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Articles 331 - 360 of 474
Full-Text Articles in Psychiatry and Psychology
An Investigation Into The Relationship Between Academic Pressure And Non-Medical Prescription Stimulant Use Among University Of South Carolina Undergraduate Students, Arslan Valimohamed
An Investigation Into The Relationship Between Academic Pressure And Non-Medical Prescription Stimulant Use Among University Of South Carolina Undergraduate Students, Arslan Valimohamed
Senior Theses
One hundred and six undergraduate students of the University of South Carolina were surveyed to understand misuse of prescription stimulants and how perceived academic pressure may play a role in this behavior. Overall, the survey revealed that 33.0% of participants reported illicit use of prescription stimulants in the last 30 days, and 52.8% reported illicitly using prescription stimulants at least once during their time in college. Data from the survey responses indicated that students perceiving academic pressure were more likely to have misused prescription stimulants at least once during their time in college, but only if these students also reported …
Probiotic Administration As An Adjuvant Therapeutic Treatment For Anxiety, Depression, And Cognitive Impairment Among Hypothyroid Patients, Erin R. Gorman
Probiotic Administration As An Adjuvant Therapeutic Treatment For Anxiety, Depression, And Cognitive Impairment Among Hypothyroid Patients, Erin R. Gorman
Selected Honors Theses
Hypothyroidism is a form of thyroid dysfunction that occurs when the thyroid gland does not make and secrete enough thyroid hormones to regulate certain processes in the body. Because thyroid hormones take part in many bodily functions, hypothyroidism can cause a large range of symptoms. Current research indicates that some strains of probiotics have beneficial effects on certain neurological and inflammatory diseases, leading to the impression that they can be used therapeutically for effective treatment of different mental health issues such as anxiety, stress, depression, and impaired memory. Because hypothyroidism often leads to such mental symptoms, it may be possible …
Do Psychopathic Birds Of A Feather Flock Together? Psychopathic Personality Traits And Romantic Preferences, Ashley L Watts, Jessica C Rohr, Katherine L Mccauley, Sarah Francis Smith, Kristin Landfield Howe, Scott O Lilienfeld
Do Psychopathic Birds Of A Feather Flock Together? Psychopathic Personality Traits And Romantic Preferences, Ashley L Watts, Jessica C Rohr, Katherine L Mccauley, Sarah Francis Smith, Kristin Landfield Howe, Scott O Lilienfeld
Staff and Researcher Publications
Objective: The goal of the present studies was to investigate whether people are especially attracted to psychopathic traits, and whether there are individual differences in such attraction.
Method: Female undergraduates (N = 270; Mage = 19; 57% White, 20% Asian, 8% Black) and female and male community members (N = 426; Mage = 37; 56% female; 81% Caucasian, 10% African American, 4% Asian) reported on their own personality and constructed their ideal mate for a dating, short-term, and long-term relationship from a list of 70 characteristics drawn from well-validated criteria for psychopathic personality and diagnostic criteria for DSM-5 personality disorders …
Forgotten Children & Bonds That Heal: The Critical Nature Of Attachment, August Ashbaker
Forgotten Children & Bonds That Heal: The Critical Nature Of Attachment, August Ashbaker
Lesley University Community of Scholars Day
Human attachment is one of the most critical factors in proper neurological and physiological development. Attachment is built through the mutuality of emotional impact, as well as the regular reception of physical touch. Infants and children who have been deprived of these vital necessities through the lacking initiatives of their caregivers—through neglect—display visible signs of its physiological, cognitive, emotional, and behavioral impact. Research has found neglect to be the highest risk factor for permanent damage to brain development in comparison to other forms of complex trauma (i.e. chronic caregiver interpersonal trauma in childhood); it is also the most prevalent …
Oxytocin Receptor Gene (Oxtr) And Father Support Interact To Predict Depressive Symptoms Postpartum, Parambir Bhatti, Taylor Delaney, Michael Poulin, Jennifer Hahn-Holbrook
Oxytocin Receptor Gene (Oxtr) And Father Support Interact To Predict Depressive Symptoms Postpartum, Parambir Bhatti, Taylor Delaney, Michael Poulin, Jennifer Hahn-Holbrook
Psychology Faculty Articles and Research
Postpartum depression (PPD) is a debilitating mental illness affecting approximately 13% of mothers after birth. Both genetic and psychosocial factors contribute to PPD risk, but very little is known about how these factors interact. We tested whether the rs53576 polymorphism in the oxytocin receptor (OXTR) gene accounts for variation in the impact of low social support as a risk factor for depression among mothers during the perinatal period. New mothers (N = 220) provided saliva or blood DNA samples and completed surveys assessing PPD symptoms and perceived social support. In a significant interaction, social support from the …
The Influence Of Stressful Life Events On The Development Of Type 2 Diabetes, Joshua Minks
The Influence Of Stressful Life Events On The Development Of Type 2 Diabetes, Joshua Minks
Dissertations
This study examined the relationship between distress and the development of Type 2 diabetes mellitus (T2DM) in the presence of established risk factors. Distress secondary to mental health disparities, stressful life events, and work conditions has been shown to promote insulin resistance and the development of T2DM.
