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Interaction Of Gaba And Excitatory Amino Acids In The Basolateral Amygdala: Role In Cardiovascular Regulation, Robert P. Soltis, Jennifer C. Cook, Adam E. Gregg, Brian J. Sanders

Scholarship and Professional Work – COPHS

Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal. The objective of the present study was to examine the interaction of GABA and excitatory amino acid (EAA) receptors in the basolateral amygdala (BLA) in regulating cardiovascular function. Microinjection of the GABA_A receptor antagonist bicuculline methiodide (BMI) or the E A A receptor agonists NMDA or AMPA into the same region of the BLA of conscious rats produced dose-related increases in heart rate and arterial pressure. Injection of the nonselective EAA receptor …