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- Cytochrome P450 (2)
- Eis (2)
- Expression vectors (2)
- Inhibitors (2)
- Nucleic acid molecules (2)
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- Polypeptides (2)
- Transgenic plants (2)
- 15-PGDH (1)
- Activators (1)
- Activity (1)
- Antifungal activity (1)
- Artificial RNA (1)
- Body weight (1)
- Human conditions (1)
- Hydrazone compounds (1)
- Image analysis (1)
- Kanamycin A (1)
- Kanamycin resistance (1)
- Modulate (1)
- Mycobacterium tuberculosis (1)
- Nanostructure (1)
- Pharmaceutical composition (1)
- Prophylactic treatment (1)
- Small molecules (1)
- Therapeutic treatment (1)
- Tuberculosis (1)
Articles 1 - 8 of 8
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Image Anaysis For Predicting Body Weight In Humans, Jeffrey S. Barrett, Chee Ng
Image Anaysis For Predicting Body Weight In Humans, Jeffrey S. Barrett, Chee Ng
Pharmaceutical Sciences Faculty Patents
Systems and methods for determining body weight predictions and human conditions are disclosed. A body weight may be predicted by capturing at least one image of a human, and determining, from the image, a body weight prediction of the human by processing the at least one image with a data processor. The body weight prediction may further be based on an age-based weight factor. A model such as a neural network model may be used to predict body weight.
Rna-Based Compositions And Adjuvants For Prophylactic And Therapeutic Treatment, Peixuan Guo, Hui Li, Emil F. Khisamutdinov, Daniel L. Jasinski
Rna-Based Compositions And Adjuvants For Prophylactic And Therapeutic Treatment, Peixuan Guo, Hui Li, Emil F. Khisamutdinov, Daniel L. Jasinski
Pharmaceutical Sciences Faculty Patents
The present invention is directed towards an artificial RNA nano structure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an …
Compositions And Methods Of Modulating 15-Pgdh Activity, Sanford Markowitz, James K. Willson V, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antezak, Stanton Gerson, Kibeom Bae, Sung Yeun Yang, Amar Desai
Compositions And Methods Of Modulating 15-Pgdh Activity, Sanford Markowitz, James K. Willson V, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antezak, Stanton Gerson, Kibeom Bae, Sung Yeun Yang, Amar Desai
Pharmaceutical Sciences Faculty Patents
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
Pharmaceutical Sciences Faculty Patents
Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey
Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey
Pharmaceutical Sciences Faculty Patents
Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston
Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston
Pharmaceutical Sciences Faculty Patents
The invention relates to isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention relates to uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.
Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston
Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston
Pharmaceutical Sciences Faculty Patents
The invention relates to isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention relates to uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.
Bishydrazone-Based Antifungal Agents, Sylvie Garneau-Tsodikova, David S. Watt
Bishydrazone-Based Antifungal Agents, Sylvie Garneau-Tsodikova, David S. Watt
Pharmaceutical Sciences Faculty Patents
Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.