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Pharmaceutical Sciences Faculty Patents

2020

Conductive channel-containing membrane

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Lipid Bilayer-Integrated Spp1 Connector Protein Nanopore And Spp1 Connector Protein Variants For Use As Lipid Bilayer-Integrated Nanopore, Peixuan Guo, Shaoying Wang May 2020

Lipid Bilayer-Integrated Spp1 Connector Protein Nanopore And Spp1 Connector Protein Variants For Use As Lipid Bilayer-Integrated Nanopore, Peixuan Guo, Shaoying Wang

Pharmaceutical Sciences Faculty Patents

A conductive channel-containing membrane includes a membrane layer, and a SPPl connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which conductance can occur when an electrical potential is applied across the membrane. A method of sensing a molecule, such as a polypeptide or nucleic acid molecule, makes use of the conductive channel- containing membrane. A method of DNA sequence makes use of the conductive channel-containing membrane.