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Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro
Effect Of Green Tea Extract On Cardiac Hypertrophy Following 5/6 Nephrectomy In The Rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga Fedorova, Alexei Bagrov, Jiang Liu, Sankaridrug Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, Joseph Shapiro
Jiang Liu
Background
Left ventricular hypertrophy commonly complicates chronic renal failure. We have observed that at least one pathway of left ventricular hypertrophy appears to involve signaling through reactive oxygen species (ROS). Green tea is a substance that appears to have substantial antioxidant activity, yet is safe and is currently widely used. We, therefore, studied whether green tea supplementation could attenuate the development of left ventricular hypertrophy in an animal model of chronic renal failure.
Methods
Male Sprague-Dawley rats were subjected to sham or remnant kidney surgery and given green tea extract (0.1% and 0.25%) or plain drinking water for the next …