Open Access. Powered by Scholars. Published by Universities.®
Pharmacy and Pharmaceutical Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (10)
- Chemicals and Drugs (9)
- Medicinal and Pharmaceutical Chemistry (7)
- Medical Sciences (6)
- Medical Specialties (5)
-
- Physical Sciences and Mathematics (5)
- Chemistry (4)
- Medical Education (4)
- Medical Pharmacology (4)
- Health Information Technology (3)
- Medicinal-Pharmaceutical Chemistry (3)
- Other Pharmacy and Pharmaceutical Sciences (3)
- Pharmaceutical Preparations (3)
- Biochemistry, Biophysics, and Structural Biology (2)
- Chemical and Pharmacologic Phenomena (2)
- Diseases (2)
- Microbiology (2)
- Molecular Biology (2)
- Pharmacology (2)
- Pharmacology, Toxicology and Environmental Health (2)
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Arts and Humanities (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Botany (1)
- Cardiology (1)
- Cardiovascular Diseases (1)
- Institution
-
- University of the Pacific (24)
- Thomas Jefferson University (4)
- Virginia Commonwealth University (4)
- Butler University (3)
- Southwestern Oklahoma State University (3)
-
- University of Kentucky (3)
- Chapman University (2)
- Claremont Colleges (2)
- Dartmouth College (2)
- The Texas Medical Center Library (2)
- University of Mississippi (2)
- University of South Carolina (2)
- Aga Khan University (1)
- Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences (1)
- Boise State University (1)
- East Tennessee State University (1)
- OhioHealth (1)
- Parkview Health (1)
- Technological University Dublin (1)
- University for Business and Technology in Kosovo (1)
- University of Nebraska Medical Center (1)
- University of Tennessee Health Science Center (1)
- University of Texas at Tyler (1)
- Western Kentucky University (1)
- Publication Year
- Publication
-
- University of the Pacific Theses and Dissertations (24)
- RURAL ROCKS (3)
- BU Well (2)
- Dartmouth Scholarship (2)
- Dissertations and Theses (Open Access) (2)
-
- Pharmacotherapy and Outcomes Science Publications (2)
- Pharmacy Faculty Articles and Research (2)
- Theses and Dissertations (2)
- Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences (1)
- Articles (1)
- College of Health Sciences Presentations (1)
- College of Pharmacy Faculty Papers (1)
- Department of Pharmacology and Experimental Therapeutics Faculty Papers (1)
- Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers (1)
- ETSU Faculty Works (1)
- Electronic Theses and Dissertations (1)
- Faculty and Student Publications (1)
- Institute for Global Health and Development (1)
- Institute of Emerging Health Professions Faculty Papers (1)
- Masters Theses & Specialist Projects (1)
- Nursing Faculty Publications and Presentations (1)
- OhioHealth Research Institute Articles (1)
- Parkview Pharmacy Department (1)
- Pharmaceutical Sciences Faculty Publications (1)
- Pharmacy Practice and Science Faculty Publications (1)
- Psychiatry Faculty Publications (1)
- Scripps Senior Theses (1)
- Senior Theses (1)
- The Transdisciplinary STEAM+ Journal (1)
- Theses & Dissertations (1)
- Publication Type
Articles 1 - 30 of 65
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
The Concise Guide To Pharmacology 2025/26: Catalytic Receptors, Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman
The Concise Guide To Pharmacology 2025/26: Catalytic Receptors, Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of …
Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir
Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Sphenocentrum jollyanum Pierre (Menispermaceae) is a West African medicinal plant used traditionally for various ailments, including malaria, diabetes, and reproductive disorders. Despite its ethnobotanical significance, comprehensive scientific validation of its pharmacological properties remains limited. This review aims to provide a comprehensive overview of the plant’s ethnobotany, phytochemistry, and pharmacological activities, integrating traditional knowledge with modern scientific insights to guide future research. A comprehensive literature search was conducted in PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Science, covering publications up to April 2025. Search terms included "Sphenocentrum jollyanum", "ethnobotanical use", "pharmacological effects", and related keywords. Relevant articles were screened, and …
Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea Stitzlein
Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea Stitzlein
Dissertations and Theses (Open Access)
Glioblastoma is the most common primary malignant brain tumor in adults, with limited treatment options resulting in a poor prognosis. Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma and contributes to tumor growth and treatment resistance. Inhibitors of LSD1 have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway alterations in glioblastoma, the interplay between LSD1 inhibition and kinase signaling pathways was investigated to identify vulnerabilities that could be exploited through rationally designed combination therapies. We hypothesized that LSD1 inhibitors would activate kinase signaling pathways, such as MAPK, and the addition of kinase …
Pro: The Use Of Sugammadex Does Not Preclude The Need For Objective Neuromuscular Monitoring., J Ross Renew, Dustin D. Linn
Pro: The Use Of Sugammadex Does Not Preclude The Need For Objective Neuromuscular Monitoring., J Ross Renew, Dustin D. Linn
Parkview Pharmacy Department
Based on strong evidence, optimal management of neuromuscular block should incorporate objective (or quantitative) neuromuscular monitoring with appropriately dosed antagonists such as sugammadex. Sugammadex has the unique ability to antagonize aminosteroidal-induced neuromuscular block at any level; however, neostigmine is a reasonable alternative at minimal levels. Blind or excessive administration of sugammadex does not eliminate the risk of patients having postoperative residual neuromuscular block. Significant variability exists in how patients respond both to neuromuscular blocking agents and their antagonists.
Strengthening The Paediatric Clinical Trial Ecosystem To Better Inform Policy And Programmes, James A. Berkley, Judd L. Walson, Glenda Gray, Fiona Russell, Zulfiqar Ahmed Bhutta, Per Ashorn, Shane A. Norris, Ebunoluwa A. Adejuyigbe, Rebecca Grais, Bernhards Ogutu
Strengthening The Paediatric Clinical Trial Ecosystem To Better Inform Policy And Programmes, James A. Berkley, Judd L. Walson, Glenda Gray, Fiona Russell, Zulfiqar Ahmed Bhutta, Per Ashorn, Shane A. Norris, Ebunoluwa A. Adejuyigbe, Rebecca Grais, Bernhards Ogutu
Institute for Global Health and Development
The first WHO Global Clinical Trials Forum was convened in November, 2023 to develop a shared vision of an effective global clinical trial infrastructure. The Paediatric Clinical Trials Working Group was formed to provide perspectives, identify challenges, and propose solutions to strengthen the paediatric clinical trials ecosystem. Participants represented paediatric disciplines, including infectious diseases, nutrition, neonatology, pharmacology, oncology, neurodevelopment, public health, and policy. Childhood diseases have profound lifelong effects on health, livelihoods, and societies. Investment in early childhood results in highly cost-effective changes to lifelong health, productivity, and human capital returns. Yet, there remain substantial gaps in knowledge on the …
Evaluation Of The Safety Of Dexmedetomidine Dosing Utilizing Adjusted Body Weight In Obese Critically Ill Patients: A Retrospective Study., Molly E Robertson, Aimee E Willett, Joshua J Mathias, Britney N Sleeckx, John O Elliott
Evaluation Of The Safety Of Dexmedetomidine Dosing Utilizing Adjusted Body Weight In Obese Critically Ill Patients: A Retrospective Study., Molly E Robertson, Aimee E Willett, Joshua J Mathias, Britney N Sleeckx, John O Elliott
OhioHealth Research Institute Articles
The purpose of this study was to evaluate the safety of dexmedetomidine dosing, utilizing adjusted body weight (AdjBW) in obese, critically ill patients. This was a retrospective cohort study of patients who received dexmedetomidine from March 2020 to April 2021. Participants received dexmedetomidine as the sole agent for sedation for ≥8 hours, were ≥18 years old, had a level of care listed as "critical care," and had an actual body weight (ABW) of at least 120% of their ideal body weight (IBW). A total of 225 participants were included. Results demonstrated that the incidence of hypotension and bradycardia was lower …
Effects Of Cross-Sex Hormone Therapy (Csht) On Aortic Reactivity And Metabolic Parameters In Gonadectomized Male And Female Rats, Rifat Ara Islam
Effects Of Cross-Sex Hormone Therapy (Csht) On Aortic Reactivity And Metabolic Parameters In Gonadectomized Male And Female Rats, Rifat Ara Islam
University of the Pacific Theses and Dissertations
With the rising awareness, the number of individuals identifying themselves as transgender in the US is increasing over the years. Cross-sex hormone therapy (CSHT) may alter cardiometabolic parameters leading to the increased risk of cardiovascular diseases (CVD) in transgender population. However, the underlying mechanisms of impaired cardiovascular functions in transgender female (male to female, MtF) or transgender male (female to male, FtM) individuals are not well documented. This study was undertaken to examine the effects of 17β-estradiol (E2)- and testosterone propionate (Tes)-treatment on key cardiometabolic parameters and aortic reactivity in castrated (CAS) male and ovariectomized (OVX) female Sprague Dawley (SD) …
Central Nervous System Antiviral Pharmacology, Sean N. Avedissian
Central Nervous System Antiviral Pharmacology, Sean N. Avedissian
Theses & Dissertations
Soon after viral infection, viruses like Human Immunodeficiency Virus (HIV) and SARS-CoV-2 can disseminate throughout the body and establish reservoirs in the central nervous system (CNS). The persistence of viruses in cells of these reservoirs is a major obstacle to virus eradication. This is due to the abundance of cells/receptors that these viruses utilize to gain entry into cells found at these various reservoir sites. Consequently, these same anatomical sites also may be pharmacologic sanctuaries, as evidenced by concentrations of antiretroviral drugs (ARVs) and antivirals (AVs) that are lower in reservoirs than those in peripheral blood; in some cases, these …
