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Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Nasal Administration Of Propranolol, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi Aug 1981

Nasal Administration Of Propranolol, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering propranolol, a known β-andrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further relates to novel dosage forms of propranolol which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.


Testing The Integrity Of Liquid Containing Hermetically Sealed Containers By The Use Of Radioactive Markers, Patrick P. Deluca, L. David Butler May 1981

Testing The Integrity Of Liquid Containing Hermetically Sealed Containers By The Use Of Radioactive Markers, Patrick P. Deluca, L. David Butler

Pharmaceutical Sciences Faculty Patents

A method for detecting leaky ampules filled with a liquid such as a parenteral solution. The ampules to be tested are immersed in a solution containing a short-lived radionuclide, and a pressure differential is imposed between the solution containing the radionuclide and the parenteral solution or other liquid contained in the ampules. The ampules are then removed from solution, decontaminated to remove any solution adhering to the outer surface and pores thereof, dried, and finally examined for electromagnetic radiation, preferably gamma radiation, emanating from the interior of the ampules which would indicate a leaky condition thereof.


Synthesis And Use Of Diagnostic Radio-Pharmaceuticals Comprising Radioactive Isotopes Of Bromine With Dyes, John W. Triplett, Randall B. Smith Mar 1981

Synthesis And Use Of Diagnostic Radio-Pharmaceuticals Comprising Radioactive Isotopes Of Bromine With Dyes, John W. Triplett, Randall B. Smith

Pharmaceutical Sciences Faculty Patents

A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with 76Br, 77 Br or 82 Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either 76 Br2, 77 Br2 or 82 Br2. This is a substitution type of …