Psychiatry and Psychology Commons^™

Discovery And Generalization Of Tissue Structures From Spatial Omics Data, Zhenqin Wu, Ayano Kondo, Monee Mcgrady, Ethan A G Baker, Benjamin Chidester, Eric Wu, Maha K Rahim, Nathan A Bracey, Vivek Charu, Raymond J Cho, Jeffrey B Cheng, Maryam Afkarian, James Zou, Aaron T Mayer, Alexandro E Trevino

Staff and Researcher Publications

Tissues are organized into anatomical and functional units at different scales. New technologies for high-dimensional molecular profiling in situ have enabled the characterization of structure-function relationships in increasing molecular detail. However, it remains a challenge to consistently identify key functional units across experiments, tissues, and disease contexts, a task that demands extensive manual annotation. Here, we present spatial cellular graph partitioning (SCGP), a flexible method for the unsupervised annotation of tissue structures. We further present a reference-query extension pipeline, SCGP-Extension, that generalizes reference tissue structure labels to previously unseen samples, performing data integration and tissue structure discovery. Our experiments demonstrate …

Using Fink’S Taxonomy In Counseling Practicum And Internship Courses, Kailey Bradley, Emily Horton Phd

Journal of Counselor Preparation and Supervision

Fink’s Learning Taxonomy expanded upon Bloom’s Learning Taxonomy to provide concrete suggestions on development of significant learning experiences. Limited research exists on implementation of Fink’s learning Taxonomy in counselor education curriculum. As such, this conceptual article illuminates how the integration of Fink’s Learning Taxonomy could be used by educators to develop significant learning experiences within counseling internship and practicum courses.

Mobile Sensing-Based Depression Severity Assessment In Participants With Heterogeneous Mental Health Conditions, Bishal Lamichhane, Nidal Moukaddam, Ashutosh Sabharwal

Faculty, Staff and Students Publications

Mobile sensing-based depression severity assessment could complement the subjective questionnaires-based assessment currently used in practice. However, previous studies on mobile sensing for depression severity assessment were conducted on homogeneous mental health condition participants; evaluation of possible generalization across heterogeneous groups has been limited. Similarly, previous studies have not investigated the potential of free-living audio data for depression severity assessment. Audio recordings from free-living could provide rich sociability features to characterize depressive states. We conducted a study with 11 healthy individuals, 13 individuals with major depressive disorder, and eight individuals with schizoaffective disorders. Communication logs and location data from the participants’ …

Building A More Resilient Physician Assistant Student: Suggestions For Implementing Mindfulness-Based Training Into Didactic Education, Sarah Cornell

Theses and Graduate Projects

Background: Burnout affects a high number of healthcare providers and compromises both provider and patient wellbeing. In addition to high turnover rates, burnout costs healthcare systems through errors, poor care outcomes, and decreased patient satisfaction. Mindfulness-based therapy delivered by phone apps has been successful in improving stress levels and burnout measures. Based on similar research with medical students, physician assistant students may benefit from early stress-reduction interventions, although the research surrounding implementation and long-term follow up is lacking.

Objective: This cross-sectional study looks at burnout rates across three cohorts at a single Master of Science in Physician Assistant Studies program …

Peer Support For Second Victims In The Healthcare Setting, Levi Gangi

Advances in Clinical Medical Research and Healthcare Delivery

Adverse and traumatic events happen regularly in healthcare settings, and often they create a clinician “second victim” who struggles with feelings of guilt, isolation, doubt, and incompetence. Research has shown that clinicians desire support in the wake of such adverse events, but that factors such as stigma, culture of perfection, and lack of an available structured peer program limit the support that might be offered. Healthcare institutions contract with EAP (employee assistance program) agencies to provide counseling for employees, but it is more likely that a second victim will seek out or welcome help first from a peer who shares …

Post Anesthesia Care Unit Comprehension Safety Program Quality Improvement Project On De-Escalation Of Patients, Mary M. Gaukler Giannavola, Basil George Verghese, Deborah Maier

Advances in Clinical Medical Research and Healthcare Delivery

Background:

Violence within the healthcare setting has risen significantly, and has crossed into areas where staff are less prepared to manage and deescalate challenging patient encounters. This lack of preparedness and confidence has led to increased staff stress, burn out, and can potentiate poor patient outcomes.

