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Articles 451 - 480 of 934
Full-Text Articles in Psychiatry and Psychology
The Varieties Of Spiritual States Triggered By Sex: A Systematic Review Of The Empirical Literature, Jenny Wade
The Varieties Of Spiritual States Triggered By Sex: A Systematic Review Of The Empirical Literature, Jenny Wade
International Journal of Transpersonal Studies
This systematic review integrates the empirical evidence of spiritual experiences triggered by sexual activity, including studies by 10 authors. Despite venerable sexual meditative traditions of embodied spiritual practices, such as Hindu Tantra, Vajrayana Buddhism, and Taoism, empirical studies of sexual spiritual experiences are in their infancy. This review presents the range of sexual altered states experiences identified to date and how they qualify as spiritual experiences phenomenologically and in terms of their lifechanging effects. Seventeen distinct sexual-spiritual states have been identified across authors, with 4 others identified at significant levels in qualitative studies by individual authors. As an emergent area …
Food Restriction And Body Image Distortion In Pregnant Mothers: Outcomes For Exposed Children, Kathryn M. Dana
Food Restriction And Body Image Distortion In Pregnant Mothers: Outcomes For Exposed Children, Kathryn M. Dana
Dissertations, Theses, and Capstone Projects
Background: Developmental trajectories in the growing child do not originate at birth. Rather, critical periods may exist in pregnancy, during which the determinants of malnutrition are especially vulnerable to the effects of stress and other complications. Prenatal malnutrition has been consistently associated with negative consequences for the growth, development, and overall physical and mental health of affected offspring in both human and animal models. While most available literature on human prenatal malnutrition comes from famine research, there is some evidence that restrictive eating disorders in pregnant women may be associated with similar outcomes.
Hypotheses: We hypothesize that prenatal exposure to …
Training And Individual Predictors Of Attitudes Toward Serious Mental Illness Amongst Clinical Psychology Doctoral Students, Lauren K. O'Connor
Training And Individual Predictors Of Attitudes Toward Serious Mental Illness Amongst Clinical Psychology Doctoral Students, Lauren K. O'Connor
Dissertations, Theses, and Capstone Projects
Clinical psychologists are grossly underrepresented in treatment provision for individuals with serious mental illness (SMI; Roe, Yanos, Lysaker, 2006). Systemic (e.g., emergence of managed care) and training-based (e.g., limitations to SMI specific training) factors contribute to the establishment of this underrepresentation, while mental health stigma amongst psychologists may play a role in perpetuating it. Many individual and experiential factors have been found to impact clinicians’ attitudes toward those with SMI (Henderson et al., 2014; Schulzes, 2007). Though many of these factors are present and relevant from the beginning of one’s career and may involve elements related to training, little research …
An Empirical Research On Developing The Framework For Managing Sexual Abstinence Issues Of The Chinese Male Seafarers, Bin Dong
Maritime Safety & Environment Management Dissertations (Dalian)
No abstract provided.
