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2022

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Articles 181 - 210 of 604

Full-Text Articles in Psychiatry and Psychology

The Impact Of Covid-19 On The Psychological Well-Being Of Surgeons In Pakistan: A Multicenter Cross-Sectional Study, Sana Zeeshan, Mehdia Rajab Ali, Rehan N. Khan, Asad R. Allana, Nida Zahid, Muhammad Kazim Najjad, Arslan A. Abro, Muhammad Ali Nadeem, Zeeshan Mughal, Irshad Ahmed Jul 2022

The Impact Of Covid-19 On The Psychological Well-Being Of Surgeons In Pakistan: A Multicenter Cross-Sectional Study, Sana Zeeshan, Mehdia Rajab Ali, Rehan N. Khan, Asad R. Allana, Nida Zahid, Muhammad Kazim Najjad, Arslan A. Abro, Muhammad Ali Nadeem, Zeeshan Mughal, Irshad Ahmed

Section of General Surgery

Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic left a profound and pervasive impact on the healthcare infrastructure on a global scale. Since its onset, the pattern of reported cases and its associated mortality had shown variability with intermittent peaks causing a significant effect on the psychological well-being of the surgeons of Pakistan. The aim of this study was to assess the effects of the COVID-19 pandemic on the mental well-being of surgeons in Pakistan. Methods This multicenter cross-sectional study was carried out to assess the impact of COVID-19 on the psychological well-being of surgeons in Pakistan. The …


Virtual Behavioral Health Treatment Satisfaction And Outcomes Across Time, Mindy R. Waite, Sara Diab, James Adefisoye Jul 2022

Virtual Behavioral Health Treatment Satisfaction And Outcomes Across Time, Mindy R. Waite, Sara Diab, James Adefisoye

Journal of Patient-Centered Research and Reviews

Purpose: The COVID-19 pandemic continues to have major and long-lasting impacts on health care delivery and mental health. As health care shifted to telehealth, legislation was adjusted to expand telehealth allowances, creating a unique opportunity to elucidate outcomes. The aim of this study was to assess long-term patient and clinician satisfaction and outcomes with virtual behavioral health.

Methods: Data were obtained over 16 months from surveys to patients and clinicians receiving/providing virtual treatment. Outcomes data also were collected from medical records of adults receiving in-person and virtual behavioral health treatment. Data were summarized using descriptive statistics. Groups were compared using …


Can Variables From The Electronic Health Record Identify Delirium At Bedside?, Ariba Khan, Kayla Heslin, Michelle Simpson, Michael L. Malone Jul 2022

Can Variables From The Electronic Health Record Identify Delirium At Bedside?, Ariba Khan, Kayla Heslin, Michelle Simpson, Michael L. Malone

Journal of Patient-Centered Research and Reviews

Delirium, a common and serious disorder in older hospitalized patients, remains underrecognized. While several delirium predictive models have been developed, only a handful have focused on electronic health record (EHR) data. This prospective cohort study of older inpatients (≥ 65 years old) aimed to determine if variables within our health system’s EHR could be used to identify delirium among hospitalized patients at the bedside. Trained researchers screened daily for delirium using the 3-minute diagnostic Confusion Assessment Method (3D-CAM). Patient demographic and clinical variables were extracted from the EHR. Among 408 participants, mean age was 75 years, 60.8% were female, and …


Abstracts From The 2022 Health Care Systems Research Network (Hcsrn) Annual Conference Jul 2022

Abstracts From The 2022 Health Care Systems Research Network (Hcsrn) Annual Conference

Journal of Patient-Centered Research and Reviews

The Health Care Systems Research Network (HCSRN) is comprised of 20 health systems with embedded research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate scientific findings, explore new collaborations, and share insights about conducting research in real-world care delivery settings. Abstracts accepted for presentation at HCSRN 2022 are published in this supplement of Journal of Patient-Centered Research and Reviews, the official journal of HCSRN’s annual conference proceedings.


