and cognitive rehabilitation in mTBI has found that higher self-efficacy is associated with greater treatment …


Ua12/2/1 College Heights Herald, Vol. 100, No. 3, Wku Student Affairs Apr 2025

Ua12/2/1 College Heights Herald, Vol. 100, No. 3, Wku Student Affairs

WKU Administration Documents

Magazine edition of the College Heights Herald for the period February 17 - April 20, 2025.

  • Wilborn, Price. You Matter & You Are Not Alone
  • Smith, Kane. Peggy Crowe Reflects on Counseling Center in Face of Staff Shortages
  • Stafford, Hallie. Help with Horses – New Beginnings Therapeutic Horse Riding
  • Hawkins, Kaylee. How a WKU Professor Helps Improve Student Mental Health – Jay Gabbard, National Alliance on Mental Illness Recovery Support Group
  • McMahon, Jake. More Than a Coach – Brent Chumbley, Track & Field
  • Simpson, Libby. WKU’s American Foundation for Suicide Prevention Brings Mental Health Into the Light
  • Hardesty, Emma. Trans …


Psychopathy And The Media: A Dangerous False Perception, Ashton L. Brophy Apr 2025

Psychopathy And The Media: A Dangerous False Perception, Ashton L. Brophy

Harding Undergraduate Research Conference

Characterized by a lack of remorse or empathy, psychopaths– sufferers of Antisocial Personality Disorder– view the world far differently than the average person. This makes psychopathy an intriguing topic of study. However, many members of the general public lack understanding about the complexities of this disorder due to the false media depictions that make it difficult to accurately identify true psychopaths. By correcting the inaccurate narrative of psychopathy fed to the public through the media, it becomes possible to recognize the responsibility that is to be laid at the feet of the psychopathic offenders who chose violence.


The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson Apr 2025

The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the influence of military mindset on personal canine selection through the lived experiences of Tennessee military veterans to enhance military cultural competency and aid in development of complimentary and integrative approaches to veteran mental health. Insufficient research exists into understanding the specific needs of reintegrating veterans and into the benefits of canine-assisted therapies. The theories which guided this study were Albert Bandura’s Social Cognitive Theory of Learning and Abraham Maslow’s Theory of Motivation. This qualitative study was further guided by axiological philosophical assumptions. Fifteen participants were recruited via email and selected …


Agenda (Pdf), Department Of Psychiatry Apr 2025

Agenda (Pdf), Department Of Psychiatry

Dept. of Psychiatry Research Symposium

The abstract booklet for the 3rd Annual Department of Psychiatry Research Symposium held April 17, 2025.


Psychological Treatment Behind The Walls:Insights From The Inside, Rogelio Serrano Apr 2025

Psychological Treatment Behind The Walls:Insights From The Inside, Rogelio Serrano

Psychology Division Scholarship

Repeated eras of mass incarceration, criminalization of marginalized communities, and substance use policies have created a revolving door of justice involved populations. The ever-increasing prison population has repeatedly become the largest contingency of mental health clientele for an overburdened mental health system. Those who work with formerly incarcerated individuals in the community often don’t know the unique set of challenges faced by practitioners within the system. Increased understanding and coordination of care can offer opportunities for sustained recovery and reduced levels of recidivism. In this presentation participants will learn about the unique insights on mental health treatment that can be …


Gray Matter Morphology And Pain-Related Disability In Young Adults With Low Back Pain, Jo Armour Smith, Rongwen Tain, Isaac Chrisman, Kelli G. Sharp, Laura M. Glynn, Linda R. Van Dillen, Jesse V. Jacobs, Steven C. Cramer Apr 2025

Gray Matter Morphology And Pain-Related Disability In Young Adults With Low Back Pain, Jo Armour Smith, Rongwen Tain, Isaac Chrisman, Kelli G. Sharp, Laura M. Glynn, Linda R. Van Dillen, Jesse V. Jacobs, Steven C. Cramer

