Pharmacy and Pharmaceutical Sciences Commons^™

3-Hydroxy-N-Methylpyrrolidone And Use As Transdermal Enhancer, George A. Digenis, Walter J. Doll, Amale Hawi

Pharmaceutical Sciences Faculty Patents

The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.

Biodegradable, Low Biological Toxicity Radiographic Contrast Medium And Method Of X-Ray Imaging, Michael J. Jay, Yun Ryo

Pharmaceutical Sciences Faculty Patents

A biodegradable, low biological toxicity, particulate radiographic contrast medium comprises biodegradable polymeric spheres of average molecular weight average diameter about 10-1,000 nm or about 0.01-1.0 micron carrying in at least radiographic contrasting amount of a radiographically opaque element.

A method of obtaining a tomographic image of the body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be taken-up by the body portion; and X-raying an area comprising the body portion.

A method of improving the contrast of a tomographic image of a …

Novel Peptidyl Carbamate Inhibitors Of The Enzyme Elastase, George A. Digenis, Bushra J. Agha

Pharmaceutical Sciences Faculty Patents

To see the abstract, please download this patent.