Methods:

A pre/post-simulation quality improvement project was performed within a tertiary hospital Post-Anesthesia Care Unit in Upstate New York to evaluate the effect of simulation on feelings of confidence and preparedness in patient de-escalation with PACU nurses and patient care technicians. The project evaluation included the Thackrey’s Clinician Confidence in Coping with Patient Aggression …

Occupational Therapy And Self-Awareness For Adolescents With Mental Health Concerns, Deriyon Johnson, Rebecca King

Summer 2024 OTD Capstone Symposium

The project created an occupation-based program to address the unique needs of adolescents at risk of mental health concerns and promote improved occupational success. The problem presented is the lack of support available to assist adolescents experiencing profound emotional and behavioral challenges, triggering negative impacts on social participation, academics, self-care, and leisure. In addition, the program will introduce coping strategies and improve daily functions to increase motivation for engagement in desired activities. The purpose of the program was to improve these areas through a series of structured activities focusing on mental health awareness, emotional regulation, and personal development. The results …

Occupational Therapy And Expressive Strategies For Youth Trauma Recovery, Darin Lewis, Rebecca King

Summer 2024 OTD Capstone Symposium

The purpose of this capstone project was to develop a program to address youth mental health concerns through expressive strategies and interventions.

Affect Regulation And Allostatic Load Over Time, Amanda E. Ng, Tara Gruenewald, Robert-Paul Juster, Claudia Trudel-Fitzgerald

Psychology Faculty Articles and Research

Objective

Emerging work suggests that affect regulation strategies (e.g., active coping, anger expression) predict disease and mortality risk, with sometimes divergent estimates by sex or education levels. However, few studies have examined potential underlying biological mechanisms. This study assessed the longitudinal association of affect regulation with future allostatic load.

Method

In 2004–2006, 574 participants from the Midlife in the United States study completed validated scales assessing use of nine general and emotion-specific regulatory strategies (e.g., denial, anger expression). As a proxy for how flexibly participants regulate their affect, variability in the use of regulatory strategies was operationalized using a standard …

Educational Experiences Of Juvenile Offenders In Minnesota, Danielle Petruska

Theses and Graduate Projects

Objective of Study. The objective of this study was to examine the impact of positive adult/teacher relationships in juvenile detention educational settings in Minnesota on juvenile offenders’ perceptions of school, as well as their future plans for attending college after high school. Method. Data were obtained from the 2019 administration of the Minnesota Student Survey, involving 280 juvenile offenders (83 girls) from correctional educational facilities. Hypotheses were tested using correlational analyses to examine the relationship between perceived adult/teacher relationships and school perceptions, as well as the association between these relationships and post-high school plans. Results. Results revealed …

Evaluating Attitudes On Health-Seeking Behavior Among A Network Of People Who Inject Drugs, Ayako Shimada, Ashley Buchanan, Natallia Katenka, Benjamin Skov, Gabrielle Lemire, Stephen Kogut, Samuel Friedman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

People who inject drugs (PWID) are often members of HIV/AIDS risk networks, where individuals engage in sexual and injection risk behavior. Engagement in HIV care is important for this population. Low socioeconomic status, stigmatization, and lack of access to medical care often complicate successful engagement in the HIV cascade of care for PWID. This study investigates how individual’s attitudes about how much control they have over HIV/AIDS risk in their life (i.e., locus of control and self-blame) affect health-seeking behavior in PWID participants and their community members. We applied causal inference methodology to PWID HIV risk networks ascertained from the …

Genomic Data Science Approaches For Understanding Human Diseases, Snehal Shah

All Dissertations

The intricate interplay of genetic predisposition, environmental influences, and lifestyle acts as the multifactorial landscape of diseases. Understanding this complexity presents a significant challenge. Molecular insights into disease mechanisms, particularly the interactions of DNA, RNA, and proteins with environmental and lifestyle factors, have revolutionized disease diagnosis, prognosis, and treatment. High-throughput technologies, such as next-generation sequencing, generate large amounts of molecular data, holding a wealth of knowledge. These datasets unveil the roles of genes and their interactions with various factors through analysis, shedding light on previously unknown molecular mechanisms underlying disease pathogenesis. Furthermore, they facilitate the discovery of biomarkers crucial for …

4d Dynamic Spatial Brain Networks At Rest Linked To Cognition Show Atypical Variability And Coupling In Schizophrenia, Krishna Pusuluri, Zening Fu, Robyn Miller, Godfrey Pearlson, Peter Kochunov, Theo G M Van Erp, Armin Iraji, Vince D Calhoun

