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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Evaluation Of Safety Outcomes Of Two Hydrocortisone Dosing Regimens In Patients In Septic Shock, Alexandra Rola, Joshua Wirtz, Daniel Kalaj, Vasil Rrushi, Megan Cadiz
Evaluation Of Safety Outcomes Of Two Hydrocortisone Dosing Regimens In Patients In Septic Shock, Alexandra Rola, Joshua Wirtz, Daniel Kalaj, Vasil Rrushi, Megan Cadiz
Posters
• Steroids are used in shock to minimize the impact of shock-induced dysregulation of inflammatory response – Hydrocortisone is preferred for its activity as a glucocorticoid and a mineralocorticoid • Available data on the use of hydrocortisone shows mixed benefit – Data to guide dosing is limited, use of 100 mg IV every 8 hours may have benefit over 50 mg IV every 6 hours • Use of steroids has been associated with potential risks, including gastrointestinal bleeding, hyperglycemia, hypernatremia, superinfection, etc.