Increasing Naloxone Co-Prescribing Among At-Risk Individuals: Evaluation Of A Quality Improvement Project In A Large Health System, Sarah Hemphill Ba, Kristen Silvia Md, Marc D. Kimball Md Jul 2022

Increasing Naloxone Co-Prescribing Among At-Risk Individuals: Evaluation Of A Quality Improvement Project In A Large Health System, Sarah Hemphill Ba, Kristen Silvia Md, Marc D. Kimball Md

Journal of Maine Medical Center

Background: Naloxone availability and early administration is key in preventing death following opioid overdose. The CDC advises that naloxone should be made available to all at-risk individuals. In 2017, providers at Maine Medical Center noted that only 6% of at-risk patients had naloxone prescriptions

Methods: Included in this study were all patients of MaineHealth, a health system comprising 9 hospitals and 30 primary care practices, serving approximately 1.1 million patients. Between 2017 and 2020, we implemented several system-wide quality improvement interventions to increase rates of naloxone co-prescribing among at-risk individuals. Risk factors included prescribed opioids ≥50 morphine milligram equivalents, concurrent …


Contribution Of Early-Life Unpredictability To Neuropsychiatric Symptom Patterns In Adulthood, Andrea D. Spadoni, Meghan Vinograd, Bruna Cuccurazzu, Katy Torres, Laura M. Glynn, Elysia P. Davis, Tallie Z. Baram, Dewleen G. Baker, Caroline M. Nievergelt, Victoria B. Risbrough Jul 2022

Contribution Of Early-Life Unpredictability To Neuropsychiatric Symptom Patterns In Adulthood, Andrea D. Spadoni, Meghan Vinograd, Bruna Cuccurazzu, Katy Torres, Laura M. Glynn, Elysia P. Davis, Tallie Z. Baram, Dewleen G. Baker, Caroline M. Nievergelt, Victoria B. Risbrough

Psychology Faculty Articles and Research

Background

Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the hypothesis that self-reported early-life unpredictability is associated with psychiatric symptoms in adult clinical populations.

Methods

Using the newly validated Questionnaire of Unpredictability in Childhood, we assessed early-life unpredictability in 156 trauma-exposed adults, of which 65% sought treatment for mood, anxiety, and/or posttraumatic stress disorder (PTSD) …


A Survey Of The Mental Health Of Uk Olympic And Paralympic Sport Athletes., Sandra D. Leyland Dr, Alan Currie Prof, Elizabeth Board Dr, Amit D. Mistry Dr, Rod Jaques Dr, Craig Ranson Dr Jul 2022

A Survey Of The Mental Health Of Uk Olympic And Paralympic Sport Athletes., Sandra D. Leyland Dr, Alan Currie Prof, Elizabeth Board Dr, Amit D. Mistry Dr, Rod Jaques Dr, Craig Ranson Dr

Journal of Athlete Development and Experience

Abstract

This study examined the prevalence of psychological distress and well-being amongst elite athletes in the UK.

An online survey was emailed to 753 athletes within the English Institute of Sport. Response rate 52.3%. 371 participants (median age 25) completed measures of psychological distress and subjective well-being alongside demographics and sport-related variables.

High or very high psychological distress was reported by 23.7%. Poor subjective well-being was reported by 18.8%. Of those reporting psychological distress, 9% also reported good subjective well-being. The odds of psychological distress and poor well-being increased if the athlete was female (OR 2.03, distress; OR 2.00, poor …


Evaluating Sbirt In A Behavioral Health Urgent Care, Christina L. Williams Jul 2022

Evaluating Sbirt In A Behavioral Health Urgent Care, Christina L. Williams

Dissertations

Background: Adolescent substance use (SU) is a major health concern. Most youth who engage in alcohol and other SU do not meet criteria for SU disorder (SUD). Nonetheless, evidence shows SU during adolescence impacts cognitive, social, and emotional development, increases risk of physical injury, and may progress to SUD in adulthood. Only half of clinicians properly screen adolescents for SU; those identified with SUD often receive no intervention. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based intervention to address this problem. The purpose of this project was to evaluate implementation of SBIRT using CRAFFT 2.1+N, a SU …


Spectral Clustering Of Single-Cell Multi-Omics Data On Multilayer Graphs, Shuyi Zhang, Jacob R Leistico, Raymond J Cho, Jeffrey B Cheng, Jun S Song Jul 2022

Spectral Clustering Of Single-Cell Multi-Omics Data On Multilayer Graphs, Shuyi Zhang, Jacob R Leistico, Raymond J Cho, Jeffrey B Cheng, Jun S Song

Staff and Researcher Publications

Motivation: Single-cell sequencing technologies that simultaneously generate multimodal cellular profiles present opportunities for improved understanding of cell heterogeneity in tissues. How the multimodal information can be integrated to obtain a common cell type identification, however, poses a computational challenge. Multilayer graphs provide a natural representation of multi-omic single-cell sequencing datasets, and finding cell clusters may be understood as a multilayer graph partition problem.