Faculty, Staff and Student Publications

Despite increasing interest in the dynamics of functional brain networks, most studies focus on the changing relationships over time between spatially static networks or regions. Here we propose an approach to study dynamic spatial brain networks in human resting state functional magnetic resonance imaging (rsfMRI) data and evaluate the temporal changes in the volumes of these 4D networks. Our results show significant volumetric coupling (i.e., synchronized shrinkage and growth) between networks during the scan, that we refer to as dynamic spatial network connectivity (dSNC). We find that several features of such dynamic spatial brain networks are associated with cognition, with …

Therapeutic Decisions And Implications In Patients With Attention Deficit Hyperactivity Disorder Versus Bipolar Disorder: Key Insights For Clinicians, Ngozi Adaralegbe, Ayotomide Oyelakin, Omobusayo Omotayo

Faculty, Staff and Student Publications

Attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (BD) are conditions that often manifest in childhood and can persist into adulthood. Due to the similarities in their clinical presentations, it is crucial for clinicians to have a thorough understanding of these disorders. Accurate differentiation of symptoms is essential for making precise diagnoses, as this directly influences treatment decisions and affects the overall functioning and quality of life of those impacted. Considered here is the case of a teenage male who initially presented with impulsivity and was diagnosed with ADHD. However, upon further evaluation, his diagnosis was revised to BD. …

Shared Delusion: Impact On The Parent-Child Relationship, Ngozi Adaralegbe, Ayotomide Oyelakin, Omobusayo Omotayo

Faculty, Staff and Student Publications

Folie à famille, also known as shared psychotic disorder among family members, is a rare and underdiagnosed psychiatric condition. This disorder, seldom discussed in the literature, is particularly notable for its impact on clinical management and parent-child relationships. The few reported cases have predominantly focused on adult populations, leaving a significant gap in understanding how this condition manifests and affects younger individuals and family dynamics. One area that remains largely unexplored in the literature is the intersection between attachment patterns and shared psychosis, particularly in the context of parent-child relationships. Understanding this intersection is crucial, as it can provide insights …

Stigma Reduction And Resiliency Training For First Responders (Srrt-Fr): A Feasibility And Initial Efficacy Evaluation, Thalia P. Nicholson

Electronic Theses and Dissertations

First responders, especially law enforcement, frequently encounter individuals experiencing substance use concerns. Previous research has documented that a greater understanding of substance use disorders promotes a decrease in stigmatizing perspectives. We present a novel approach to training law enforcement officers to improve their interactions with community members exhibiting substance use disorders, while also promoting their professional well-being. The present study sought to evaluate the feasibility and acceptability of the Stigma Reduction and Resiliency Training for First Responders (SRRT-FR) in a sample of law enforcement officers, as well as its efficacy in decreasing stigmatizing perspectives towards substance use disorders and increasing …

Psychological Pitfalls Of The Modern Percussionist: A Survey Of Coping Mechanisms For Downward Spirals In Mental Health, Andrew Naughton

UNLV Theses, Dissertations, Professional Papers, and Capstones

This document explores three key facets of mental health significantly impacting percussionists in both educational and professional settings: Imposter Syndrome, sleep deprivation, and stress management. The primary focus is to understand the impact of these psychological conditions on percussionists and discover effective approaches to prevent, alleviate, or manage these ailments. This document is divided into four sections. The initial section delineates the concept of “Imposter Syndrome” and discusses its various manifestations as encountered by percussionists in both educational and professional environments. The second section discusses the consequences of sleep deprivation on mental well-being when it is disregarded. The third section …

General Psychology 2e, Will Stutterheim

All Open Educational Resources

General Psychology 2e offers an insightful exploration into the complexities of the field of psychology and all that it has to offer. This book provides a thorough introduction to the foundational principles of psychology, covering essential theories, research findings, and applications that illustrate the intricate workings of the mind.

