Psychiatry and Psychology Commons^™

C-Fos Identification Of Neuroanatomical Sites Associated With Haloperidol And Clozapine Disruption Of Maternal Behavior In The Rat, Changjiu Zhao, Ming Li

Department of Psychology: Faculty Publications

Rat maternal behavior is a complex social behavior. Most antipsychotic drugs disrupt active maternal responses (e.g., pup retrieval, pup licking and nest building). Our previous work shows that typical antipsychotic haloperidol disrupts maternal behavior by blocking dopamine D₂ receptors, whereas atypical clozapine works by blocking 5-HT_2A/2C receptors. The present study used c-Fos immunohistochemistry technique, together with pharmacological tools and behavioral observations, and delineated the neuroanatomical bases of the disruptive effects of haloperidol and clozapine. Postpartum female rats were treated with haloperidol (0.2 mg/kg sc) or clozapine (10.0 mg/kg sc), with or without pretreatment of quinpirole (a selective dopamine …

Iptakalim: A Potential Antipsychotic Drug With Novel Mechanisms?, Tao Sun, Changjiu Zhao, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Iptakalim is a novel putative adenosine triphosphate (ATP)-sensitive potassium (K_ATP) channel opener. In the brain, iptakalim is thought to act on the neuronal and astrocytic plasma membrane and/or mitochondrial K_ATP channels. Because iptakalim demonstrates an action on the regulation of dopamine and glutamate release in the forebrain regions, we examined its potential antipsychotic efficacy in several preclinical tests. First, we show that iptakalim is effective in reducing amphetamine- and phencyclidine-induced hyperlocomotion as well as selectively disrupting conditioned avoidance responding. Next, we show that combined iptakalim and amphetamine treatment produces a reduction on prepulse inhibition of acoustic startle …

The Relationship Between The Perception Of Axes Of Symmetry And Spatial Memory During Early Childhood, Margaret R. Ortmann, Anne R. Schutte

Department of Psychology: Faculty Publications

Early in development, there is a transition in spatial working memory (SWM). When remembering a location in a homogeneous space (e.g., in a sandbox), young children are biased toward the midline symmetry axis of the space. Over development, a transition occurs that leads to older children being biased away from midline. The dynamic field theory (DFT) explains this transition in biases as being caused by a change in the precision of neural interaction in SWM and improvements in the perception of midline. According to the DFT, young children perceive midline, but there is a quantitative improvement in the perception of …

Prenatal Tobacco Exposure: Developmental Outcomes In The Neonatal Period, Kimberly Andrews Espy, Hua Fang, Craig Johnson, Christian Stopp, Sandra A. Wiebe, Jennifer Respass

Department of Psychology: Faculty Publications

Smoking during pregnancy is a persistent public health problem that has been linked to later adverse outcomes. The neonatal period— the first month of life—carries substantial developmental change in regulatory skills and is the period when tobacco metabolites are cleared physiologically. Studies to date mostly have used cross-sectional designs that limit characterizing potential impacts of prenatal tobacco exposure on the development of key self-regulatory processes and cannot disentangle short-term withdrawal effects from residual exposure-related impacts. In this study, pregnant participants (N = 304) were recruited prospectively during pregnancy, and smoking was measured at multiple time points, with both self-report and …

Aging And The Vulnerability Of Speech To Dual Task Demands, Susan Kemper, Ralynn Schmalzried, Lesa Hoffman, Ruth Herman

Department of Psychology: Faculty Publications

Tracking a digital pursuit rotor task was used to measure dual task costs of language production by young and older adults. Tracking performance by both groups was affected by dual task demands: time on target declined and tracking error increased as dual task demands increased from the baseline condition to a moderately demanding dual task condition to a more demanding dual task condition. When dual task demands were moderate, older adults’ speech rate declined but their fluency, grammatical complexity, and content were unaffected. When the dual task was more demanding, older adults’ speech, like young adults’ speech, became highly fragmented, …

Donor Payoffs And Other-Regarding Preferences In Cotton-Top Tamarins (Saguinus Oedipus), Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Helping others at no cost to oneself is a simple way to demonstrate other-regarding preferences. Yet, primates exhibit mixed results for other-regarding preferences: chimpanzees and tamarins do not show these effects, whereas capuchin monkeys and marmosets preferentially give food to others. One factor of relevance to this no-cost food donation is the payoff to the donor. Though donors always receive the same payoffs regardless of their choice, previous work varies in whether they receive either a food reward or no food reward. Here, I tested cotton-top tamarins in a preferential giving task. Subjects could choose from two tools, one of …