Results: We introduce two spectral algorithms on multilayer graphs, spectral clustering on multilayer graphs and the weighted locally linear (WLL) method, to cluster cells in multi-omic single-cell sequencing datasets. We connect these algorithms through a unifying mathematical …


Age-Related Changes In Diffuse Optical Tomography Sensitivity Profiles From Childhood To Adulthood, Xiaoxue Fu Ph.D., John E. Richards Jul 2022

Age-Related Changes In Diffuse Optical Tomography Sensitivity Profiles From Childhood To Adulthood, Xiaoxue Fu Ph.D., John E. Richards

Faculty Publications

Significance: Diffuse optical tomography (DOT) uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the brain location that generates the hemodynamic signal require accurate descriptions of the DOT sensitivity to the underlying cortex. DOT sensitivity profiles are different in infants compared with adults. However, the descriptions of DOT sensitivity profiles from early childhood to adulthood are lacking despite the continuous head and brain development.

Aim: We aim to investigate age-related differences in DOT sensitivity profiles in individuals aged from 2 to 34 years with narrow age ranges of 0.5 or 1 year.

Approach: We implemented …


Visualizing Depressive Symptom Improvement: Implementing The 17-Item Hamilton Depression Rating Scale, Briana Raterman Jul 2022

Visualizing Depressive Symptom Improvement: Implementing The 17-Item Hamilton Depression Rating Scale, Briana Raterman

Dissertations

Visualizing Depressive Symptom Improvement: Implementing the 17-Item Hamilton Depression Rating Scale

Abstract

Problem

Depression, a mental health diagnosis, has affected about 18.5% of adults (Villarroel & Terlizzi, 2020). Ketamine, a medication initially used as an anesthetic, has improved depressive symptoms in individuals struggling with treatment-resistant depression.

Method

This quality improvement (QI) project used the 17-item Hamilton Depression Rating Scale questionnaire to assess depressive symptom changes in patients receiving intramuscular ketamine for treatment-resistant depression. The questionnaire was administered to patients pre-and post-intramuscular ketamine administration. The data was collected on injections one, three, and six on each participant’s set schedule of injections …


Life Matters, Marina Fischer Jul 2022

Life Matters, Marina Fischer

Dissertations

Problem: One of the challenges facing many primary care providers is managing hypertension. Hypertension contributes to cardiovascular disease events. Consequently, the high occurrence of hypertension related visits signifies a clinical practice gap in hypertension management resulting in substandard blood pressure outcomes. The purpose of this clinical scholarship project was to assess the difference of pre and post Quality of Life Scale (QOLS) scores in a hypertensive population.

Methods: This quality improvement project used a longitudinal, observational design with prospective data collection. The sample included newly diagnosed hypertensive adults ages 21 to 64 years old. The sample was administered the World …


Evaluating Patient Health Questionnaire-9 (Phq-9) Use In Burn Survivors, Chelsey Friend Jul 2022

Evaluating Patient Health Questionnaire-9 (Phq-9) Use In Burn Survivors, Chelsey Friend

Dissertations

Problem: A burn injury affects both psychological and physical health, resulting in a greater than 50% major depressive disorder morbidity. The purpose of this quality improvement (QI) project is to evaluate the use of the Patient Health Questionnaire-9 (PHQ-9) in adult burn survivors, with an aim to increase the use of the screening tool.