Subjects (N=79) diagnosed with T2DM within the previous six months were recruited from SSM Health Centers and VA Medical Centers in the greater St. Louis area. They completed the Recent Life Changes Questionnaire, ENRICHD Social Support Instrument, and a demographic survey and analyses were conducted to determine differences between the veteran …
Affiliation, Aggression, And Selectivity Of Peer Relationships In Meadow And Prairie Voles, Nicole S. Lee, Nastacia L. Goodwin, Katherine E. Freitas, Annaliese K. Beery
Affiliation, Aggression, And Selectivity Of Peer Relationships In Meadow And Prairie Voles, Nicole S. Lee, Nastacia L. Goodwin, Katherine E. Freitas, Annaliese K. Beery
Psychology: Faculty Publications
Relationships between adult peers are central to the structure of social groups. In some species, selective preferences for specific peers provide a foundation for consistent group composition. These preferences may be shaped by affiliation toward familiar individuals, and/or by aversion to unfamiliar individuals. We compared peer interactions in two vole species that form selective preferences for familiar same-sex individuals but differ in mating system. Prairie voles (Microtus ochrogaster) form pair bonds with mates and may reside in family groups. Meadow voles (Microtus pennsylvanicus) are promiscuous breeders that form communal winter groups in the wild, and exhibit …
Meeting Point: Partner Dancing As Couple's Therapy, Rami Eckhaus
Meeting Point: Partner Dancing As Couple's Therapy, Rami Eckhaus
Expressive Therapies Dissertations
This dissertation research explored the experience of partner dancing as a therapeutic process that reflects upon the dynamics and interactions of couples who are in the process of couple's therapy. The research also aimed to gain insight on the ways in which the experience of partner dancing can support these couples' therapeutic processes. Partner dancing is a dance-form that is based on the interaction between two individuals. Such interaction requires the dancing couples to communicate on many levels that may uncover layers of their relational dynamics. In this research, five couples who were undergoing couple's therapy were asked to participate …
Systematic Literature Review Of Quetiapine For The Treatment Of Psychosis In Patients With Parkinsonism, Jack J. Chen, Henry Hua, Lilian Massihi, Ivan Portillo, Azita Alipour, William Ondo, Khashayar Dashtipour
Systematic Literature Review Of Quetiapine For The Treatment Of Psychosis In Patients With Parkinsonism, Jack J. Chen, Henry Hua, Lilian Massihi, Ivan Portillo, Azita Alipour, William Ondo, Khashayar Dashtipour
Library Articles and Research
Objective:
The purpose of this article was to determine the efficacy and tolerability of quetiapine compared with placebo or other interventions for psychosis in parkinsonism.
Methods:
Participants with a diagnosis of parkinsonism participated in randomized controlled trials (RCTs) investigating the efficacy and tolerability of quetiapine for psychotic symptoms within a defined follow-up period. The authors conducted searches on PubMed, Cochrane Controlled Register of Trials, and EMBASE for articles published from January 1991 to October 2017. Study methodology and patient- and treatment-level data were independently extracted and summarized by using descriptive statistics. Studies underwent quality assessment for risk of bias.