Evaluation Of Mechanism Of Action And Toxicity Of Novel Psychoactive Substances (Nps) Identified As Cannabinomimetics, Robert Michael Sears
Evaluation Of Mechanism Of Action And Toxicity Of Novel Psychoactive Substances (Nps) Identified As Cannabinomimetics, Robert Michael Sears
Theses and Dissertations
Synthetic cannabinoid receptor agonists (SCRA), also referred to as synthetic cannabinoids (SCs), pose a significant public health risk, create an undue burden on local emergency departments, and present significant challenges for law enforcement officers and forensic laboratories. SCs are a diverse group of compounds sold with the intent to illicit psychoactive responses like tetrahydrocannabinol (THC), the primary psychoactive component in marijuana. Since their initial detection in 2004, illicit use of SCs has grown in popularity. Recognizing the dangers of SC use, the Drug Enforcement Agency has moved to schedule the analytes routinely identified in street drugs. Despite these efforts, the …
January / February / March 2024, Randy Curry, Cindy Brooks
January / February / March 2024, Randy Curry, Cindy Brooks
RURAL ROCKS
This is the January, February, and March issue of Rural Rocks from the SWOSU College of Pharmacy.
November / December 2023, Randy Curry, Cindy Brooks
November / December 2023, Randy Curry, Cindy Brooks
RURAL ROCKS
This is the November & December 2023 issue of Rural Rocks from the SWOSU College of Pharmacy.
September / October 2023, Randy Curry, Cindy Brooks
September / October 2023, Randy Curry, Cindy Brooks
RURAL ROCKS
This is the September & October 2023 issue of Rural Rocks from the SWOSU College of Pharmacy.
Role Of Cysteine Redox State In Altering The Epithelial-Mesenchymal Transition In Lung Cancer, Md Anisur Rahman
Role Of Cysteine Redox State In Altering The Epithelial-Mesenchymal Transition In Lung Cancer, Md Anisur Rahman
University of the Pacific Theses and Dissertations
Epithelial-mesenchymal transition is a process by which cancer cells increase their capability for metastasis. EMT involves conversion of epithelial cells into a mesenchymal phenotype which makes cancer cells more invasive and motile. Lung cancer has the highest mortality rate among different types of cancers globally. Lung cancer exists in various types, the most prevalent of which is non-small cell lung cancer (NSCLC). Several factors, including oxidative stress, can induce EMT in cancer cells. However, the mechanism of how reactive oxygen species (ROS)-induced changes in cysteine redox state affect EMT remains elusive. Our studies aim to understand this mechanism by inducing …
Targeting Ribonucleotide Reductase For Breast Cancer Treatment, Nahid Sultana
Targeting Ribonucleotide Reductase For Breast Cancer Treatment, Nahid Sultana
University of the Pacific Theses and Dissertations
Breast cancer is the second most common type of cancer in the world. Hormone receptor (HR) positive breast cancer (BC) is a prevalent disease accounting for approximately 2 million new cases globally. Almost 70-80% of breast cancer patients are women with a positive score for the estrogen receptor (ER). Triple-negative breast cancer (TNBC) which have a negative score for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor type 2 (HER2) is considered an aggressive histological breast cancer subtype with limited treatment options.Frequently, doxorubicin (DOXO)-based chemotherapy is utilized in this patient population due to the lack of …
Isolation And Characterization Of Flavonoid Naringenin And Evaluation Of Cytotoxic And Biological Efficacy Of Water Lilly (Nymphaea Mexicana Zucc.), Shajrath Din, Saima Hamid, Aadil Yaseen, Ali Mohd Yatoo
Isolation And Characterization Of Flavonoid Naringenin And Evaluation Of Cytotoxic And Biological Efficacy Of Water Lilly (Nymphaea Mexicana Zucc.), Shajrath Din, Saima Hamid, Aadil Yaseen, Ali Mohd Yatoo
Faculty and Student Publications
Despite its limited exploration, Nymphaea mexicana Zucc. can be beneficial if pharmacology, isolation, and biological evaluation are given attention. It is an aquatic species that belongs to the family Nymphaeaceae. The thrust area of the work was the extraction, isolation, and biological evaluation of different extracts of the N. mexicana Zucc. plant. The primary goal of this research was to assess the antimicrobial, antioxidant, and anticancer activities of the extracts and to isolate the target naringenin compound. Comparative FT IR analysis of different extracts of this plant revealed the presence of functional groups of plant secondary metabolites, including polyphenols, flavonoids, …
