Open Access. Powered by Scholars. Published by Universities.®

Pharmacy and Pharmaceutical Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2007

Selected Works

Articles 1 - 13 of 13

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Tumor-Targeted Induction Of Oxystress For Cancer Therapy., Arun K. Iyer Jul 2007

Tumor-Targeted Induction Of Oxystress For Cancer Therapy., Arun K. Iyer

Arun Iyer

Reactive oxygen species (ROS), such as superoxide anion radicals (O.-2) and hydrogen peroxide (H2O2) are potentially harmful by-products of normal cellular metabolism that directly affect cellular functions. ROS is generated by all aerobic organisms and it seems to be indispensable for signal transduction pathways that regulate cell growth and reduction-oxidation (redox) status. However, overproduction of these highly reactive oxygen metabolites can initiate lethal chain reactions, which involve oxidation and damage to structures that are crucial for cellular integrity and survival. In fact, many antitumor agents, such as vinblastine, cisplatin, mitomycin C, doxorubicin, camptothecin, inostamycin, neocarzinostatin and many others exhibit antitumor …

Go to article

Nutrition In Critical Care, Jane Gervasio Jun 2007

Nutrition In Critical Care, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Go to article

From Vegas To Boise: A Theme Of Collaborative Research, Mark Rudin Jun 2007

From Vegas To Boise: A Theme Of Collaborative Research, Mark Rudin

Mark J. Rudin

Lake Mead, USA serves as an excellent field laboratory for studying a number of environmental processes, including the distribution and rate of sediment deposition, the bioavailability of anthropogenic contaminants in water and sediment columns, and the impact of naturally-occurring events such as fires and floods on lake ecosystems. Attempts at understanding this body of water, critical to the viability of over 20 million people, requires expertise and experience across a substantial number of disciplines. A research team comprised of representatives from academia and several federal agencies collected lakefloor side-scan sonar and seismic reflection measurements, along with sediment cores, in various …

Go to article

Tpn Without Lipids In The Icu, Jane Gervasio May 2007

Tpn Without Lipids In The Icu, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Go to article

Effects Of Trans-Fatty Acids And Omega-3’S, Jane Gervasio Apr 2007

Effects Of Trans-Fatty Acids And Omega-3’S, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Go to article

Outsourcing The Packaging Function, Rihaz Z. Chughatta Apr 2007

Outsourcing The Packaging Function, Rihaz Z. Chughatta

Rihaz Z Chughatta

If you are currently working in the packaging department of a major corporation in the pharmaceutical, food or consumer products industry, you have probably been exposed to some form of outsourcing, which is a global trend that has emerged over the past decade, and continues to evolve, within the packaging field.

Go to article

High-Loading Nanosized Micelles Of Copoly(Styrene-Maleic Acid)-Zinc Protoporphyrin For Targeted Delivery Of A Potent Heme Oxygenase Inhibitor., Arun Iyer Mar 2007

High-Loading Nanosized Micelles Of Copoly(Styrene-Maleic Acid)-Zinc Protoporphyrin For Targeted Delivery Of A Potent Heme Oxygenase Inhibitor., Arun Iyer

Arun Iyer

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin (ZnPP). The micelles were constructed by subtle pH adjustments to form non-covalent interaction between the hydrophobic ZnPP and amphiphilic SMA. The micelles (SMA-ZnPP) thus formed were nanoparticles with narrow size distribution in water (mean diameter 176.5nm), having tunable loading (from 15% to 60% w/w of ZnPP) with remarkable aqueous solubility. SMA-ZnPP had an average molecular size of 144kDa as determined by size-exclusion chromatography (SEC), this size is a marked increase from the molecular weight of free ZnPP (626.03Da), suggesting the formation of micellar structure. The …

Go to article

Risks Of Herbal Remedies: More Of The Bad And The Ugly, Richard Philp Feb 2007

Risks Of Herbal Remedies: More Of The Bad And The Ugly, Richard Philp

Richard B. Philp

The widespread and increasing use of herbal remedies has increased the risk, and the documentation, of adverse effects. This paper describes some of these that have occurred since 2004. Cases are discussed in which herbal remedies (St. John’s wort, echinacea, grapefruit juice) have altered the metabolism of prescription drugs. Others have interfered with diagnostic laboratory tests (Chan Su, Dan Shen) or caused pseudoaldosteronism due to their (unidentified) content of glycyerrhizin. Aristolochia spp. have caused nephropathy. Hypersensitivity reactions (spice ginger and others), increased sensitivity to ultraviolet therapy (PUVA) (St. John’s wort) have been reported and the consumption of blue cohosh by …

Go to article

Nutrition Support Review, Jane Gervasio Jan 2007

Nutrition Support Review, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Go to article

Dohad, Influenza And Economists, Stephen E. Snyder Jan 2007

Dohad, Influenza And Economists, Stephen E. Snyder

stephen e snyder

The Developmental Origin of Disease and Health hypothesizes that the early-life, including pre-natal, shocks to health. affects individuals’ later-life health and mortality. Following a line of research established by Doug Almond (2006), we examine whether the 1918 influenza epidemic is a health shock which is orthogonal to chronic health status. Almond, however, does not present results on mortality rates. Our findings are that 1) cross sectional data does not exist which would allow us to treat the influenza epidemic as a field experiment with state-by-state variation, and that when we use what data exists, controlling for geographic variation in health, …

Go to article

Medication Delivery In Critical Illness, Jane Gervasio Dec 2006

Medication Delivery In Critical Illness, Jane Gervasio

Jane M. Gervasio

No abstract provided.

Go to article

Molecular Targets For Antiepileptic Drug Development, Brian S. Meldrum, Michael A. Rogawski Dec 2006

Molecular Targets For Antiepileptic Drug Development, Brian S. Meldrum, Michael A. Rogawski

Michael A. Rogawski

This review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the genetics of idiopathic epilepsies, can be applied to the search for improved antiepileptic drugs (AEDs). Marketed AEDs predominantly target voltage-gated cation channels (the alpha subunits of voltage-gated Na+ channels and also T-type voltage-gated Ca2+ channels) or influence GABA-mediated inhibition. Recently, alpha2-delta voltage-gated Ca2+ channel subunits and the SV2A synaptic vesicle protein have been recognized as likely targets. Genetic studies of familial idiopathic epilepsies have identified numerous genes associated with diverse epilepsy syndromes, including genes encoding Na+ …

Go to article

Multiple Chemical Sensitivity: Psychological Or Somatic?, Richard B. Philp Dec 2006

Multiple Chemical Sensitivity: Psychological Or Somatic?, Richard B. Philp

Richard B. Philp

Multiple chemical sensitivity (MCS) is one of a complex group of related disorders that includes fibromyalgia, chronic fatigue syndrome, acute anxiety disorder, and sick building syndrome that share some symptomatology and that are sometimes grouped under the category of idiopathic environmental intolerance or IEIs. In MCS the individual (female in 4 of 5 cases) reacts in an aversive manner to a host of inhaled chemicals (odors) after an initial “sensitizing” exposure. This group is characterized by the absence of any definitive, objective, diagnostic criteria. Because of this these conditions are generally felt to have a predominantly psychological etiology. Nevertheless, there …

Go to article