Results: …
Evaluating Commonalities Between Different Medically Unexplained Symptoms, Dan Guo, Maria Kleinstäuber, Malcolm Henry Johnson, Frederick Sundram
Evaluating Commonalities Between Different Medically Unexplained Symptoms, Dan Guo, Maria Kleinstäuber, Malcolm Henry Johnson, Frederick Sundram
Psychology Faculty Publications
This commentary presents commonalities in medically unexplained symptoms (MUS) across multiple organ systems, including symptoms, aetiological mechanisms, comorbidity with mental health disorders, symptom burden and impact on quality of life. Further, treatment outcomes and barriers in the clinician–patient relationship, and cross-cultural experiences are highlighted. This discussion is necessary in aiding an improved understanding and management of MUS due to the interconnectedness underlying MUS presentations across the spectrum of medical specialties.
Unveiling The Mask:Sexual Trauma's Impact On Academic Achievement, Behavior, And Self-Identity, Teshaunda Hannor-Walker, Sarah Kitchens, Lacey Ricks
Unveiling The Mask:Sexual Trauma's Impact On Academic Achievement, Behavior, And Self-Identity, Teshaunda Hannor-Walker, Sarah Kitchens, Lacey Ricks
National Youth Advocacy & Resilience Conference
Sexual trauma is an unfortunate but a common and often masked experience for many students in America. While sexual trauma in itself is not a mental health disorder, it can become a risk factor for many academic and mental health problems. Trauma-informed schools can play an important role in helping students deal with the aftercare of a traumatic experience.
Developing A Computer Game For Measuring Delay Discounting, Haylee Downey, Ryan L. Becker
Developing A Computer Game For Measuring Delay Discounting, Haylee Downey, Ryan L. Becker
Research on Capitol Hill
Would you prefer $75 now or $100 in the future? What about an unhealthy dessert now or good health in the future? Both of these questions involve a smaller sooner reward option and a larger later reward option. These types of choices can be described in part by delay discounting.
- Delay discounting is the tendency for rewards to lose value when they are presented after a delay .
- Impulsivity is defined as a pattern of choosing smaller sooner rewards. High levels of impulsivity are associated with problematic behaviors.
High levels of impulsivity are associated with high levels of delay discounting. …
An Exploration Of Why Healthcare Professionals Under-Report Observed Patient Aggression, Sydney Bonta
An Exploration Of Why Healthcare Professionals Under-Report Observed Patient Aggression, Sydney Bonta
UNO Student Research and Creative Activity Fair
An Exploration of Why Healthcare Professionals Under-Report Observed Patient Aggression
Authors: Sydney Bonta & Lisa L. Scherer, Ph.D.
Advisor: Lisa L. Scherer, Ph.D.
According to the 2011 US Bureau of Justice Statistics report, medical professionals experienced the third highest proportion of workplace violence (WPV), with violence primarily emanating from patient. In a national survey of nurses employed in hospitals, 76% stated that they had encountered some sort of violence in their workplace (Speroni, Fitch, Dawson, Dugan, Atherton, & Leesburg, 2014). Similarly, patient aggression against physicians has long been a problem (Morrison, Lantos, Levinson, 1998). Despite this widespread exposure to WPV …
The Effect Of Arm Swing On Countermovement Vertical Jump Performance, Arash Mohammadzadeh Gonabadi
The Effect Of Arm Swing On Countermovement Vertical Jump Performance, Arash Mohammadzadeh Gonabadi
UNO Student Research and Creative Activity Fair
Vertical jumping is one of the popular ways to evaluate ankle-knee efficiency in athletic population. Arm swing can play a crucial role in enhancing vertical jump performance. This study aimed to address the differences in kinetic and kinematic parameters during countermovement jump motion with arm swing (AS) and no arm swing (NAS). We used OpenSim to examine the efficacy of AS in reducing the impulse applied to the body and changes in range of lower limb joint angles at landing instant. We calculated the maximum vertical peak of the ground reaction force and impulse generated at landing in two different …
Estimating Variations In Metabolic Cost Within The Stride Cycle During Level And Uphill Walking, Arash Mohammadzadeh Gonabadi
Estimating Variations In Metabolic Cost Within The Stride Cycle During Level And Uphill Walking, Arash Mohammadzadeh Gonabadi
