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Articles 1711 - 1740 of 2003
Full-Text Articles in Psychiatry and Psychology
The Effects Of Alpha Stimulation On Induced Anxiety, Nolan Thomas Hill
The Effects Of Alpha Stimulation On Induced Anxiety, Nolan Thomas Hill
Electronic Theses and Dissertations
Anxiety is defined as an emotional and physical reaction that prepares us to confront a feared stimulus. Among the many measureable changes induced by anxiety are changes in facial electromyography (EMG), heart rate (HR), and sweat gland activity (EDG). At a pathological level anxiety interferes with cognitive processes. Currently, when anxiety crosses into the pathological level, it is treated with a variety of therapies that share in their use of periods of exposure to anxiety-inducing stimuli. Several devices have been developed to alter brain activity by transcranial electrical stimulation (TCES). One such device, Alpha-Stim®, has been shown to …
Research Brief: "Impact Of Parents' Wartime Military Deployment And Injury On Young Children's Safety And Mental Health", Institute For Veterans And Military Families At Syracuse University
Research Brief: "Impact Of Parents' Wartime Military Deployment And Injury On Young Children's Safety And Mental Health", Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
This brief is about the relationship between the mental health of military children and parental deployment. In policy and practice, healthcare providers and teachers should understand the risks during the post-deployment period and the DoD should implement programs to help military families during the post-deployment period. Suggestions for future research include conducting a study over time on this topic, as well as expanding the sample to include longer and multiple deployments and various age groups of children within military families.
Knowledge And Attitudes Of Parkinson's Disease In Rural And Urban Mukono District, Uganda: A Cross-Sectional, Community-Based Study, Martha Sajatovic
Knowledge And Attitudes Of Parkinson's Disease In Rural And Urban Mukono District, Uganda: A Cross-Sectional, Community-Based Study, Martha Sajatovic
Faculty Scholarship
Background. Parkinson's disease (PD) negatively affects the quality of life. There is limited information on PD published from Africa. Lack of adequate knowledge poses a barrier in the provision of appropriate treatment and care for individuals with PD. Methods. A cross-sectional survey was conducted in urban and rural Mukono district, central Uganda. Through the systematic sampling method, data were gathered from 377 adult participants, interviewed on selected aspects of PD knowledge and attitudes. Results. Of the 377 participants, 47% were from urban settings and 68% (260/377) were women with a median age (IQR) of 34 (26-48) years. Half of the …
Standards Of Evidence For Efficacy, Effectiveness, And Scale-Up Research In Prevention Science: Next Generation., Denise C. Gottfredson, Thomas D. Cook, Frances E.M. Gardner, Deborah Gorman-Smith, George W. Howe, Irwin N. Sandler, Kathryn M. Zafft
Standards Of Evidence For Efficacy, Effectiveness, And Scale-Up Research In Prevention Science: Next Generation., Denise C. Gottfredson, Thomas D. Cook, Frances E.M. Gardner, Deborah Gorman-Smith, George W. Howe, Irwin N. Sandler, Kathryn M. Zafft
Psychiatry and Behavioral Sciences Faculty Publications
A decade ago, the Society of Prevention Research (SPR) endorsed a set of standards for evidence related to research on prevention interventions. These standards (Flay et al., Prevention Science 6:151-175, 2005) were intended in part to increase consistency in reviews of prevention research that often generated disparate lists of effective interventions due to the application of different standards for what was considered to be necessary to demonstrate effectiveness. In 2013, SPR's Board of Directors decided that the field has progressed sufficiently to warrant a review and, if necessary, publication of "the next generation" of standards of evidence. The Board convened …
Behavioural Charactertics Of Patients Vulnerable For Repeated Hospitalisation, Amresh Srivastava, Coralee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt
Behavioural Charactertics Of Patients Vulnerable For Repeated Hospitalisation, Amresh Srivastava, Coralee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt
Data and Test Instruments
Background Re-hospitalization which takes place in about 30 to 50% postdischarge patienst, leads to poor outcome, increased rate of mortality and consumes more than 2/3 of budgetary allocations. Inability to identify vulnerable candidates for repeated admissions limits our options for strategic treatment. Methods In this prospective study conducted at Regional Mental Health Care ( Presently Parkwood Institute) 101 patienst ( 51 feamles, mean age 43 years), were examined using standard psychometric tools on parameters of clinical, psychopathological, suicide behaviour and resiliency for their risk and preventive characerstics. Results We assessed 101 subjects (51 females) with mean age of 42 years. …
Brain Maturation, Poverty And Social Exclusion: Shifting Paradigms Of Psychopathology, Amresh Srivastava
Brain Maturation, Poverty And Social Exclusion: Shifting Paradigms Of Psychopathology, Amresh Srivastava
Psychiatry Presentations
Abstract for lecture
Poverty is a major risk factor for mental disorders. Neuroimaging studies show path are breaking findings to explain why ppeople living in poverty suffer from improper development and maturation of brain due to neuronal loss. It sets in much before the child is born and leads to increased vulnerability for mental disorders.
