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Articles 481 - 510 of 2003
Full-Text Articles in Psychiatry and Psychology
Implementation Of A Validated Suicide Screening Tool In A University Student Health Center, Tessa Welniak, Bailey Coslor, Cathrin Carithers
Implementation Of A Validated Suicide Screening Tool In A University Student Health Center, Tessa Welniak, Bailey Coslor, Cathrin Carithers
Doctor of Nursing Practice Projects: College of Nursing
Purpose. Suicide is the second leading cause of death among adults in the United States and Nebraska. Death by suicide impacts millions of adults every year in the United States but warning signs are often missed during visits with primary care providers. The University of Nebraska at Kearney (UNK) Student Health Center (SHC), like many other primary care clinics, did not routinely screen patients for suicide risk. According to the Joint Commission, all patients over 12 years of age should be screened for suicide using a validated screening tool if the visit is for any behavioral health concern. The project’s …
The Correlation Of Consistent Exercise With Depressive Symptoms, John Gericke, Tara Pellegrino, Robert Steer
The Correlation Of Consistent Exercise With Depressive Symptoms, John Gericke, Tara Pellegrino, Robert Steer
Rowan-Virtua Research Day
Background: Depression is a major health issue that affects an estimated 350 million people worldwide. Typically, depression is associated with individuals who follow a poor diet and are physically inactive. Exercise is one form of treatment for depression and has been shown to reduce the risk of depression and protect against the onset of depression. The PHQ-9 Depression Score is a tool used to screen individuals for depression on a scale from 0-27. The goal of this study is to identify a relationship between consistent exercise and depression symptoms.
Methods: An original Qualtrics survey was created to be distributed with …
The Effect Of Guided Meditation On Student Doctor-Patient Interactions, Aneela Rampersad, Samantha Plasner
The Effect Of Guided Meditation On Student Doctor-Patient Interactions, Aneela Rampersad, Samantha Plasner
Rowan-Virtua Research Day
Healthcare students are under stress and can use different methods to cope with it. Mindfulness techniques such as guided meditation has been used as a way of helping these students reduce their stress levels. The purpose of this study was to investigate whether guided meditation has an effect on student doctors that translates into more positive interactions with patients. This study found that the student doctors who completed guided meditation felt less frustrated and less impatient while interacting with patients than student doctors who did not perform the guided meditation. Future studies on this topic should recruit more participants so …
The Effect Of Covid-19 Pandemic On Sanitation Practices And Anxiety In The General Population, Leah Cliatt, Joanna Petrides
The Effect Of Covid-19 Pandemic On Sanitation Practices And Anxiety In The General Population, Leah Cliatt, Joanna Petrides
Rowan-Virtua Research Day
Background: Illness anxiety and fear of contracting coronavirus increased considerably during the COVID-19 pandemic. The media, being in lockdown, and cyberchondria had the largest impact on the population’s anxiety surrounding illness. While this kind of reaction to illness is expected during the pandemic, there is limited data on post-pandemic illness anxiety levels in the general population. Patients’ perception of disease impacts medicine at every level; medical professionals need to understand the concerns and fears of their patients in order to treat the post-pandemic patient. We hypothesized that sanitation practices and anxiety surrounding illness have not returned to baseline pre-COVID-19 …
Over The Counter Overdose: A Case Of Tylenol Toxicity, Swet M. Patel, James A. Espinosa, Alan Lucerna
Over The Counter Overdose: A Case Of Tylenol Toxicity, Swet M. Patel, James A. Espinosa, Alan Lucerna
Rowan-Virtua Research Day