Applying Theoretical Models Of Positive Emotion To Improve Pediatric Asthma: A Positive Psychology Approach, Brooke N. Jenkins, Judith T. Moskowitz, Jill Halterman, Zeev N. Kain
Applying Theoretical Models Of Positive Emotion To Improve Pediatric Asthma: A Positive Psychology Approach, Brooke N. Jenkins, Judith T. Moskowitz, Jill Halterman, Zeev N. Kain
Psychology Faculty Articles and Research
Positive emotion, encompassing feelings such as joy and happiness, has been shown to predict a multitude of health outcomes. However, the role of positive emotion in pediatric asthma is not understood. No work to date has examined how positive emotion may offer benefits to children and adolescents with asthma. Based on theory and models of positive emotion and health, we hypothesize that positive emotion may improve asthma outcomes through mediators such as health behaviors and health-relevant physiological functioning. Moreover, boosting positive emotion during times of stress may be particularly relevant in mitigating asthma symptoms. In the present commentary, we elaborate …
Economic Insecurity, Poverty, And Parental Alcohol Misuse, Joey Tucciarone
Economic Insecurity, Poverty, And Parental Alcohol Misuse, Joey Tucciarone
Electronic Theses and Dissertations
Because parental alcohol misuse is associated with numerous negative outcomes for drinkers and other family members, it is important to examine factors predictive of alcohol misuse patterns among parents living with at least one child under the age of 18. Two possible factors include economic insecurity and poverty. This study sought to address whether measures of economic insecurity (i.e., housing and/or food insecurity in the past 12 months) and a dichotomous measure of poverty predict parental binge drinking and parental heavy alcohol consumption in a large population-based sample. It was hypothesized that economic insecurity and poverty, analyzed separately, would predict …
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Journal of Wellness
The essential question of the relationship between consciousness and matter is ignored in medical school curricula, leading to a machine-like view of the human being that contributes to physician burnout and intellectual dissatisfaction. The evidence suggesting that the brain may not be the seat of consciousness is generally ignored to preserve the worldview of the primacy of matter. By investigating new frameworks detailing the nature of consciousness at different levels of hierarchy, we can bring intellectual rigor to a once opaque subject that supports a fundamental reality about our experience: We are human beings, not only human bodies.
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
All NMU Master's Theses
Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …
The Biopsychosocial Model And Clinical Decision Science In The Age Of Black Lives Matter: A Clinical Reflection, Abdul-Rahman M. Suleiman, Samer Ilayan
The Biopsychosocial Model And Clinical Decision Science In The Age Of Black Lives Matter: A Clinical Reflection, Abdul-Rahman M. Suleiman, Samer Ilayan
Clinical Research in Practice: The Journal of Team Hippocrates
The author reflects on the biopsychosocial considerations of elevated blood pressure in teenage African American youth during the era of Black Lives Matter (BLM). Parallels are drawn between Dr. Engel’s biopsychosocial model and clinical decision science.
Art And Empathy: Self Discovery In A Dark Forest, Younser Lee
Art And Empathy: Self Discovery In A Dark Forest, Younser Lee
Graduate School of Art Theses
According to the National Institute of Mental Health, 40 million people report feelings of depression, anxiety, and stress as the world moves at an increasingly rapid pace and faces unprecedented challenges. However, many ignore these negative thoughts and fail to acknowledge them as a serious issue. My art, which shares my own experiences, creates safe, cathartic places for viewers to think about their own emotional experiences. Crucial to this process is my use of daily objects and the creation of individualized, participatory, and multisensory experiences.
My art relates to daily life and the negative emotions that we experience daily. I …
The Prevalence Of Postpartum Depression In Black And Hispanic Women In New Jersey, Courtney Chineme, Rachel Shmuts, Chris Canlas
The Prevalence Of Postpartum Depression In Black And Hispanic Women In New Jersey, Courtney Chineme, Rachel Shmuts, Chris Canlas
Rowan-Virtua Research Day
