Psychiatry and Psychology Commons^™

Mind, Body And Race: A Look Into How Implicit Biases Influence The Perception Of Emotion, Faiza Ahmad, Adam Anderson, James Dalton Rounds, Christina Chick, Alize Hill

Research Symposium

Background: Most research examining the effects of implicit race-based biases in emotion perception has focused on the perception of Black faces as being angry. Limited work has been done examining the perception of “approach” emotions such as fear. Furthermore, most studies have predominantly used White subjects. Our study examined the role of implicit racial biases in shaping the perception of both anger and fear in White, Black and Asian participants.

Methods: 78 participants completed a Go/NoGo task in which they were asked to categorize different race faces as portraying either anger or fear. Participants would be asked to press the …

Fornix Volumetric Increase During Aging Associates To Microglia Activation Leading To Defective Cognitive Performance, Marcela Cárdenas Tueme, Luis Ángel Trujillo-Villarreal, Victor Ramírez-Amaya, Eduardo Garza-Villarreal, Alberto Camacho-Morales, Diana Reséndez-Pérez

Research Symposium

Background: Ageing displays a low-grade pro-inflammatory profile in blood and brain. It has been documented proinflammatory cytokines accumulation leading to neuroinflammation during aging. Aged brains integrate pro inflammatory cytokines accumulation, active microglia and volumetric changes which correlates with defective cognitive performance and neurodegeneration.

Methods: Mice from 2-,12- and 20-months-old of age were submitted to different memory tests: Y-maze, Barnes maze, object location test and object location test. Afterwards, we performed structural MRI to evaluate macrostructural changes related to memory and learning regions. Following this, we also evaluated in peripheral blood and in brain tissue the presence of pro-inflammatory cytokines …

Representation Of Racial And Ethnic Minorities And Their Preferences For Mood Stabilizing Treatment Selection For Bipolar Disorder: A Systematic Review, Francisco J. Barrera, Manuel Gardea, Juan Garzon, Ryan Toledo, Ana Paula Bonner, Andrea Maraboto, Mark Frye, Ihsan Salloum

Research Symposium

Background: The use of second-generation antipsychotics for bipolar disorder (BD) has increased in the past years¹Concerns on potential serious medical side effects and need for blood level monitoring of some traditional mood stabilizers along with other factors have influenced this change. Shared decision-making (SDM) strategies have been implemented in clinical settings due to their ability to engage patients in the process of treatment selection.² Within minority groups with mental illnesses, socioeconomic factors, individual concerns, and cultural variations in clinical presentations, are often overlooked or misrepresented when assessing the patient’s treatment preferences. Although several studies evaluating the …

Bitten To The Bone: A Case Of Anxiety-Induced Osteomyelitis, Jose A. Rivera, Daniel Aragon, Daniela Hernandez

Research Symposium

Background: Onychophagia is a habitual nail-biting disorder, usually associated with mental or emotional diseases. It affects 20–30% of the population in all age groups. Human bites have the potential to become serious injuries due to high virulence in the human oral flora and may often require hospital admission, antibiotics and even debridement in the operating room. Thus, repetitive nail biting has the potential to be limb-threatening if not treated early and appropriately.

Case Presentation: Patient is a 49-year-old gentleman with a past medical history of severe refractory anxiety treated with hydroxyzine and scheduled alprazolam, after failing multiple other treatments, …

Adverse Childhood Experiences And Resilience In Medical School Students: A Scope Of Medical Literature, Andrea Soto Abarca, Yvette Cortino, Juan Carlos Lopez Alvarenga, Maya Guevara

Research Symposium

Background: Adverse childhood experiences (ACEs) represent types of childhood trauma that are associated with long-term negative effects on health and wellbeing. An elevated number of ACEs can lead to depression, suicidality, alcoholism, and substance use. Factors that can protect a person from increased health risks include resilience, which is broadly defined as the ability to bounce back from adversity. Few studies have analyzed the exposure of ACEs in medical students, however, there is extensive literature on how low levels of resilience are linked to higher rates of depression, fatigue, and burnout among medical students. Little is known about the …

The Difficulty In The Diagnosis And Management Of Antidepressant Discontinuation Syndrome, Sidney Charm D. Reyes

School of Medicine Publications

Background: Antidepressant discontinuation syndrome (ADS) is a condition that occurs in about 20% of patients following the abrupt reduction/stoppage of any antidepressant medication that has been taken continuously for at least one month.