Physical Therapy Faculty Articles and Research

Structural neuroplasticity in the brain may contribute to the persistence of low back pain (LBP) symptoms and the disability associated with them. It is not known if structural adaptations are evident early in the lifespan in young adults with LBP. This study compared gray matter in cortical sensorimotor regions in young adults with and without persistent LBP and identified gray matter and clinical predictors of pain-related disability. Eighty-two individuals with and without a history of LBP participated. Peak and average gray matter density in cortical sensorimotor regions of interest was quantified using voxel-based morphometry. Pain-related disability, pain intensity, pain duration, …


Biopsychosocial-Based Exercise Model For Rheumatic Diseases Via Telerehabilitation: A Case Series With A One Year Follow Up, Nazlı Elif Nacar, Nur Banu Karaca, Zeynep Irem Bulut, Erkin Oguz Sarı, Senem Bulut, Yavuz Yakut, Sevim Oksüz, Sedat Kiraz, Edibe Unal Apr 2025

Biopsychosocial-Based Exercise Model For Rheumatic Diseases Via Telerehabilitation: A Case Series With A One Year Follow Up, Nazlı Elif Nacar, Nur Banu Karaca, Zeynep Irem Bulut, Erkin Oguz Sarı, Senem Bulut, Yavuz Yakut, Sevim Oksüz, Sedat Kiraz, Edibe Unal

Internet Journal of Allied Health Sciences and Practice

Purpose: This study aims to examine the sustainability of the biopsychosocial exercise performed by telerehabilitation on individuals with rheumatic disease, with and without supervision, and investigate the effect of the biopsychosocial-based exercise model on biopsychosocial status, general health status, and anxiety-depression levels of individuals. Method: Twenty patients with rheumatic diseases performed a biopsychosocial-based exercise model Cognitive Exercise Therapy Approach via telerehabilitation with physiotherapist-supervised and unsupervised exercises who continued for three sessions per week for 12 months. Outcome measures were Health Assessment Questionnaire, Hospital Anxiety and Depression Scale, and Cognitive Exercise Therapy Approach -Biopsychosocial Questionnaire. Patients were assessed at baseline, 3rd, …


Perinatal Mood And Anxiety Disorders (Pmads): A Scoping Review, Christina Willis Bsn, Rn, Nia Wells Bsn, Rn, Miranda Smith Bsn, Rn, Kate Fouquier Cnm, Phd, Facnm Apr 2025

Perinatal Mood And Anxiety Disorders (Pmads): A Scoping Review, Christina Willis Bsn, Rn, Nia Wells Bsn, Rn, Miranda Smith Bsn, Rn, Kate Fouquier Cnm, Phd, Facnm

Doctor of Nursing Practice Projects

Purpose/Background Perinatal Mood and Anxiety Disorders (PMADs), including postpartum depression, anxiety, and psychosis, significantly impact maternal and infant health. This scoping review consolidates current literature on PMADs, emphasizing prevalence, risk factors, screening, and treatment. The primary aim is to identify research gaps and inform clinical guidelines to enhance perinatal care.

Methods A literature search followed PRISMA guidelines from August 2022 to November 2024. Databases searched included PubMed, CINAHL, Scopus, and Google Scholar, using terms such as "perinatal mood disorders" and "maternal mental health." Inclusion criteria were English-language studies from the past decade addressing PMADs during pregnancy and up to one …


Behere Nevada: Partnership And Policy, Sara Hunt Apr 2025

Behere Nevada: Partnership And Policy, Sara Hunt

Community Engagement Expo Research Posters

Partnership: Nevada ranks 51st in the nation for mental illness prevalence and access to care (Mental Health America). Significant shortages in mental health professions, especially in rural areas. Other states using policy and funding to implement a “grow our own” model for behavioral health workforce development. Proposed a behavioral health workforce development center for Nevada.