Postpartum depression (PPD) is defined as symptoms of major depressive disorder (MDD) within one month of giving birth with the prevalence in the United States being 10-15%. There are well documented instances of racial differences and their effects on maternal outcomes including infant, maternal mortality and postpartum mood disorders. In New Jersey, there are monitoring systems that explore the relationships between maternal characteristics such as race, age, education level, insurance status, and racial bias and how they may correlate with higher incidences of Postpartum Depression (PPD) in these communities of women. The purpose of this comparative study is to analyze …
Neuroactivational And Behavioral Correlates Of Psychosocial Stress-Induced Cocaine Seeking In Rats, Nicole M. Hinds, Ireneusz D. Wojtas, Desta M. Pulley, Stephany J. Mcdonald, Samantha De Guzman, Nicole E. Hubbard, Colin M. Kulick-Soper, Jessica J. Debski, Bianca Patel, Daniel Manvich
Neuroactivational And Behavioral Correlates Of Psychosocial Stress-Induced Cocaine Seeking In Rats, Nicole M. Hinds, Ireneusz D. Wojtas, Desta M. Pulley, Stephany J. Mcdonald, Samantha De Guzman, Nicole E. Hubbard, Colin M. Kulick-Soper, Jessica J. Debski, Bianca Patel, Daniel Manvich
Rowan-Virtua Research Day
A prominent feature of cocaine abuse is a high risk of relapse even despite prolonged periods of abstinence. Psychosocial stress is thought to be a major contributor to the onset of cocaine craving and relapse in human substance abusers, yet most preclinical models of stress-induced relapse employ physical stressors (e.g., unpredictable footshock) or pharmacological stressors (e.g., yohimbine to elicit a drug seeking response) and do not rely upon psychosocial stress per se. Importantly, social stressors are well known to activate distinct neural circuits within the brain as compared to other stressors. It is therefore possible that currently available animal models …
Case Of New Onset Alice In Wonderland Syndrome In Adolescent After Prolonged Hospitalization, Michaela Margolis, Timothy Wong, Richard Hadi
Case Of New Onset Alice In Wonderland Syndrome In Adolescent After Prolonged Hospitalization, Michaela Margolis, Timothy Wong, Richard Hadi
Rowan-Virtua Research Day
Alice in wonderland syndrome (AIWS) has been described as body image illusions involving distortions of the size, mass, or shape of the patient’s own body or its position in space, often occurring with depersonalization and derealization. Most cases typically affect young children.
Common distortions are micropsia, macropsia, metamorphopsia, and pelopsia.
The term was adopted from the book by Lewis Carroll, wherein the main character perceived her size and shape to change in different scenarios.
These distortions are often expressed as sensory perceptions rather than illusions or hallucinations, and are often distressing to the patient.
AIWS onset has been found to …
Do You K Now D.O.?: Pre Medical Students’ Knowledge Of Osteopathic Medicine And Its Relation To Burnout, Philip Collins, Laura Collins, Gianna Bowler Darrow, Jennifer C Sepede
Do You K Now D.O.?: Pre Medical Students’ Knowledge Of Osteopathic Medicine And Its Relation To Burnout, Philip Collins, Laura Collins, Gianna Bowler Darrow, Jennifer C Sepede
Rowan-Virtua Research Day
It is estimated that in the near future there will be a shortage of physicians available to keep up with the needs of a growing older population. To try to account for this, medical schools are expanding class sizes and new schools are being created. While both allopathic and osteopathic schools are expanding, osteopathic schools are doing so a much faster rate. Unfortunately, it seems many students enter their undergraduate careers unaware of osteopathic medicine despite having an interest in medical school. Undergraduate student interest in becoming a medical doctor continues to rise, but so too does the difficulty of …
How College Men Describe Their Understanding Of Sexual Assault, Sarah Anolik
How College Men Describe Their Understanding Of Sexual Assault, Sarah Anolik
Dissertations, 2020-current
Despite the proliferation of many vital bystander intervention programs across the country, approximately one in four college women will experience sexual violence. Though it was once believed that a small minority of men were responsible for the vast majority of sexual violence, an estimated 12%-25% of college men report having used sexual violence as an undergraduate student. Research across disciplines suggests several factors associated with the perpetration of sexual violence. While numerous studies have explored these constructs quantitatively on and off college campuses, there have been far fewer qualitative studies that provide insight into how men who have perpetrated violence …