Case Presentation: We present a 36-year-old Hispanic woman who initially presented for evaluation of flu-like symptoms (subjective fever, rhinorrhea) and worsening body aches, trouble sleeping, and headaches for the past three days. She also reported recent exposure to a sick co-worker. Rapid flu, strep, and COVID tests came back negative. Pt was diagnosed with a viral URI and was discharged with counseling on supportive treatment. The patient …

Characterization Of Childhood Trauma, Hippocampal Mediation And Cannabis Use In A Large Dataset Of Psychosis And Non-Psychosis Individuals, Elisabetta C. Del Re, Walid Yassin, Victor Zeng, Sarah Keedy, Ney Alliey-Rodriguez, Elena Ivleva, Scott Hill, Nicole Rychagov, Jennifer E. Mcdowell, Jeffrey R. Bishop

School of Medicine Publications

Background

Cannabis use (CA) and childhood trauma (CT) independently increase the risk of earlier psychosis onset; but their interaction in relation to psychosis risk and association with endocannabinoid-receptor rich brain regions, i.e. the hippocampus (HP), remains unclear. The objective was to determine whether lower age of psychosis onset (AgePsyOnset) is associated with CA and CT through mediation by the HP volumes, and genetic risk, as measured by schizophrenia polygene scores (SZ-PGRS).

Methods

Cross-sectional, case-control, multicenter sample from 5 metropolitan US regions. Participants (n = 1185) included 397 controls not affected by psychosis (HC); 209 participants with bipolar disorder type-1; …

The Relationship Of Trait-Like Compassion With Epigenetic Aging: The Population-Based Prospective Young Finns Study, Henrik Dobewall, Liisa Keltikangas-Järvinen, Saara Marttila, Pashupati P. Mishra, Aino Saarinen, C. Robert Cloninger, Igor Zwir, Mika Kähönen, Mikko Hurme, Olli Raitakari, Terho Lehtimäki, Mirka Hintsanen

School of Medicine Publications

Introduction: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current study examines whether epigenetic aging is a potential biological mechanism that explains the link between prosociality and longevity.

Methods: We used data from the Young Finns Study that follows six birth-cohorts from age 3–18 to 19–49. Trait-like compassion for others was measured with the Temperament and Character Inventory in the years 1997 and 2001. Epigenetic age acceleration and telomere …

A Pilot Investigation Of Differential Hydroxymethylation Levels In Patient-Derived Neural Stem Cells Implicates Altered Cortical Development In Bipolar Disorder, Ashish Kumar, Mark Z. Kos, Donna Roybal, Melanie A. Carless

School of Medicine Publications

Introduction: Bipolar disorder (BD) is a chronic mental illness characterized by recurrent episodes of mania and depression and associated with social and cognitive disturbances. Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribute to the pathogenesis of BD, suggesting a key role in epigenetic regulation during neurodevelopment. 5-hydroxymethylcytosine (5hmC) is an epigenetic variant of particular interest, as it is highly expressed in the brain and is implicated in neurodevelopment, and psychiatric and neurological disorders.

Methods: Induced pluripotent stem cells (iPSCs) were generated from the white blood cells of two adolescent patients with …

Co-Alteration Network Architecture Of Major Depressive Disorder: A Multi-Modal Neuroimaging Assessment Of Large-Scale Disease Effects, Jodie P. Gray, Jordi Manuello, Aaron F. Alexander-Bloch, Cassandra Leonardo, Crystal Franklin, Sueng Choi, Franco Cauda, Tommaso Costa, John Blangero, David C. Glahn, Peter T. Fox

School of Medicine Publications

Major depressive disorder (MDD) exhibits diverse symptomology and neuroimaging studies report widespread disruption of key brain areas. Numerous theories underpinning the network degeneration hypothesis (NDH) posit that neuropsychiatric diseases selectively target brain areas via meaningful network mechanisms rather than as indistinct disease effects. The present study tests the hypothesis that MDD is a network-based disorder, both structurally and functionally. Coordinate-based meta-analysis and Activation Likelihood Estimation (CBMA-ALE) were used to assess the convergence of findings from 92 previously published studies in depression. An extension of CBMA-ALE was then used to generate a node-and-edge network model representing the co-alteration of brain areas …

Xylazine In The Opioid Epidemic: A Systematic Review Of Case Reports And Clinical Implications, Shahana Ayub, Shanli Parnia, Karuna Poddar, Anil K. Bachu, Amanda Sullivan, Ali M. Khan, Saeed Ahmed, Lakshit Jain

School of Medicine Publications

Introduction and objectives: The opioid overdose epidemic is exacerbated by the emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can potentiate opioid effects while also causing toxic and potentially fatal side effects. This systematic review aims to assess the impact of Xylazine use and overdoses within the opioid epidemic context.