The Combinatory Effects Of Pediatric Obesity And Ontogeny On Monocarboxylate Transporter Expression In Tissues Of Drug Disposition, Michael Ng
University of the Pacific Theses and Dissertations
Proton-coupled and sodium-dependent monocarboxylate transporters are encoded by the SLC16A and SLC5A gene family of solute carriers, and are responsible for the transport of essential nutrients such as L-lactate, pyruvate, and ketone bodies. Basigin, or CD147, acts as an ancillary protein for MCT1 and MCT4, and is involved in membrane surface expression of transporters. MCT's are also involved in the shuttling of monocarboxylic xenobiotics across cell membranes, including the drugs valproate and gamma hydroxybutyrate. MCT’s are also important for normal mammalian development, particularly during embryogenesis and early neonatal life. Previous studies have shown that ketogenic diets increase MCT expression in …
Peripherally Restricted Opioid Conjugates And Its Use As Pharmacological Probes And Potential Therapeutics, Md Tariqul Haque Tuhin
Peripherally Restricted Opioid Conjugates And Its Use As Pharmacological Probes And Potential Therapeutics, Md Tariqul Haque Tuhin
University of the Pacific Theses and Dissertations
Opioid-induced constipation (OIC) is one of the major adverse effects of opioid analgesics used by millions of patients each year. While progress has been made, there remains a significant unmet medical need in the treatment of OIC. Major gaps remain in our understanding of the role of the gastrointestinal tract and central nervous system (CNS) in precipitating OIC. For the last four decades, numerous investigations to study the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly believed to have limited penetration across the blood-brain barrier (BBB). Several preclinical and clinical …
Comparative Neuropharmacology And Pharmacokinetics Of Methamphetamine And Its Thiophene Analog Methiopropamine In Rodents, Silja Skogstad Tuv, Marianne Skov-Skov Bergh, Jannike Mørch Andersen, Synne Steinsland, Vigdis Vindenes, Michael H Baumann, Marilyn A. Huestis, Inger Lise Bogen
Comparative Neuropharmacology And Pharmacokinetics Of Methamphetamine And Its Thiophene Analog Methiopropamine In Rodents, Silja Skogstad Tuv, Marianne Skov-Skov Bergh, Jannike Mørch Andersen, Synne Steinsland, Vigdis Vindenes, Michael H Baumann, Marilyn A. Huestis, Inger Lise Bogen
Institute of Emerging Health Professions Faculty Papers
Methiopropamine is a novel psychoactive substance (NPS) that is associated with several cases of clinical toxicity, yet little information is available regarding its neuropharmacological prop-erties. Here, we employed in vitro and in vivo methods to compare the pharmacokinetics and neu-robiological effects of methiopropamine and its structural analog methamphetamine. Methiopro-pamine was rapidly distributed to the blood and brain after injection in C57BL/6 mice, with a phar-macokinetic profile similar to that of methamphetamine. Methiopropamine induced psychomotor activity, but higher doses were needed (Emax 12.5 mg/kg; i.p.) compared to methamphetamine (Emax 3.75 mg/kg; i.p.). A steep increase in locomotor activity was seen after …
Evaluating Patient's Knowledge Regarding Opioid Prescriptions In An Independent Community Pharmacy: A Pilot Study, Lauren Chars Pharmd, Patricia Devine Pharmd, Tyler Girton Pharmd
Evaluating Patient's Knowledge Regarding Opioid Prescriptions In An Independent Community Pharmacy: A Pilot Study, Lauren Chars Pharmd, Patricia Devine Pharmd, Tyler Girton Pharmd
BU Well
This study evaluated patients’ knowledge regarding their opioid prescriptions and identified what resources were used to educate patients on their opioid prescriptions. Patients receiving an opioid prescription from an independent pharmacy were given a link to complete a nine-question anonymous survey about their awareness of their prescription being an opioid, how and what education they received, and from whom. The authors hope that the findings of this research will help to better understand effective ways to combat the opioid epidemic and promote patient safety through effective opioid education.