The text begins with a historical overview of psychology, tracing its evolution from philosophical roots to its establishment as a scientific discipline. It then delves into essential topics regarding stress and mental health disorders and concludes with therapy and treatment approaches. It then covers research in psychology, biopsychology, consciousness, and perception. …

Moral Disengagement And The Tendency To Engage In Academic Dishonesty In Prelicensure Nursing Students, Sarah Guimaraes

Electronic Theses and Dissertations

Despite decades of research, academic dishonesty remains a significant concern in nursing education. The connection of academic dishonesty to dishonest clinical practice presents a moral imperative for nurse researchers to find new facets of understanding these phenomena. Literature regarding moral disengagement in health care is minimal and is even less prevalent in the context of nursing education. The purpose of this study was to determine the effects of moral disengagement on prelicensure nursing students’ tendencies to engage in academic dishonesty in their last or next to last semester of a nursing program. A correlational design via survey method was used. …

Cerebrovascular Reactivity Mri As A Biomarker For Cerebral Small Vessel Disease–Related Cognitive Decline: Multi-Site Validation In The Markvcid Consortium, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Cuimei Xu, Dengrong Jiang, Jay J. Pillai, Emma Lucke, Christopher E. Bauer, Brian T. Gold, Steven M. Greenburg, Karl G. Helmer, Kay Jann, Gregory Jicha, Joel Kramer, Pauline Maillard, Rachel M. Mulavelil, Pavel Rodriguez, Claudia L. Satizabal, Kristin Schwab, Sudha Seshadri, Herpreet Singh, Ángel G. Velarde Dediós, Danny J. J. Wang, Rita R. Kalyani, Abhay Moghekar, Paul B. Rosenberg, Sevil Yasar, Marilyn Albert, Hanzhang Lu

Neurology Faculty Publications

INTRODUCTION: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis.

METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.

RESULTS: CVR …

Relationships Between Trauma Types And Psychotic Symptoms: A Network Analysis Of Patients With Psychotic Disorders In A Large, Multi-Country Study In East Africa, Anne Stevenson, Supriya Misra, Engida Girma, Adela-Maria Isvoranu, Dickens Akena, Melkam Alemayehu, Lukoye Atwoli, Bizu Gelaye, Stella Gichuru, Symon Kariuki

Internal Medicine, East Africa

Background: The link between trauma exposure and psychotic disorders is well-established. Further, specific types of trauma may be associated with specific psychotic symptoms. Network analysis is an approach that can advance our understanding of the associations across trauma types and psychotic symptoms. Methods: We conducted a network analysis with data from 16,628 adult participants (mean age [standard deviation] = 36.3 years [11.5]; 55.8% males) with psychotic disorders in East Africa recruited between 2018 and 2023. We used the Life Events Checklist and the Mini International Neuropsychiatric Interview to determine whether specific trauma types experienced over the life course and specific …

An Examination Of Traumatic Brain Injury And Genes For Neurotrophins And Apolipoprotein E In Predicting Cognitive Function In Older Adults: The Cache County Study, Mikaela A. Drewel

All Graduate Theses and Dissertations, Fall 2023 to Present

Recovery from a traumatic brain injury (TBI) is influenced by a wide array of factors including age at incidence, number, and severity as well as genetic factors, some of which exhibit sex-dependent effects. This study examines how TBI history influences rate of cognitive decline in older adults, exploring the characteristics of TBI (e.g., number, severity, and timing) as predictors and interactions of TBI history with genetic variants suspected to play a role in brain health and late-life cognitive functioning. These genes include the Apolipoprotein E (APOE) as well as brain derived neurotrophic factor (BDNF) and its receptors. This study analyzed …

Synaptic Fidelity For Drug Development: Is It Time To Move Beyond Glutamate Release And Receptors?, Chadi G Abdallah, Amanda J F Tamman

Faculty, Staff and Students Publications

No abstract provided.

A Content Analysis Of Self-Report Child Anxiety Measures, Minjee Kook, Jane W Clinger, Eric Lee, Sophie C Schneider, Eric A Storch, Andrew G Guzick

Faculty, Staff and Students Publications

A clear understanding of the item content of psychological assessments is critical but often overlooked. This study describes the content overlap of seven commonly used and psychometrically validated measures of anxiety among children and adolescents. Symptom codes were created for all items across measures and items were sorted by these codes, which all fell into specific symptom categories. We conducted two analyses of all items: a "bottom-up" content categorization approach, which used symptom categories that were developed during this study, and a "top-down" DSM-5 categorization which mapped items onto symptoms of anxiety disorders in the DSM-5. Findings reveal a weak …

Cognitive Behavioral Therapy Factors Related To Outcomes In Depression Among Youth With Hiv, Betsy D Kennard, Larry K Brown, Kristin Baltrusaitis, Miriam Chernoff, Graham J Emslie, Jessica Jones, Sarah Buisson, Jaime Deville, Megan Wilkins, Amber Bunch, Chivon Mcmullen Jackson, Christy Beneri, David E Shapiro

Faculty, Staff and Students Publications

PURPOSE: This is a secondary analysis of a multi-site, cluster (site) randomized trial of the efficacy of a combined Health and Wellness Cognitive Behavior Therapy (H&W CBT) and medication management approach for depression in youth with HIV (YWH) compared to standard care. In this study, we explored the association between H&W CBT factors and depression outcomes after 24 weeks of treatment to discover treatment elements associated with symptom reduction.