Recent findings show that changes in brain structure and function due to lack of brain maturation is directly related to poverty. A number of these changes are end result of neuronal survival in the most fundamental neuronal matrix. These findings along with other biological correlates …
Implicit And Explicit Self-Esteem As Predictors Of Reactive And Proactive Aggression In Adolescent Boys And Girls, Maya Suter, Sebastien Urben, Sandrine Pihet, Cybele Bertoni, Jill De Ridder, Philippe Stephan
Implicit And Explicit Self-Esteem As Predictors Of Reactive And Proactive Aggression In Adolescent Boys And Girls, Maya Suter, Sebastien Urben, Sandrine Pihet, Cybele Bertoni, Jill De Ridder, Philippe Stephan
Journal of Adolescent and Family Health
This study aims at examining gender differences and their association with implicit and explicit self-esteem (SE), and reactive and proactive aggression in adolescents. Hundred and eighteen adolescents (60 boys and 58 girls) performed the Implicit Association Test assessing implicit SE. The Rosenberg Self-Esteem scale was used to measure explicit SE. Reactive and proactive aggression were assessed with the self-report Reactive and Proactive Aggression Scale. Results showed that girls characterized by both low explicit and implicit SE (insecure SE), or by high explicit but low implicit SE (defensive SE), showed more reactive aggression than girls reporting high explicit and implicit SE …
Research Brief: "Prevalence Of Suicidality Among Hispanic And African American Veterans Following Surgery", Institute For Veterans And Military Families At Syracuse University
Research Brief: "Prevalence Of Suicidality Among Hispanic And African American Veterans Following Surgery", Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
This brief is about the likelihood of suicidal behavior and ideation among African Americans and Hispanic Americans after surgery. In policy and practice, pain medications should be prescribed after major surgery, health professionals should evaluate for both physical and psychological suffering several months after surgery, and also provide more services to the patient if necessary; the VHA should expand its suicide prevention program and tailor interventions toward cultural subgroups. Suggestions for future research include looking at prescriber and patient characteristics when prescribing pain medication, looking at the differences in post-surgery coping by race, and relying on data from veterans about …
Should Suicide Behaviour Be An Outcome Parameter For Mental Disorder, Amresh Srivastava
Should Suicide Behaviour Be An Outcome Parameter For Mental Disorder, Amresh Srivastava
Data and Test Instruments
Suicide and mental illness are closely related to each other. A high number of people who commit suicide suffer from a mental illness, and a high number of mentally ill patients exhibit suicide behavior. Suicide behavior is a significant aspect of mental illness. It is consistently observed throughout the course of illness, seen in the prodromal stage, during acute phase of remission, in residual phase and whenever illness relapses. A number of times, mental disorder improves but suicide behavior persists. 10-15% patients attempt suicide in the initial phase of an illness. More than half of the patients get hospitalized due …
Early Mortality And Functional Outcome After Acute Stroke In Uganda: Prospective Study With 30 Day Follow-Up, Martha Sajatovic
Early Mortality And Functional Outcome After Acute Stroke In Uganda: Prospective Study With 30 Day Follow-Up, Martha Sajatovic
Faculty Scholarship
Identification of early outcomes post stroke and their predictors is important in stroke management strategies. We prospectively analysed 30-day outcomes (mortality and functional ability) after stroke and their predictors among patients admitted within 7 days post event to a national referral hospital in Uganda. This was a prospective study of acute stroke patients consecutively enrolled between February and July 2014. Social demographics, clinical, laboratory, imaging characteristics, outcomes (all through 30 days), time of death were assessed using standardised questionnaires. Multiple regression was used to analyse the independent influence of factors on outcomes. Of 127 patients, 88 (69.3 %) had ischemic …
Executive Function Predictors Of Children's Talk, Jacqlyne D. Weber
Executive Function Predictors Of Children's Talk, Jacqlyne D. Weber
Undergraduate Honors Theses
Relatively few studies have investigated the relationship between executive functioning (EF) and language development, and even fewer have researched hot and cool EF as a predictor language development. This study is an investigation into the relationship between EF and language development in preschool aged children. More specifically, the ability for hot or cool EF to predict language, this will be the focus of the study. It was found that hot EF was a better predictor of language development in preschool aged children.
