Psychiatry and Psychology Commons^™

Common And Specific Impairments In Attention Functioning In Girls With Chromosome 22q11.2 Deletion, Fragile X Or Turner Syndromes., A I. Quintero, Elliott A. Beaton, Danielle J. Harvey, Judith L. Ross, Tony J. Simon

Psychology Faculty Publications

Background:

Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention.

Methods:

Girls with 22q11.2DS, FXS, or TS and typically developing (TD) …

Processing Of Affective Faces Varying In Valence And Intensity In Shy Adults: An Event-Related Fmri Study, Erica Tatham, Louis A. Schmidt, Elliott A. Beaton, Jay Schulkin, Geoffrey B. Hall

Psychology Faculty Publications

Recent behavioral and electrocortical studies have found that shy and socially anxious adults are hypersensitive to the processing of negative and ambiguous facial emotions. We attempted to extend these findings by examining the neural correlates of affective face processing in shy adults using an event-related fMRI design. We presented pairs of faces that varied in affective valence and intensity. The faces were morphed to alter the degree of intensity of the emotional expressive faces. Twenty-four (12 shy and 12 non-shy) young adult participants then made same/different judgments to these faces while in an MR scanner. We found that shy adults …

Impaired Object Tracking In Children With Chromosome 22q11.2 Deletion Syndrome, Margarita H. Cabaral, Elliott A. Beaton, Joel Stoddard, Tony J. Simon

Psychology Faculty Publications

Background:

Chromosome 22q11.2 Deletion Syndrome (22q11.2DS) occurs in approximately 1:4,000 live births with a complex and variable presentation that includes medical, socioemotional and psychological symptoms with intellectual impairment. Cognitive impairments in spatiotemporal and visuospatial attention have also been reported. However, maintenance of selective attention to dynamic and interacting objects has not been systematically investigated in children with 22q11.2DS.

Methods:

We used a multiple object tracking task to assay capacity and resolution performance of children with 22q11.2DS aged 7 to 14 years versus age-matched typically developing (TD) peers.

Results:

Children with 22q11.2DS but not TD children demonstrated impaired performance when task …

How Might Stress Contribute To Increased Risk For Schizophrenia In Children With Chromosome 22q11.2 Deletion Syndrome?, Elliott A. Beaton, Tony J. Simon

Psychology Faculty Publications

The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with
a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has been under investigation for over 30 years (Walker et al. 2008), the stress–diathesis model has yet to be investigated in children with
22q11.2DS. Children with 22q11.2DS face serious medical, behavioral, and socioemotional challenges from infancy into adulthood. Chronic stress elevates glucocorticoids, decreases immunocompetence, negatively impacts brain
development and function, and is associated with psychiatric illness in adulthood. Drawing knowledge from the extant and well-developed …

Increased Incidence And Size Of The Cavum Septum Pellicidum In Children With Chromosome 22q11.2 Deletion Syndrome, Elliott A. Beaton, Y Qin, V Nguyen, J Stoddard, J D. Pinter, T J. Simon

Psychology Faculty Publications

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a result of a hemizygotic microdeletion that results in a variety of impairments in children including greater risk for psychiatric ailments in adulthood. We used high-resolution magnetic resonance imaging to accurately quantify the length and, for the first time, volume, of the cavum septum pellucidum (CSP) in children aged 7 to 14years with 22q11.2DS and typically developing (TD) controls. Significantly greater anteroposterior length and greater CSP volumes were found in children with 22q11.2DS compared with controls. Furthermore, the largest CSP were found only in the 22q11.2DS group and with a much higher incidence than …

Resting And Reactive Frontal Brain Electrical Activity (Eeg) Among A Non-Clinical Sample Of Socially Anxious Adults: Does Concurrent Depressive Mood Matter?, Elliott A. Beaton, Louis A. Schmidt, A R. Ashbaugh, D L. Santesso, M M. Antony, R E. Mccabe

Psychology Faculty Publications

A number of studies have noted that the pattern of resting frontal brain electrical activity (EEG) is related to individual differences in affective style in healthy infants, children, and adults and some clinical populations when symptoms are reduced or in remission. We measured self-reported trait shyness and sociability, concurrent depressive mood, and frontal brain electrical activity (EEG) at rest and in anticipation of a speech task in a non-clinical sample of healthy young adults selected for high and low social anxiety. Although the patterns of resting and reactive frontal EEG asymmetry did not distinguish among individual differences in social anxiety, …