Supporting Elementary Educators Through A Nervous System Regulation And Social-Emotional Learning Skills Workshop Intervention: An Musc Capstone Project, Lily Morgan Apr 2025

Supporting Elementary Educators Through A Nervous System Regulation And Social-Emotional Learning Skills Workshop Intervention: An Musc Capstone Project, Lily Morgan

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Teachers have a great influence on developing children’s emotional intelligence, regulatory capacity, and occupational engagement. These professionals also happen to report some of the highest rates of stress, mental health challenges (Agyapong, B. et al, 2022), and burnout (Xie, M., et al, 2022). Providing teachers with education and support on nervous system regulation, social-emotional learning skills, and related topics can improve their ability to manage job stress, enhance modeling and interactions with students, and improve their quality of life. This project aimed to enhance knowledge, provide access to resources, and serve to support elementary educators at an inner-city school in …


A New Paliperidone Palmitate Formulation: How Is It Different And Where Does It Fit In Our Array Of Choices For Long-Acting Formulations Of Risperidone And Paliperidone?, Justin Faden, Leslie Citrome Apr 2025

A New Paliperidone Palmitate Formulation: How Is It Different And Where Does It Fit In Our Array Of Choices For Long-Acting Formulations Of Risperidone And Paliperidone?, Justin Faden, Leslie Citrome

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Long-acting injectable (LAI) antipsychotics have been shown to enhance treatment adherence and outcomes in individuals with schizophrenia, schizoaffective disorder, and bipolar disorder. In recent years, the U.S. Food and Drug Administration (FDA) has approved several LAIs with differing amenities of care, such as mode of administration, duration of oral medication supplementation, dosing frequency, needle gauge and size, and injection volume, amongst others. Additionally, several LAIs are distinct formulations of risperidone and paliperidone, making it difficult to distinguish between formulations, and many providers are unfamiliar with these newer agents. In 2024, a once-monthly LAI formulation of paliperidone palmitate, manufactured by Luye …


Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz Apr 2025

Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz

ONU Student Research Colloquium

Fear-related disorders are often treated with exposure therapy, a technique based on the concept of extinction. However, this type of therapy is ineffective for many individuals, so finding a pharmacological adjunct that augments the extinction of fear could lead to better treatment outcomes. In recent preclinical work, investigators have shown that psychedelics can accelerate the extinction of fear, potentially through their impact on neurotrophic signaling. We previously found that psilocybin exerted sex-dependent effects on the extinction of conditioned fear to an isolated cue (i.e., a tone). Specifically, psilocybin enhanced the extinction of cue fear in male rats but impaired it …


A Narrative Review Of Military Reverse Triage., Daniel J Hurst Apr 2025

A Narrative Review Of Military Reverse Triage., Daniel J Hurst

Rowan-Virtua School of Osteopathic Medicine Departmental Research

INTRODUCTION: Military reverse triage has been described at several points in the literature. However, an extensive review of the concept and any gaps that may exist has not been conducted. This narrative review seeks to understand how reverse triage is used in the military literature and how it might be implemented in practice, as well as the documented historical applications of reverse triage.

MATERIALS AND METHODS: Four databases were searched manually for English-language articles: PubMed, SCOPUS, JSTOR, and Worldwide Political Science Abstracts. In addition, a manual search of references, U.S. DoD, and NATO doctrine, as well as other published works …


Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano Apr 2025

Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Driving under the influence of cannabis increases the risk of motor vehicle collisions. In some jurisdictions, deterrence rests on the ability to detect delta-9-tetrahydrocannabinol (THC) in blood. Recent evidence suggests that there may be a nuanced relationship of blood THC to driving.

OBJECTIVE: The purpose of this systematic review was to summarize all published papers investigating the presence of a linear relationship between blood THC and driving, primarily measured by simulated driving in the lab.