We report a case of a 51-year-old man presenting to the Emergency Department (ED) with suicidal ideations (SI) endorsing an intentional overdose of acetaminophen. Just as important is the clinical presentation; it is equally important to obtain a detailed history of patient's presentation leading to the ED visit when evaluating a suicide attempt. Tylenol (acetaminophen) is a common over the counter (OTC) medication available to the public. Management of Tylenol overdose follows a standard outline of things to observe and intervene on. In this case, we discuss how Tylenol overdose is managed in a clinical setting through a patient who …
Investigation Of The Utility Of A Ptsd Coaching Mobile App To Address Mental Health Services Demand In A Primary Care Clinic: Analysis Of Caps-5 Measures, Sindhura Nemani, Danielle Rae Schweitzer, Anne C. Jones
Investigation Of The Utility Of A Ptsd Coaching Mobile App To Address Mental Health Services Demand In A Primary Care Clinic: Analysis Of Caps-5 Measures, Sindhura Nemani, Danielle Rae Schweitzer, Anne C. Jones
Rowan-Virtua Research Day
The COVID-19 pandemic affected countless people globally, resulting in a greater need for mental health professionals and resources1. The demand for mental health care is soaring yet the limitation of resources has strained the healthcare system, making it challenging to help patients in a timely manner2. This poster represents a snapshot of a larger project that is striving to investigate an intervention to help bridge the gap between patient need and prompt referral through a warm handoff approach and use of the PTSD Coach mobile application as well as exploring patients’ satisfaction3,4,5,6,8,9. In this …
Using Fmri To Assess Effectiveness Of Olanzapine Treatment For Schizophrenia, William Kyle Copenhaver, David F. Lo, Hanna Rothenberg, Eeshan Khurana, Valerie Rome, Uzayr Wasif, Don D. Shamilov
Using Fmri To Assess Effectiveness Of Olanzapine Treatment For Schizophrenia, William Kyle Copenhaver, David F. Lo, Hanna Rothenberg, Eeshan Khurana, Valerie Rome, Uzayr Wasif, Don D. Shamilov
Rowan-Virtua Research Day
Schizophrenia is a complex mental illness with neurobiological underpinnings and misconceptions about violence. Schizophrenia is associated with high levels of creativity and structural traits like fewer D2 receptors. Patients face reduced life expectancy due to cardiovascular diseases and cope through smoking and sedentariness. Treatment involves pharmacological antipsychotics like olanzapine and nonpharmacological approaches. Olanzapine works by antagonizing D2 receptors but has side effects like weight gain and diabetes risk. fMRI is used to study treatment mechanisms and predict response, but research on olanzapine's brain network effects is limited.
Review Of Missing Data Elements For Client Enrollment In The Minority Aids Initiative For High-Risk Men Of Nj, Vrushank Shah
Review Of Missing Data Elements For Client Enrollment In The Minority Aids Initiative For High-Risk Men Of Nj, Vrushank Shah
Rowan-Virtua Research Day
The Minority AIDS Initiative study funded in NMI seeks to enhance healthcare outcomes for underserved individuals. Implementing outreach programs, the initiative provides healthcare and post-treatment follow-up to this demographic. The proposed project, a component of this study, concentrates on individuals with substance abuse disorder, specifically targeting those who have been onboarded but subsequently lost to follow-up. In the United States, approximately 20 million people are diagnosed with substance abuse disorder, yet in 2016, only 3.8 million received treatment. Within this cohort, between 20% and 70% of individuals undergoing residential substance abuse treatment disengage before completion. Various factors hinder the sustained …
Efficacy Of Psilocybin In The Treatment Of Substance And Alcohol Use Disorders, Hanna Brancaccio
Efficacy Of Psilocybin In The Treatment Of Substance And Alcohol Use Disorders, Hanna Brancaccio
Rowan-Virtua Research Day
Introduction: Substance use disorder (SUD) and alcohol use disorder (AUD) are major public health crises, affecting millions of Americans. Current treatment options include behavioral therapies and medications. In this review, we explored psilocybin’s efficacy in treating SUD and AUD.
Methods: Key terms were used to search databases to identify articles that addressed psilocybin in the treatment of SUD. Included in the review were indexed, peer-reviewed, primary sources that were published within the last 10 years. Excluded studies were non-peer reviewed, not relevant to the thesis, and did not have an English translation.
