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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Tobacco/Hiv-1-Induced Myeloid Cell-Derived Extracellular Vesicles In Hiv-1 Pathogenesis, Sanjana Haque
Tobacco/Hiv-1-Induced Myeloid Cell-Derived Extracellular Vesicles In Hiv-1 Pathogenesis, Sanjana Haque
Theses and Dissertations (ETD)
Introduction. Smoking, which is highly prevalent in people living with HIV/AIDS, has been shown to exacerbate HIV-1 replication, in part via cytochrome P450 (CYP)-induced oxidative stress. CYP enzymes metabolize cigarette smoke condensate (CSC), causing oxidative stress and cytotoxicity. Our previous studies have demonstrated that CSC and specific CSC constituents, benzo(a)pyrene and nicotine, potentially induce CYPs, resulting in higher oxidative stress and subsequent exacerbation of HIV-1 replication in monocytes and macrophages. However, the exact mechanism behind tobacco-induced, oxidative stress-mediated enhancement of HIV-1 replication is still poorly understood. Extracellular vesicles (EVs) have recently gained attention for their unique nature as intercellular messengers …
Assessing Risk Factors For Esophageal Cancer, Mahadev Rao Dr
Assessing Risk Factors For Esophageal Cancer, Mahadev Rao Dr
Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations
Background: Esophageal cancer (EC) stands the 6th most frequent cause of death due to cancer worldwide.It is mainly classified into mainly Esophageal squamous cell carcinoma (ESCC) and Esophageal adenocarcinoma (EAC). The incidence extends from Eastern to Central Asia. Although there are advances in the management and treatment of EC patients, the generaloutcome is very poor. It is mainly because of the diagnosis during its advanced stages and due to the absence of early clinical symptoms. Therefore, it is an important health challenge .A clear picture regarding the risk factors and other patient demographics may help to improve the management of …
Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar
Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar
Theses and Dissertations
The purpose of this investigation was to evaluate the effects of smoking and gender on 1) tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) in a population of healthy subjects and 2) TIQs in an alcohol-dependent population undergoing in-patient detoxification. Comparison in plasma TIQs between the populations was additionally conducted. To support the clinical investigations, a HPLC-FD method was developed and validated to assess plasma concentrations of BCs, harman and norharman, while a HPLC-ESI-MS/MS method was validated to quantify the TIQs, R/S-salsolinol along with dopamine. Forty-one young volunteers were recruited including 19 nonsmokers (NS), 11 light smokers (LS) and 11 heavy smokers (HS), …