Tradtional Alcohol Use Among Rural Yi Minority In China: An Application Of Theory Of Planned Behavior, Yonghua Feng
Tradtional Alcohol Use Among Rural Yi Minority In China: An Application Of Theory Of Planned Behavior, Yonghua Feng
College of Education and Human Sciences: Dissertations, Theses, and Student Research
It is estimated that 25% of the alcohol consumed in China as traditional alcohol. This study explored the drinking patterns and the motives to use traditional alcohol among a sample of the Yi minority in southern China. The Theory of Planned Behavior was used to explore motives.
Based on initial fieldwork among the Yi a questionnaire was developed to provide data to describe traditional alcohol use and to assess the constructs of attitude, subjective norms and perceived behavioral control as expressed the Theory of Planned Behavior. The questionnaire was refined and the results served as an adequate measurement to explore …
A Technology-Enabled Adherence Enhancement System For People With Bipolar Disorder: Results From A Feasibility And Patient Acceptance Analysis, Martha Sajatovic, Kristina A. Cassidy, Johnny Sams, Edna Fuentes-Casiano
A Technology-Enabled Adherence Enhancement System For People With Bipolar Disorder: Results From A Feasibility And Patient Acceptance Analysis, Martha Sajatovic, Kristina A. Cassidy, Johnny Sams, Edna Fuentes-Casiano
Faculty Scholarship
Objective: As poor medication adherence is common in bipolar disorder (BD), technology-assisted approaches may help to monitor and enhance adherence. This study evaluated preliminary feasibility, patient satisfaction and effects on adherence, BD knowledge, and BD symptoms associated with the use of a multicomponent technology-assisted adherence enhancement system. Methods: This prospective study tested the system in five BD patients over a 15-day period. System components included: 1) an automated pill cap with remote monitoring sensor; 2) a multimedia adherence enhancement program; and 3) a treatment incentive program. This study evaluated system usability, patient satisfaction and effects on adherence (Morisky scale), knowledge …
Sleep Hygiene Practices: A Cross Cultural Survey Of Sleeping And Dreaming In College Students, Ivan Noe Martinez Salazar
Sleep Hygiene Practices: A Cross Cultural Survey Of Sleeping And Dreaming In College Students, Ivan Noe Martinez Salazar
Masters Theses
There is consensus that a sizeable percentage of people in most developed countries do not obtain adequate amounts or quality of sleep. These disruptions in sleep, when chronic and severe, can lead to psychological, behavioral and health consequences. The focus on behavioral and contextual factors that impact sleep has been termed “sleep hygiene”. An on-line anonymous survey collected sociodemographic information, as well as self-reports on sleep, sleep hygiene practices and dreaming across two cultural groups (English & Spanish speaking responders). A total of 204 participants (majority of them college and graduate students) answered the survey. Both cultural groups, English and …
Research Brief: "Alcohol Use And Craving Among Veterans With Mental Health Disorders And Mild Traumatic Brain Injury", Institute For Veterans And Military Families At Syracuse University
Research Brief: "Alcohol Use And Craving Among Veterans With Mental Health Disorders And Mild Traumatic Brain Injury", Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
This brief is about the relation between alcohol craving and mental health disorders among veterans, and how mental health disorders impact alcohol cravings. For policy and practices, the research shows that alcohol cravings and mental health disorders among veterans could be a sign for risk of alcohol use disorder. It also shows that the VA should assess veterans for alcohol use disorder, and also research more ties between mental health disorders and alcohol use. Suggestions for future research include conducting the study in a larger, more representative population, as well as involving families in measuring alcohol use/cravings to ensure less …
How Are Therapeutic Professionals Interpreting Ethics In Practice With Migrant Clients?, Madeline A. Brenner
How Are Therapeutic Professionals Interpreting Ethics In Practice With Migrant Clients?, Madeline A. Brenner
Art Therapy Counseling Final Research Projects