UNO Student Research and Creative Activity Fair
Indirect calorimetry provides the average cost of a stride cycle and prevents from identifying which part of the gait cycle causes increased metabolic cost in patients, however, recent simulation methods allow estimating the time profile of metabolic cost within the stride cycle. In this study, we compare the estimations of the time profile of the metabolic cost of two simulation methods for level and uphill walking. We used kinematic, kinetic and electromyography data from level and uphill walking (one participant) to estimate the time profiles of metabolic cost using the muscle-level metabolic model of Umberger using electromyography and kinematic data …
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
UNO Student Research and Creative Activity Fair
Stimulants are a class of drugs that have a variety of effects on the brain, including changes in receptor activity in the brain areas responsible for- memory, attention, emotion, motor control, and the reward pathway. Stimulants may be generally classified by their availability. For example, prescription stimulants, which include drugs such as methylphenidate (Concerta™, Ritalin™) and mixed amphetamine salts (Adderall™), must be prescribed by medical professionals. Another regulated stimulant, albeit one available without a prescription, is nicotine; a highly addictive chemical that is age-restricted by the U.S. federal government. Nicotine is found in tobacco products, and in tobacco-free alternatives including …
Request For Applications: Neuroscience Summer Research Education Program, University Of Mississippi. Brain Wellness Constellation
Request For Applications: Neuroscience Summer Research Education Program, University Of Mississippi. Brain Wellness Constellation
Brain Wellness
The Brain Wellness Undergraduate Summer Research Program is an initiative of the UM-UMMC Flagship Constellations. The program will provide stipends to undergraduate students for collaborative research experiences in neuroscience related to brain wellness. In this way it will serve to develop new pipelines for pre-graduate and pre-medical students interested in neuroscience to gain research experience and develop collaborative connections between neuroscience faculty at the Oxford and Jackson campuses.
The Lived Experiences Of Parenting Children With Food Allergies: A Phenomenological Study, Anne Zavell
The Lived Experiences Of Parenting Children With Food Allergies: A Phenomenological Study, Anne Zavell
Dissertations
This phenomenological study focuses on five mothers' experiences of the phenomenon of living with a diagnosed food allergy in the family. Attention is given to the contexts or situations that have typically influenced or affected their experiences, including the impact of the diagnoses, travel and restaurants, friendships, sibling relationships, and anxiety. There is a major emphasis on these mothers' experiences advocating for the needs of their children in schools, including their strategies, concerns, and frustrations. Policies related to food allergies are reviewed from the contemporary and historical perspectives, with recommendations for policy change. The lived experiences of food allergy mothers …
Feeling Green: The Benefits Of Green Space On Urbanites' Mental Health, Kathryn A. Hoagland
Feeling Green: The Benefits Of Green Space On Urbanites' Mental Health, Kathryn A. Hoagland
Liberal Arts and Engineering Studies
This investigation intends to determine the best methods for incorporating public green space into dense urban areas, for the betterment of residents' mental health. Data from studies showing differences in the prevalence of anxiety and depression in urban and rural areas are discussed alongside data from studies looking at the effect that certain types of green space might have on mental health. While there is no exact consensus on the extent to which nature has positive effects on mental health there is enough of a correlation to argue for the implementation of public green spaces in urban design, in order …
A Case Of Flecainide Toxicity In A Young Male, Ifrah Butt, Umair Shaikh, Marlena Fernandez, Sameer Shaharyar, Daniel Heller
A Case Of Flecainide Toxicity In A Young Male, Ifrah Butt, Umair Shaikh, Marlena Fernandez, Sameer Shaharyar, Daniel Heller
Internal Medicine
No abstract provided.