Methods: A mixed-methods pre/post-survey design with an educational component was utilized to assess nurse knowledge, confidence, willingness, and barriers to completion of the PHQ-9. Aggregate data were collected to determine PHQ-9 completion rates for patients admitted to and discharged from the unit during the two months …


Mothers’ Reflections On Cat Ownership For A Child With Autism Spectrum Disorder During Covid-19, Saskia Keville, Sophia De Vita, Amanda K. Ludlow Jul 2022

Mothers’ Reflections On Cat Ownership For A Child With Autism Spectrum Disorder During Covid-19, Saskia Keville, Sophia De Vita, Amanda K. Ludlow

People and Animals: The International Journal of Research and Practice

Animal- assisted interventions are increasingly used as a complementary therapy in clinical practice to support people with autism spectrum disorder (ASD), with promising outcomes compared to traditional therapies. Less is understood about the therapeutic benefits of more accessible and affordable small pet ownership for families with a child with ASD, alongside the pets’ welfare living in these homes. This study explored the experiences of cat ownership for young people with ASD from the perspective of their mothers during a time of transition generated by COVID-19. Semi-structured interviews were conducted with six mothers and transcripts analyzed using reflexive thematic analysis. Three …


Associations Of Discrimination With Drinking Behavior In Multiracial College Students: Protective Role Of Racial Socialization, Fatima Dobani Jul 2022

Associations Of Discrimination With Drinking Behavior In Multiracial College Students: Protective Role Of Racial Socialization, Fatima Dobani

Theses - ALL

Despite the rapid growth of the Multiracial population in the United States, less is known about correlates of their health behaviors. Nascent findings demonstrate elevated rates of drinking behavior among Multiracial college students compared to their monoracial counterparts. Theoretical models posit that racial socialization by primary caregivers may change the magnitude of the relationship of discrimination with drinking behavior among Multiracial individuals. The role of racial socialization, however, has not been tested specifically among Multiracial college students. In this cross-sectional survey study, 193 undergraduate students (Mage = 20 years [SD = 1.33]; 30% male; 33% Greek affiliated) reporting lifetime alcohol …


The Importance Of Treatment Integrity: Examining The Effect Of Dosage On Intervention Outcomes, Samantha C. Maguire Jul 2022

The Importance Of Treatment Integrity: Examining The Effect Of Dosage On Intervention Outcomes, Samantha C. Maguire

Theses - ALL

Treatment integrity is a critical component to evaluating the impact of interventions (Collier-Meek et al., 2018). However, one frequently underreported and unacknowledged dimension of treatment integrity is intervention dosage. Determining the amount of treatment (i.e., dosage) necessary to produce desired changes is important to increasing our understanding of the impact of an intervention and the development of a more efficient and precise method of organizing and delivering treatments (Codding et al., 2016). Utilizing data (n = 391) from four individual randomized control trials and three clustered randomized control trials, the purpose of the present study was to descriptively examine the …


Change In Students’ Peer Evaluations Of Requirements Elicitation Interviews Across The Pre-Pandemic And Pandemic-Affected Semesters, Dmytro Babik, Iryna Babik Jul 2022

Change In Students’ Peer Evaluations Of Requirements Elicitation Interviews Across The Pre-Pandemic And Pandemic-Affected Semesters, Dmytro Babik, Iryna Babik

Psychological Sciences Faculty Publications and Presentations

Successful development of an information system to solve a business problem depends on the analyst’s ability to elicit system requirements from a user. This complex competency could be trained via critical peer evaluation of the requirements elicitation (RE) interviews. In this study, 294 students across four pre-pandemic and two COVID-19 pandemic-affected semesters evaluated recorded sample RE interviews of low and high quality. A piecewise regression modeling was used to examine the change in students’ evaluations separately for the pre-pandemic and pandemic-affected semesters. Current results showed that students exhibited inflated evaluation scores (relative to instructors’ scores) for the high-quality, but not …


Moral Distress During Covid-19: The Importance Of Perceived Organizational Support For Hospital Nurses, Abigail Latimer, Melanie D. Otis, Gia Mudd-Martin, Debra K. Moser Jul 2022

Moral Distress During Covid-19: The Importance Of Perceived Organizational Support For Hospital Nurses, Abigail Latimer, Melanie D. Otis, Gia Mudd-Martin, Debra K. Moser

