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Pharmacy and Pharmaceutical Sciences Commons™
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- BChE polypeptide (2)
- Butyrylcholinesterase (2)
- Catalytic (2)
- Cocaine hydrolysis (2)
- Derivatives (2)
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- Efficiency (2)
- Activity (1)
- Agents (1)
- Aluminum (1)
- Ammonium (1)
- Analgesic (1)
- Anesthetic (1)
- Anesthetics (1)
- Anti-cancer (1)
- Antileukemic (1)
- Benzocaine (1)
- Bis-quaternary (1)
- Cell (1)
- Compounds (1)
- Cytotoxic (1)
- Excipients (1)
- Flow-through filter (1)
- Inflammatory pain (1)
- Inhibitors (1)
- Medical solutions (1)
- Metal ion (1)
- Methylated triterpenes (1)
- Mithramycin (1)
- Neuropathic pain (1)
- Nociceptive pain (1)
Articles 1 - 9 of 9
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Bis-Quaternary Ammonium Salts As Pain Modulating Agents, Joseph R. Holtman, Peter A. Crooks, Linda Phyliss Dwoskin, J. Michael Mcintosh
Bis-Quaternary Ammonium Salts As Pain Modulating Agents, Joseph R. Holtman, Peter A. Crooks, Linda Phyliss Dwoskin, J. Michael Mcintosh
Pharmaceutical Sciences Faculty Patents
Provided are methods for using his-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
Proteasome Inhibitors, Kyung Bo Kim, Venod Kasam, Wooin Lee, Dong-Eun Kim, Zachary Miller, Chang-Guo Zhan, Do-Min Lee
Proteasome Inhibitors, Kyung Bo Kim, Venod Kasam, Wooin Lee, Dong-Eun Kim, Zachary Miller, Chang-Guo Zhan, Do-Min Lee
Pharmaceutical Sciences Faculty Patents
To see this patent's abstract, please download it.
Method And System For Producing Triterpenes, Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David Watt
Method And System For Producing Triterpenes, Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David Watt
Pharmaceutical Sciences Faculty Patents
A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid sequences encoding triterpene methyltransferases such as triterpene methyltransferases 1, 2, 3. Advantageously, the method and system includes transgenic plant cells via an expression vector for triterpene methyltransferase and optionally various triterpene synthase and prenyltransferase all with tags directing these enzymes to the chloroplast of the transgenic plant cells for using the chloroplast methyl erythritol phosphate (MEP) pathway in the triterpene biogenesis.
Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
Pharmaceutical Sciences Faculty Patents
To read this abstract, please download this patent.
Semi-Synthetic Mithramycin Derivatives With Anti-Cancer Activity, Jürgen Rohr, Daniel Scott, Markos Leggas, Jhong-Min Chen, Oleg V. Tsodikov
Semi-Synthetic Mithramycin Derivatives With Anti-Cancer Activity, Jürgen Rohr, Daniel Scott, Markos Leggas, Jhong-Min Chen, Oleg V. Tsodikov
Pharmaceutical Sciences Faculty Patents
Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or other cancer or neuro-disease associated with an aberrant erythroblast transformation- specific transcription factor.
High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang
High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang
Pharmaceutical Sciences Faculty Patents
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (-)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (-)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Sustained Release Of Topical Anesthetics, Michael Jay
Sustained Release Of Topical Anesthetics, Michael Jay
Pharmaceutical Sciences Faculty Patents
A composition and method to alleviate oral mucosal discomfort and irritation in an orthodontic patient. A wax matrix containing less that 15% analgesic/anesthetic agent such as benzocaine and excipients enhanced and extended release of the analgesic/anesthetic agent compared to known art formulations. The composition exhibited desirable aesthetic properties, was easy to apply, and the relatively lower concentration of active agent provided enhanced safety.
High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Liu Xue, Shurong Hou
High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Liu Xue, Shurong Hou
Pharmaceutical Sciences Faculty Patents
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Flow-Through Filter To Remove Aluminum From Medical Solutions, Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
Flow-Through Filter To Remove Aluminum From Medical Solutions, Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
Pharmaceutical Sciences Faculty Patents
A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent.