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In-Vitro Assessment Of Cb1/Cb2 Receptor Binding And Function, Joey M. Davis
In-Vitro Assessment Of Cb1/Cb2 Receptor Binding And Function, Joey M. Davis
Honors Theses
Cannabinoid receptors CB1 and CB2 are G protein-coupled receptors that have a variety of physiological effects on the human body. Many natural product agonists and antagonists are presumed to interact with the cannabinoid receptors and are therefore heavily studied in drug discovery. Assays are used to study the binding of compounds to these receptors. However, a limited number of these assays are efficient in determining the functional activity of ligands associated with CB1 and CB2. Of those, many use radioactivity which is both expensive and potentially dangerous to the researcher. In this study, we first validated the assays already found …