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Psychology Faculty Publications
Allostatic load . Children . Cortisol . Developmental disorder . Genotype . Hypothalamic– pituitary–adrenal axis (HPA axis) . Socioemotional development . Schizophrenia . Stress–diathesis . Velo-cardio-facial syndrome (VCFS)
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Full-Text Articles in Psychiatry and Psychology
How Might Stress Contribute To Increased Risk For Schizophrenia In Children With Chromosome 22q11.2 Deletion Syndrome?, Elliott A. Beaton, Tony J. Simon
How Might Stress Contribute To Increased Risk For Schizophrenia In Children With Chromosome 22q11.2 Deletion Syndrome?, Elliott A. Beaton, Tony J. Simon
Psychology Faculty Publications
The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with
a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has been under investigation for over 30 years (Walker et al. 2008), the stress–diathesis model has yet to be investigated in children with
22q11.2DS. Children with 22q11.2DS face serious medical, behavioral, and socioemotional challenges from infancy into adulthood. Chronic stress elevates glucocorticoids, decreases immunocompetence, negatively impacts brain
development and function, and is associated with psychiatric illness in adulthood. Drawing knowledge from the extant and well-developed …