Online Mmorpg Games In China: Player Motivations And The Mediating Role Of Flow, Jiaxin Liu
Online Mmorpg Games In China: Player Motivations And The Mediating Role Of Flow, Jiaxin Liu
USF Tampa Graduate Theses and Dissertations
Massively Multiplayer Online Role-Playing Games (MMORPGs) are gaining popularity and are being used widely in China. The aim of this study is to explore the relationship between the motivation and the experience of MMORPG players, and the effects of playing MMORPG through an extensive online survey of more than 300 Chinese participants (n = 305). Specifically, the findings support the complex relationship between variables, including the direct effects on motivation and flow, on the time the players invest in MMORPG games, and the mediated effects on motivations through flow. In addition to the importance of direct and indirect effects on …
Exploring The Structure Of Narcissism: Toward An Integrated Solution, Michael L. Crowe, Donald R. Lynam, W. Keith Campbell, Joshua D. Miller
Exploring The Structure Of Narcissism: Toward An Integrated Solution, Michael L. Crowe, Donald R. Lynam, W. Keith Campbell, Joshua D. Miller
Department of Psychological Sciences Faculty Publications
Objective
Despite decades of work on narcissism, there remain many active areas of exploration and debate including a clear and consensual description of its underlying components. Understanding narcissism's factor structure is necessary for the precise measurement and investigation of specific psychological and behavioral processes. The aim of the current study was to explore the structure of narcissism by examining it at varying hierarchical levels.
Method
Participants recruited from Amazon's Mechanical Turk (N = 591) completed 303 narcissism items encompassing 46 narcissism scales and subscales. Criterion variables measuring the five-factor model, self-esteem, aggression, and externalizing behavior were also collected.
Results
A …
Decoding Attentional State To Faces And Scenes Using Eeg Brainwaves, Reza Abiri, Soheil Borhani, Yang Jiang, Xiaopeng Zhao
Decoding Attentional State To Faces And Scenes Using Eeg Brainwaves, Reza Abiri, Soheil Borhani, Yang Jiang, Xiaopeng Zhao
Behavioral Science Faculty Publications
Attention is the ability to facilitate processing perceptually salient information while blocking the irrelevant information to an ongoing task. For example, visual attention is a complex phenomenon of searching for a target while filtering out competing stimuli. In the present study, we developed a new Brain-Computer Interface (BCI) platform to decode brainwave patterns during sustained attention in a participant. Scalp electroencephalography (EEG) signals using a wireless headset were collected in real time during a visual attention task. In our experimental protocol, we primed participants to discriminate a sequence of composite images. Each image was a fair superimposition of a scene …
Liaison Psychiatry Services In Wales, Tayyeb Tahir, Adam Watkins, Philip Slack
Liaison Psychiatry Services In Wales, Tayyeb Tahir, Adam Watkins, Philip Slack
Brain and Mind Institute
Aims and method: Recent funding from Welsh Government for mental health has helped to develop liaison psychiatry services in Wales. Systematic data collection was undertaken to map the liaison psychiatry services in Wales in collaboration with the Royal College of Psychiatrists in Wales and Public Health Wales 1000 Lives Improvement. A questionnaire was designed and circulated to all the health boards in Wales to gather information to map liaison psychiatry services in Wales. Up-to-date information was confirmed in January 2018, via email.
Results: Over the past 2 years, liaison psychiatry services have been set up in six out of …
Exploring Determinants Of Behavioral Chronotype In A Diurnal-Rodent Model Of Human Physiology, Roberto Refinetti, Gabrielle Earle, G. J. Kenagy
Exploring Determinants Of Behavioral Chronotype In A Diurnal-Rodent Model Of Human Physiology, Roberto Refinetti, Gabrielle Earle, G. J. Kenagy
Psychological Sciences Faculty Publications and Presentations
studies conducted with human participants have shown that differences in chronotype, defined as individual patterns of early or late beginning of daily activity, have implications for many biobehavioral processes, such as cognitive performance, mood, impulsivity, academic achievement of college students, and mental health. However, the determinants of individual variation in chronotype have not been investigated. Basic research on circadian rhythms has provided a basis for investigating the causes of chronotype variation, but experimental tests of pertinent hypotheses are difficult to conduct with human subjects. This limitation can be overcome by use of animal models. This study was conducted with a …
The Anatomy Of An Insult: Popular Derogatory Terms Connote Important Individual Differences In Agreeableness/Antagonism, Courtland S. Hyatt, Jessica L. Maples-Keller, Chelsea E. Sleep, Donald R. Lynam, Joshua D. Miller
The Anatomy Of An Insult: Popular Derogatory Terms Connote Important Individual Differences In Agreeableness/Antagonism, Courtland S. Hyatt, Jessica L. Maples-Keller, Chelsea E. Sleep, Donald R. Lynam, Joshua D. Miller
Department of Psychological Sciences Faculty Publications
In the current series of studies, we investigate the psychosocial connotations of common insults. In Studies 1 and 2, we investigated the most frequently used insults to denigrate men and women (asshole, dick, bitch), and generated trait profiles that can be considered prototypical of each insult. In Studies 3 and 4, we examined how these insults are relevant to other key indicators of interpersonal functioning, including aggression, social information processing, personality disorders, and substance use. We also gathered thin-slice and informant reports. Each of the insults was associated with trait Antagonism, as well as other behaviors that comprise Antagonism’s nomological …
Betrayed Partners And Men With Poisoned Souls: Interview With A Former Sex Buyer In Germany, Ingeborg Kraus
Betrayed Partners And Men With Poisoned Souls: Interview With A Former Sex Buyer In Germany, Ingeborg Kraus
Dignity: A Journal of Analysis of Exploitation and Violence
No abstract provided.