UK CARES Faculty Publications

Moral distress, or the inability to act congruent with moral beliefs, has been of concern for healthcare professionals especially since the COVID-19 pandemic. Hospital nurses are particularly affected in their roles with mounting administrative pressures and demands. We examined whether general and COVID- specific support in employing healthcare organizations predicted moral distress in a sample of inpatient hospital nurses. A total of 248 nurses completed the Measure of Moral Distress for Healthcare Professionals, Survey of Perceived Organizational Support, COVID Organizational Support survey, and the Hospital Ethical Climate Scale. We found that general and COVID-related organizational support were predictors of moral …


10-Minute Ebd: Stimulant Medications, Rampant Caries, And Prevention, Madison Thomas Bs, Nancy Poznick Dds, Melanie E. Mayberry Dds, Ms-Hcm Jul 2022

10-Minute Ebd: Stimulant Medications, Rampant Caries, And Prevention, Madison Thomas Bs, Nancy Poznick Dds, Melanie E. Mayberry Dds, Ms-Hcm

The Journal of the Michigan Dental Association

The 10-Minute Evidence-Based Dentistry Column illustrates how to implement the evidence-based dentistry search process to quickly identify and apply the best literature to answer a clinical question. Through critical appraisal, the author of this article answers the clinical question of a connection between stimulant medications, rampant caries, and prevention, with a focus on the impact of ADHD medication on oral health. The term "meth mouth" often associated with dental decay is discussed in the context of xerostomia (dry mouth), a common side effect of stimulant medications. The article uses the PICO (Population, Intervention, Comparison, Outcome) system to formulate a research …


‘Mapping’ Moral Engagement In The Solution-Focused Approach Through Macintyre’S Model Of Practice, Brian K. Jennings Jul 2022

‘Mapping’ Moral Engagement In The Solution-Focused Approach Through Macintyre’S Model Of Practice, Brian K. Jennings

Journal of Solution Focused Practices

I attempt to answer Trish Walsh’s two questions about the ‘maps’ that might exist for moral engagement in the ‘helping’ professions and how these might relate to the Solution-Focused Approach (Walsh, 2010). I seek to do this by exploring the narrative of the emergence of the Solution Focused Approach from the perspective of Alasdair MacIntyre’s concept of a ‘practice’ (MacIntyre, 1985) with the aim of providing the basis for ‘map’ for moral engagement by Solution-Focused Practitioners. To this end I attempt to interpret the Solution Focused Approach as a MacIntyreian ‘practice’ in which virtues (as ‘human qualities’) emerge out of …


Health Inequities As Measured By The Eq-5d-5l During Covid-19: Results From New York In Healthy And Diseased Persons, Erica I. Lubetkin, Di Long, Juanita A. Haagsma, Mathieu F. Janssen, Gouke J. Bonsel Jul 2022

Health Inequities As Measured By The Eq-5d-5l During Covid-19: Results From New York In Healthy And Diseased Persons, Erica I. Lubetkin, Di Long, Juanita A. Haagsma, Mathieu F. Janssen, Gouke J. Bonsel

Publications and Research

Introduction: The effects of the COVID-19 pandemic caused considerable psychological and physical effects in healthy and diseased New Yorkers aside from the effects in those who were infected. We investigated the relationship between known risk-enhancing and health-promoting factors (social and medical), comorbidity indicators, and, as the primary outcome, health-related quality of life (HRQoL).

Methods: Between April 22 and May 5, 2020, a market research agency (Dynata) administered a digital survey including the EQ-5D-5L and items related to individual characteristics, social position, occupational and insurance status, living situation, exposures (smoking and COVID-19), detailed chronic conditions, and experienced access to care to …


Simulated Owl Predation During Foraging Differentially Alters Choice And Fear Behavior Between Sex In Rats, Meghan M. Olsen Jul 2022

Simulated Owl Predation During Foraging Differentially Alters Choice And Fear Behavior Between Sex In Rats, Meghan M. Olsen

Research Psychology Theses

Existing research on the predator cue circuit has indicated there are observed differences between sexes of animals either directly or indirectly exposed to a predator stimulus. Exposure increases predator directed attention, and overrides other motivational systems (hunger, pain, reproductive behavior). Little research has explored whether exposure to predation is associated with differential responses to non-predator related decision-making across a variety of tasks. Therefore, understanding the prioritization of motivational states when a predator stressor is present can aid in understanding sex differences in these processes in both adaptative and maladaptive conditions. To determine how repeated exposure to a predator stressor differentially …


J Mich Dent Assoc July 2022 Jul 2022

J Mich Dent Assoc July 2022

The Journal of the Michigan Dental Association

Monthly, The Journal of the Michigan Dental Association brings news, information, and feature articles to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists! In this July 2022 issue, the reader will find the following original content:

  • A cover feature on negotiating reimbursement rates with PPO contracts.
  • A cover feature on guarding against employee embezzlement.
  • A 10-Minute EBD on rampant caries management and prevention with ADHD patients taking stimulant medications.
  • A Back Page look at the 2022 MDA award winners.
  • News you need: an Editorial, guidance on dental practice cybersecurity, and regular department …


Cannabis Sleep Aid Use In Daily College Life: An Intensive Longitudinal Assessment Approach, Patricia A. Goodhines Jul 2022

Cannabis Sleep Aid Use In Daily College Life: An Intensive Longitudinal Assessment Approach, Patricia A. Goodhines

Dissertations - ALL

Objective: Emerging evidence suggests that college cannabis sleep aid use may increase vulnerability to diurnal impairment, despite proximal sleep-related benefits. In contrast, relatively little is known about proximal precipitants of cannabis sleep aid use in daily college life. The identification of modifiable, situational intervention points preceding cannabis sleep aid use in daily college life is critical to accelerate the development of college harm reduction efforts. This 14-night mixed methods study tested temporal associations of THC-based cannabis sleep aid use with cognitive arousal-based precipitants (consistent with cognitive theory of insomnia) and sleep outcomes.

Method: Daily diary (pre-sleep and waking) and actigraphy …


The Utilization And Validation Of The Human Factors Intervention Matrix And The Companion Assessment Tool Faces In The Development Of Novel Interventions, Victoria Lew Jul 2022

The Utilization And Validation Of The Human Factors Intervention Matrix And The Companion Assessment Tool Faces In The Development Of Novel Interventions, Victoria Lew

Doctoral Dissertations and Master's Theses

The purpose of the current project was to utilize and validate the Human Factors Intervention Matrix (HFIX) and the companion assessment tool FACES regarding developing and ranking novel interventions. This was completed by 1. Uncovering whether brainstorming with HFIX generated a higher quantity, quality, and broader breadth of ideas compared to traditional brainstorming, and 2. Seeing whether the modality in which HFIX was utilized affected the quantity, quality, and breadth of ideas generated. This research employed a 2x2 between-subjects experimental design (n = 120) where participants were assigned to groups of three in one of the four conditions. Analyses …


Distress Tolerance: Prospective Associations With Cognitive-Behavioral Therapy Outcomes In Adults With Posttraumatic Stress And Substance Use Disorders, Anka A Vujanovic, Heather E Webber, Shelby J Mcgrew, Charles E Green, Scott D Lane, Joy M Schmitz Jul 2022

Distress Tolerance: Prospective Associations With Cognitive-Behavioral Therapy Outcomes In Adults With Posttraumatic Stress And Substance Use Disorders, Anka A Vujanovic, Heather E Webber, Shelby J Mcgrew, Charles E Green, Scott D Lane, Joy M Schmitz

Faculty, Staff and Student Publications

Distress tolerance (DT; perceived or actual ability to tolerate aversive physical or emotional states) is related to both posttraumatic stress disorder (PTSD) symptoms and substance use disorders (SUD). This investigation evaluates self-report and behavioral measures of DT as potential predictors of PTSD and SUD cognitive-behavioral therapy outcomes. Participants included 41 treatment-seeking adults (53.7% women; 73.2% African American; Mage= 44.90, SD = 9.68) who met at least four symptoms of DSM-5 PTSD and DSM-IV substance dependence, assessed via structured interviews. At baseline (pre-treatment), participants completed the Distress Tolerance Scale (DTS), Mirror-Tracing Persistence Task (MTPT), Breath Holding task, and Paced Auditory …


Non-Alcoholic Fatty Liver Disease And Depression: Evidence For Genotype × Environment Interaction In Mexican Americans, Eron G. Manusov, Vincent P. Diego, Khalid Sheikh, Sandra Laston, John Blangero, Sarah Williams-Blangero Jul 2022