Results: The psychodynamic antidepressant effects of psilocybin mark …
Relationship Between Caregiver Burden And Socioeconomic Status, Nikitha Pappachen, Maithri Goud
Relationship Between Caregiver Burden And Socioeconomic Status, Nikitha Pappachen, Maithri Goud
Rowan-Virtua Research Day
In this study, caregiver burden measures the psychosocial strain a caregiver experiences as a result of caring for a person with autism. In addition, this study focuses on the effect of socioeconomic status on caregiver burden. A previous study found an association between lower primary caregiver education level and more sleep problems for children with autism3. Thus, the finding focuses on the child with autism as opposed to the caregiver burden. Other studies focus on elements that affect caregiver burden such as sleep quality, mental health, and cultural aspects. If it is known that socioeconomic status significantly affects …
Gut Microbiome And Nutrition Interplay In Regulating And Improving Autism Spectrum Disorder Related Social Symptoms, Irenonsen Juliet Eigbe, Christian Moya Gamboa, Jana Gjini, Jaydeep Mukherjee, Susrut Dube
Gut Microbiome And Nutrition Interplay In Regulating And Improving Autism Spectrum Disorder Related Social Symptoms, Irenonsen Juliet Eigbe, Christian Moya Gamboa, Jana Gjini, Jaydeep Mukherjee, Susrut Dube
Rowan-Virtua Research Day
The composition of the gut microbiome has been shown to play a role in the onset of neurological disorders, including Autism Spectrum Disorder(ASD). A small variety of recent research articles identify a possible link between onset and severity of ASD related behaviors and the composition of the gut microbiome. The purpose of this review is to identify gaps in the current understanding of the role that nutrition plays in changing the gut microbiome and subsequently altering the onset and severity of behavioral phenotypes in children with ASD. Inclusion criteria comprises peer-reviewed publications relating to children with autism. Exclusion criteria consists …
Factors Affecting Caregiver Burden In Informal Caregivers Of Patients With Autism Spectrum Disorder, Brian Joseph Mathew, Maduka Gunasinghe, Usmaan Al-Shehab, Samrat Gollapudi, Prince Patel, Maithri Goud
Factors Affecting Caregiver Burden In Informal Caregivers Of Patients With Autism Spectrum Disorder, Brian Joseph Mathew, Maduka Gunasinghe, Usmaan Al-Shehab, Samrat Gollapudi, Prince Patel, Maithri Goud
Rowan-Virtua Research Day
Individuals with Autism Spectrum Disorder (ASD) often require lifelong care to meet their daily needs, which is typically provided by informal sources like family members as well as formal caregivers from home health agencies. The persistent stress of raising a child with ASD can potentially lead to parental burnout, highlighting the importance of understanding the struggles faced by these caregivers. Clinicians must prioritize the well-being of both the individuals with ASD and their dedicated caregivers by gaining a comprehensive understanding of the challenges they encounter.
Our research aims to investigate and comprehend the specific challenges faced by caregivers of individuals …
Review Of Psychogenic Nonepileptic Seizures And Patient-Centered Approaches To Care, Rabeel Ahmad, Rebekah Dietrich, Munaza Khan
Review Of Psychogenic Nonepileptic Seizures And Patient-Centered Approaches To Care, Rabeel Ahmad, Rebekah Dietrich, Munaza Khan
Rowan-Virtua Research Day
Psychogenic nonepileptic seizures (PNES) are defined as involuntary experiential and behavioral responses to internal or external stimuli. They are behaviors, not associated with pathological alterations in the physiology of the brain. Although some of them mimic syncope, they have historically been regarded to clinically resemble epileptic episodes.
There is a multiplicity of different names for this condition. PNES is the most widely used term, though the term "functional seizures" is increasingly used. Alternatives such as "psychogenic seizures," "dissociative seizures," "psychogenic nonepileptic attacks" (PNEA), and "nonepileptic seizures" are also used.
