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Transdermal Delivery Of Drugs With Microneedles—Potential And Challenges, Kevin B. Ita
Transdermal Delivery Of Drugs With Microneedles—Potential And Challenges, Kevin B. Ita
Faculty Publications & Research of the TUC College of Pharmacy
Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving. There are also hydrogel-forming microneedles. A special attention is paid to hydrogel-forming microneedles. These are innovative microneedles which do not contain drugs but imbibe interstitial …
Solid Microneedles For Transdermal Delivery Of Amantadine Hydrochloride And Pramipexole Dihydrochloride, Mylien T. Hoang, Kevin B. Ita, Daniel A. Bair
Solid Microneedles For Transdermal Delivery Of Amantadine Hydrochloride And Pramipexole Dihydrochloride, Mylien T. Hoang, Kevin B. Ita, Daniel A. Bair
Faculty Publications & Research of the TUC College of Pharmacy
The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and characterization of the microchannel depth was performed using confocal laser scanning microscopy (CLSM) to demonstrate microchannel formation following microneedle roller application. We also report, for the first time, the use of TA.XT Plus Texture Analyzer to characterize burst force in pig skin for transdermal drug delivery experiments. This is the force required to rupture pig skin. The mean passive flux of amantadine hydrochloride, determined using a …