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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Electronic Theses and Dissertations
The fruit of the American cranberry (Vaccinium macrocarpon Aiton, Ericaceae) is a comfood and a top selling dietary supplement in the U.S. Cranberry juice is traditionally used for the prevention of urinary tract infections (UTIs), many of which are caused by P-fimbriated Escherichia coli. Human urine produced after cranberry juice consumption can prevent E. coli adhesion, but the urinary metabolites responsible for this activity are currently not known. High-molecular weight components of cranberry juice, specifically proanthocyanidin oligomers (PACs), are currently believed to be responsible for the ability of cranberry juice to prevent UTIs. Cranberry PACs can prevent the adherence of …
Structural Characterization And Bioactivity Of Cranberry Oligosaccharides, Kimberly M. Auker
Structural Characterization And Bioactivity Of Cranberry Oligosaccharides, Kimberly M. Auker
Electronic Theses and Dissertations
Complex carbohydrates from plant sources, such as the fruits of cranberry (Vaccinium macrocarpon Aiton), promote human health in a variety of ways. However, complete studies of carbohydrate function often hinge on a detailed understanding and thorough elucidation of the chemical structure. Several methods have been used in the structure elucidation of cranberry oligosaccharides, such as derivatization folloby analysis using gas chromatography-mass spectrometry (GC-MS). In this manner, the identity and quantity of glycosyl units within two cranberry oligosaccharides were investigated through hydrolysis of the oligomers and subsequent synthesis of trimethylsilyl and alditol acetate derivatives. Further analysis using partially methylated alditol acetate …