The Adaptive Nature Of Impulsivity, Jeffrey R. Stevens, David W. Stephens

Department of Psychology: Faculty Publications

An old joke circulates among animal behavior instructors. One can, the joke goes, divide the topics of animal behavior into four Fs: fighting, fleeing, feeding, and reproduction. This somewhat tired joke carries considerable truth. Animals behaving in nature surely must make decisions about conflicts, predator avoidance, feeding, and mating. Male crickets, for example, are notoriously combative. Studies have shown, however, that they escalate fights in some situations and retreat to fight another day in others (Beaugrand, 1997; Parker, 1974; Parker & Rubenstein, 1981). Squirrels, like many small animals, respond to the presence or absence of protective cover; for example, they …

Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

A Clark’s nutcracker (Nucifraga columbiana) flies to the top of a pine tree and selects one of the many cones. She twists and pecks at the stem until the cone breaks free from the branch and, with one foot, holds the cone in the crotch of a branch. She then repeatedly hammers her long bill in between the scales of the cone. After forcing out one of the seeds, she tips her head back a bit, clicks the seed in her bill a few times, and closes her bill. A few minutes later, the shredded cone drops to …

Understanding Child Sexual Behavior Problems: A Developmental Psychopathology Framework, Natasha Elkovitch, Robert D. Latzman, David J. Hansen, Mary Fran Flood

Department of Psychology: Faculty Publications

entific community. While a heterogeneous group, children with sexual behavior problems consistently demonstrate a number of problems related to adjustment and overall development. In order to appropriately intervene with these children, a comprehensive understanding of etiology is imperative. The overarching goal of the present paper is to review the extant research on mechanisms associated with the development of problematic sexual behavior in childhood within a developmental psychopathology framework. What is known about normative and nonnormative sexual behavior in childhood is reviewed, highlighting definitional challenges and age-related developmental differences. Further, the relationship between child sexual abuse and child sexual behavior problems …

The Receptor Mechanisms Underlying The Disruptive Effects Of Haloperidol And Clozapine On Rat Maternal Behavior: A Double Dissociation Between Dopamine D2 And 5-Ht2a/2c Receptors, Changjiu Zhao, Ming Li

Department of Psychology: Faculty Publications

Many antipsychotic drugs disrupt active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses in postpartum female rats. However, the neurochemical mechanisms underlying such a disruptive effect remain to be determined. This study examined the neurochemical mechanisms that mediate the disruptive effects of haloperidol (a typical antipsychotic) and clozapine (an atypical antipsychotic) on rat maternal behavior. Postpartum rats were administered with haloperidol (0.2 mg/kg, sc) or clozapine (10.0 mg/kg, sc) together with either vehicle (saline or water), quinpirole (a selective dopamine D₂/D₃ agonist, 0.5 or 1.0 mg/kg, sc), or …

The Early Development Of Gender Differences, Matthew H. Mcintyre, Carolyn P. Edwards

Department of Psychology: Faculty Publications

This article reviews findings from anthropology, psychology, and other disciplines about the role of biological factors in the development of sex differences in human behavior, including biological theories, the developmental course of sex differences, and the interaction of biological and cultural gendering processes at different ages. Current evidence suggests that major biological influences on individual differences in human gender, to the extent that they exist, operate primarily in early development, during and especially prior to puberty. Biological effects are likely to be mediated by relatively simple processes, like temperament, which are then elaborated through social interactions (as with mother and …

Correlated And Coupled Within-Person Change In Emotional And Behavior Disturbance In Individuals With Intellectual Disability, Scott M. Hofer, Kylie M. Gray, Andrea M. Piccinin, Andrew Mackinnon, Daniel E. Bontempo, Stewart L. Enfield, Lesa Hoffman, Trevor Parmenter, Bruce J. Tonge

Department of Psychology: Faculty Publications

Individual change and variation in emotional/behavioral disturbance in children and adolescents with intellectual disability has received little empirical investigation. Based on 11 years of longitudinal data from the Australian Child to Adult Development Study, we report associations among individual differences in level, rate of change, and occasion-specific variation across subscales of theDevelopmental Behavior Checklist (DBC) with 506 participants who had intellectual disability and were ages 5 to 19 years at study entry. Correlations among the five DBC subscales ranged from .43 to .66 for level, .43 to .88 for rate of change, and .31 to .61 for occasion-specific variation, with …

