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Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Interactions Of Sodium Ethacrynate In Intravenous Admixture With Selected Cardiovascular And Psychotherapeutic Agents, Patrick N. Catania
Interactions Of Sodium Ethacrynate In Intravenous Admixture With Selected Cardiovascular And Psychotherapeutic Agents, Patrick N. Catania
University of the Pacific Theses and Dissertations
The possibility of drug incompatibilities is a matter of serious concern when administering two or more therapeutic agents. This is especially true in the case of parenteral administration when one must be aware not only of therapeutic interactions but also chemical and physical reactions that might occur.
In order to avoid incompatibilities, drug manufacturers have suggested that parenteral solutions be used immediately after reconstitution and that admixtures of parenteral products not be administered wherever possible (1,2). Physicians have also stressed the importance in avoiding multiple drug therapy (3,4). In spite of these suggestions, the practice of multiple drug therapy is …
Differential Spectrophotometric Analysis Of Intravenous Admixtures Containing Metaraminol With Selected Corticosteroids, Frederick Erin Turner
Differential Spectrophotometric Analysis Of Intravenous Admixtures Containing Metaraminol With Selected Corticosteroids, Frederick Erin Turner
University of the Pacific Theses and Dissertations
Intravenous admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their selection.
Because the majority of the reports published, to date, have used a visible change as the criterion for judging compatibility, it was the purpose of this study to demonstrate the use of spectrophotometric analysis to detect the occurrence of chemical interactions between two components of an intravenous admixture.