When Self-Care Is Not Enough: Reflections On How To Make Trauma-Intensive Clinical Work More Sustainable, Brianna C. Delker
When Self-Care Is Not Enough: Reflections On How To Make Trauma-Intensive Clinical Work More Sustainable, Brianna C. Delker
Dignity: A Journal of Analysis of Exploitation and Violence
As a psychology resident on the psychiatry consultation-liaison service at a trauma center, I was asked by another trainee how I cope with the devastating cases of traumatic injury and abuse that we witnessed regularly on the service. This trainee’s courageous question about how we as providers cope sustainably with bearing witness to trauma coincided with my own reflection on the limits of “self-care” as it is often discussed and practiced in human service professions. In this article, I argue that an activity-based approach to self-care is not enough for providers in trauma-intensive service settings and must be complemented with …
The Influence Of Unpredictable, Fragmented Parental Signals On The Developing Brain, Laura M. Glynn, Tallie Z. Baram
The Influence Of Unpredictable, Fragmented Parental Signals On The Developing Brain, Laura M. Glynn, Tallie Z. Baram
Psychology Faculty Articles and Research
Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children’s mental health. Existing literature on maternal signals has focused almost exclusively on their quality and valence (e.g. maternal depression, sensitivity). Here we identify a novel dimension of maternal signals: their patterns and especially their predictability/unpredictability, as an important determinant of children’s neurodevelopment. We find that unpredictable maternal mood and behavior presage risk for child and adolescent psychopathology. In experimental models, fragmented/unpredictable …
Adgrl3 (Lphn3) Variants Predict Substance Use Disorder, Mauricio Arcos-Burgos, Jorge I. Vélez, Ariel F. Martinez, Marta Ribasés, Josep A. Ramos-Quiroga, Cristina Sánchez-Mora, Vanesa Richarte, Carlos Roncero, Bru Cormand, Noelia Fernández-Castillo, Miguel Casas, Francisco Lopera, David A. Pineda, Juan D. Palacio, Johan E. Acosta-López, Martha L. Cervantes-Henriquez, Manuel G. Sánchez-Rojas, Pedro J. Puentes-Rozo, Brooke S. G. Molina, Mta Cooperative Group, Margaret T. Boden, Deeann Wallis, Brett Lidbury, Saul Newman, Simon Easteal, James Swanson, Hardip Patel, Nora Volkow, Maria T. Acosta, Francisco X. Castellanos, Jose De Leon
Adgrl3 (Lphn3) Variants Predict Substance Use Disorder, Mauricio Arcos-Burgos, Jorge I. Vélez, Ariel F. Martinez, Marta Ribasés, Josep A. Ramos-Quiroga, Cristina Sánchez-Mora, Vanesa Richarte, Carlos Roncero, Bru Cormand, Noelia Fernández-Castillo, Miguel Casas, Francisco Lopera, David A. Pineda, Juan D. Palacio, Johan E. Acosta-López, Martha L. Cervantes-Henriquez, Manuel G. Sánchez-Rojas, Pedro J. Puentes-Rozo, Brooke S. G. Molina, Mta Cooperative Group, Margaret T. Boden, Deeann Wallis, Brett Lidbury, Saul Newman, Simon Easteal, James Swanson, Hardip Patel, Nora Volkow, Maria T. Acosta, Francisco X. Castellanos, Jose De Leon
Psychiatry Faculty Publications
Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal samples from disparate regions of the world (n = 2698), recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we …