Investigation Of Endocannabinoid Modulation Of Conditioned Responding Evoked By A Nicotine Cs And The Pavlovian Stimulus Effects Of Cp 55,940 In Adult Male Rats, Jennifer E. Murray, Nicole R. Wells, George D. Lyford, Rick A. Bevins

Department of Psychology: Faculty Publications

Rationale — The cannabinoid CB1 receptor antagonist/inverse agonist rimonabant (SR 141716) has been shown to block reinforcing and rewarding effects of nicotine. Research has not investigated whether the cannabinoid system is involved in the interoceptive stimulus effects of nicotine functioning as a conditional stimulus (CS).
Objective — We examined the effects of rimonabant and the CB_1/2 receptor agonist, CP 55,940, on responding evoked by a nicotine CS in rats. Additionally, we determined whether CP 55,940 functioned as a CS or a Pavlovian positive drug feature
Materials and methods — Pavlovian discrimination training involved intermixed nicotine (0.2 mg base/kg) and …

Is Animal Cruelty A “Red Flag” For Family Violence?: Investigating Co-Occurring Violence Toward Children, Partners, And Pets, Sarah Degrue, David K. Dilillo

Department of Psychology: Faculty Publications

Cross-reporting legislation, which permits child and animal welfare investigators to refer families with substantiated child maltreatment or animal cruelty for investigation by parallel agencies, has recently been adopted in several U.S. jurisdictions. The current study sheds light on the underlying assumption of these policies—that animal cruelty and family violence commonly co-occur. Exposure to family violence and animal cruelty is retrospectively assessed using a sample of 860 college students. Results suggest that animal abuse may be a red flag indicative of family violence in the home. Specifically, about 60% of participants who have witnessed or perpetrated animal cruelty as a child …

Individual Differences In Responses To Nicotine: Tracking Changes From Adolescence To Adulthood, Ming Li, Alexa Mead, Rick A. Bevins

Department of Psychology: Faculty Publications

Aim: The present study determined the extent to which individual differences in responses to the psychostimulating effect of nicotine during adolescence predict similar individual differences during adulthood in rats. We also examined the possible long-term effects of adolescent nicotine exposure on adult prepulse inhibition (PPI) of the acoustic startle response, a measure of sensorimotor gating ability.

Methods: During the adolescent phase, rats were administered saline, 0.10, 0.40, or 0.60 mg/kg nicotine via subcutaneous injections for 8 days, and motor activity was measured daily. During the adult phase, these rats were treated with the same nicotine dose as in adolescence for …

Food Exemplar Salience: What Foods Do People Think Of When You Tell Them To Change Their Diet?, Carolyn R. Brown-Kramer, Marc T. Kiviniemi, Julie A. Winseman

Department of Psychology: Faculty Publications

Understanding which specific foods easily come to mind when individuals consider categories of dietary behavior may help explain observed patterns of dietary intake. We examined which specific behavioral exemplars are most easily retrieved from memory when individuals consider broad dietary categories. Participants reported specific foods that come to mind when considering high fat foods, low fat foods, and fruits/vegetables. Salient foods differed from those suggested in dietary guidelines, were distinct from those known to be major diet components, and showed a non-trivial number of incorrect responses. These findings have implications for understanding how individuals respond to dietary guidelines and devising …

Going Beyond The Specifics: Generalization Of Single Actions, But Not Temporal Order, At 9 Months, Angela F. Lukowski, Sandra A. Wiebe, Patricia J. Bauer

Department of Psychology: Faculty Publications

We examined generalization in 9-month-old infants after a 24-hour delay using deferred imitation. Infants flexibly applied their knowledge of sequence actions across changes in props even though they had no opportunity for immediate imitation.

Avoidance-Suppressing Effect Of Antipsychotic Drugs Is Progressively Potentiated After Repeated Administration: An Interoceptive Drug State Mechanism, Alexa Lucille Mead, Ming Li

Department of Psychology: Faculty Publications

Antipsychotic drugs selectively suppress conditioned avoidance response. Using a two-way active avoidance response paradigm, we examined the role of drug-induced interoceptive state in the mediation of avoidance-suppressive effect. In Experiment 1, we found that rats intermittently treated with olanzapine (OLZ) (1.0 mg/kg, s.c.) or haloperidol (0.03 mg/kg, s.c.) on the 1st day of a 3-day cycle for seven cycles exhibited a progressive across-session decline in avoidance responding, despite the fact that they exhibited a comparable high level of avoidance responding on the 3rd day of each cycle during the drug-free retraining session. In Experiments 2 and 3, rats that were …

