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Pharmacy and Pharmaceutical Sciences Commons™
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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Effect Of Nanoparticle Weight On The Cellular Uptake And Drug Delivery Potential Of Plga Nanoparticles, Prabhat Kattel, Shoukath Sulthana, JiřÍ Trousil, Dinesh Shrestha, David Pearson, Santosh Aryal
Effect Of Nanoparticle Weight On The Cellular Uptake And Drug Delivery Potential Of Plga Nanoparticles, Prabhat Kattel, Shoukath Sulthana, JiřÍ Trousil, Dinesh Shrestha, David Pearson, Santosh Aryal
Pharmacy Faculty Publications and Presentations
Biodegradable and biocompatible polymeric nanoparticles (NPs) stand out as a key tool for improving drug bioavailability, reducing the inherent toxicity, and targeting the intended site. Most importantly, the ease of polymer synthesis and its derivatization to add functional properties makes them potentially ideal to fulfill the requirements for intended therapeutic applications. Among many polymers, US FDA-approved poly(L-lactic-co-glycolic) acid (PLGA) is a widely used biocompatible and biodegradable co-polymer in drug delivery and in implantable biomaterials. While many studies have been conducted using PLGA NPs as a drug delivery system, less attention has been given to understanding the effect of NP weight …
Indocyanine-Type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy Of Cancer, Ramesh Marasini, Santosh Aryal
Indocyanine-Type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy Of Cancer, Ramesh Marasini, Santosh Aryal
Pharmacy Faculty Publications and Presentations
Organic small-molecule photosensitizers are well-characterized and known for the light-responsive treatment modality including photodynamic therapy. Compared with ultraviolet−visible (UV−vis) light used in conventional photodynamic therapy with organic photosensitizers, near-infrared (NIR) light from 700 to 900 nm is less absorbed and scattered by biological tissue such as hemoglobin, lipids, and water, and thus, the use of NIR excitation can greatly increase the penetration depth and emission. Additionally, NIR light has lower energy than UV−vis that can be beneficial due to less activation of fluorophores present in tissues upon NIR irradiation. However, the low water stability, nonspecific distribution, and short circulation halflife …