Non-Alcoholic Fatty Liver Disease And Depression: Evidence For Genotype × Environment Interaction In Mexican Americans, Eron G. Manusov, Vincent P. Diego, Khalid Sheikh, Sandra Laston, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G × E interactions for hepatic fibrosis × BDI-II. These findings provide evidence that genetic factors …


Dose-Related Effects Of Ketamine For Antidepressant-Resistant Symptoms Of Posttraumatic Stress Disorder In Veterans And Active Duty Military: A Double-Blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial, Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A Sherif, Eric J Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M Southwick, Ismene L Petrakis, Rebecca R Burson, Kevin B Guthmiller, Argelio L López-Roca, Karl A Lautenschlager, John P Mccallin, Matthew B Hoch, Alexandar Timchenko, Sergio E Souza, Charles E Bryant, Jim Mintz, Brett T Litz, Douglas E Williamson, Terence M Keane, Alan L Peterson, John H Krystal Jul 2022

Dose-Related Effects Of Ketamine For Antidepressant-Resistant Symptoms Of Posttraumatic Stress Disorder In Veterans And Active Duty Military: A Double-Blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial, Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A Sherif, Eric J Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M Southwick, Ismene L Petrakis, Rebecca R Burson, Kevin B Guthmiller, Argelio L López-Roca, Karl A Lautenschlager, John P Mccallin, Matthew B Hoch, Alexandar Timchenko, Sergio E Souza, Charles E Bryant, Jim Mintz, Brett T Litz, Douglas E Williamson, Terence M Keane, Alan L Peterson, John H Krystal

Staff and Researcher Publications

This study tested the efficacy of repeated intravenous ketamine doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n = 158) who failed previous antidepressant treatment were randomized to 8 infusions administered twice weekly of intravenous placebo (n = 54), low dose (0.2 mg/kg; n = 53) or standard dose (0.5 mg/kg; n = 51) ketamine. Participants were assessed at baseline, during treatment, and for 4 weeks after their last infusion. Primary analyses used mixed effects models. The primary outcome measure was the self-report PTSD Checklist for DSM-5 (PCL-5), and secondary outcome …


Examining The Social Validity Of Parent Training: Post-Participation Parent Perceptions And Reflections Of Group Triple P, Nycole C. Kauk Jul 2022

Examining The Social Validity Of Parent Training: Post-Participation Parent Perceptions And Reflections Of Group Triple P, Nycole C. Kauk

USF Tampa Graduate Theses and Dissertations

Child behavior problems are highly prevalent and impactful on the child and their family system, bringing both short-term and long-term consequences (Sanders, 2012). Many risk factors for child behavior problems are modifiable via the use of Behavioral Family Interventions, such as behavioral parent training programs (Kazdin, 1991). Behavioral Family Interventions (BFI) modify factors within the family system to minimize modifiable risk factors and engineer protective factors to produce behavior change (Kazdin, 1991). While several manualized behavioral parenting interventions exist, the Triple P parenting program is one of the most researched and effective programs used internationally, particularly the Level 4 package; …


Gender Dysphoria Versus Acute Psychosis: Can One Properly Diagnose Gender Dysphoria Solely During Acute Psychosis?, Kristy A. Fisher, Samantha Scemla, Clara L. Alvarez Villalba, Jessica Kroin Jun 2022

Gender Dysphoria Versus Acute Psychosis: Can One Properly Diagnose Gender Dysphoria Solely During Acute Psychosis?, Kristy A. Fisher, Samantha Scemla, Clara L. Alvarez Villalba, Jessica Kroin

HCA Healthcare Journal of Medicine

Gender dysphoria occurs when a discrepancy between one’s sex assigned at birth and one’s gender identity causes distress or impairment in function, which can lead ultimately to seeking treatment in the forms of psychotherapy, hormonal therapy, and/or gender-affirming surgery. Clinical care guidelines also recommend pharmacological treatment of psychiatric comorbidities if indicated. A review of the current literature demonstrates comorbidity between gender dysphoria and psychosis, including cases of gender dysphoria with schizophrenia and the occurrence of gender dysphoria symptoms during manic or psychotic episodes. The existing literature has yet to specifically examine gender dysphoria amongst individuals with schizoaffective disorder. The authors …