What Matters, And What Matters Most, For Change In Life Satisfaction In The Oldest-Old? A Study Over 6 Years Among Individuals 80+, Anne Ingeborg Berg, Lesa Hoffman, Linda Björk Hassing, Gerald M. Mcclearn, Boo Johansson

Department of Psychology: Faculty Publications

Objectives: The study investigates whether markers of life satisfaction identified in a cross-sectional study – quality of social network, self-rated health, depressive symptoms, locus of control and widowhood, in addition to financial satisfaction and the personality traits of extraversion and neuroticism - predict change in life satisfaction (LSI-Z) across four measurement occasions during a 6-year period in individuals aged 80+. Method: Data were drawn from the Swedish OCTO-Twin-study of individuals aged 80 and older. Results: Growth curve analysis showed a relatively consistent significant linear decline in life satisfaction, but certain markers predicted change in life satisfaction. The …

The Dynamic Nature Of Knowledge: Insights From A Dynamic Field Model Of Children’S Novel Noun Generalization, Larissa K. Samuelson, Anne R. Schutte, Jessica S. Horst

Department of Psychology: Faculty Publications

This paper examines the tie between knowledge and behavior in a noun generalization context. An experiment directly comparing noun generalizations of children at the same point in development in forced-choice and yes/no tasks reveals task-specific differences in the way children’s knowledge of nominal categories is brought to bear in a moment. To understand the cognitive system that produced these differences, the real-time decision processes in these tasks were instantiated in a dynamic field model. The model captures both qualitative and quantitative differences in performance across tasks and reveals constraints on the nature of children’s accumulated knowledge. Additional simulations of developmental …

Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding In Phencyclidine-Pretreated Or Amphetamine-Pretreated Rats By Selectively Weakening Motivational Salience Of Conditioned Stimulus, Ming Li, Wei He, Alexa Mead

Department of Psychology: Faculty Publications

The rat conditioned avoidance response model is a well-established preclinical behavioral model predictive of antipsychotic efficacy. All clinically approved antipsychotic drugs disrupt conditioned avoidance responding – a feature that distinguishes them from other psychotherapeutics. We previously showed that the typical antipsychotic drug haloperidol disrupts avoidance responding by progressively attenuating the motivational salience of the conditioned stimulus (CS) in normal rats. In this study, using two pharmacological rat models of schizophrenia [e.g. phencyclidine (PCP) or amphetamine sensitization], we examined whether atypicals such as olanzapine or risperidone disrupt avoidance responding through the same behavioral mechanism. Rats were first pretreated with PCP, amphetamine, …

Acquired Appetitive Responding To Intravenous Nicotine Reflects A Pavlovian Conditioned Association, Jennifer E. Murray, Rick A. Bevins

Department of Psychology: Faculty Publications

Recent research examining Pavlovian appetitive conditioning has extended the associative properties of nicotine from the unconditioned stimulus or reward to include the role of a conditional stimulus (CS), capable of acquiring the ability to evoke a conditioned response. To date, published research has used presession extravascular injections to examine nicotine as a contextual CS in that appetitive Pavlovian drug discrimination task. Two studies in the current research examined whether a nicotine CS can function discretely, multiple times within a session using passive iv infusions. In Experiment 1, rats readily acquired a discrimination in conditioned responding between nicotine and saline infusions …

Gene–Environment Interactions Across Development: Exploring Drd2 Genotype And Prenatal Smoking Effects On Self-Regulation, Sandra A. Wiebe, Kimberly Andrews Espy, Christian Stopp, Jennifer Respass, Peter Stewart, Travis R. Jameson, David G. Gilbert, Jodi I. Huggenvik

Department of Psychology: Faculty Publications

Genetic factors dynamically interact with both pre- and postnatal environmental influences to shape development. Considerable attention has been devoted to gene–environment interactions (G × E) on important outcomes (A. Caspi & T. E. Moffitt, 2006). It is also important to consider the possibility that these G × E effects may vary across development, particularly for constructs like self-regulation that emerge slowly, depend on brain regions that change qualitatively in different developmental periods, and thus may be manifested differently. To illustrate one approach to exploring such developmental patterns, the relation between variation in the TaqIA polymorphism, related to D2 dopamine receptor …

Epistatic Interaction Between Comt And Dat1 Genes On Eating Behavior: A Pilot Study, Samantha L. Hersrud, Scott F. Stoltenberg

Department of Psychology: Faculty Publications

Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3’ UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 …

How Should The Effectiveness Of The Eppp Be Judged?, David Dilillo, George C. Tremblay