Animals On Drugs: The Role Of Pharmacists In Veterinary Medicine, Kylie Kelley
Animals On Drugs: The Role Of Pharmacists In Veterinary Medicine, Kylie Kelley
BU Well
With medication errors and unpreparedness of pharmacists in handling pet prescriptions becoming more prevalent, to compensate the deficiency there should be an increase in education and interprofessional collaboration. By providing pharmacists with a thorough education of animal pharmacology, pharmacists would more effectively thrive within their scope of practice and improve pet safety and collaboration with other veterinary healthcare providers. Whether a student pharmacist wants to specialize in veterinary pharmacy or retail pharmacy, it is important for the animal’s well-being that someone who verifies the prescriptions does so correctly and with the knowledge needed to make informed decisions for animal patients.
Post-Translational Modification And Degradation Mechanisms Of The Aryl Hydrocarbon Receptor, Yujie Yang
Post-Translational Modification And Degradation Mechanisms Of The Aryl Hydrocarbon Receptor, Yujie Yang
University of the Pacific Theses and Dissertations
The aryl hydrocarbon receptor (AHR) is a transcription factor first discovered to be activated by exogenous ligands, such as dioxins, and helps promote downstream gene (e.g. CYP1A1) transcription to metabolize the toxicants. With the reports of various AHR targets genes, the expression levels and activities of AHR have been implicated in many physiological and pathological situations. Understanding how AHR protein level is regulated would provide more information to target AHR. AHR stays in the cytosol in the absence of ligand in a complex with HSP90, p23 and XAP2. After ligand activation, AHR translocates into the nucleus, fulfilling its transactivation function …
Impact Of 17-Beta Estradiol And Moderate-Intensity Exercise On Mesenteric Arterial Function Of Uc Davis Type-2 Diabetes Mellitus Rats, Md Rahatullah Razan
Impact Of 17-Beta Estradiol And Moderate-Intensity Exercise On Mesenteric Arterial Function Of Uc Davis Type-2 Diabetes Mellitus Rats, Md Rahatullah Razan
University of the Pacific Theses and Dissertations
The studies in this dissertation were designed to investigate the impacts of estrogen (17-β estradiol/E2) and moderate-intensity exercise (MIE) on the mesenteric arterial (MA) function of the University of California Davis type-2 diabetes mellitus (UCD-T2DM) Rat model. Our recent report suggests that diabetes impairs MA vasorelaxation in both sexes of the UCD-T2DM model. Particularly, we reported that MA from prediabetic male rats showed a greater impairment compared to that in prediabetic females. However, when females become diabetic, they exhibit a greater vascular dysfunction than males. Therefore, the aim of the first study was to investigate whether female sex hormone, specifically …
Clinically Relevant Interactions Between Atypical Antipsychotics And Anti-Infective Agents, Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose De Leon
Clinically Relevant Interactions Between Atypical Antipsychotics And Anti-Infective Agents, Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose De Leon
Psychiatry Faculty Publications
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics and most commonly used anti-infective agents (13 atypical antipsychotics by 61 anti-infective agents/classes leading to 793 individual searches). Additional relevant articles were obtained from citations and from prior review articles written by the authors. Based on prior DI articles and our current understanding of PK and PD mechanism, we developed …
Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities And Limitations, Victoria Yan
Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities And Limitations, Victoria Yan
Dissertations and Theses (Open Access)
Phosphate and phosphonates are chemical moieties with historical precedence in anticancer and antiviral nucleotide analogues. Synchronous to modern efforts identifying novel therapeutic targets in cancer, such chemical moieties are being investigated in the design of novel inhibitors with antineoplastic potential. A central challenge to the delivery of phosph(on)ate-containing drugs is their anionic character at physiological pH, which portends poor membrane permeability. This limitation has been successfully overcome through the use of prodrugs. When attached to the phosph(on)ate moiety, prodrugs mask the negative charge and easily enable cell permeability. Upon cellular entry, the promoieties are enzymatically or environmentally cleaved to unveil …
