Open Access. Powered by Scholars. Published by Universities.®
Pharmacy and Pharmaceutical Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
The British University in Egypt
Ammania aegyptiaca; myricetin 3-O-β-4C1-(600-O-galloylglucopyranoside) 7-O-β-4C1glucopyranoside; digestive enzymes; molecular docking; diabetes
Articles 1 - 1 of 1
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Antidiabetic Activity And In Silico Molecular Docking Of Polyphenols From Ammannia Baccifera L. Subsp. Aegyptiaca (Willd.) Koehne Waste: Structure Elucidation Of Undescribed Acylated Flavonol Diglucoside, Noha Swilam, Mahmoud Nawwar, Rasha Radwan, Eman Mostafa
Antidiabetic Activity And In Silico Molecular Docking Of Polyphenols From Ammannia Baccifera L. Subsp. Aegyptiaca (Willd.) Koehne Waste: Structure Elucidation Of Undescribed Acylated Flavonol Diglucoside, Noha Swilam, Mahmoud Nawwar, Rasha Radwan, Eman Mostafa
Pharmacy
Chemical investigation of the aerial parts of Ammania aegyptiaca ethanol extract (AEEE) showed high concentrations of polyphenol and flavonoid content, with notable antioxidant activity. Undescribed acylated diglucoside flavonol myricetin 3-O-β-4C1-(600-O-galloyl glucopyranoside) 7-Oβ-4C1-glucopyranoside (MGGG) was isolated from the aerial parts of AEEE, along with four known polyphenols that had not been characterized previously from AEEE. The inhibitory effects of MGGG, AEEE, and all compounds against α-amylase, pancreatic lipase and β-glucosidase were assessed. In addition, molecular docking was used to determine the inhibition of digestive enzymes, and this confirmed that the MGGG interacted strongly with the active site residues of these enzymes, …