Department of Psychology: Faculty Publications

We join Brian A. Sharpless and Jacques P. Barber (2009) in calling for strengthening the evidence base supporting the Examination for Professional Practice in Psychology (EPPP), particularly in the areas of criterion and predictive validity. Although 1 clear purpose of the EPPP is to assess core areas of knowledge, materials from the Association of State and Provincial Psychology Boards are less clear as to whether the EPPP is also intended to predict future performance as a psychologist. If the EPPP is expected to protect the public from poorly trained psychologists, then data supporting its use for that purpose are urgently …

The Receptor Mechanisms Underlying The Disruptive Effects Of Haloperidol And Clozapine On Rat Maternal Behavior: A Double Dissociation Between Dopamine D2 And 5-Ht2a/2c Receptors, Zhao Changjiu, Ming Li

Department of Psychology: Faculty Publications

Many antipsychotic drugs disrupt active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses in postpartum female rats. However, the neurochemical mechanisms underlying such a disruptive effect remain to be determined. This study examined the neurochemical mechanisms that mediate the disruptive effects of haloperidol (a typical antipsychotic) and clozapine (an atypical antipsychotic) on rat maternal behavior. Postpartum rats were administered with haloperidol (0.2 mg/kg, sc) or clozapine (10.0 mg/kg, sc) together with either vehicle (saline or water), quinpirole (a selective dopamine D₂/D₃ agonist, 0.5 or 1.0 mg/kg, sc), or …

Nonoffending Parent Expectations Of Sexually Abused Children: Predictive Factors And Influence On Children’S Recovery, Haig Kouyoumdjian, Andrea R. Perry, David J. Hansen

Department of Psychology: Faculty Publications

This study examined the influence of parental expectations on the functioning of sexually abused children. Participants included 67 sexually abused youth and 63 of their nonoffending primary caregivers. Parental expectations about how sexual abuse will impact children were predictive of parents’ ratings of children’s behavior at pretreatment, while parental expectations of children’s overall future functioning were not predictive of parents’ ratings of children’s behavior. Parental expectations about how sexual abuse will impact their children and about their children’s overall future functioning were not predictive of parents’ ratings of children’s behavior at posttreatment. Results highlight the influential role the sexual abuse …

An Investigation Of The Behavioral Mechanisms Of Antipsychotic Action Using A Drug-Drug Conditioning Paradigm, Ming Li, Wei He, Alexa Mead

Department of Psychology: Faculty Publications

Antipsychotic drugs at noncataleptic doses selectively suppress conditioned avoidance response in rats. In our previous study, we had used a two-way active avoidance response paradigm to show that the antipsychotic-induced interoceptive state is one of the mechanisms underlying the avoidance-disruptive effect of antipsychotics. In this study, we sought to further examine this mechanism using a novel drug-drug conditioning procedure. We made use of the fact that both the typical neuroleptic haloperidol and the atypical neuroleptic olanzapine disrupt conditioned avoidance responding, whereas chlordiazepoxide (an anxiolytic) does not. We reasoned that if the antipsychotic interoceptive state is important in causing a disruption …

Responding To Societal Devaluation: Effects Of Perceived Personal And Group Discrimination On The Ethnic Group Identification And Personal Self-Esteem Of Latino/Latina Adolescents, Brian E. Armenta, Jennifer S. Hunt

Department of Psychology: Faculty Publications

The Rejection-Identification model (Branscombe, Schmitt, & Harvey, 1999) posits that perceived discrimination may lead to increased ingroup identification, which can help maintain psychological well-being in the face of societal devaluation. To address unknown aspects of this model, we examined the effects of perceived per¬sonal and group discrimination on the group identification and personal self-esteem of Latino/Latina adolescents. Results showed that perceived group discrimination was related to higher personal self-esteem via direct and indirect routes (i.e. through group identification). However, perceived personal discrimination was directly and indirectly associated with lower personal self-esteem. Moreover, these two levels of discrimination showed interactive effects …

Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Clinical obervations indicate that antipsychotic action starts early and increases in magnitude with repeated treatment. Animal models that faithfully capture this time course of action are few. Inhibition of hyperlocomotion induced by amphetamine or phencyclidine has been widely used as a screening tool for the antipsychotic activity of a drug. We thus investigated whether repeated antipsychotic treatment could produce an early-onset and progressively increased antagonistic effect on amphetamine or phencyclidine-induced hyperlocomotion as a way of assessing the validity of such models in capturing time course of antipsychotic action. One each of the five consecutive test days, different groups of rats …