Death Anxiety, Artmaking And The Facilitation Of Death Discourse, Heather Conley
Death Anxiety, Artmaking And The Facilitation Of Death Discourse, Heather Conley
Art Therapy Counseling Final Research Projects
Discussion about death, known as death discourse, has been historically limited to the confines of the palliative care, elderly and hospice arenas (Bradshaw, 1996; Granek, 2013; Safrai, 2013; Zimmerman, 2012). This study examined the impact of artmaking on facilitating death discourse in college-aged students from a midwestern United States campus. A mixed methods design was implemented in which participants completed the Communication Apprehension about Death Scale (CADS; Carmack & DeGroot, 2016), an artmaking directive addressing feelings about death, followed by a Post-Artmaking Reflection about their artwork. Following a 10-day time period after the artmaking session, participants were re-administered the CADS …
Developing The Facilitative Health And Well-Being Tool: Freeing Writing, William O. Fogarty
Developing The Facilitative Health And Well-Being Tool: Freeing Writing, William O. Fogarty
Creativity and Change Leadership Graduate Student Master's Projects
Research into processes of self, including self-concept clarity, identity, and meaning and purpose in life, has demonstrated that human beings that feel they know themselves tend to experience positive health and well-being outcomes, while people who feel they don’t know themselves tend to experience more negative health and well-being outcomes. These findings indicate that knowing oneself is essential. Thus, the facilitative tool I am creating with this Master’s Project, Freeing Writing, combines the power of self-knowledge and self-discovery with the healing power of expressive writing. In this manuscript, I synthesize the scientific research, Design Thinking process, and real-world experiences which …
The Value Of Community Psychiatric Services For The Elderly’S Dementia Caregiver Group: Exploring The Perspectives Of Participants, Elise Greto
Patient Experience Journal
Community Psychiatric Services for the Elderly (CPSE) at a large teaching hospital in Toronto has offered a monthly support group for caregivers of persons with dementia for over 30 years. Participants were surveyed in January 2018 about group attendance, benefits of attending the group, and areas for improvement. Results are shared in this case study. A total of 8 participants responded to the survey with a response rate of 47%. The feedback was predominantly positive. The most prevailing theme that emerged from the survey responses was group members’ appreciation for the opportunity to meet with one another to discuss relevant …
What Is The Readiness Potential?, Aaron Schurger, Pengbo 'Ben' Hu, Joanna Pak, Adina L. Roskies
What Is The Readiness Potential?, Aaron Schurger, Pengbo 'Ben' Hu, Joanna Pak, Adina L. Roskies
Psychology Faculty Articles and Research
The readiness potential (RP) has been widely interpreted to indicate preparation for movement and is used to argue that our brains decide before we do. It thus has been a fulcrum for discussion about the neuroscience of free will.
Recent computational models provide an alternative framework for thinking about the significance of the RP, suggesting instead that the RP is a natural result of the operation of a stochastic accumulator process of decision-making, analyzed by time-locking to threshold-crossing events.
These models call for a reevaluation of: (i) the ontological standing of the RP as reflecting a real, causally efficacious signal …
The Social And The Psychological Impact Of Endometriosis On The Romanian Urban Population, Iulia Baciu, Alecsandra Irimie-Ana, Anca Maria Panaitescu, Gheorghe Peltecu, Corina Gica, Nicolae Gica
The Social And The Psychological Impact Of Endometriosis On The Romanian Urban Population, Iulia Baciu, Alecsandra Irimie-Ana, Anca Maria Panaitescu, Gheorghe Peltecu, Corina Gica, Nicolae Gica
Journal of Mind and Medical Sciences
Objectives. Our study assesses the social and psychological impact of the symptoms of endometriosis. Materials and methods. This crosssectional study was conducted from January 2014 to January 2016. The research involved two groups. The study instrument, the EHP-5 questionnaire, was completed by the respondents on the admission date or on the routine gynecological visit day. Results. Endometriosis has a negative social and psychological impact on women’s life, the most affected areas being work, fertility and sexual activity. Moreover, pain and the negative perception of self-image are major sources of distress. Conclusion. The symptoms and effects of endometriosis, especially chronic pelvic …