Association Between Cultural Factors And Postpartum Depression, Usha Modukuru
Association Between Cultural Factors And Postpartum Depression, Usha Modukuru
Rowan-Virtua Research Day
Postpartum depression (PPD) is present in 17.22% of the world population. The negative physical and psychological impacts of PPD impact not only the mother, but also those around her. This raises the importance of identifying factors contributing to its onset. Studies have shown that PPD prevalence rates vary between non-Western and Western regions of the world. Cultural postpartum practices differed significantly region to region. Search terms including postpartum depression and cultures were used to find peer-reviewed articles, primary surveys, and patient interviews between 2013-2023. Qualitative analyses were performed on the results. Ethnokinship cultures, commonly present in non-Western countries, prioritized social …
Utilization Of Depression Screening In Patients With Type 2 Diabetes Mellitus, John T. Norris Bsn, Rn, Dnp-Pmhnp Student, Robin Gordon Bsn, Rn, Dnp-Pmhnp Student, Margaret Harvey Phd, Aprn-Bc, Acnp, Chfn, Laura Reed Dnp, Fnp-Bc
Utilization Of Depression Screening In Patients With Type 2 Diabetes Mellitus, John T. Norris Bsn, Rn, Dnp-Pmhnp Student, Robin Gordon Bsn, Rn, Dnp-Pmhnp Student, Margaret Harvey Phd, Aprn-Bc, Acnp, Chfn, Laura Reed Dnp, Fnp-Bc
Doctor of Nursing Practice Projects
Purpose/Background
Type 2 diabetes is a chronic metabolic disorder affecting millions of individuals worldwide. Research has shown that individuals with diabetes are at a higher risk of developing depression in comparison to those of the general population. Depression affects the individual's emotional well-being and has a significant impact on the management and outcomes of diabetes (Mather, 2022). This research study aims to investigate the feasibility and effectiveness of implementing the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is one the most effective assessment tools available to identify symptoms of depression (Celik, 2020).
Methods
In this retrospective chart review, at least 50 …
Social Media Addiction Affecting Mental Health Of College Women, Praneetha Rajkumar, Don D. Shamilov, David F. Lo
Social Media Addiction Affecting Mental Health Of College Women, Praneetha Rajkumar, Don D. Shamilov, David F. Lo
Rowan-Virtua Research Day
In our digital society, many teenagers and young adults use the many forms of social media, which are applications that enable users to create, share, and view content. Addiction to sites such as Instagram, TikTok, and Snapchat is a rising concern due to the impact it has on the mental health of young women, particularly those aged 18-25. Addiction can result in spending an unreasonable amount of time on social media, being overly preoccupied with social media content, or having day-to-day activities that revolve around social media usage. Different sources of data were reviewed to understand why mental health concerns …
Impact Of Acceptance Date On Medical Students' Stress & Academic Success, Portia Tasnim Shaheed, Alissa Hochman
Impact Of Acceptance Date On Medical Students' Stress & Academic Success, Portia Tasnim Shaheed, Alissa Hochman
Rowan-Virtua Research Day
Each year, medical school admissions committees use various predictive factors to determine the demographics of their incoming cohorts, including undergraduate or graduate GPAs, MCAT scores, socioeconomic background, gap years, and more. Put together, these factors can paint a picture of how ready an applicant is to face the rigors of medical school. Once applicants are accepted, they face similar life stressors accompanied by the transition to medical school, but the amount of time they have to handle these life stressors is variable depending on when they are admitted. This study aimed to determine if late acceptance into medical school would …
Evaluating The Prevalence Of Postpartum Substance Use In South Jersey, Hebba Ahmad, Joanna Petrides
Evaluating The Prevalence Of Postpartum Substance Use In South Jersey, Hebba Ahmad, Joanna Petrides
Rowan-Virtua Research Day
The goal of this study was to evaluate the prevalence of substance use among women who experience postpartum depression. Looking at South Jersey women in particular, we aimed to compare the rates of women who began to engage in substance use after undergoing labor within the past one year who are covered by private health insurance versus those with Medicaid coverage. A retrospective chart review was performed, and although the small sample size limited our attempts at data analysis, it revealed that there is work to be done in this field. There needs to be methods in reducing the stigma …
Biopsychosocial Case Report, David F. Lo, Gaurav Kumar, Don D. Shamilov
Biopsychosocial Case Report, David F. Lo, Gaurav Kumar, Don D. Shamilov
Rowan-Virtua Research Day
Ms. R, a 32-year-old Hispanic female, suffers from severe anxiety exacerbated by a car accident and past struggles with depression and substance use. Evaluation reveals hypothyroidism, mild anemia, and GAD as the primary diagnosis. Factors contributing to her condition include genetic predispositions, medical issues, and social stressors. Treatment involves pharmacotherapy, psychotherapy, and monitoring her physiological health. Research on wearable data for GAD severity offers potential insights for her treatment. A holistic approach, considering biological, psychological, and social factors, guides her tailored treatment plan for overall well-being.
Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy, Prince Patel, Samrat Gollapudi, Brian Joseph Mathew, Bhaumik Patel
Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy, Prince Patel, Samrat Gollapudi, Brian Joseph Mathew, Bhaumik Patel
Rowan-Virtua Research Day
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar databases using relevant keywords related to psychedelics, connectivity, therapy, and fMRI. Only studies involving major psychedelic compounds (LSD, psilocybin, ayahuasca) and measuring outcomes via fMRI were included.
The findings from the reviewed studies suggest that psychedelics induce acute disruptions in normal large-scale brain network patterns, leading to a compromised modular but …
Doxazosin Immediate Release As Alternative Treatment For Nightmares In Post-Traumatic Stress Disorder: A Case Report, Danyaal Khan, Christie Richardson, Martin Forsberg
Doxazosin Immediate Release As Alternative Treatment For Nightmares In Post-Traumatic Stress Disorder: A Case Report, Danyaal Khan, Christie Richardson, Martin Forsberg
Rowan-Virtua Research Day
Nightmares and flashbacks are common debilitating symptoms of post-traumatic stress disorder (PTSD) that can disrupt daily functioning in patients. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of PTSD intrusion symptoms, although its short half-life is limiting. Doxazosin, another alpha-1 antagonist, is starting to be investigated in the treatment of PTSD-related nightmares due to its smaller side effect profile and longer half-life. In our case report, we present a case of a patient with PTSD-related nightmares who was successfully treated with doxazosin following relapse of symptoms after discontinuation of prazosin. The success of doxazosin immediate …
Exploring The Connection Between Diabetes Distress And Diabulimia, Stephen Poos, Misha Faerovitch, Celeste Pinto, Nima Jamalkhani, Fahad Chaudhri, Satara Khan, David F. Lo, Kaitlin Mcgowan, Ashaki Martin, Don D. Shamilov
Exploring The Connection Between Diabetes Distress And Diabulimia, Stephen Poos, Misha Faerovitch, Celeste Pinto, Nima Jamalkhani, Fahad Chaudhri, Satara Khan, David F. Lo, Kaitlin Mcgowan, Ashaki Martin, Don D. Shamilov
Rowan-Virtua Research Day
Diabulimia is a disordered eating behavior that involves an individual with type 1 DM withholding insulin injection to lose weight. Diabetes distress, a term used to describe the psychological stress associated with managing diabetes, is believed to be the cause of this condition. This review aims to assess whether individuals with diabulimia have measurable evidence of diabetes distress. Studies that described patients qualitative experiences with Diabulimia were matched and compared to the criteria in the Diabetes Distress Scale. Over 40 of the 185 individuals across twelve studies were found to meet one or more criteria from the Diabetes Distress Scale. …
Alpha 7 Nicotinic Acetylcholine Receptor Expression In The Hippocampus Of Patients With Schizophrenia, Shruti Varshney, Ananya Nethikunta, Minjal Patel, Mary Kosciuk, Randel L. Swanson, Venkat Venkataraman, Robert Nagele, Eric Goldwaser, Nimish K. Acharya
Alpha 7 Nicotinic Acetylcholine Receptor Expression In The Hippocampus Of Patients With Schizophrenia, Shruti Varshney, Ananya Nethikunta, Minjal Patel, Mary Kosciuk, Randel L. Swanson, Venkat Venkataraman, Robert Nagele, Eric Goldwaser, Nimish K. Acharya
Rowan-Virtua Research Day
