Pharmacy and Pharmaceutical Sciences Commons^™

Differential Effects Of Serotonin Antagonists On Hypothermia And Stereotyped Behavior Induced By Apomorphine And Lergotrile In Rats, Rolin Lee Wade

University of the Pacific Theses and Dissertations

The naturally occuring ergot alkaloids of the fungus, Claviceps purpurea, and their many derivatives have been of neuropharmacological interest for many years because of their ability to affect peripheral and central adrenergic and serotonergic systems. More recently, selected compounds such as lergotile (2-chloro-6-methyl ergoline-8-beta acetonitrile) and and bromocriptine (2-bromo-alpha-ergocryptine), have been given additional attention due to their possible therapeutic potential in the treatment of parkinson’s disease, acromegaly and other disorders. There have been considerable data published attempting to establish the mechanism(s) whereby the ergot compounds exert their effects. A large portion of these experiments involves the interaction of ergot compounds …

Release Of Salicylic Acid From Lanolin Alcohol-Ethyl Cellulose Films, Arshad Rahim Khan

University of the Pacific Theses and Dissertations

In the present study lanolin alcohol films were investigated as potential drug delivery systems for the controlled release of salicylic acid. A series of experiments were conducted in vitro to study the release of salicylic acid from these films. The effect of changes in film composition and stirrer speed on drug release were examined. Seven film compositions with varying proportions of lanolin alcohol and ethyl cellulose were prepared over the ethyl cellulose concentrations of 0-30% w/w, while keeping the drug concentration at 2.5% w/w. The release data obtained in this study were examined by the Q vs ¹_/2 relationship …

In Vitro Comparative Studies On The Effect Of Vinblastine Sulfate And Hyperthermia On Normal And Transformed Human Lung Fibroblasts, Fernando Alberto Duk

University of the Pacific Theses and Dissertations

Although the differential response of malignant cells to hyperthermia was observed at the end of the last century, few investigations into the phenomenon were made until fairly recently. At first the results obtained were inconsistent due mostly to the inefficient techniques in use at the time. The advent of cell and tissue culture, increased knowledge in tumor biology, advances in molecular biology, and the development of equipment which could raise and monitor the temperature of tumors during hyperthermic treatments, have made the study of the effects of supranormal temperature on malignant neoplasias substantially more reliable.

The effectiveness of the combined …

Pharmacologic Investigation In Mice Of The Effects Of Narcotic Antagonists On Dopamine Agonist Reversal Of Oxotremorine Or Reserpine, Mike Minoru Namba

University of the Pacific Theses and Dissertations

In the present study, two different drugs were used to induce a Parkinson-like condition. The first drug was the centrally acting cholinergic agonist oxotremorine (OXTM) which readily induces tremor and rigidity in mice (54). This tremor has been reported to be antagonized by dopamine agonists such as L-dopa and apomorphine (50,54,55) as well as by anticholinergic drugs such as scopolamine (46) . The other drug used was reserpine which interferes with the neuronal storage of dopamine and results in its depletion in the brain (56). Reserpine induces tremor, rigidity, blepharoptosis (a drooping of the eyelids), and catalepsy (48,57-59). The catalepsy …