Alexithymia And Physical Outcomes In Psychosomatic Subjects: A Cross-Sectional Study, Liam Alexander Mackenzie Myles, Emanuele Maria Merlo
Alexithymia And Physical Outcomes In Psychosomatic Subjects: A Cross-Sectional Study, Liam Alexander Mackenzie Myles, Emanuele Maria Merlo
Journal of Mind and Medical Sciences
Backgrounds. Alexithymia is a relevant phenomenon, occurring transversally to healthy subjects and individuals affected by several conditions. Its role is considerable, according to current state of the art several conditions emerged as influenced, maintained and worsened by alexithymic structures and figures. The present study was aimed at highlighting the existing relations, the differences and the directions assumed by alexithymic factors and health status in patients affected by psychosomatic conditions. Methods. The sample consisted of 150 participants, 42 males (28.0%) and 108 females (72.0%), aged 26 to 78 years old with a mean of 42.24 years old (SD = 12.39). Subjects …
Positive Psychological Well‐Being And Cardiovascular Disease: Exploring Mechanistic And Developmental Pathways, Julia K. Boehm
Positive Psychological Well‐Being And Cardiovascular Disease: Exploring Mechanistic And Developmental Pathways, Julia K. Boehm
Psychology Faculty Articles and Research
Empirical research regarding the health benefits of positive psychological well‐being (e.g., positive emotions, life satisfaction, purpose in life, and optimism) has flourished in recent years, particularly with regard to cardiovascular disease. This paper reviews the state of evidence for well‐being's association with cardiovascular disease in both healthy individuals and those diagnosed with a disease. Prospective studies consistently indicate well‐being reduces cardiovascular events in healthy and, to a lesser extent, patient populations. Potential pathways that link well‐being with cardiovascular disease are discussed (including health behaviors, physiological processes, and stress buffering), although the existing evidence is mostly cross‐sectional which limits conclusions about …
1st Place Contest Entry: Psychogenic Non-Epileptic Seizures Disorder: Treatment After The Diagnostic Odyssey, Heather Andrini, Ashley Okhovat, Sydni Au Hoy
1st Place Contest Entry: Psychogenic Non-Epileptic Seizures Disorder: Treatment After The Diagnostic Odyssey, Heather Andrini, Ashley Okhovat, Sydni Au Hoy
Kevin and Tam Ross Undergraduate Research Prize
This is Heather Andrini, Ashley Okhovat, and Sydni Au Hoy's submission for the 2021 Kevin and Tam Ross Undergraduate Research Prize, which won first place. It contains thier essay on using library resources, a summary of their research project on psychogenic non-epileptic seizures (PNES) disorder, and their works cited list.
Heather, Ashley, and Sydni are juniors at Chapman University, majoring in Biological Sciences. Their faculty mentor is Dr. Gregory Goldsmith.
Understanding The Traumatized Brain, Sam Marion, Elizabeth Marston
Understanding The Traumatized Brain, Sam Marion, Elizabeth Marston
National Youth Advocacy & Resilience Conference
Students who have experienced trauma are often in need of behavioral intervention due to challenging behaviors and reactivity. Understanding the body’s threat response system gives insight into these behaviors and allows for empathy within the interventions. This presentation will outline basic neuroscience theories, propose interventions focused on self-regulation, and demonstrate how adding basic elements to existing interventions can increase efficacy.
Super Placebos: A Feasibility Study Combining Contextual Factors To Promote Placebo Effects, Jay A. Olson, Michael Lifshitz, Amir Raz, Samuel P. L. Veissière
Super Placebos: A Feasibility Study Combining Contextual Factors To Promote Placebo Effects, Jay A. Olson, Michael Lifshitz, Amir Raz, Samuel P. L. Veissière
Psychology Faculty Articles and Research
Background: Ample evidence demonstrates that placebo effects are modulated by contextual factors. Few interventions, however, attempt to combine a broad range of these factors. Here, we explore the therapeutic power of placebos by leveraging factors including social proof, positive suggestion, and social learning. This study aimed to test the feasibility of an elaborate “super placebo” intervention to reduce symptoms of various disorders in a pediatric population.