Method: A systematic search was conducted following PRISMA guidelines to identify relevant case reports, and case series related to Xylazine use. A comprehensive literature search included databases like Web of Science, PubMed, Embase, and Google Scholar, utilizing keywords and Medical Subject Headings (MeSH) terms related to …

Implementing The Who Caregivers Skills Training Program With Caregivers Of Autistic Children Via Telehealth In Rural Communities, Cecilia Montiel-Nava, Megan Tregnago, Jeanne Marshall, Kristin Sohl, Alicia Brewer Curran, Melissa Mahurin, Melissa Warne-Griggs, Who Cst Team, Pamela Dixon

Psychological Science Faculty Publications

Background: For families with autistic children living in rural areas, limited access to services partly results from a shortage of providers and extensive travel time. Telehealth brings the possibility of implementing alternative delivery modalities of Parent Mediated Interventions (PMIs) with the potential to decrease barriers to accessing services. This study aimed to evaluate the feasibility and acceptability of implementing the World Health Organization-Caregivers Skills Training program (WHO-CST) via an online, synchronous group format in rural Missouri.

Methods: We used a mixed methods design to collect qualitative and quantitative data from caregivers and program facilitators at baseline and the end of …

Non-Alcoholic Fatty Liver Disease And Depression: Evidence For Genotype × Environment Interaction In Mexican Americans, Eron G. Manusov, Vincent P. Diego, Khalid Sheikh, Sandra Laston, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G × E interactions for hepatic fibrosis × BDI-II. These findings provide evidence that genetic factors …

Does Insomnia Increase The Risk Of Suicide In Hospitalized Patients With Major Depressive Disorder? A Nationwide Inpatient Analysis From 2006 To 2015, Zeeshan Mansuri, Abhishek Reddy, Ramu Vadukapuram, Mounica Thootkur, Chintan Trivedi

School of Medicine Publications

Introduction. nsomnia is an important symptom associated with major depressive disorder (MDD). In addition, it is one of the risk factors for suicide. Studies have shown the relationship be-tween insomnia and suicidal behavior in patients with MDD. However, this association has not been evaluated in a large sample of hospitalized patients.

Objectives. To evaluate the suicidal be-havior in MDD patients with insomnia compared to those without insomnia.

Methods. From the National Inpatient Sample (NIS 2006–2015) database using the ICD-9 code, patients’ data were obtained with the primary diagnosis of MDD and comorbid diagnosis of insomnia disorders (MDD+I). These patients were …

Adverse Childhood Experiences And Resilience In Medical School Students: A Scope Of Medical Literature, Andrea Soto Abarca, Yvette Cortino, Juan C. Lopez-Alvarenga, Maya Guevara

MEDI 9331 Scholarly Activities Clinical Years

Background: Adverse childhood experiences (ACEs) represent certain types of childhood trauma that are associated with long-term negative effects on health and wellbeing. The elevated number of ACEs can lead to depression, suicidality, alcoholism, and substance use. Factors that can protect a person from increased health risks include resilience, which is broadly defined as the ability to overcome challenges or bounce back from adversity. Few studies have analyzed the exposure of ACEs in medical students, however, there has been extensive literature on how low levels of resilience are linked to higher rates of depression, fatigue, and burnout among medical students. …

Photography: A Culturally Sensitive Bereavement Aid?, Rebecca M. Reséndiz Rodriguez

School of Medicine Publications

No abstract provided.

Challenges In Treating Cancer Patients With Unstable Psychiatric Disorder, Val Bellman, Nina Russell, Kartik Depala, Alexandra Dellenbaugh, Saral Desai, Ramu Vadukapuram, Shweta Patel, Sushma Srinivas

School of Medicine Publications

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with imatinib/dasatinib therapy. Psychiatrically, he was stabilized on …

Comparing The Trends Of Postpartum Depression Screening Scores During And Before The Covid-19 Pandemic, Elif S. Duran, Dung Dang, Tony Ogburn

MEDI 9331 Scholarly Activities Clinical Years

Introduction:

Postpartum depression includes major and minor depressive disorders affecting women in the time period after childbirth. The studies reviewed in our literature found that the COVID-19 pandemic has increased the risk of postpartum depression for women. Our study location, the Rio Grande Valley is one of the hardest-hit locations by the COVID-19 pandemic in the United States. Our patient population is also one with the higher risk factors for postpartum depression. As such, we are expecting the psychological impact of the pandemic to be even more magnified, and thus, actions need to be taken to support the vulnerable population …

Uncovering The Complex Genetics Of Human Character, Igor Zwir, Javier Arnedo, Coral Del-Val, Laura Pulkki-Råback, Bettina Konte, Sarah S. Yang, Rocio Romero-Zaliz, Mirka Hintsanen, Kevin M. Cloninger, Gabriel A. De Erausquin

School of Medicine Publications

Human personality is 30–60% heritable according to twin and adoption studies. Hundreds of genetic variants are expected to influence its complex development, but few have been identified. We used a machine learning method for genome-wide association studies (GWAS) to uncover complex genotypic–phenotypic networks and environmental interactions. The Temperament and Character Inventory (TCI) measured the self-regulatory components of personality critical for health (i.e., the character traits of self-directedness, cooperativeness, and self-transcendence). In a discovery sample of 2149 healthy Finns, we identified sets of single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (i.e., SNP sets) regardless of phenotype. Second, we identified five …

The Effectiveness Of Selective Serotonin Reuptake Inhibitors For Treatment Of Obsessive-Compulsive Disorder In Adolescents And Children: A Systematic Review And Meta-Analysis, Vijaya P. Kotapati, Ali M. Khan, Sara Dar, Gulshan Begum, Ramya Bachu, Mahwish Adnan, Aarij Zubair, Rizwan A. Ahmed

School of Medicine Publications

Background: Obsessive-compulsive disorder (OCD) is a common behavioral disorder among adolescents and children. The selective serotonin reuptake inhibitors (SSRIs) are the first pharmacological choice for this condition due to mild adverse effect profile.

Objective: This systematic review was performed to evaluate the efficacy of SSRI for OCD in adolescents and children.

Methods: Search terms were entered into PubMed, PsycINFO, Scopus, CINAHL, and Google Scholar. The included studies were randomized, placebo-controlled trials of SSRIs conducted in populations of children and adolescents younger than 18 years. Change from baseline Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), end-treatment CY-BOCS with respective SD, and response and …

Role Of Naltrexone In Improving Compulsive Drinking In Psychogenic Polydipsia, Sukaina Rizvi, Jeffery Gold, Ali M. Khan

School of Medicine Publications

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials …

Use Of Gabapentin In The Treatment Of Substance Use And Psychiatric Disorders: A Systematic Review, Saeed Ahmed, Ramya Bachu, Vijaya P. Kotapati, Mahwish Adnan, Rizwan A. Ahmed, Umer Farooq, Hina Saeed, Ali M. Khan, Aarij Zubair, Iqra Qamar, Gulshan Begum

School of Medicine Publications

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use disorders. This review aimed to perform a systematic analysis of peer-reviewed published literature on the efficacy of GBP in the treatment of psychiatric disorders and substance use disorders.

Methods: This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …

Use Of Transcranial Magnetic Stimulation For Depression, Sukaina Rizvi, Ali M. Khan

School of Medicine Publications

Transcranial magnetic stimulation (TMS), a research tool with various effects on brain cells, can depolarize cerebral neurons noninvasively. This method offers temporal and spatial resolution and can be combined with other neurocognitive and neuro-experimental techniques. Prefrontal TMS therapy repeated daily for four to six weeks is a neuromodulation technique approved by the US Food and Drug Administration for the treatment of major depressive disorder (MDD) in patients resistant to medications. This technique utilizes electromagnetic induction to excite neuronal cells. Several recent studies have enhanced our understanding of this novel treatment intervention. This report reviews recent studies on the mechanism of …

A Review Of The Mechanism Of Antagonism Of N-Methyl-D-Aspartate Receptor By Ketamine In Treatment-Resistant Depression, Yasar Sattar, John Wilson, Ali M. Khan, Mahwish Adnan, Daniel Azzopardi Larios, Shristi Shrestha, Quazi Rahman, Zeeshan Mansuri, Ali Hassan, Nirav B. Patel

School of Medicine Publications

The biochemical processes involved in depression go beyond serotonin, norepinephrine, and dopamine. The N-methyl-D-aspartate (NMDA) receptor has a major role in the neurophysiology of depression. Ketamine, one of the prototypical NMDA antagonists, works rapidly in controlling depressive symptoms, including acutely suicidal behavior, by just a single injection. Ketamine may rapidly increase the glutamate levels and lead to structural neuronal changes. Increased neuronal dendritic growth may contribute to synaptogenesis and an increase in brain-derived neurotrophic factor (BDNF). Activation of the mechanistic target of rapamycin (mTOR), as well as increased levels of BDNF, may increase long-term potentiation and result in an improvement …

Principal Component Analysis Of Early Alcohol, Drug And Tobacco Use With Major Depressive Disorder In Us Adults, Kesheng Wang, Ying Liu, Youssoufou Ouedraogo, Nianyang Wang, Xin Xie, Chun Xu, Xingguang Luo

Health & Biomedical Sciences Faculty Publications

Early alcohol, tobacco and drug use prior to 18 years old are comorbid and correlated. This study included 6239 adults with major depressive disorder (MDD) in the past year and 72,010 controls from the combined data of 2013 and 2014 National Survey on Drug Use and Health (NSDUH). To deal with multicollinearity existing among 17 variables related to early alcohol, tobacco and drug use prior to 18 years old, we used principal component analysis (PCA) to infer PC scores and then use weighted multiple logistic regression analyses to estimate the associations of potential factors and PC scores with MDD. The …

Roller Derby As A Form Of Self-Empowerment: An Examination Of Female Athletes' Resilience To Intimate Partner Violence, Esmeralda Castillo

Theses and Dissertations

The purpose of this study is to explore if playing roller derby can yield one more resilient to Intimate Partner Violence (IPV). IPV is a major wellness concern to our present lives. However, there are many who experience violence, yet do not develop debilitating symptoms. The subject of resilience has emerged to account for this. Resilience can be interpreted as “bouncing back” from adversity, and adapting well to sources of stress (American Psychological Association, n.d.). Sport psychologists have recognized sport as a site for the development of resilient qualities. For females, team sports offer a context to experience empowerment. The …

Reanalyzing The Activity Anorexia Protocol Using An Addiction Theory, Rolando Alfredo Botello

Theses and Dissertations

One researched and developed phenomenon is activity anorexia (AA) in rats and its resemblance to the human pathology anorexia nervosa (AN). Researchers have long relied on this comparative model for AN as AA. This study aims to reanalyze the overt physiological phenomena of AA to test an addictive theory against the prevalent AA theory. Equal numbers of subjects could eat or run during a one hour feeding period and all activity was monitored per 30 minutes. Results showed that daily running correlated with an increase in food consumption with no effect of food suppression. The only factor that regressed to …

Analysis Of Ptprk Polymorphisms In Association With Risk And Age At Onset Of Alzheimer’S Disease, Cancer Risk, And Cholesterol, Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang

Health & Biomedical Sciences Faculty Publications

The human receptor-type protein-tyrosine phosphatase kappa (PTPRK) gene is highly expressed in human brain and is previously associated with neuropsychiatric disorders and cancer. This study investigated the association of 52 single nucleotide polymorphisms (SNPs) in the PTPRK with the risk and age at onset (AAO) of Alzheimer’s disease (AD) in 791 AD patients and 782 controls. Five SNPs (top SNP rs4895829 with p=0.0125) were associated with the risk of AD based on a multiple logistic regression (p

The Development Of Theory Of Mind And Inhibitory Processing Among 7-11 Year Old Mexican And Mexican American Children, Daniela Kuri

Theses and Dissertations

The present study examined the relationships among demographic factors and aspects of social and cognitive development in 130 predominantly bilingual Mexican and Mexican-American 7-to-11-year-old children residing in Mexico and the United States. Measures assessed children’s WMLS-R Picture Vocabulary, inhibitory processing, visual-spatial problem solving, and theory of mind development. Demographic information was obtained from parents. Intercorrelations among age, WMLS-R Picture Vocabulary , inhibitory processing, visual-spatial problem solving, and theory of mind (ToM) revealed that ToM related to inhibitory processing, but not with visual-spatial problem solving skills, after controlling for age. Findings suggest that cultural and other individual factors might play an …

Predictors Of Attitudes Towards Law Enforcement Among Hispanics Living In The U.S.-Mexico Border Region, Ivan Avila

Theses and Dissertations

Previous research has shown that minorities hold negative attitudes towards members of law enforcement. Contact with law enforcement has been shown as a major predictor of attitudes towards law enforcement among minorities. Research on this subject has primarily focused on Blacks’ attitudes towards police. Hispanics have been the focus of only a small amount of research on police contact and attitudes towards law enforcement. This study examined contact and attitudes towards several law enforcement entities: local police, state troopers, and border patrol agents. The current study took place along the U.S.-Mexico border, an area with a high population of Hispanics, …