The research study aimed to understand the praxis of mental health professionals working with immigrant and refugee populations in relation to ethical guidelines and agency protocols. Through practice-led inquiry, seven mental health professionals were interviewed from differing therapeutic backgrounds and orientations; including Marriage and Family Therapy, Clinical Social Work, Counseling, and Art Therapy. The researcher sought to identify how theory of therapeutic professionals differ, where professionals are engaging in culturally competent practice and what impact this has on the therapeutic relationship. Participants identified the key components of a positive therapeutic relationship include trust, cultural competency, approach, presence, as well as …
Guilty By Reason Of Insanity: Unforeseen Consequences Of California's Deinstitutionalization Policy, Jen Rushforth
Guilty By Reason Of Insanity: Unforeseen Consequences Of California's Deinstitutionalization Policy, Jen Rushforth
Themis: Research Journal of Justice Studies and Forensic Science
Beginning with the passage of the Lanterman-Petris- Short Act in 1969, deinstitutionalization in California has had a devastating effect on the mentally ill. Instead of affording the mentally ill with more rights and protections, the process of shutting down state psychiatric hospitals and impeding psychiatric care for those in need caused a cascade effect leading to an increase of homelessness and incarceration. Over the past four decades, prisons and jails in California have become the de facto state mental hospitals, with severely mentally ill individuals having nearly a four-to-one chance of ending up in jail or prison over a psychiatric …
An Investigation Of Aerobic Fitness, Perceived Quality Of Life And The Direct Effects Of Self-Determination Theory In College Students 2015, Alanna Darling
An Investigation Of Aerobic Fitness, Perceived Quality Of Life And The Direct Effects Of Self-Determination Theory In College Students 2015, Alanna Darling
Master's Theses
There have been numerous studies examining the association between physical activity, motivation and quality of life. In contrast, studies focusing on aerobic fitness and its relationship with levels of motivation and perceived quality of life are lacking. The purpose of this study was to explore the relationship between a direct measure of aerobic fitness, behavioral regulations, and perceptions of quality of life in college-aged sample. Participants included both males (n=129; 21.1±1.8 years) and females (n=89; 20.8±1.4 years) who completed the Behavioral Regulations of Exercise Questionnaire-2 sub-scores and Perceived Quality of Life (PQoL) instruments. Participants then performed the Queen’s College Step …
The Skinny On Eating Attitudes, Body Image, And The Thin-Ideal In College Women, Lyndsay N. Greene
The Skinny On Eating Attitudes, Body Image, And The Thin-Ideal In College Women, Lyndsay N. Greene
Undergraduate Theses and Capstone Projects
There is evidence of a link between body image and disordered eating among females, and some research that suggests exposure to the media exacerbates both body dissatisfaction and eating pathology. Despite these claims, little research has been done on the effects that exposure to photo-shopped images specifically has on body dissatisfaction and eating pathology. The present study sought to further understand the relationship between cognitive distortions of body image and eating attitudes and to examine the effects that exposure to the thin-ideal found in the media has on body dissatisfaction among college aged women. Eighty female college students answered questions …
The Flip-Side To Readmission: Focused After-Care, Amresh Srivastava
The Flip-Side To Readmission: Focused After-Care, Amresh Srivastava
Data and Test Instruments
paper 1. Suicidality in hospitalized early psychosis patients at time of discharge The purpose of this study was to investigate the presence and nature of suicidal risk among early psychosis patients at the time of discharge from hospital. Is it only related to the involvement of a suicidal attempt at admission? Thirty such patients, who were admitted after a suicide attempt were compared with 30 patients similarly diagnosed, but admitted for clinical reasons not involving a suicide attempt. Dependent measures of psychopathology, adjustment and suicidality were used. It was found that the two groups did not differ in suicidality, which …
Frontal Lobe And Psychopathy, Shawna Germain
Frontal Lobe And Psychopathy, Shawna Germain
Themis: Research Journal of Justice Studies and Forensic Science