Methods: In a single-arm qualitative study, participants entered an inactive MRI scanner which they were told could help their brain heal itself through the power of suggestion. The sample included 11 children (6–13 years …
Exploring Attentional And Emotional Biases As A Function Of Trauma And Dissociation Symptomology, Claudia Clinchard
Exploring Attentional And Emotional Biases As A Function Of Trauma And Dissociation Symptomology, Claudia Clinchard
Department of Psychology: Dissertations, Theses, and Student Research
There is evidence that threatening facial expressions (e.g., angry faces) direct attention toward the target, and that for facial expressions that are less threatening but still convey negative valence (e.g., fear faces) direct attention outward and to one’s environment, therefore causing a shift in memory performance and attentional bias depending on the level of threat in emotional facial expressions presented. Extant literature provides evidence for attentional biases both towards and away from threat in those with posttraumatic stress disorder (PTSD) symptomology. The current study aimed to replicate the previous findings of the effects stimulus and emotion have on memory performance …
Oxytocin, Cortisol, And Cognitive Control During Acute And Naturalistic Stress, Shari Young Kuchenbecker, Sarah D. Pressman, Jared Celniker, Karen M. Grewen, Ken D. Sumida, Naveen Jonathan, Brendan Everett, George M. Slavich
Oxytocin, Cortisol, And Cognitive Control During Acute And Naturalistic Stress, Shari Young Kuchenbecker, Sarah D. Pressman, Jared Celniker, Karen M. Grewen, Ken D. Sumida, Naveen Jonathan, Brendan Everett, George M. Slavich
Health Sciences and Kinesiology Faculty Articles
Although stress is a strong risk factor for poor health, especially for women, it remains unclear how stress affects the key neurohormones cortisol and oxytocin, which influence stress-related risk and resilience. Whereas cortisol mediates energy mobilization during stress, oxytocin has anti-inflammatory, anxiolytic, and analgesic effects that support social connection and survival across the lifespan. However, how these neurohormones interrelate and are associated with cognitive control of emotional information during stress remains unclear. To address these issues, we recruited 37 college-aged women (Mage = 19.19, SD = 1.58) and randomly assigned each to a one-hour experimental session consisting of …
Aberrant Maturation Of The Uncinate Fasciculus Follows Exposure To Unpredictable Patterns Of Maternal Signals, Steven J. Granger, Laura M. Glynn, Curt A. Sandman, Steven L. Small, Andre Obenaus, David B. Keator, Tallie Z. Baram, Hal S. Stern, Michael A. Yassa, Elyssia Poggi Davis
Aberrant Maturation Of The Uncinate Fasciculus Follows Exposure To Unpredictable Patterns Of Maternal Signals, Steven J. Granger, Laura M. Glynn, Curt A. Sandman, Steven L. Small, Andre Obenaus, David B. Keator, Tallie Z. Baram, Hal S. Stern, Michael A. Yassa, Elyssia Poggi Davis
Psychology Faculty Articles and Research
Across species, unpredictable patterns of maternal behavior are emerging as novel predictors of aberrant cognitive and emotional outcomes later in life. In animal models, exposure to unpredictable patterns of maternal behavior alters brain circuit maturation and cognitive and emotional outcomes. However, whether exposure to such signals in humans alters the development of brain pathways is unknown. In mother–child dyads, we tested the hypothesis that exposure to more unpredictable maternal signals in infancy is associated with aberrant maturation of corticolimbic pathways. We focused on the uncinate fasciculus, the primary fiber bundle connecting the amygdala to the orbitofrontal cortex and a key …
Assessment Of Major Depressive Disorders Through Neuroimaging Studies And Their Treatment Methods, Jevetha Vijayadasan, Diksha Raghunathan, Sivakumar Rajagopal, Rahul Soangra
Assessment Of Major Depressive Disorders Through Neuroimaging Studies And Their Treatment Methods, Jevetha Vijayadasan, Diksha Raghunathan, Sivakumar Rajagopal, Rahul Soangra
Physical Therapy Faculty Articles and Research
Many mental disorders are caused due to improper regulation of the brain and depression is one such. It affects both children and adults and is very common among teenagers. There are many challenges clinicians face regarding the management of this disease. These challenges have prompted the development of various neuroimaging techniques that effectively diagnose the condition. The main techniques are Magnetic resonance imaging (MRI) and Positron emission tomography (PET) which have gained momentum over the years. Advanced MRI techniques help study certain regions of the brain such as hippocampus and amygdala. Effective treatments for depression include antidepressant medications and brain …
Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar
Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar
Pharmacy Faculty Articles and Research
Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the …