OUTCOMES: The main outcomes assessed included "weaving"/lateral control (eg, standard deviation of lateral position), speed, car following (following distance; coherence), reaction time, and overall …


Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood Apr 2025

Hdac5 Enzymatic Activity Regulates Scn4b Expression To Control Relapse-Like Cocaine Seeking, Daniel J. Wood

MUSC Theses and Dissertations

Substance Use Disorder (SUD) is a relapsing disorder characterized by repeated seeking and use of psychoactive substances despite negative consequences to the individual. Epigenetic changes within the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are thought to underly the lasting propensity to relapse in SUD. The epigenetic enzyme histone deacetylase 5 (HDAC5) in NAc MSNs limits the formation of reward-cue associations in rodent models of drug seeking, but not sucrose seeking, leading to decreased relapse-like behavior. However, whether HDAC5 reduces drug seeking behavior through its own deacetylase activity or through the recruitment of co-repressors is unknown. Furthermore, these …


Cell Type-Specific Multi-Omics Analysis Of Cocaine Use Disorder In The Human Caudate Nucleus, Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P Völker, Svenja Müller, Anita C Hansson, Thomas D Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M M Oliveira, Consuelo Walss-Bass, Rick E Bernardi, Philipp Koch, Stephanie H Witt Apr 2025

Cell Type-Specific Multi-Omics Analysis Of Cocaine Use Disorder In The Human Caudate Nucleus, Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P Völker, Svenja Müller, Anita C Hansson, Thomas D Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M M Oliveira, Consuelo Walss-Bass, Rick E Bernardi, Philipp Koch, Stephanie H Witt

Faculty, Staff and Student Publications

Structural and functional alterations in the brain's reward circuitry are present in cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. To investigate these mechanisms, we performed single-nuclei multiome profiling on postmortem caudate nucleus tissue from six individuals with CocUD and eight controls. We profiled 30,030 nuclei, identifying 13 cell types including D1- and D2-medium spiny neurons (MSNs) and glial cells. We observed 1485 differentially regulated genes and 10,342 differentially accessible peaks, with alterations in MSNs and astrocytes related to neurotransmitter activity and synapse organization. Gene regulatory network analysis identified transcription factors including ZEB1 as exhibiting distinct CocUD-specific subclusters, …


Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva Apr 2025

Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva

Faculty Publications

We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …


52 - The Intersection Of Trauma Type And Alcohol Use In College Women: Examining Maladaptive Coping In A High-Risk Population, Mira I. Hopkins, Christopher T. Latourrette, Niya Richardson, Mellyssa G. Deoliveira, Sage E. Hawn Apr 2025

52 - The Intersection Of Trauma Type And Alcohol Use In College Women: Examining Maladaptive Coping In A High-Risk Population, Mira I. Hopkins, Christopher T. Latourrette, Niya Richardson, Mellyssa G. Deoliveira, Sage E. Hawn

Undergraduate Research Symposium

This study examines how different types of trauma exposure, interpersonal and non-interpersonal, relate to alcohol use as a coping mechanism in college women with trauma histories. Given the unique social and environmental pressures of college life, this research aims to highlight the ways in which trauma and substance use intersect in this high-risk population.


Impact Of Parental Adhd Status On Screen Time Allowance In Children: Insights From Nhis Data, Chase Moscovic Apr 2025

Impact Of Parental Adhd Status On Screen Time Allowance In Children: Insights From Nhis Data, Chase Moscovic

Medical Student Research Symposium

Title: Impact of Parental ADHD Status on Screen Time Allowance in Children: Insights from NHIS Data

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) affects both children and adults, with significant implications for daily functioning. While research has examined the impact of ADHD on children's screen time, less is known about how parental ADHD may influence screen time practices. This study explores the relationship between parental ADHD status and their regulation of children's screen time, a critical aspect of neurodevelopment in an increasingly digital world.

Methods: We analyzed data from the 2019–2023 National Health Interview Survey (NHIS), which includes U.S. household data on health …