Plk1 Pbd Selective Inhibition As A Potential Cancer Therapy, Lauren E. Wilder
Plk1 Pbd Selective Inhibition As A Potential Cancer Therapy, Lauren E. Wilder
Senior Theses
Polo-Like Kinase 1 (PLK1) is a protein that has been found to be overexpressed in a variety of cancers including prostate and colorectal cancers, and it is often an indicator of poor patient prognosis. It has functions in initiating, maintaining, and completing mitosis, so it has an important role in controlling the proliferation of cells. PLK1 contains a highly conserved catalytic kinase domain and a less-conserved Polo Box Domain (PBD). Inhibiting the phospho-ligand binding of the PBD is a potential cancer therapy because it would prevent the cell from properly completing the cell cycle, thus inducing apoptosis. In Dr. McInnes’ …
Bioactive Indanes: Development And Validation Of An Lc-Ms/Ms Bioanalytical Method For The Determination Of Ph46a, A New Potential Anti-Inflammatory Agent, In Dog And Rat Plasma And Its Application To A Pharmacokinetic Study In Dog, Gaia Scalabrino, Tao Zhang, Neil Frankish, Helen Sheridan
Bioactive Indanes: Development And Validation Of An Lc-Ms/Ms Bioanalytical Method For The Determination Of Ph46a, A New Potential Anti-Inflammatory Agent, In Dog And Rat Plasma And Its Application To A Pharmacokinetic Study In Dog, Gaia Scalabrino, Tao Zhang, Neil Frankish, Helen Sheridan
Articles
A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical development, in in vivo pre-clinical studies PH46A showed potent anti-inflammatory properties, which can be targeted at a range of diseases, including inflammatory bowel disease (IBD). To support the pre-clinical development of this drug candidate, we developed a LC MS/MS method for determining PH46 (the acid form of PH46A salt) in both dog and rat plasma using Compound 1 as internal standard (IS). Those species …
The Use Of Ibuprofen And Our Knowledge About It, Dafina Krasniqi, Engjell Thaqi, Donika Berisha, Gentian Bibaj, Fjolla Kryeziu
The Use Of Ibuprofen And Our Knowledge About It, Dafina Krasniqi, Engjell Thaqi, Donika Berisha, Gentian Bibaj, Fjolla Kryeziu
UBT International Conference
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug class that is used for treating pain, fever, and inflammation. It can be used by mouth or intravenous. It typically begins working within an hour. Usual adult dose for pain or fever is 200 to 400 mg orally every 4 to 6 hours as needed. Side effects include nausea, dyspepsia, diarrhea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure. Infrequent side effects include esophageal ulceration, heart failure, high blood levels of potassium, kidney …
Mass Caffeination, Michael J. Leach
Mass Caffeination, Michael J. Leach
The Transdisciplinary STEAM+ Journal
This poem reflects on caffeine intake in modern society from the perspective of a pharmacologist. It is a free verse, concrete poem that communicates the science of caffeine through both words and visual images.
The Role Of Sex Hormones On Monocarboxylate Transporter Expression In Tissues Related To Drug Disposition, Jieyun Cao
The Role Of Sex Hormones On Monocarboxylate Transporter Expression In Tissues Related To Drug Disposition, Jieyun Cao
University of the Pacific Theses and Dissertations
Proton- and sodium-dependent monocarboxylate transporters (MCTs (SLC16A) and SMCTs (SLC5A)) transport monocarboxylates such as ketone bodies, lactate and pyruvate, as well as drugs such as gamma-hydroxybutyric acid. CD147 acts as an ancillary protein for MCT1 and MCT4, and is involved in membrane trafficking. Previously, it has been shown that MCT expression changes under different sex hormone conditions in skeletal muscle and Sertoli cells. However, it is unknown if MCTs, SMCTs or CD147 demonstrate sex differences in tissues where they play an important role in drug disposition. Monocarboxylate transporter substrates GHB and valproic acid have demonstrated sex differences in pharmacokinetic profiles. …
Intrapulmonary Inoculation Of Multicellular Tumor Spheroids To Construct An Orthotopic Lung Cancer Xenograft Model That Mimics Four Clinical Stages Of Non-Small Cell Lung Cancer, Yingbo Huang
University of the Pacific Theses and Dissertations
Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development and progression of lung cancer as seen …