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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
The Impact Of Multidrug-Resistant Organisms On Outcomes In Patients With Diabetic Foot Infections, Oryan Henig, Jason M. Pogue, Emily Martin, Umar Hayat, Mahmoud Ja'ara, Paul E. Kilgore, Raymond Cha, Sorab Dhar, Keith S. Kaye
The Impact Of Multidrug-Resistant Organisms On Outcomes In Patients With Diabetic Foot Infections, Oryan Henig, Jason M. Pogue, Emily Martin, Umar Hayat, Mahmoud Ja'ara, Paul E. Kilgore, Raymond Cha, Sorab Dhar, Keith S. Kaye
Department of Pharmacy Practice
Background. Multidrug-resistant organisms (MDROs) are important diabetic foot infection (DFI) pathogens. This study evaluated the impact of DFIs associated with MDRO pathogens (DFI-MDRO) on clinical outcomes.
Methods. Adults admitted to Detroit Medical Center from January 2012 to December 2015 with culture-positive DFI were included. Associations between outcomes and DFI-MDRO (evaluated as a single group that included methicillin-resistant Staphylococcus aureus [MRSA], vancomycin-resistant enterococci, Enterobacteriaceae resistant to third-generation cephalosporin [3GCR-EC], Acinetobacter baumannii, and Pseudomonas aeruginosa) were analyzed. Outcomes included above- and below-knee lower extremity amputation (LEA), readmissions, and mortality within a year after DFI. A propensity score predicting the likelihood …