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Articles 1 - 9 of 9
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang
Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang
Pharmaceutical Sciences Faculty Patents
Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.
Bis-Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Marharyta Pivavarchyk
Bis-Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Marharyta Pivavarchyk
Pharmaceutical Sciences Faculty Patents
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
Enantioselective Synthesis Of (+) And (–)-2-[1-(2,6-Dichlorophenoxy)-Ethyl]-1,3-Diazacyclopent-2-Ene, Peter A. Crooks, Ashish Pramod Vartak
Enantioselective Synthesis Of (+) And (–)-2-[1-(2,6-Dichlorophenoxy)-Ethyl]-1,3-Diazacyclopent-2-Ene, Peter A. Crooks, Ashish Pramod Vartak
Pharmaceutical Sciences Faculty Patents
Methods for the enantioselective synthesis of (+) and (−) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene involve converting (+) or (−) 1-methyl-1-[2,6-dichlorophenoxy]ethanamide to an (+) or (−) imino-ether intermediate by electrophilic attack of the amide oxygen by a trimethoxonium ion and, without isolation, converting the (+) or (−) imino-ether intermediate to (+) or (−) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene by adding ethylene diamine; and optionally converting the (+) or (−) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene into a pharmaceutically acceptable acid addition salt thereof.
Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, David Bom, Thomas Burke
Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, David Bom, Thomas Burke
Pharmaceutical Sciences Faculty Patents
To read this abstract, please download this patent.
Bioactive Peptide-Based Probes, Clair D. Hicks, Peter A. Crooks
Bioactive Peptide-Based Probes, Clair D. Hicks, Peter A. Crooks
Pharmaceutical Sciences Faculty Patents
A method for preparing a site-specific peptide probe, wherein the peptide is specific to a receptor, includes modifying a marker to include a tether molecule and covalently binding the tether molecule to the peptide. The present invention also provides a labeled probe, comprising a peptide specific for a receptor and a marker. The marker is modified to include a tether molecule capable of covalently binding to the peptide. The peptide is typically derived from a bacteriophage or is a synthetic analog or derivative of the peptide. The receptor will typically be found on a surface of a bacterial cell. The …
Derivatives Of Mithramycin And Methods Of Making And Uses Thereof, Jürgen Rohr, Lily L. Remsing, Mohammad Ner-E-Alam, Jose A. Salas, Carmen Mendez, Alfredo F. Brana, Ana M. Gonzalez
Derivatives Of Mithramycin And Methods Of Making And Uses Thereof, Jürgen Rohr, Lily L. Remsing, Mohammad Ner-E-Alam, Jose A. Salas, Carmen Mendez, Alfredo F. Brana, Ana M. Gonzalez
Pharmaceutical Sciences Faculty Patents
The invention, in one aspect, generally relates to mithramycin derivatives from mutated Streptomyces argillaceus and their production. The invention also relates using the derivatives for the treatment of various diseases. Finally, the invention relates to a mutated Streptomyces argillaceus useful in the production of the mithramycin derivatives.
Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, Bom David, Thomas Burke
Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, Bom David, Thomas Burke
Pharmaceutical Sciences Faculty Patents
To see this abstract, please download this patent.
Iodo-Nonoxynol-9-Derivatives And Methods For Their Use, George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel
Iodo-Nonoxynol-9-Derivatives And Methods For Their Use, George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel
Pharmaceutical Sciences Faculty Patents
Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.
Peptide Elastase Inhibitors And Methods, George Digenis, Bushra J. Agha, Kiyoshi Tsuji
Peptide Elastase Inhibitors And Methods, George Digenis, Bushra J. Agha, Kiyoshi Tsuji
Pharmaceutical Sciences Faculty Patents
To read this abstract, please download this patent.