METHODS: Participants (12-24 years of age) were YWH in the United States (US) diagnosed with moderate to severe depression [Quick Inventory of Depressive Symptomatology (QIDS), Clinician-Rated score ≥ 11]. Thirteen US …

Comparative Effectiveness Research Trial For Antidepressant Incomplete And Non-Responders With Treatment Resistant Depression (Ascertain-Trd) A Randomized Clinical Trial, George I Papakostas, Madhukar H Trivedi, Richard C Shelton, Dan V Iosifescu, Michael E Thase, Manish K Jha, Sanjay J Mathew, Charles Debattista, Mehmet E Dokucu, Olga Brawman-Mintzer, Glenn W Currier, William Vaughn Mccall, Mandana Modirrousta, Matthew Macaluso, Alexander Bystritsky, Fidel Vila Rodriguez, Erik B Nelson, Albert S Yeung, Anna Feeney, Leslie C Macgregor, Thomas Carmody, Maurizio Fava

Staff and Researcher Publications

Further research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacological augmentation is superior to antidepressant switch, or vice-versa. The objective of this study was to compare the effectiveness of augmentation with aripiprazole or repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine XR (or duloxetine for those not eligible to receive venlafaxine) for treatment-resistant depression. In this multi-site, 8-week, randomized, open-label study, 278 subjects (196 females and 82 males, mean age 45.6 years (SD 15.3)) with …

Exploring Psychology Graduate Students’ Desire And Ability To Discuss Their Personal Trauma History With Clinical Supervisors, Madeleine Lane

Dissertations

Inspired by the archetype of the “wounded healer,” described by Carl Jung as a psychologist who enters the field with psychological wounds of their own, and the prevalence of such wounded healers in the mental health field today, this study aimed to explore clinical psychology doctoral students’ experiences of self-disclosure of their personal trauma history, a specific type of psychological wound, in clinical supervision. The goal was to explore whether and how students’ trauma history is discussed in clinical supervision; the importance of such discussions for students’ professional and personal development; and the impact of having or not having …

Exploring The Relationship Between Cognitive Inflexibility And Anxiety In Youth On The Autism Spectrum, Farah Mahmud

Theses, Dissertations and Culminating Projects

Anxiety symptoms are prevalent among autistic youth but frequently get overlooked due to issues of diagnostic overlap and atypical presentations of anxiety (Kerns et al., 2014; Wood & Gadow, 2010). Emerging literature suggests that cognitive differences specific to autism, such as cognitive inflexibility, may be associated with vulnerability of developing and maintain anxiety symptoms (Stark et al., 2021). Cognitive flexibility (CF), the ability to shift thinking and attention according to situational demands, is thought to be impaired in many autistic children, given the behavioral rigidity observed in this population (Geurts et al., 2009). However, further work is needed to tease …

Exploring Complete Mental Health Screening Using Adolescent Self-Reports, Stephanie A. Vinal

All Graduate Theses and Dissertations, Fall 2023 to Present

This study comprises two separate papers that ultimately aim to create and support the use of a new school screening tool to identify student risk for a variety of school-based problems as well as identify their individual strengths. Complete mental health screening refers to a process by which the entire student body of a school is administered a screening tool in order to cast a wide net and increase the likelihood of identifying any student at risk for behavioral, social, emotional, or academic difficulties. By identifying student strengths as well as their risk for problems, schools are better aimed at …

Purpose In Life And Associated Cognitive And Affective Mechanisms, Louis Fang, Alfred Allan, Joanne M. Dickson

Research outputs 2022 to 2026

Purpose in life is a well-established contributor to positive well-being. However, for a more comprehensive understanding of purpose in life, further exploration is needed about the processes implicated in purpose from a cognitive and affective perspective. This scoping review aims to identify the cognitive and/or affective mechanisms (CAMs) correlating with purpose in life and to examine these relationships based on relevant existing literature. Using search terms related to CAMs and purpose in life, we conducted a comprehensive search across five databases (Web of Science, Medline, Pubmed, Scopus, and psycinfo) to identify those examining the relationship between these constructs. Ninety-nine manuscripts …