Background: Schizophrenia (SZ) is a heterogenous psychiatric condition characterized by disruptions in cognition, social activity, affect, and perception often associated with a varied combination of positive and negative symptoms. The pathophysiology behind SZ remains poorly elucidated. Earlier reports have cited the importance of the alpha 7 nicotinic acetylcholine receptors (α7nAChR) in the hippocampus and the receptor’s association with auditory sensory gating and cognitive function. Specifically, variations in the expression and functionality of α7nAChR can be linked to auditory hallucinations experienced by patients with SZ and several therapies have been researched that target α7nAChRs. However, there are very few primary research …
Program Curricula For Preparing Medical Professionals On Early Childhood Mental Health, Socio-Emotional Development, And Adverse Childhood Experiences In Primary Care Settings: A Phenomenological Study, Jesutomilola O. Olayemi
Program Curricula For Preparing Medical Professionals On Early Childhood Mental Health, Socio-Emotional Development, And Adverse Childhood Experiences In Primary Care Settings: A Phenomenological Study, Jesutomilola O. Olayemi
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Primary care settings serve as the frontline for addressing the holistic well-being of individuals and particularly for children, they play a pivotal role in shaping early childhood experiences. Pediatric primary care physicians are pivotal in addressing the scarcity of mental health resources for children aged zero to five. There is limited knowledge regarding the competence of pediatric primary care providers in providing developmentally appropriate mental health care in early childhood. Therefore, this phenomenological study examined how early childhood mental health, social-emotional development, and adverse childhood experiences and their related screening practices were integrated into the curricula for preparing prospective pediatric …
Examining Theoretically Derived Mechanisms Underlying The Relationships Between Sexual Arousal, Alcohol Use History, And Sexual Aggression, Kailey Ann Richner
Examining Theoretically Derived Mechanisms Underlying The Relationships Between Sexual Arousal, Alcohol Use History, And Sexual Aggression, Kailey Ann Richner
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Various interventions have attempted to reduce the rates of sexual violence perpetrated by college men; however, meta-analyses suggest interventions need to further evaluate theoretically derived mechanisms to improve outcomes (Malamuth et al., 2018; DeGue et al., 2014; Vladutiu, et al., 2011). To address this concern, the present study utilized the Integrated Theory of Sexual Offending (ITSO; Ward et al., 2016; Ward & Beech, 2008; 2006) to explore mechanisms underlying the relationships between sexual arousal, alcohol use history (AUH), and sexual aggression. Working memory, impulsivity, and affective forecasting paradigms were selected to map onto the ITSO’s neuropsychological mechanisms. The interaction between …
The C-Terminal Domain Of Minc Inhibits Assembly Of The Z Ring In Escherichia Coli, Gabriel R Fries, Sarah H Sperry, Tamsyn E Van Rheenen, Emma Morton
The C-Terminal Domain Of Minc Inhibits Assembly Of The Z Ring In Escherichia Coli, Gabriel R Fries, Sarah H Sperry, Tamsyn E Van Rheenen, Emma Morton
Faculty, Staff and Student Publications
No abstract provided.
Methamphetamine Activates Microglia And Increases Production Of Pro-Inflammatory Chemokine C-C Ligand 2, Colton Bredenkamp
Methamphetamine Activates Microglia And Increases Production Of Pro-Inflammatory Chemokine C-C Ligand 2, Colton Bredenkamp
Theses/Capstones/Creative Projects
Methamphetamine (meth) use continues to increase in the United States despite the apparent health risks that involve neuroinflammation and brain damage. Because neuroinflammation underlies several substance-use and neurological disorders, we investigated whether microglia, the resident immune cells in the brain, are activated and consequently increase production of pro-inflammatory chemokines such as C- C chemokine ligand 2 (CCL2) in the presence of increasing amounts of meth. To address this, we exposed immortalized microglia cells (IMG) isolated from mature mouse brains to increasing concentrations of meth (0, 10, 50, 100, 500 µM) and analyzed for the expression levels of activation markers (CD11b …
Implementation And Effectiveness Of Stress Management Strategies Among Stem Students At The University Of Nebraska-Lincoln, Dylan Hiser
Honors Program: Senior Projects (Public)
High-stakes exams often induce significant stress among STEM (Science, Technology, Engineering, and Math) students, impacting their academic performance and overall well-being. As the opportunity for careers in STEM grows rapidly, understanding the stressors that students face remains critical in mitigating the effects of this stress and ensuring the success of these students. The objective of this study is to determine how well STEM students respond to recommended interventions that mitigate exam stress and to identify trends in these students’ exam scores. To accomplish this, a set of surveys was sent to undergraduate STEM students at the University of Nebraska-Lincoln. The …
Cross-Cohort Replicable Resting-State Functional Connectivity In Predicting Symptoms And Cognition Of Schizophrenia, Chunzhi Zhao, Rongtao Jiang, Juan Bustillo, Peter Kochunov, Jessica A Turner, Chuang Liang, Zening Fu, Daoqiang Zhang, Shile Qi, Vince D Calhoun
Cross-Cohort Replicable Resting-State Functional Connectivity In Predicting Symptoms And Cognition Of Schizophrenia, Chunzhi Zhao, Rongtao Jiang, Juan Bustillo, Peter Kochunov, Jessica A Turner, Chuang Liang, Zening Fu, Daoqiang Zhang, Shile Qi, Vince D Calhoun
Faculty, Staff and Student Publications
Schizophrenia (SZ) is a debilitating mental illness characterized by adolescence or early adulthood onset of psychosis, positive and negative symptoms, as well as cognitive impairments. Despite a plethora of studies leveraging functional connectivity (FC) from functional magnetic resonance imaging (fMRI) to predict symptoms and cognitive impairments of SZ, the findings have exhibited great heterogeneity. We aimed to identify congruous and replicable connectivity patterns capable of predicting positive and negative symptoms as well as cognitive impairments in SZ. Predictable functional connections (FCs) were identified by employing an individualized prediction model, whose replicability was further evaluated across three independent cohorts (BSNIP, SZ …
Examining The Relationship Between Anxiety Severity And Autism-Related Challenges During Cognitive Behavioral Therapy For Children With Autism, Madeleine N Fuselier, Andrew G Guzick, Jafar Bakhshaie, Jeffrey J Wood, Philip C Kendall, Connor M Kerns, Brent J Small, Wayne K Goodman, Eric A Storch
Examining The Relationship Between Anxiety Severity And Autism-Related Challenges During Cognitive Behavioral Therapy For Children With Autism, Madeleine N Fuselier, Andrew G Guzick, Jafar Bakhshaie, Jeffrey J Wood, Philip C Kendall, Connor M Kerns, Brent J Small, Wayne K Goodman, Eric A Storch
Faculty, Staff and Students Publications
PURPOSE: Using data from a randomized clinical trial evaluating cognitive behavioral therapy (CBT) for children with autism and co-occurring anxiety, this study examined the relationship between autism features and anxiety symptoms throughout CBT.
METHODS: Two multilevel mediation analyses were run which examined the mediating role of changes in anxiety for changes in two core features of autism, (a) repetitive and restrictive behaviors (RRBs) and (b) social communication/interaction impairments, between pre- and post-treatment.
RESULTS: Indirect effects between time and autism characteristics were significant for both models, indicating that as anxiety changes, so do RRBs and social communication/interaction as the outcomes respectively. …