This research paper presents an analysis of the functions of the frontal lobe and how damage to the frontal lobe correlates to psychopathy. Initially, it will look at how damage to the frontal lobe obstructs frontal lobe functions. The decrease in executive function, due to a reduction of blood flow to the frontal lobe following a subarachnoid hemorrhage, is explored. The correlation between cortical thickness and impulsiveness in adolescence is examined. Subsequently, the issue is then examined through the observation of groups with psychopathy and how the diagnosis relates to their frontal lobes. One study compares individuals with psychopathy to …
Depression And Spiritual Predictors Of Wellness In Family Caregivers Of Individuals With Alzheimer’S Disease, Christine Green
Depression And Spiritual Predictors Of Wellness In Family Caregivers Of Individuals With Alzheimer’S Disease, Christine Green
Doctor of Psychology (PsyD)
This study investigated the role of spirituality in family caregivers of individuals with Alzheimer’s disease as a means of lessening the development of depressive symptomology arising through caregiver burden. For this study, there were 41 caregiver participants taking care of a family member with Alzheimer’s disease. The population was obtained through various divisions of the Alzheimer’s Association of the United States of America. Participants completed a basic demographic survey, the General Well-Being Schedule, the Patient Health Questionnaire- 9, and the Spiritual Experience Index. Two groups, religious and non-religious, had their mental health functioning compared. Results from the 41 surveys suggest …
Increasing Physical Activity In Young Adults With Autism Spectrum Disorder, Katherine B. Lalonde
Increasing Physical Activity In Young Adults With Autism Spectrum Disorder, Katherine B. Lalonde
Dissertations
Experts recommend that individuals walk 10,000 steps or more per day and doing so has been shown to have several health benefits. Unfortunately, many people fall short of 10,000 steps per day. Exercise levels are characteristically lower in people with Autism Spectrum Disorders (ASD) than in people without ASD. The present study comprised two experiments that used goal setting and reinforcement to increase physical activity in young adults with ASD. The first study employed a multiple-baseline-across-participants design in combination with a reversal design to determine the effects of a treatment package on the number of daily steps taken by young …
Measuring Patient Experience In A Safety Net Setting: Lessons Learned, Nina Shabbat, Katy Dobbins, Sonja Seglin, Kristin Davis
Measuring Patient Experience In A Safety Net Setting: Lessons Learned, Nina Shabbat, Katy Dobbins, Sonja Seglin, Kristin Davis
Patient Experience Journal
Safety net providers have faced barriers in administering patient experience surveys due to a lack of resources and survey expertise, but this problem has received little attention in the literature. In this manuscript, we offer lessons learned from the administration of a patient experience survey at a mid-size behavioral health care agency serving a safety net population. Specifically, we discuss resource needs, methods of increasing response rate among transient populations, methods for engaging stakeholders and clinical staff in quality improvement initiatives, and considerations for responding to setbacks and challenges dynamically. We also offer insight on the effective dissemination of results …
The Plight Of The Lucluc: Examining The Deadly Mystery Of Nodding Syndrome, Ethan K. Mcgann
The Plight Of The Lucluc: Examining The Deadly Mystery Of Nodding Syndrome, Ethan K. Mcgann
Senior Honors Theses
Nodding syndrome (NS) is an emerging epidemic neurological disease that is shrouded in mystery. It is currently only found in the post-conflict regions of South Sudan, northern Uganda, and Tanzania. NS occurs in children from the ages of five to fifteen and is characterized by a loss of motor control in the neck muscles. Seizure episodes can range in intensity from atonic to tonic-clonic, and the onset of the first episode generally marks the beginning of a decline in the child’s physical and mental health. NS is a progressive disease that generally results in physical wasting, stunted growth, behavioral difficulties, …
Piecing The Puzzle Together With The Use Of Physical Therapy, Mikayla Pruitt
Piecing The Puzzle Together With The Use Of Physical Therapy, Mikayla Pruitt
Honors Projects
For my Honors Project I decided to create a set of exercise cards for children with autism. The front of each card had a picture symbolizing the exercise/activity, and on the back included directions, supplies and tips to complete the activity. The following is a selection of a few exercise cards from each of the four exercise sections, as well as the title card, table of contents cards, information cards, and source cards.
Belief About Nicotine Selectively Modulates Value And Reward Prediction Error Signals In Smokers, Xiaosi Gu, Terry Lohrenz, Ramiro Salas, Philip R. Baldwin, Alireza Soltani
Belief About Nicotine Selectively Modulates Value And Reward Prediction Error Signals In Smokers, Xiaosi Gu, Terry Lohrenz, Ramiro Salas, Philip R. Baldwin, Alireza Soltani
Dartmouth Scholarship
Little is known about how prior beliefs impact biophysically described processes in the presence of neuroactive drugs, which presents a profound challenge to the understanding of the mechanisms and treatments of addiction. We engineered smokers' prior beliefs about the presence of nicotine in a cigarette smoked before a functional magnetic resonance imaging session where subjects carried out a sequential choice task. Using a model-based approach, we show that smokers' beliefs about nicotine specifically modulated learning signals (value and reward prediction error) defined by a computational model of mesolimbic dopamine systems. Belief of "no nicotine in cigarette" (compared with "nicotine in …
Exposure To Kynurenic Acid During Adolescence Increases Sign-Tracking And Impairs Long-Term Potentiation In Adulthood, Nicole E. Deangeli, Travis P. Todd, Stephen E. Chang, Hermes H. Yeh, Pamela W. Yeh, David J. Bucci
Exposure To Kynurenic Acid During Adolescence Increases Sign-Tracking And Impairs Long-Term Potentiation In Adulthood, Nicole E. Deangeli, Travis P. Todd, Stephen E. Chang, Hermes H. Yeh, Pamela W. Yeh, David J. Bucci
Dartmouth Scholarship
Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of schizophrenia, as well as the propensity to develop co-occurring substance abuse disorders. Presently, there are few treatments for persons with a dual diagnosis and little is known about the neural substrates that underlie co-occurring schizophrenia and substance abuse. One goal of the present study was to determine if a change in the concentration of kynurenic acid (KYNA), a tryptophan metabolite that is increased in the brains of people with schizophrenia, affects reward-related behavior. KYNA is an endogenous antagonist of NMDA glutamate receptors and …
Mental Health Disorders In Child And Adolescent Survivors Of Post-War Landmine Explosions., Mohammad Ali Hemmati, Hamid Shokoohi, Mehdi Masoumi, Shahriar Khateri, Mohammadreza Soroush, Ehsan Modirian, Mahtab Poor Zamany Nejat Kermany, Maryam Hosseini, Batool Mousavi
Mental Health Disorders In Child And Adolescent Survivors Of Post-War Landmine Explosions., Mohammad Ali Hemmati, Hamid Shokoohi, Mehdi Masoumi, Shahriar Khateri, Mohammadreza Soroush, Ehsan Modirian, Mahtab Poor Zamany Nejat Kermany, Maryam Hosseini, Batool Mousavi
Emergency Medicine Faculty Publications
BACKGROUND: To describe the mental health status of 78 child and adolescent survivors of post-war landmine explosions.
METHODS: Child and adolescent survivors of landmine explosions who were younger than 18 years old at the time of the study were identified and enrolled in this study. The mental health status of the participants was assessed by general health assessment and psychiatric examinations. Psychiatric assessment and diagnosis were undertaken using the Diagnostic and Statistical Manual for mental disorders (DSM-IV) criteria. A psychiatrist visited and interviewed each survivor and identified psychiatric disorders.
RESULTS: Seventy-eight child and adolescent survivors with a mean age of …
Insistence On Sameness Relates To Increased Covariance Of Gray Matter Structure In Autism Spectrum Disorder., Ian W Eisenberg, Gregory L Wallace, Lauren Kenworthy, Stephen J Gotts, Alex Martin
Insistence On Sameness Relates To Increased Covariance Of Gray Matter Structure In Autism Spectrum Disorder., Ian W Eisenberg, Gregory L Wallace, Lauren Kenworthy, Stephen J Gotts, Alex Martin
Psychiatry and Behavioral Sciences Faculty Publications
BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain …